TRPD - BACSU - GREMLIN Contacts

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TRPD - Anthranilate phosphoribosyltransferase

UniProt:	P03947	Sequences: MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILAHRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGAKIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHVAGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSSRDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNIFENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEEEIYA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	338 (329)
Sequences:	5019 (3276)
Seq/√Len:	180.6

ECOLI - TRPGD YBIB
BACSU - TRPD
HALSA - TRPD Q9HNW7
SULSO - TRPD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
275_N	280_K	3.945	1.00
7_L	18_E	3.551	1.00
325_Q	328_R	3.538	1.00
99_A	316_T	3.404	1.00
16_A	58_K	3.264	1.00
286_L	318_T	3.069	1.00
278_E	323_A	2.869	1.00
225_L	231_T	2.776	1.00
138_S	142_T	2.722	1.00
13_T	46_R	2.687	1.00
249_E	255_N	2.577	1.00
271_Y	275_N	2.536	1.00
265_S	268_E	2.500	1.00
20_E	58_K	2.495	1.00
199_G	243_E	2.378	1.00
100_A	316_T	2.374	1.00
20_E	62_A	2.368	1.00
315_E	319_S	2.337	1.00
225_L	295_A	2.325	1.00
32_T	166_E	2.295	1.00
305_S	308_E	2.244	1.00
198_A	234_I	2.217	1.00
140_I	146_G	2.216	1.00
38_G	41_S	2.216	1.00
24_N	63_H	2.205	1.00
92_A	273_I	2.191	1.00
15_T	18_E	2.147	1.00
54_A	207_T	2.071	1.00
132_T	135_K	2.056	1.00
257_R	260_D	2.021	1.00
290_A	314_L	2.013	1.00
100_A	297_I	1.964	1.00
7_L	12_K	1.940	1.00
22_L	39_I	1.921	1.00
16_A	55_G	1.875	1.00
136_V	146_G	1.862	1.00
26_M	36_M	1.829	1.00
32_T	35_E	1.828	1.00
321_G	324_A	1.815	1.00
303_T	309_G	1.813	1.00
235_E	244_Y	1.800	1.00
311_E	314_L	1.793	1.00
102_A	297_I	1.776	1.00
214_M	299_T	1.769	1.00
25_M	30_E	1.765	1.00
227_I	256_G	1.759	1.00
124_E	267_K	1.758	1.00
263_V	269_S	1.749	1.00
195_V	232_D	1.746	1.00
96_V	289_T	1.741	1.00
24_N	62_A	1.704	1.00
97_A	102_A	1.699	1.00
219_R	232_D	1.697	1.00
199_G	203_S	1.688	1.00
19_A	56_F	1.675	1.00
143_N	325_Q	1.675	1.00
206_E	236_L	1.672	1.00
294_G	309_G	1.658	1.00
28_A	63_H	1.648	1.00
233_V	244_Y	1.623	1.00
234_I	241_R	1.615	1.00
324_A	327_E	1.615	1.00
247_S	255_N	1.598	1.00
247_S	250_D	1.588	1.00
99_A	325_Q	1.583	1.00
214_M	295_A	1.574	1.00
127_V	329_L	1.556	1.00
60_M	180_S	1.552	1.00
135_K	138_S	1.535	1.00
97_A	296_A	1.530	1.00
55_G	59_A	1.527	1.00
137_K	141_E	1.521	1.00
304_A	308_E	1.513	1.00
131_T	135_K	1.503	1.00
274_Q	330_K	1.493	1.00
24_N	59_A	1.490	1.00
302_I	312_L	1.482	1.00
186_K	211_K	1.478	1.00
323_A	327_E	1.472	1.00
324_A	328_R	1.470	1.00
93_S	293_A	1.469	1.00
41_S	169_F	1.460	1.00
286_L	314_L	1.430	1.00
145_M	329_L	1.426	1.00
264_Q	269_S	1.423	1.00
294_G	298_Y	1.422	1.00
77_C	188_Q	1.410	1.00
56_F	172_V	1.403	1.00
230_P	245_T	1.399	1.00
98_S	325_Q	1.387	1.00
143_N	332_K	1.372	1.00
4_F	22_L	1.372	1.00
259_E	262_Q	1.366	1.00
38_G	167_L	1.360	1.00
327_E	330_K	1.358	1.00
33_P	166_E	1.355	1.00
89_I	288_I	1.354	1.00
68_D	137_K	1.353	1.00
175_L	197_K	1.350	1.00
102_A	302_I	1.345	1.00
314_L	318_T	1.342	1.00
66_T	184_Q	1.340	1.00
50_P	54_A	1.335	1.00
131_T	139_S	1.334	1.00
13_T	49_T	1.333	1.00
13_T	51_E	1.327	1.00
110_R	120_D	1.327	1.00
9_V	41_S	1.326	1.00
279_N	318_T	1.313	1.00
212_H	237_K	1.311	1.00
139_S	332_K	1.304	1.00
44_A	48_E	1.297	1.00
213_V	236_L	1.291	1.00
9_V	169_F	1.290	1.00
84_I	222_L	1.283	1.00
23_M	56_F	1.273	1.00
125_L	270_A	1.271	1.00
36_M	163_T	1.266	1.00
74_V	296_A	1.259	1.00
121_V	273_I	1.258	1.00
256_G	284_S	1.251	1.00
219_R	229_A	1.242	1.00
39_I	43_L	1.239	1.00
205_L	213_V	1.227	1.00
16_A	207_T	1.226	1.00
51_E	55_G	1.223	1.00
293_A	313_A	1.220	1.00
274_Q	278_E	1.217	1.00
277_F	322_A	1.212	1.00
24_N	28_A	1.209	1.00
127_V	330_K	1.196	1.00
274_Q	327_E	1.195	1.00
41_S	45_H	1.195	1.00
210_P	213_V	1.185	1.00
22_L	31_M	1.181	1.00
34_S	166_E	1.179	1.00
220_D	229_A	1.175	1.00
315_E	321_G	1.157	1.00
121_V	270_A	1.157	1.00
290_A	310_T	1.140	1.00
34_S	37_G	1.139	1.00
128_S	135_K	1.131	1.00
230_P	247_S	1.122	1.00
73_I	185_A	1.119	1.00
309_G	313_A	1.109	1.00
51_E	207_T	1.106	1.00
20_E	59_A	1.100	1.00
50_P	204_A	1.095	1.00
110_R	123_E	1.093	1.00
232_D	243_E	1.092	1.00
102_A	300_A	1.090	1.00
303_T	312_L	1.089	1.00
31_M	36_M	1.079	1.00
119_A	149_F	1.071	1.00
226_S	229_A	1.070	1.00
96_V	293_A	1.065	1.00
327_E	331_Q	1.062	1.00
328_R	331_Q	1.059	1.00
157_M	160_V	1.056	1.00
234_I	243_E	1.048	1.00
34_S	163_T	1.042	1.00
142_T	328_R	1.028	1.00
270_A	274_Q	1.027	1.00
232_D	245_T	1.018	0.99
160_V	163_T	1.016	0.99
17_G	20_E	1.016	0.99
59_A	63_H	1.015	0.99
19_A	55_G	1.003	0.99
139_S	143_N	0.988	0.99
6_Q	10_D	0.986	0.99
97_A	104_I	0.983	0.99
11_G	46_R	0.983	0.99
264_Q	268_E	0.982	0.99
294_G	310_T	0.976	0.99
72_D	186_K	0.975	0.99
312_L	316_T	0.968	0.99
14_L	52_E	0.967	0.99
54_A	58_K	0.967	0.99
93_S	97_A	0.967	0.99
203_S	206_E	0.961	0.99
60_M	157_M	0.955	0.99
225_L	246_V	0.952	0.99
212_H	235_E	0.951	0.99
39_I	56_F	0.945	0.99
247_S	251_F	0.942	0.99
218_S	229_A	0.940	0.99
36_M	160_V	0.938	0.99
311_E	315_E	0.938	0.99
307_K	311_E	0.934	0.99
236_L	241_R	0.926	0.99
260_D	284_S	0.925	0.99
35_E	166_E	0.924	0.99
87_F	272_L	0.923	0.99
136_V	153_Y	0.918	0.99
312_L	315_E	0.915	0.99
188_Q	210_P	0.913	0.99
206_E	241_R	0.909	0.99
187_R	211_K	0.909	0.99
253_F	291_F	0.907	0.99
235_E	298_Y	0.905	0.99
25_M	31_M	0.902	0.99
246_V	251_F	0.902	0.99
287_S	314_L	0.896	0.99
298_Y	305_S	0.894	0.99
276_I	285_A	0.891	0.99
73_I	105_A	0.890	0.99
227_I	288_I	0.890	0.99
251_F	310_T	0.885	0.99
266_P	270_A	0.881	0.98
115_K	265_S	0.881	0.98
46_R	52_E	0.874	0.98
48_E	53_L	0.872	0.98
274_Q	323_A	0.870	0.98
127_V	145_M	0.869	0.98
227_I	261_L	0.865	0.98
162_G	166_E	0.860	0.98
298_Y	309_G	0.859	0.98
271_Y	274_Q	0.855	0.98
57_V	208_F	0.855	0.98
267_K	271_Y	0.853	0.98
219_R	230_P	0.852	0.98
231_T	248_P	0.850	0.98
27_M	60_M	0.847	0.98
189_V	216_V	0.843	0.98
9_V	44_A	0.841	0.98
298_Y	303_T	0.841	0.98
282_S	285_A	0.836	0.98
219_R	245_T	0.835	0.98
103_K	141_E	0.834	0.98
20_E	55_G	0.833	0.98
16_A	51_E	0.830	0.98
225_L	291_F	0.827	0.98
294_G	306_L	0.826	0.98
256_G	287_S	0.824	0.98
112_V	151_P	0.823	0.98
97_A	103_K	0.823	0.98
48_E	170_R	0.820	0.98
22_L	36_M	0.814	0.97
176_L	188_Q	0.814	0.97
20_E	24_N	0.812	0.97
231_T	235_E	0.807	0.97
136_V	140_I	0.803	0.97
77_C	118_S	0.795	0.97
70_L	141_E	0.794	0.97
76_T	93_S	0.788	0.97
50_P	203_S	0.784	0.97
21_T	25_M	0.780	0.97
97_A	293_A	0.779	0.97
187_R	212_H	0.778	0.97
61_R	184_Q	0.774	0.97
301_G	309_G	0.773	0.96
143_N	329_L	0.768	0.96
214_M	298_Y	0.766	0.96
97_A	100_A	0.764	0.96
187_R	299_T	0.764	0.96
249_E	254_T	0.763	0.96
72_D	187_R	0.760	0.96
96_V	317_I	0.757	0.96
65_L	155_S	0.756	0.96
217_S	221_G	0.754	0.96
74_V	104_I	0.751	0.96
142_T	332_K	0.747	0.96
133_P	137_K	0.747	0.96
54_A	204_A	0.746	0.96
276_I	289_T	0.745	0.96
33_P	159_H	0.745	0.96
84_I	258_L	0.743	0.96
77_C	93_S	0.742	0.96
138_S	141_E	0.742	0.96
310_T	314_L	0.742	0.96
16_A	54_A	0.740	0.96
53_L	204_A	0.740	0.96
256_G	261_L	0.738	0.95
33_P	163_T	0.738	0.95
19_A	172_V	0.738	0.95
31_M	35_E	0.733	0.95
316_T	322_A	0.732	0.95
38_G	169_F	0.729	0.95
96_V	313_A	0.728	0.95
290_A	318_T	0.728	0.95
76_T	188_Q	0.727	0.95
74_V	102_A	0.725	0.95
192_V	201_M	0.723	0.95
82_D	85_S	0.716	0.95
275_N	281_S	0.716	0.95
268_E	271_Y	0.715	0.95
8_C	42_I	0.714	0.95
125_L	326_L	0.713	0.95
281_S	284_S	0.713	0.95
190_I	201_M	0.712	0.94
253_F	310_T	0.711	0.94
33_P	162_G	0.711	0.94
26_M	160_V	0.710	0.94
58_K	62_A	0.708	0.94
90_S	147_F	0.707	0.94
286_L	290_A	0.705	0.94
127_V	326_L	0.705	0.94
49_T	52_E	0.704	0.94
135_K	139_S	0.703	0.94
17_G	21_T	0.702	0.94
124_E	266_P	0.701	0.94
222_L	225_L	0.700	0.94
76_T	118_S	0.699	0.94
316_T	319_S	0.698	0.94
250_D	307_K	0.697	0.94
298_Y	306_L	0.696	0.94
92_A	276_I	0.696	0.94
295_A	306_L	0.696	0.94
277_F	323_A	0.694	0.94
76_T	94_A	0.694	0.94
197_K	200_L	0.691	0.94
201_M	215_F	0.690	0.94
29_A	159_H	0.689	0.93
231_T	236_L	0.689	0.93
82_D	86_T	0.688	0.93
232_D	235_E	0.686	0.93
136_V	148_L	0.686	0.93
87_F	285_A	0.684	0.93
132_T	152_L	0.684	0.93
233_V	237_K	0.682	0.93
220_D	226_S	0.681	0.93
269_S	272_L	0.680	0.93
157_M	180_S	0.678	0.93
193_Y	197_K	0.678	0.93
78_G	82_D	0.677	0.93
60_M	176_L	0.677	0.93
97_A	297_I	0.673	0.93
203_S	241_R	0.672	0.93
42_I	46_R	0.670	0.93
229_A	232_D	0.670	0.93
50_P	207_T	0.668	0.92
67_V	136_V	0.667	0.92
91_T	122_L	0.666	0.92
27_M	180_S	0.666	0.92
22_L	26_M	0.663	0.92
82_D	114_S	0.662	0.92
43_L	48_E	0.662	0.92
254_T	287_S	0.662	0.92
235_E	242_R	0.661	0.92
199_G	234_I	0.661	0.92
64_A	180_S	0.660	0.92
95_I	325_Q	0.658	0.92
70_L	137_K	0.657	0.92
325_Q	329_L	0.656	0.92
297_I	303_T	0.654	0.92
301_G	312_L	0.651	0.91
116_S	266_P	0.645	0.91
321_G	325_Q	0.644	0.91
236_L	239_G	0.641	0.91
57_V	60_M	0.640	0.91
40_L	160_V	0.640	0.91
139_S	146_G	0.639	0.91
237_K	242_R	0.637	0.91
218_S	226_S	0.637	0.91
85_S	262_Q	0.632	0.90
294_G	313_A	0.632	0.90
92_A	289_T	0.632	0.90
86_T	222_L	0.631	0.90
316_T	321_G	0.631	0.90
308_E	312_L	0.628	0.90
27_M	159_H	0.627	0.90
61_R	208_F	0.625	0.90
121_V	125_L	0.625	0.90
266_P	269_S	0.625	0.90
232_D	236_L	0.624	0.90
214_M	244_Y	0.624	0.90
228_T	257_R	0.624	0.90
297_I	309_G	0.624	0.90
95_I	145_M	0.623	0.90
269_S	273_I	0.621	0.89
9_V	45_H	0.617	0.89
86_T	89_I	0.616	0.89
95_I	329_L	0.616	0.89
284_S	287_S	0.612	0.89
222_L	258_L	0.612	0.89
83_G	113_S	0.612	0.89
103_K	144_N	0.611	0.89
306_L	309_G	0.610	0.89
7_L	11_G	0.610	0.89
134_E	138_S	0.608	0.88
272_L	276_I	0.608	0.88
297_I	313_A	0.607	0.88
282_S	318_T	0.605	0.88
94_A	145_M	0.605	0.88
130_Q	152_L	0.604	0.88
37_G	163_T	0.604	0.88
296_A	299_T	0.603	0.88
22_L	25_M	0.603	0.88
220_D	258_L	0.603	0.88
187_R	300_A	0.602	0.88
326_L	330_K	0.600	0.88
100_A	313_A	0.600	0.88
225_L	251_F	0.599	0.88
206_E	240_E	0.598	0.88
11_G	45_H	0.598	0.88
44_A	168_G	0.596	0.87
128_S	131_T	0.594	0.87
40_L	157_M	0.593	0.87
92_A	317_I	0.593	0.87
290_A	294_G	0.590	0.87
72_D	103_K	0.588	0.87
119_A	129_I	0.587	0.87
136_V	139_S	0.586	0.87
79_T	82_D	0.586	0.87
233_V	236_L	0.585	0.86
92_A	277_F	0.584	0.86
119_A	147_F	0.583	0.86
84_I	262_Q	0.581	0.86
220_D	228_T	0.581	0.86
50_P	200_L	0.577	0.86
74_V	299_T	0.576	0.86
268_E	272_L	0.576	0.86
65_L	133_P	0.576	0.86
214_M	233_V	0.575	0.85
32_T	163_T	0.575	0.85
297_I	302_I	0.573	0.85
256_G	260_D	0.571	0.85
123_E	129_I	0.570	0.85
143_N	328_R	0.569	0.85
171_T	174_N	0.568	0.85
290_A	313_A	0.568	0.85
322_A	326_L	0.566	0.85
42_I	45_H	0.566	0.85
72_D	302_I	0.566	0.85
189_V	299_T	0.565	0.84
249_E	252_G	0.562	0.84
320_G	323_A	0.561	0.84
99_A	322_A	0.560	0.84
37_G	41_S	0.560	0.84
19_A	23_M	0.559	0.84
134_E	137_K	0.558	0.84
144_N	325_Q	0.558	0.84
212_H	301_G	0.557	0.84
244_Y	298_Y	0.557	0.84
205_L	210_P	0.557	0.84
316_T	325_Q	0.557	0.84
293_A	296_A	0.554	0.83
206_E	239_G	0.552	0.83
41_S	167_L	0.551	0.83
57_V	176_L	0.550	0.83
53_L	175_L	0.549	0.83
23_M	172_V	0.547	0.83
151_P	165_K	0.547	0.83
273_I	277_F	0.547	0.83
38_G	45_H	0.545	0.82
118_S	121_V	0.545	0.82
119_A	123_E	0.544	0.82
59_A	62_A	0.543	0.82
56_F	176_L	0.542	0.82
198_A	232_D	0.540	0.82
315_E	318_T	0.540	0.82
124_E	270_A	0.539	0.82
195_V	243_E	0.539	0.82
96_V	322_A	0.538	0.82
4_F	25_M	0.536	0.81
76_T	189_V	0.534	0.81
74_V	300_A	0.533	0.81
71_P	103_K	0.532	0.81
203_S	207_T	0.532	0.81
304_A	312_L	0.532	0.81
38_G	42_I	0.532	0.81
81_G	177_G	0.532	0.81
328_R	332_K	0.531	0.81
95_I	326_L	0.531	0.81
263_V	272_L	0.531	0.81
227_I	284_S	0.530	0.81
228_T	258_L	0.529	0.80
7_L	15_T	0.526	0.80
198_A	243_E	0.526	0.80
281_S	318_T	0.522	0.80
8_C	39_I	0.520	0.79
73_I	103_K	0.519	0.79
16_A	20_E	0.519	0.79
286_L	289_T	0.518	0.79
188_Q	213_V	0.518	0.79
228_T	260_D	0.518	0.79
105_A	148_L	0.516	0.79
95_I	277_F	0.516	0.79
85_S	115_K	0.515	0.79
308_E	311_E	0.515	0.79
211_K	238_D	0.515	0.79
190_I	215_F	0.514	0.79
34_S	41_S	0.513	0.78
291_F	310_T	0.513	0.78
298_Y	302_I	0.512	0.78
95_I	127_V	0.512	0.78
57_V	61_R	0.511	0.78
76_T	296_A	0.510	0.78
253_F	290_A	0.509	0.78
38_G	163_T	0.508	0.78
15_T	55_G	0.507	0.78
163_T	166_E	0.503	0.77
96_V	99_A	0.501	0.77
18_E	55_G	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gtnA	2	0.9645	100	0.033	Contact Map
1vquA	2	0.9793	100	0.035	Contact Map
4giuA	2	0.9852	100	0.036	Contact Map
1khdA	2	0.9734	100	0.042	Contact Map
4hkmA	2	0.9675	100	0.05	Contact Map
2elcA	4	0.9704	100	0.059	Contact Map
1o17A	2	0.9852	100	0.059	Contact Map
4muoA	2	0.8846	100	0.138	Contact Map
3h5qA	2	0.8817	100	0.272	Contact Map
1brwA	2	0.8817	100	0.279	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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