GREMLIN Database
TRPE - Anthranilate synthase component 1
UniProt: P03963 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 515 (456)
Sequences: 5029 (3330)
Seq/√Len: 155.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
360_E388_R4.3861.00
359_A387_G4.2531.00
408_L432_G4.0651.00
231_K235_M3.6131.00
360_E391_K3.6021.00
99_N394_H3.5271.00
318_R333_E3.2091.00
308_H386_T3.1761.00
473_V476_A3.0661.00
260_E459_V2.9801.00
244_Y249_D2.9551.00
367_P386_T2.9251.00
244_Y422_E2.8761.00
231_K475_E2.8661.00
317_T378_V2.7721.00
46_Y64_G2.7441.00
368_E371_K2.7251.00
235_M475_E2.6621.00
234_F466_A2.5811.00
230_E233_A2.5711.00
243_S247_A2.5371.00
93_E96_E2.5141.00
260_E461_S2.5041.00
95_K98_L2.4791.00
415_R418_Q2.4731.00
436_A446_S2.4391.00
332_V336_K2.3891.00
365_S386_T2.3851.00
262_P459_V2.3461.00
390_K393_V2.3301.00
331_K374_S2.3301.00
229_Y237_D2.3291.00
59_R160_D2.3211.00
328_E332_V2.3091.00
236_A239_E2.3071.00
393_V397_D2.2911.00
126_Y417_M2.2781.00
307_G388_R2.2731.00
25_T165_N2.2571.00
267_A292_E2.2491.00
293_I430_T2.1671.00
250_I253_G2.1601.00
37_I45_T2.1151.00
308_H388_R2.1141.00
335_M381_I2.0491.00
355_I359_A2.0301.00
94_L98_L2.0181.00
320_R327_D2.0151.00
241_I253_G2.0131.00
372_I381_I1.9971.00
62_F158_A1.9851.00
46_Y121_V1.9311.00
405_A448_I1.9191.00
324_K328_E1.9151.00
328_E331_K1.9131.00
38_E272_R1.9041.00
284_Y435_I1.8991.00
93_E400_M1.8841.00
228_N426_T1.8631.00
93_E98_L1.8581.00
294_V455_V1.8491.00
36_M201_M1.8381.00
36_M159_Y1.8091.00
266_D269_E1.7881.00
284_Y295_G1.7861.00
455_V460_A1.7801.00
475_E479_E1.7781.00
374_S379_M1.7631.00
419_L423_L1.7571.00
239_E242_K1.7491.00
322_A326_E1.7341.00
326_E329_R1.7321.00
252_Q467_G1.6971.00
358_V401_S1.6851.00
311_I351_A1.6721.00
430_T449_T1.6531.00
255_L466_A1.6481.00
321_G326_E1.6471.00
231_K478_Y1.6461.00
479_E483_N1.6441.00
329_R333_E1.6381.00
239_E474_P1.6251.00
287_K292_E1.6151.00
330_L333_E1.6121.00
98_L102_N1.6101.00
314_I382_I1.6081.00
312_H373_V1.5801.00
241_I255_L1.5751.00
155_T193_E1.5651.00
360_E390_K1.5601.00
127_D421_Q1.5591.00
323_D326_E1.5551.00
309_L359_A1.5271.00
120_A152_V1.5191.00
243_S246_K1.5181.00
399_L438_I1.5171.00
141_K144_D1.5101.00
453_M460_A1.5041.00
337_D340_E1.4941.00
33_P159_Y1.4801.00
263_I455_V1.4711.00
124_L128_M1.4701.00
244_Y415_R1.4681.00
321_G330_L1.4511.00
300_R445_D1.4471.00
355_I387_G1.4441.00
238_V474_P1.4441.00
240_K422_E1.4441.00
225_V261_V1.4321.00
373_V382_I1.4301.00
235_M239_E1.4291.00
312_H368_E1.4151.00
399_L446_S1.4111.00
466_A481_S1.4021.00
49_E275_R1.3961.00
295_G447_C1.3891.00
356_G362_G1.3801.00
255_L468_I1.3761.00
257_Q481_S1.3731.00
310_E386_T1.3621.00
331_K372_I1.3551.00
244_Y419_L1.3521.00
304_V398_A1.3471.00
127_D427_P1.3431.00
309_L355_I1.3411.00
233_A236_A1.3391.00
305_Q443_N1.3391.00
61_S161_H1.3331.00
235_M474_P1.3191.00
285_Y292_E1.3171.00
233_A425_P1.3161.00
270_L455_V1.3151.00
238_V468_I1.3101.00
325_A329_R1.3071.00
284_Y293_I1.3071.00
168_F194_L1.2921.00
226_S262_P1.2921.00
187_F191_H1.2891.00
345_Y369_F1.2851.00
437_Y445_D1.2801.00
240_K243_S1.2791.00
168_F197_L1.2761.00
415_R422_E1.2751.00
476_A479_E1.2681.00
231_K479_E1.2671.00
389_L398_A1.2671.00
158_A169_I1.2671.00
479_E482_C1.2601.00
348_V369_F1.2581.00
267_A455_V1.2531.00
236_A240_K1.2521.00
124_L438_I1.2511.00
31_L39_K1.2481.00
478_Y482_C1.2381.00
138_S421_Q1.2371.00
430_T454_S1.2361.00
233_A237_D1.2301.00
256_S463_Q1.2281.00
135_S418_Q1.2271.00
367_P384_V1.2271.00
254_V465_G1.2091.00
304_V309_L1.2041.00
453_M488_L1.1781.00
232_S236_A1.1741.00
345_Y370_T1.1701.00
273_V494_I1.1691.00
462_I489_L1.1631.00
44_I70_T1.1541.00
72_K79_S1.1511.00
329_R332_V1.1501.00
270_L453_M1.1491.00
270_L294_V1.1331.00
240_K244_Y1.1331.00
341_K370_T1.1291.00
284_Y447_C1.1271.00
355_I402_A1.1231.00
396_V438_I1.1221.00
246_K470_A1.1221.00
250_I416_A1.1161.00
152_V440_F1.1161.00
227_S257_Q1.1131.00
262_P458_G1.1131.00
159_Y166_V1.1131.00
464_A485_A1.1101.00
278_N296_S1.1081.00
331_K379_M1.1050.99
141_K427_P1.1010.99
241_I468_I1.1000.99
229_Y425_P1.0860.99
145_M454_S1.0810.99
282_Y300_R1.0790.99
268_F285_Y1.0760.99
239_E243_S1.0760.99
194_L198_I1.0600.99
490_K493_H1.0590.99
312_H384_V1.0590.99
241_I250_I1.0570.99
295_G435_I1.0570.99
49_E271_Y1.0560.99
68_F152_V1.0560.99
478_Y481_S1.0540.99
315_A407_T1.0500.99
157_I166_V1.0490.99
168_F198_I1.0480.99
67_P153_C1.0480.99
258_K461_S1.0450.99
253_G420_L1.0450.99
68_F154_R1.0420.99
116_F121_V1.0400.99
263_I270_L1.0390.99
439_G443_N1.0370.99
155_T170_Q1.0360.99
267_A285_Y1.0330.99
94_L148_C1.0290.99
150_L446_S1.0280.99
304_V395_P1.0270.99
257_Q482_C1.0210.99
435_I449_T1.0210.99
466_A476_A1.0200.99
360_E363_S1.0190.99
115_P305_Q1.0190.99
130_P137_P1.0160.99
25_T167_H1.0140.99
130_P421_Q1.0120.99
96_E100_W1.0120.99
143_T461_S1.0110.99
29_D32_T1.0110.99
263_I460_A1.0090.99
310_E384_V1.0090.99
259_F482_C1.0050.99
124_L150_L1.0040.99
486_G490_K1.0020.99
257_Q478_Y0.9990.99
271_Y275_R0.9990.99
72_K149_M0.9980.99
29_D272_R0.9950.99
70_T149_M0.9910.99
95_K102_N0.9900.99
253_G419_L0.9880.99
261_V460_A0.9880.99
332_V335_M0.9880.99
142_E426_T0.9850.99
225_V489_L0.9820.99
149_M288_L0.9820.99
136_V418_Q0.9800.99
99_N103_T0.9790.99
462_I485_A0.9740.99
139_H421_Q0.9670.99
301_L311_I0.9660.99
347_L407_T0.9590.99
421_Q427_P0.9560.99
315_A347_L0.9540.99
315_A344_H0.9500.98
283_M296_S0.9490.98
223_E262_P0.9460.98
434_C446_S0.9460.98
318_R330_L0.9460.98
304_V389_L0.9450.98
309_L398_A0.9420.98
129_I417_M0.9400.98
94_L102_N0.9380.98
307_G391_K0.9370.98
280_S283_M0.9350.98
254_V409_T0.9310.98
319_K330_L0.9300.98
335_M372_I0.9300.98
64_G121_V0.9290.98
254_V408_L0.9280.98
46_Y153_C0.9280.98
74_E77_R0.9280.98
278_N377_H0.9270.98
116_F119_G0.9230.98
290_D456_K0.9210.98
132_I403_F0.9210.98
249_D415_R0.9200.98
42_R66_N0.9200.98
356_G361_Y0.9120.98
127_D130_P0.9100.98
301_L402_A0.9100.98
128_M148_C0.9090.98
242_K246_K0.9080.98
319_K483_N0.9070.98
191_H195_Q0.9030.98
280_S377_H0.8990.98
66_N155_T0.8960.98
42_R287_K0.8950.98
375_F382_I0.8940.98
188_H192_L0.8920.98
156_L169_I0.8900.98
226_S260_E0.8880.98
128_M131_L0.8870.98
125_S147_K0.8840.98
96_E99_N0.8830.98
227_S481_S0.8820.98
199_E203_D0.8820.98
344_H347_L0.8810.97
198_I202_M0.8770.97
242_K470_A0.8760.97
59_R162_E0.8750.97
306_D443_N0.8650.97
37_I285_Y0.8650.97
32_T35_Q0.8640.97
334_L372_I0.8640.97
124_L399_L0.8610.97
99_N397_D0.8600.97
149_M291_R0.8590.97
259_F489_L0.8580.97
232_S235_M0.8520.97
98_L105_Y0.8520.97
300_R310_E0.8460.97
121_V286_M0.8440.97
273_V495_A0.8430.97
241_I423_L0.8430.97
85_S88_L0.8410.97
193_E196_N0.8410.97
254_V432_G0.8410.97
307_G360_E0.8390.97
415_R419_L0.8350.97
337_D476_A0.8330.96
62_F156_L0.8330.96
395_P444_I0.8310.96
124_L148_C0.8300.96
196_N200_K0.8280.96
133_E414_I0.8210.96
368_E384_V0.8200.96
318_R340_E0.8200.96
195_Q199_E0.8170.96
68_F120_A0.8160.96
419_L422_E0.8150.96
195_Q198_I0.8140.96
319_K322_A0.8130.96
228_N260_E0.8120.96
145_M291_R0.8110.96
453_M462_I0.8110.96
100_W103_T0.8080.96
264_K458_G0.8080.96
60_Y158_A0.8080.96
239_E246_K0.8050.96
292_E455_V0.8030.96
93_E97_V0.8010.96
144_D456_K0.7990.96
123_Y430_T0.7990.96
271_Y294_V0.7980.96
99_N400_M0.7980.96
99_N102_N0.7980.96
124_L446_S0.7970.95
253_G416_A0.7920.95
366_V369_F0.7860.95
34_I272_R0.7840.95
319_K479_E0.7840.95
229_Y233_A0.7800.95
319_K476_A0.7800.95
341_K369_F0.7790.95
37_I63_I0.7780.95
134_P418_Q0.7770.95
132_I400_M0.7720.95
131_L147_K0.7720.95
65_L155_T0.7710.95
244_Y418_Q0.7710.95
326_E330_L0.7700.95
405_A447_C0.7700.95
258_K426_T0.7680.94
94_L131_L0.7650.94
93_E131_L0.7600.94
344_H407_T0.7600.94
92_N98_L0.7590.94
291_R456_K0.7580.94
340_E476_A0.7580.94
312_H371_K0.7560.94
344_H432_G0.7560.94
311_I402_A0.7530.94
250_I419_L0.7480.94
74_E79_S0.7460.94
103_T394_H0.7460.94
311_I355_I0.7450.94
301_L351_A0.7440.94
130_P147_K0.7420.93
235_M473_V0.7420.93
372_I379_M0.7410.93
116_F445_D0.7400.93
82_D85_S0.7370.93
73_E78_F0.7360.93
318_R483_N0.7360.93
145_M430_T0.7350.93
300_R312_H0.7350.93
408_L450_I0.7340.93
377_H487_A0.7330.93
237_D255_L0.7320.93
376_S487_A0.7300.93
98_L104_T0.7300.93
371_K384_V0.7270.93
399_L444_I0.7260.93
74_E147_K0.7220.92
228_N257_Q0.7210.92
333_E336_K0.7210.92
97_V100_W0.7180.92
489_L493_H0.7160.92
344_H351_A0.7160.92
363_S388_R0.7150.92
171_Y440_F0.7130.92
238_V242_K0.7100.92
89_Y92_N0.7100.92
302_I398_A0.7090.92
344_H379_M0.7090.92
129_I132_I0.7070.92
414_I417_M0.7070.92
73_E131_L0.7070.92
293_I435_I0.7060.92
408_L448_I0.7060.92
82_D86_K0.7030.91
62_F121_V0.7020.91
235_M238_V0.7010.91
351_A405_A0.7000.91
237_D241_I0.6990.91
83_Q86_K0.6990.91
133_E357_R0.6980.91
98_L150_L0.6980.91
304_V444_I0.6970.91
426_T463_Q0.6950.91
143_T427_P0.6920.91
277_V377_H0.6880.91
72_K81_A0.6860.90
137_P427_P0.6860.90
36_M157_I0.6850.90
258_K463_Q0.6850.90
49_E283_M0.6850.90
53_D58_S0.6840.90
293_I449_T0.6840.90
245_I470_A0.6820.90
92_N96_E0.6820.90
278_N487_A0.6810.90
137_P421_Q0.6800.90
301_L315_A0.6780.90
323_D329_R0.6770.90
286_M435_I0.6760.90
35_Q39_K0.6750.90
304_V307_G0.6730.90
319_K326_E0.6730.90
438_I444_I0.6700.89
358_V398_A0.6700.89
335_M341_K0.6690.89
288_L291_R0.6680.89
41_D287_K0.6670.89
402_A447_C0.6650.89
37_I268_F0.6650.89
196_N199_E0.6650.89
73_E148_C0.6640.89
192_L196_N0.6630.89
255_L423_L0.6620.89
77_R89_Y0.6620.89
124_L436_A0.6610.89
241_I420_L0.6560.88
268_F272_R0.6560.88
394_H397_D0.6550.88
311_I385_V0.6530.88
242_K474_P0.6510.88
92_N102_N0.6510.88
405_A408_L0.6510.88
39_K204_Q0.6500.88
198_I201_M0.6490.88
45_T287_K0.6490.88
301_L344_H0.6490.88
309_L389_L0.6480.88
403_F448_I0.6480.88
38_E268_F0.6480.88
95_K128_M0.6480.88
350_L406_G0.6420.87
256_S465_G0.6410.87
293_I452_T0.6390.87
189_Q192_L0.6380.87
238_V466_A0.6380.87
172_A190_N0.6380.87
347_L466_A0.6350.87
309_L387_G0.6350.87
455_V458_G0.6340.87
256_S481_S0.6330.87
130_P136_V0.6330.87
92_N100_W0.6330.87
146_E291_R0.6310.86
341_K381_I0.6310.86
224_T493_H0.6310.86
315_A466_A0.6300.86
68_F440_F0.6280.86
365_S388_R0.6270.86
351_A432_G0.6250.86
407_T466_A0.6240.86
31_L35_Q0.6220.86
318_R379_M0.6220.86
380_H467_G0.6220.86
335_M338_E0.6200.85
353_N357_R0.6200.85
388_R391_K0.6200.85
33_P166_V0.6200.85
254_V380_H0.6190.85
29_D34_I0.6190.85
79_S88_L0.6180.85
78_F97_V0.6170.85
303_H310_E0.6150.85
254_V351_A0.6150.85
147_K427_P0.6140.85
119_G440_F0.6140.85
234_F481_S0.6140.85
82_D88_L0.6130.85
325_A328_E0.6130.85
102_N105_Y0.6120.85
34_I268_F0.6120.85
259_F464_A0.6120.85
267_A287_K0.6110.85
351_A447_C0.6110.85
342_A471_D0.6090.84
99_N396_V0.6090.84
295_G405_A0.6080.84
91_G94_L0.6080.84
483_N486_G0.6070.84
227_S464_A0.6060.84
482_C486_G0.6050.84
284_Y405_A0.6050.84
356_G359_A0.6030.84
139_H425_P0.6020.84
295_G408_L0.6010.84
28_V32_T0.5990.83
432_G447_C0.5970.83
418_Q422_E0.5960.83
101_M104_T0.5960.83
340_E466_A0.5950.83
143_T258_K0.5950.83
416_A467_G0.5940.83
71_I97_V0.5940.83
124_L403_F0.5930.83
63_I157_I0.5930.83
143_T429_E0.5920.83
69_L80_A0.5910.83
81_A84_D0.5910.83
344_H348_V0.5900.83
414_I418_Q0.5900.83
333_E337_D0.5900.83
338_E471_D0.5880.82
491_T495_A0.5880.82
43_E289_L0.5880.82
254_V295_G0.5870.82
190_N201_M0.5870.82
157_I197_L0.5860.82
302_I402_A0.5860.82
254_V405_A0.5850.82
188_H191_H0.5840.82
454_S461_S0.5840.82
51_K54_T0.5830.82
82_D87_S0.5830.82
277_V490_K0.5820.82
70_T151_F0.5810.82
153_C156_L0.5810.82
490_K494_I0.5810.82
468_I476_A0.5810.82
44_I149_M0.5810.82
257_Q452_T0.5810.82
62_F437_Y0.5800.81
341_K345_Y0.5790.81
91_G99_N0.5780.81
33_P49_E0.5770.81
126_Y409_T0.5770.81
312_H375_F0.5760.81
252_Q380_H0.5760.81
284_Y452_T0.5750.81
193_E198_I0.5720.81
141_K456_K0.5710.80
101_M105_Y0.5700.80
237_D425_P0.5700.80
133_E136_V0.5690.80
301_L347_L0.5690.80
327_D379_M0.5690.80
96_E102_N0.5690.80
197_L201_M0.5680.80
340_E407_T0.5680.80
229_Y257_Q0.5670.80
94_L104_T0.5670.80
103_T106_K0.5660.80
227_S478_Y0.5650.80
270_L460_A0.5640.80
403_F432_G0.5630.80
254_V447_C0.5620.79
314_I450_I0.5590.79
76_G131_L0.5570.79
117_V441_D0.5570.79
289_L292_E0.5570.79
235_M478_Y0.5560.79
155_T168_F0.5540.78
464_A481_S0.5540.78
344_H383_S0.5540.78
105_Y440_F0.5540.78
35_Q38_E0.5530.78
241_I419_L0.5530.78
115_P303_H0.5520.78
405_A432_G0.5510.78
256_S407_T0.5510.78
231_K257_Q0.5500.78
349_D352_R0.5500.78
160_D165_N0.5500.78
294_V452_T0.5490.78
325_A391_K0.5480.78
349_D354_D0.5470.78
249_D353_N0.5470.78
117_V439_G0.5460.77
267_A294_V0.5460.77
252_Q469_V0.5460.77
116_F156_L0.5460.77
157_I168_F0.5450.77
310_E367_P0.5430.77
307_G389_L0.5430.77
161_H164_K0.5430.77
331_K335_M0.5420.77
65_L197_L0.5410.77
30_T38_E0.5400.77
40_L63_I0.5400.77
453_M491_T0.5400.77
48_L286_M0.5390.77
307_G392_G0.5380.76
336_K341_K0.5380.76
280_S487_A0.5380.76
261_V492_I0.5370.76
279_P296_S0.5360.76
123_Y145_M0.5360.76
294_V453_M0.5360.76
456_K459_V0.5360.76
286_M293_I0.5360.76
265_A270_L0.5350.76
129_I133_E0.5350.76
220_P264_K0.5350.76
296_S488_L0.5350.76
84_D87_S0.5340.76
485_A489_L0.5340.76
351_A407_T0.5330.76
91_G95_K0.5320.76
273_V493_H0.5320.76
252_Q416_A0.5300.75
178_E189_Q0.5260.75
301_L407_T0.5250.75
51_K283_M0.5240.75
66_N193_E0.5240.75
49_E347_L0.5240.75
129_I421_Q0.5240.75
242_K469_V0.5230.74
320_R374_S0.5230.74
422_E425_P0.5230.74
62_F116_F0.5220.74
237_D423_L0.5210.74
42_R200_K0.5210.74
274_L488_L0.5210.74
69_L101_M0.5200.74
230_E235_M0.5200.74
300_R303_H0.5200.74
277_V491_T0.5190.74
408_L488_L0.5190.74
34_I47_L0.5190.74
344_H374_S0.5190.74
141_K258_K0.5180.74
395_P442_G0.5180.74
380_H408_L0.5180.74
41_D266_D0.5170.74
402_A446_S0.5170.74
79_S87_S0.5170.74
254_V416_A0.5170.74
120_A150_L0.5170.74
338_E341_K0.5150.73
340_E347_L0.5130.73
407_T463_Q0.5120.73
139_H142_E0.5110.73
49_E315_A0.5100.73
284_Y294_V0.5100.73
234_F255_L0.5090.72
77_R88_L0.5090.72
245_I250_I0.5090.72
92_N97_V0.5090.72
347_L351_A0.5090.72
296_S437_Y0.5090.72
94_L105_Y0.5050.72
199_E219_T0.5050.72
228_N258_K0.5040.72
352_R411_A0.5030.72
120_A440_F0.5020.71
97_V101_M0.5020.71
142_E258_K0.5010.71
254_V284_Y0.5010.71
368_E373_V0.5000.71
122_G150_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i1qA 2 0.899 100 0.227 Contact Map
1k0eA 1 0.8485 100 0.231 Contact Map
4grhA 1 0.8311 100 0.248 Contact Map
1qdlA 1 0.8 100 0.257 Contact Map
3logA 1 0.8621 100 0.3 Contact Map
3h9mA 1 0.7573 100 0.305 Contact Map
2fn0A 2 0.7942 100 0.337 Contact Map
3gseA 1 0.8058 100 0.395 Contact Map
3bzmA 1 0.8136 100 0.427 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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