GREMLIN Database
TRPD - Anthranilate phosphoribosyltransferase
UniProt: P03947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (329)
Sequences: 5019 (3276)
Seq/√Len: 180.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_N280_K3.9451.00
7_L18_E3.5511.00
325_Q328_R3.5381.00
99_A316_T3.4041.00
16_A58_K3.2641.00
286_L318_T3.0691.00
278_E323_A2.8691.00
225_L231_T2.7761.00
138_S142_T2.7221.00
13_T46_R2.6871.00
249_E255_N2.5771.00
271_Y275_N2.5361.00
265_S268_E2.5001.00
20_E58_K2.4951.00
199_G243_E2.3781.00
100_A316_T2.3741.00
20_E62_A2.3681.00
315_E319_S2.3371.00
225_L295_A2.3251.00
32_T166_E2.2951.00
305_S308_E2.2441.00
198_A234_I2.2171.00
140_I146_G2.2161.00
38_G41_S2.2161.00
24_N63_H2.2051.00
92_A273_I2.1911.00
15_T18_E2.1471.00
54_A207_T2.0711.00
132_T135_K2.0561.00
257_R260_D2.0211.00
290_A314_L2.0131.00
100_A297_I1.9641.00
7_L12_K1.9401.00
22_L39_I1.9211.00
16_A55_G1.8751.00
136_V146_G1.8621.00
26_M36_M1.8291.00
32_T35_E1.8281.00
321_G324_A1.8151.00
303_T309_G1.8131.00
235_E244_Y1.8001.00
311_E314_L1.7931.00
102_A297_I1.7761.00
214_M299_T1.7691.00
25_M30_E1.7651.00
227_I256_G1.7591.00
124_E267_K1.7581.00
263_V269_S1.7491.00
195_V232_D1.7461.00
96_V289_T1.7411.00
24_N62_A1.7041.00
97_A102_A1.6991.00
219_R232_D1.6971.00
199_G203_S1.6881.00
19_A56_F1.6751.00
143_N325_Q1.6751.00
206_E236_L1.6721.00
294_G309_G1.6581.00
28_A63_H1.6481.00
233_V244_Y1.6231.00
234_I241_R1.6151.00
324_A327_E1.6151.00
247_S255_N1.5981.00
247_S250_D1.5881.00
99_A325_Q1.5831.00
214_M295_A1.5741.00
127_V329_L1.5561.00
60_M180_S1.5521.00
135_K138_S1.5351.00
97_A296_A1.5301.00
55_G59_A1.5271.00
137_K141_E1.5211.00
304_A308_E1.5131.00
131_T135_K1.5031.00
274_Q330_K1.4931.00
24_N59_A1.4901.00
302_I312_L1.4821.00
186_K211_K1.4781.00
323_A327_E1.4721.00
324_A328_R1.4701.00
93_S293_A1.4691.00
41_S169_F1.4601.00
286_L314_L1.4301.00
145_M329_L1.4261.00
264_Q269_S1.4231.00
294_G298_Y1.4221.00
77_C188_Q1.4101.00
56_F172_V1.4031.00
230_P245_T1.3991.00
98_S325_Q1.3871.00
143_N332_K1.3721.00
4_F22_L1.3721.00
259_E262_Q1.3661.00
38_G167_L1.3601.00
327_E330_K1.3581.00
33_P166_E1.3551.00
89_I288_I1.3541.00
68_D137_K1.3531.00
175_L197_K1.3501.00
102_A302_I1.3451.00
314_L318_T1.3421.00
66_T184_Q1.3401.00
50_P54_A1.3351.00
131_T139_S1.3341.00
13_T49_T1.3331.00
13_T51_E1.3271.00
110_R120_D1.3271.00
9_V41_S1.3261.00
279_N318_T1.3131.00
212_H237_K1.3111.00
139_S332_K1.3041.00
44_A48_E1.2971.00
213_V236_L1.2911.00
9_V169_F1.2901.00
84_I222_L1.2831.00
23_M56_F1.2731.00
125_L270_A1.2711.00
36_M163_T1.2661.00
74_V296_A1.2591.00
121_V273_I1.2581.00
256_G284_S1.2511.00
219_R229_A1.2421.00
39_I43_L1.2391.00
205_L213_V1.2271.00
16_A207_T1.2261.00
51_E55_G1.2231.00
293_A313_A1.2201.00
274_Q278_E1.2171.00
277_F322_A1.2121.00
24_N28_A1.2091.00
127_V330_K1.1961.00
274_Q327_E1.1951.00
41_S45_H1.1951.00
210_P213_V1.1851.00
22_L31_M1.1811.00
34_S166_E1.1791.00
220_D229_A1.1751.00
315_E321_G1.1571.00
121_V270_A1.1571.00
290_A310_T1.1401.00
34_S37_G1.1391.00
128_S135_K1.1311.00
230_P247_S1.1221.00
73_I185_A1.1191.00
309_G313_A1.1091.00
51_E207_T1.1061.00
20_E59_A1.1001.00
50_P204_A1.0951.00
110_R123_E1.0931.00
232_D243_E1.0921.00
102_A300_A1.0901.00
303_T312_L1.0891.00
31_M36_M1.0791.00
119_A149_F1.0711.00
226_S229_A1.0701.00
96_V293_A1.0651.00
327_E331_Q1.0621.00
328_R331_Q1.0591.00
157_M160_V1.0561.00
234_I243_E1.0481.00
34_S163_T1.0421.00
142_T328_R1.0281.00
270_A274_Q1.0271.00
232_D245_T1.0180.99
160_V163_T1.0160.99
17_G20_E1.0160.99
59_A63_H1.0150.99
19_A55_G1.0030.99
139_S143_N0.9880.99
6_Q10_D0.9860.99
97_A104_I0.9830.99
11_G46_R0.9830.99
264_Q268_E0.9820.99
294_G310_T0.9760.99
72_D186_K0.9750.99
312_L316_T0.9680.99
14_L52_E0.9670.99
54_A58_K0.9670.99
93_S97_A0.9670.99
203_S206_E0.9610.99
60_M157_M0.9550.99
225_L246_V0.9520.99
212_H235_E0.9510.99
39_I56_F0.9450.99
247_S251_F0.9420.99
218_S229_A0.9400.99
36_M160_V0.9380.99
311_E315_E0.9380.99
307_K311_E0.9340.99
236_L241_R0.9260.99
260_D284_S0.9250.99
35_E166_E0.9240.99
87_F272_L0.9230.99
136_V153_Y0.9180.99
312_L315_E0.9150.99
188_Q210_P0.9130.99
206_E241_R0.9090.99
187_R211_K0.9090.99
253_F291_F0.9070.99
235_E298_Y0.9050.99
25_M31_M0.9020.99
246_V251_F0.9020.99
287_S314_L0.8960.99
298_Y305_S0.8940.99
276_I285_A0.8910.99
73_I105_A0.8900.99
227_I288_I0.8900.99
251_F310_T0.8850.99
266_P270_A0.8810.98
115_K265_S0.8810.98
46_R52_E0.8740.98
48_E53_L0.8720.98
274_Q323_A0.8700.98
127_V145_M0.8690.98
227_I261_L0.8650.98
162_G166_E0.8600.98
298_Y309_G0.8590.98
271_Y274_Q0.8550.98
57_V208_F0.8550.98
267_K271_Y0.8530.98
219_R230_P0.8520.98
231_T248_P0.8500.98
27_M60_M0.8470.98
189_V216_V0.8430.98
9_V44_A0.8410.98
298_Y303_T0.8410.98
282_S285_A0.8360.98
219_R245_T0.8350.98
103_K141_E0.8340.98
20_E55_G0.8330.98
16_A51_E0.8300.98
225_L291_F0.8270.98
294_G306_L0.8260.98
256_G287_S0.8240.98
112_V151_P0.8230.98
97_A103_K0.8230.98
48_E170_R0.8200.98
22_L36_M0.8140.97
176_L188_Q0.8140.97
20_E24_N0.8120.97
231_T235_E0.8070.97
136_V140_I0.8030.97
77_C118_S0.7950.97
70_L141_E0.7940.97
76_T93_S0.7880.97
50_P203_S0.7840.97
21_T25_M0.7800.97
97_A293_A0.7790.97
187_R212_H0.7780.97
61_R184_Q0.7740.97
301_G309_G0.7730.96
143_N329_L0.7680.96
214_M298_Y0.7660.96
97_A100_A0.7640.96
187_R299_T0.7640.96
249_E254_T0.7630.96
72_D187_R0.7600.96
96_V317_I0.7570.96
65_L155_S0.7560.96
217_S221_G0.7540.96
74_V104_I0.7510.96
142_T332_K0.7470.96
133_P137_K0.7470.96
54_A204_A0.7460.96
276_I289_T0.7450.96
33_P159_H0.7450.96
84_I258_L0.7430.96
77_C93_S0.7420.96
138_S141_E0.7420.96
310_T314_L0.7420.96
16_A54_A0.7400.96
53_L204_A0.7400.96
256_G261_L0.7380.95
33_P163_T0.7380.95
19_A172_V0.7380.95
31_M35_E0.7330.95
316_T322_A0.7320.95
38_G169_F0.7290.95
96_V313_A0.7280.95
290_A318_T0.7280.95
76_T188_Q0.7270.95
74_V102_A0.7250.95
192_V201_M0.7230.95
82_D85_S0.7160.95
275_N281_S0.7160.95
268_E271_Y0.7150.95
8_C42_I0.7140.95
125_L326_L0.7130.95
281_S284_S0.7130.95
190_I201_M0.7120.94
253_F310_T0.7110.94
33_P162_G0.7110.94
26_M160_V0.7100.94
58_K62_A0.7080.94
90_S147_F0.7070.94
286_L290_A0.7050.94
127_V326_L0.7050.94
49_T52_E0.7040.94
135_K139_S0.7030.94
17_G21_T0.7020.94
124_E266_P0.7010.94
222_L225_L0.7000.94
76_T118_S0.6990.94
316_T319_S0.6980.94
250_D307_K0.6970.94
298_Y306_L0.6960.94
92_A276_I0.6960.94
295_A306_L0.6960.94
277_F323_A0.6940.94
76_T94_A0.6940.94
197_K200_L0.6910.94
201_M215_F0.6900.94
29_A159_H0.6890.93
231_T236_L0.6890.93
82_D86_T0.6880.93
232_D235_E0.6860.93
136_V148_L0.6860.93
87_F285_A0.6840.93
132_T152_L0.6840.93
233_V237_K0.6820.93
220_D226_S0.6810.93
269_S272_L0.6800.93
157_M180_S0.6780.93
193_Y197_K0.6780.93
78_G82_D0.6770.93
60_M176_L0.6770.93
97_A297_I0.6730.93
203_S241_R0.6720.93
42_I46_R0.6700.93
229_A232_D0.6700.93
50_P207_T0.6680.92
67_V136_V0.6670.92
91_T122_L0.6660.92
27_M180_S0.6660.92
22_L26_M0.6630.92
82_D114_S0.6620.92
43_L48_E0.6620.92
254_T287_S0.6620.92
235_E242_R0.6610.92
199_G234_I0.6610.92
64_A180_S0.6600.92
95_I325_Q0.6580.92
70_L137_K0.6570.92
325_Q329_L0.6560.92
297_I303_T0.6540.92
301_G312_L0.6510.91
116_S266_P0.6450.91
321_G325_Q0.6440.91
236_L239_G0.6410.91
57_V60_M0.6400.91
40_L160_V0.6400.91
139_S146_G0.6390.91
237_K242_R0.6370.91
218_S226_S0.6370.91
85_S262_Q0.6320.90
294_G313_A0.6320.90
92_A289_T0.6320.90
86_T222_L0.6310.90
316_T321_G0.6310.90
308_E312_L0.6280.90
27_M159_H0.6270.90
61_R208_F0.6250.90
121_V125_L0.6250.90
266_P269_S0.6250.90
232_D236_L0.6240.90
214_M244_Y0.6240.90
228_T257_R0.6240.90
297_I309_G0.6240.90
95_I145_M0.6230.90
269_S273_I0.6210.89
9_V45_H0.6170.89
86_T89_I0.6160.89
95_I329_L0.6160.89
284_S287_S0.6120.89
222_L258_L0.6120.89
83_G113_S0.6120.89
103_K144_N0.6110.89
306_L309_G0.6100.89
7_L11_G0.6100.89
134_E138_S0.6080.88
272_L276_I0.6080.88
297_I313_A0.6070.88
282_S318_T0.6050.88
94_A145_M0.6050.88
130_Q152_L0.6040.88
37_G163_T0.6040.88
296_A299_T0.6030.88
22_L25_M0.6030.88
220_D258_L0.6030.88
187_R300_A0.6020.88
326_L330_K0.6000.88
100_A313_A0.6000.88
225_L251_F0.5990.88
206_E240_E0.5980.88
11_G45_H0.5980.88
44_A168_G0.5960.87
128_S131_T0.5940.87
40_L157_M0.5930.87
92_A317_I0.5930.87
290_A294_G0.5900.87
72_D103_K0.5880.87
119_A129_I0.5870.87
136_V139_S0.5860.87
79_T82_D0.5860.87
233_V236_L0.5850.86
92_A277_F0.5840.86
119_A147_F0.5830.86
84_I262_Q0.5810.86
220_D228_T0.5810.86
50_P200_L0.5770.86
74_V299_T0.5760.86
268_E272_L0.5760.86
65_L133_P0.5760.86
214_M233_V0.5750.85
32_T163_T0.5750.85
297_I302_I0.5730.85
256_G260_D0.5710.85
123_E129_I0.5700.85
143_N328_R0.5690.85
171_T174_N0.5680.85
290_A313_A0.5680.85
322_A326_L0.5660.85
42_I45_H0.5660.85
72_D302_I0.5660.85
189_V299_T0.5650.84
249_E252_G0.5620.84
320_G323_A0.5610.84
99_A322_A0.5600.84
37_G41_S0.5600.84
19_A23_M0.5590.84
134_E137_K0.5580.84
144_N325_Q0.5580.84
212_H301_G0.5570.84
244_Y298_Y0.5570.84
205_L210_P0.5570.84
316_T325_Q0.5570.84
293_A296_A0.5540.83
206_E239_G0.5520.83
41_S167_L0.5510.83
57_V176_L0.5500.83
53_L175_L0.5490.83
23_M172_V0.5470.83
151_P165_K0.5470.83
273_I277_F0.5470.83
38_G45_H0.5450.82
118_S121_V0.5450.82
119_A123_E0.5440.82
59_A62_A0.5430.82
56_F176_L0.5420.82
198_A232_D0.5400.82
315_E318_T0.5400.82
124_E270_A0.5390.82
195_V243_E0.5390.82
96_V322_A0.5380.82
4_F25_M0.5360.81
76_T189_V0.5340.81
74_V300_A0.5330.81
71_P103_K0.5320.81
203_S207_T0.5320.81
304_A312_L0.5320.81
38_G42_I0.5320.81
81_G177_G0.5320.81
328_R332_K0.5310.81
95_I326_L0.5310.81
263_V272_L0.5310.81
227_I284_S0.5300.81
228_T258_L0.5290.80
7_L15_T0.5260.80
198_A243_E0.5260.80
281_S318_T0.5220.80
8_C39_I0.5200.79
73_I103_K0.5190.79
16_A20_E0.5190.79
286_L289_T0.5180.79
188_Q213_V0.5180.79
228_T260_D0.5180.79
105_A148_L0.5160.79
95_I277_F0.5160.79
85_S115_K0.5150.79
308_E311_E0.5150.79
211_K238_D0.5150.79
190_I215_F0.5140.79
34_S41_S0.5130.78
291_F310_T0.5130.78
298_Y302_I0.5120.78
95_I127_V0.5120.78
57_V61_R0.5110.78
76_T296_A0.5100.78
253_F290_A0.5090.78
38_G163_T0.5080.78
15_T55_G0.5070.78
163_T166_E0.5030.77
96_V99_A0.5010.77
18_E55_G0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gtnA 2 0.9645 100 0.033 Contact Map
1vquA 2 0.9793 100 0.035 Contact Map
4giuA 2 0.9852 100 0.036 Contact Map
1khdA 2 0.9734 100 0.042 Contact Map
4hkmA 2 0.9675 100 0.05 Contact Map
2elcA 4 0.9704 100 0.059 Contact Map
1o17A 2 0.9852 100 0.059 Contact Map
4muoA 2 0.8846 100 0.138 Contact Map
3h5qA 2 0.8817 100 0.272 Contact Map
1brwA 2 0.8817 100 0.279 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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