GREMLIN Database
TRPC - Indole-3-glycerol phosphate synthase
UniProt: P03964 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (244)
Sequences: 3727 (2447)
Seq/√Len: 156.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_P164_Q3.9371.00
6_I132_V3.3581.00
90_N121_I3.3051.00
8_Q85_F3.2341.00
134_D137_H3.0531.00
192_E218_F2.5821.00
159_A193_Q2.5291.00
28_S151_D2.5201.00
116_E144_E2.4111.00
17_V111_D2.4031.00
49_A87_Q2.3651.00
242_A245_A2.3581.00
61_V64_Q2.3131.00
8_Q84_P2.2881.00
205_V226_A2.2841.00
112_S140_E2.2551.00
159_A197_L2.2171.00
70_E101_S2.1721.00
97_K124_D2.1041.00
30_K172_D2.0871.00
213_L217_T2.0831.00
238_S241_K2.0731.00
146_G172_D1.9991.00
142_Y152_V1.9601.00
115_V126_I1.9571.00
28_S31_E1.9231.00
191_T224_A1.9191.00
189_K192_E1.8401.00
216_L227_V1.8351.00
137_H140_E1.8321.00
156_V162_L1.8311.00
176_V204_L1.8201.00
145_A152_V1.7991.00
42_L243_I1.7891.00
189_K193_Q1.7881.00
162_L198_V1.7021.00
91_S94_S1.7021.00
135_P167_K1.6931.00
30_K34_A1.6831.00
131_E161_T1.6651.00
16_L113_L1.6631.00
16_L117_E1.6561.00
71_A240_R1.6231.00
142_Y146_G1.6041.00
93_L104_V1.5971.00
12_E82_D1.5841.00
55_L87_Q1.5741.00
8_Q11_E1.5721.00
195_A204_L1.5641.00
116_E148_K1.5621.00
211_G232_S1.5321.00
206_S219_V1.5141.00
9_K12_E1.5091.00
192_E222_H1.5001.00
198_V204_L1.4861.00
130_G165_I1.4821.00
63_V96_V1.4641.00
106_R117_E1.4631.00
77_I100_V1.4551.00
180_N183_T1.4351.00
191_T206_S1.4341.00
218_F222_H1.4211.00
115_V141_L1.4051.00
90_N106_R1.3981.00
48_K92_Y1.3871.00
112_S144_E1.3801.00
76_A125_A1.3761.00
53_K231_E1.3451.00
139_H143_L1.3291.00
144_E147_E1.3261.00
180_N185_E1.3251.00
128_L133_L1.3041.00
241_K245_A1.2971.00
163_E197_L1.2901.00
97_K104_V1.2841.00
40_I227_V1.2771.00
27_R124_D1.2721.00
130_G138_L1.2611.00
94_S121_I1.2461.00
236_Q242_A1.2441.00
151_D173_I1.2371.00
145_A150_M1.2321.00
142_Y171_P1.2221.00
142_Y168_V1.2221.00
9_K82_D1.2211.00
143_L147_E1.2141.00
55_L58_E1.2081.00
217_T221_E1.2061.00
187_S193_Q1.1941.00
231_E235_R1.1931.00
70_E102_I1.1891.00
126_I145_A1.1881.00
63_V95_D1.1831.00
70_E100_V1.1811.00
160_S163_E1.1661.00
29_F76_A1.1641.00
153_L205_V1.1411.00
40_I216_L1.1391.00
23_P26_K1.1261.00
239_Q243_I1.1261.00
162_L194_I1.1261.00
106_R118_S1.1241.00
72_A240_R1.1241.00
89_E92_Y1.1151.00
10_K137_H1.1141.00
240_R244_H1.1111.00
67_K99_A1.1061.00
91_S95_D1.1051.00
15_T19_P1.0920.99
210_I216_L1.0900.99
162_L197_L1.0890.99
62_P96_V1.0720.99
6_I10_K1.0660.99
130_G164_Q1.0610.99
12_E83_T1.0570.99
67_K71_A1.0560.99
7_K10_K1.0540.99
16_L90_N1.0520.99
144_E148_K1.0500.99
68_D72_A1.0490.99
131_E182_K1.0480.99
142_Y169_F1.0460.99
46_V96_V1.0330.99
15_T18_L1.0270.99
60_F92_Y1.0130.99
34_A203_L1.0110.99
62_P66_A1.0100.99
5_I9_K1.0050.99
48_K87_Q1.0030.99
44_A74_A0.9920.99
68_D240_R0.9840.99
17_V113_L0.9770.99
214_E217_T0.9760.99
83_T89_E0.9680.99
189_K218_F0.9680.99
216_L229_I0.9660.99
36_P39_F0.9640.99
4_K8_Q0.9620.99
212_S215_H0.9620.99
158_D182_K0.9580.99
11_E14_K0.9550.99
90_N117_E0.9540.99
146_G152_V0.9530.99
26_K119_R0.9490.98
213_L220_N0.9470.98
1_M184_F0.9410.98
31_E35_S0.9380.98
30_K151_D0.9360.98
154_V171_P0.9350.98
180_N190_Q0.9320.98
63_V99_A0.9320.98
112_S137_H0.9290.98
9_K83_T0.9160.98
171_P174_L0.9160.98
12_E84_P0.9150.98
190_Q193_Q0.9140.98
211_G215_H0.9120.98
8_Q12_E0.9070.98
195_A224_A0.9070.98
3_E7_K0.8990.98
178_N191_T0.8900.98
165_I171_P0.8840.98
210_I219_V0.8840.98
53_K235_R0.8820.98
29_F125_A0.8730.97
166_L202_S0.8720.97
66_A100_V0.8690.97
215_H218_F0.8660.97
56_I234_M0.8550.97
4_K85_F0.8540.97
219_V224_A0.8520.97
92_Y95_D0.8510.97
110_I141_L0.8490.97
178_N206_S0.8430.97
168_V171_P0.8360.97
146_G151_D0.8340.97
63_V67_K0.8310.96
140_E144_E0.8300.96
30_K173_I0.8250.96
115_V144_E0.8250.96
184_F231_E0.8230.96
141_L144_E0.8210.96
46_V60_F0.8160.96
30_K203_L0.8140.96
36_P75_D0.8140.96
4_K84_P0.8140.96
34_A172_D0.8140.96
48_K55_L0.8140.96
203_L226_A0.8100.96
136_L140_E0.8050.96
72_A243_I0.8020.96
43_I205_V0.7980.96
191_T204_L0.7940.95
48_K60_F0.7910.95
153_L175_G0.7910.95
20_V113_L0.7910.95
232_S242_A0.7850.95
65_I239_Q0.7850.95
68_D239_Q0.7840.95
79_V104_V0.7840.95
173_I203_L0.7820.95
206_S224_A0.7810.95
42_L227_V0.7780.95
94_S98_R0.7780.95
56_I235_R0.7760.95
175_G207_E0.7700.95
178_N219_V0.7680.95
114_Q141_L0.7670.95
139_H167_K0.7640.94
31_E151_D0.7640.94
52_S80_L0.7630.94
12_E16_L0.7630.94
178_N190_Q0.7580.94
192_E224_A0.7570.94
107_K208_S0.7570.94
210_I229_I0.7570.94
92_Y96_V0.7560.94
110_I115_V0.7440.94
57_K239_Q0.7390.93
60_F65_I0.7350.93
96_V100_V0.7300.93
158_D161_T0.7260.93
33_L226_A0.7160.92
11_E15_T0.7150.92
115_V150_M0.7130.92
219_V227_V0.7120.92
55_L60_F0.7110.92
57_K65_I0.7100.92
130_G154_V0.7090.92
166_L198_V0.7080.92
163_E166_L0.7060.92
46_V66_A0.7020.91
64_Q68_D0.7000.91
65_I234_M0.7000.91
171_P202_S0.6970.91
236_Q245_A0.6960.91
229_I246_L0.6950.91
119_R150_M0.6940.91
159_A163_E0.6920.91
7_K11_E0.6900.91
9_K13_V0.6890.91
240_R243_I0.6880.91
125_A152_V0.6870.91
41_G75_D0.6860.91
186_T209_G0.6830.90
135_P139_H0.6800.90
20_V120_R0.6790.90
9_K16_L0.6760.90
166_L199_P0.6750.90
118_S126_I0.6720.90
76_A173_I0.6710.90
68_D238_S0.6660.89
82_D85_F0.6650.89
53_K211_G0.6650.89
13_V16_L0.6640.89
198_V202_S0.6590.89
131_E157_H0.6530.88
34_A225_R0.6490.88
109_F208_S0.6480.88
218_F221_E0.6470.88
157_H207_E0.6460.88
81_T106_R0.6460.88
112_S141_L0.6460.88
186_T206_S0.6380.87
83_T90_N0.6360.87
140_E143_L0.6350.87
110_I114_Q0.6350.87
60_F87_Q0.6330.87
77_I96_V0.6330.87
128_L141_L0.6330.87
42_L239_Q0.6320.87
14_K17_V0.6310.87
118_S121_I0.6310.87
23_P119_R0.6300.86
96_V99_A0.6290.86
242_A246_L0.6280.86
128_L138_L0.6250.86
241_K244_H0.6210.86
25_E119_R0.6200.86
178_N188_V0.6190.85
74_A243_I0.6160.85
208_S228_L0.6150.85
16_L20_V0.6140.85
110_I128_L0.6110.85
243_I247_F0.6090.85
113_L116_E0.6080.84
29_F151_D0.6040.84
107_K127_L0.6030.84
156_V190_Q0.6000.84
154_V165_I0.5990.84
133_L137_H0.5970.83
174_L202_S0.5950.83
66_A99_A0.5940.83
194_I198_V0.5940.83
66_A96_V0.5900.83
81_T93_L0.5890.83
29_F173_I0.5890.83
172_D201_E0.5850.82
4_K7_K0.5840.82
97_K118_S0.5830.82
79_V96_V0.5820.82
125_A151_D0.5800.82
160_S164_Q0.5780.81
61_V95_D0.5760.81
49_A55_L0.5730.81
80_L228_L0.5680.80
52_S175_G0.5670.80
33_L41_G0.5650.80
60_F234_M0.5640.80
176_V191_T0.5620.80
127_L228_L0.5620.80
42_L247_F0.5620.80
146_G169_F0.5590.79
166_L174_L0.5580.79
39_F225_R0.5570.79
96_V104_V0.5560.79
136_L139_H0.5560.79
57_K60_F0.5560.79
162_L204_L0.5550.79
13_V82_D0.5540.79
161_T164_Q0.5510.78
66_A77_I0.5510.78
193_Q197_L0.5480.78
73_K102_I0.5470.78
69_Y77_I0.5470.78
27_R101_S0.5440.77
80_L208_S0.5440.77
137_H141_L0.5440.77
138_L154_V0.5440.77
82_D184_F0.5430.77
40_I247_F0.5420.77
130_G161_T0.5410.77
76_A151_D0.5400.77
229_I232_S0.5360.76
232_S236_Q0.5330.76
50_S54_G0.5310.76
163_E167_K0.5310.76
5_I85_F0.5300.76
95_D99_A0.5300.76
188_V191_T0.5290.75
22_Q25_E0.5270.75
107_K155_E0.5240.75
3_E182_K0.5240.75
188_V210_I0.5240.75
9_K85_F0.5230.75
36_P41_G0.5200.74
82_D87_Q0.5200.74
190_Q194_I0.5180.74
129_I181_L0.5150.73
41_G226_A0.5140.73
35_S39_F0.5130.73
162_L195_A0.5120.73
64_Q67_K0.5110.73
115_V148_K0.5100.73
15_T237_T0.5090.73
6_I85_F0.5090.73
46_V65_I0.5090.73
14_K18_L0.5060.72
156_V165_I0.5060.72
233_L247_F0.5040.72
48_K57_K0.5030.72
1_M4_K0.5030.72
127_L208_S0.5030.72
74_A77_I0.5020.72
186_T231_E0.5010.71
194_I197_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1piiA 1 0.9799 100 0.292 Contact Map
1i4nA 1 0.9839 100 0.333 Contact Map
3tsmA 2 0.996 100 0.344 Contact Map
4a29A 1 0.9639 100 0.362 Contact Map
3qjaA 1 0.9357 100 0.374 Contact Map
1vc4A 2 0.9719 100 0.381 Contact Map
1hg3A 3 0.8153 100 0.639 Contact Map
1w0mA 3 0.8072 99.9 0.668 Contact Map
1jvnA 1 0.9277 99.9 0.692 Contact Map
2yzrA 5 0.8233 99.9 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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