GREMLIN Database
FLA - Flagellin
UniProt: P02968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (262)
Sequences: 6164 (4194)
Seq/√Len: 259.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_R222_D4.6111.00
113_Q117_S3.6391.00
83_T123_I3.3611.00
90_V116_I3.2741.00
89_R115_E3.0221.00
29_K271_E2.7931.00
261_S265_D2.7681.00
105_K108_D2.7071.00
131_E136_K2.6811.00
35_R42_D2.5531.00
270_K274_E2.4831.00
63_S250_S2.4191.00
53_R260_E2.3991.00
60_E253_G2.3911.00
19_N285_S2.3471.00
118_A121_D2.3301.00
86_I123_I2.2901.00
122_E125_G2.2801.00
34_L264_R2.2681.00
266_V271_E2.2651.00
86_I119_L2.2601.00
260_E264_R2.2261.00
36_I45_G2.2021.00
66_S246_I2.1111.00
89_R93_L2.0921.00
26_N278_N2.0731.00
73_I235_L2.0551.00
77_E232_R2.0281.00
61_M64_K2.0061.00
25_K29_K1.9951.00
106_A110_Q1.9181.00
57_R92_E1.9001.00
87_L221_V1.8171.00
90_V119_L1.7841.00
94_V218_L1.7691.00
131_E134_G1.7441.00
28_E38_R1.7221.00
53_R264_R1.7111.00
79_A130_T1.7091.00
49_S264_R1.7021.00
208_D214_F1.6761.00
93_L115_E1.6621.00
110_Q114_D1.6501.00
112_I116_I1.6301.00
82_E85_A1.6051.00
142_Y155_L1.5941.00
231_Q234_K1.5741.00
108_D111_S1.5581.00
89_R92_E1.5471.00
87_L225_I1.5351.00
45_G263_I1.5331.00
117_S121_D1.5251.00
70_I243_E1.5231.00
42_D45_G1.5111.00
87_L228_V1.4941.00
90_V221_V1.4761.00
93_L112_I1.4591.00
83_T228_V1.4561.00
86_I126_I1.4231.00
107_T110_Q1.4221.00
36_I49_S1.4131.00
114_D234_K1.3771.00
59_L249_L1.3751.00
175_G178_A1.3681.00
107_T226_N1.3621.00
79_A126_I1.3521.00
247_N250_S1.3481.00
86_I122_E1.3461.00
97_A112_I1.3421.00
113_Q116_I1.3391.00
210_A213_G1.3371.00
26_N274_E1.3371.00
276_T279_N1.3251.00
99_N102_T1.3191.00
117_S120_T1.3151.00
14_N18_S1.3051.00
111_S114_D1.2951.00
222_D226_N1.2921.00
171_I174_M1.2881.00
80_L228_V1.2871.00
253_G257_T1.2721.00
120_T124_D1.2651.00
272_M276_T1.2621.00
80_L83_T1.2551.00
103_Q108_D1.2541.00
91_R95_V1.2521.00
84_H225_I1.2371.00
69_G157_F1.2361.00
83_T86_I1.2261.00
98_G215_D1.2261.00
30_L271_E1.2251.00
112_I208_D1.2221.00
81_T85_A1.2201.00
56_I257_T1.1811.00
125_G129_R1.1681.00
50_E53_R1.1621.00
66_S249_L1.1601.00
67_Q246_I1.1531.00
82_E126_I1.1481.00
88_Q91_R1.1471.00
26_N271_E1.1431.00
83_T126_I1.1421.00
84_H229_S1.1411.00
136_K139_D1.1401.00
36_I41_D1.1301.00
275_F279_N1.1221.00
127_S175_G1.1131.00
103_Q112_I1.1071.00
96_Q112_I1.1061.00
258_A262_R1.1001.00
124_D176_A1.0831.00
84_H88_Q1.0771.00
51_K108_D1.0701.00
70_I246_I1.0701.00
219_K223_E1.0631.00
209_T213_G1.0581.00
160_G165_Q1.0551.00
207_A213_G1.0491.00
216_A220_V1.0481.00
206_A210_A1.0451.00
131_E165_Q1.0411.00
22_A278_N1.0371.00
18_S22_A1.0361.00
88_Q225_I1.0291.00
287_A291_Q1.0241.00
99_N103_Q1.0201.00
118_A238_V1.0201.00
272_M275_F1.0191.00
268_M272_M1.0161.00
63_S253_G1.0121.00
56_I256_L1.0111.00
124_D128_N1.0091.00
165_Q171_I1.0071.00
223_E226_N1.0041.00
128_N139_D1.0001.00
60_E63_S0.9951.00
28_E32_S0.9941.00
26_N266_V0.9911.00
95_V218_L0.9881.00
8_A24_Q0.9841.00
62_A249_L0.9831.00
234_K238_V0.9811.00
61_M92_E0.9781.00
66_S242_L0.9731.00
64_K68_D0.9721.00
59_L253_G0.9711.00
94_V221_V0.9681.00
282_S286_Q0.9661.00
90_V120_T0.9651.00
211_D215_D0.9601.00
142_Y171_I0.9601.00
210_A214_F0.9591.00
173_D178_A0.9581.00
91_R218_L0.9561.00
34_L266_V0.9511.00
212_I216_A0.9491.00
159_I167_I0.9481.00
223_E227_Q0.9441.00
49_S260_E0.9441.00
208_D213_G0.9391.00
161_A165_Q0.9261.00
19_N22_A0.9191.00
28_E37_N0.9171.00
177_D182_K0.9151.00
70_I239_Q0.9121.00
180_G183_E0.9111.00
23_S27_M0.9091.00
61_M65_N0.9081.00
84_H228_V0.9081.00
154_N158_Q0.9051.00
32_S37_N0.9051.00
81_T232_R0.9031.00
274_E277_K0.8951.00
15_R32_S0.8941.00
89_R119_L0.8911.00
13_L17_S0.8871.00
94_V214_F0.8851.00
114_D230_S0.8831.00
71_S132_F0.8771.00
158_Q161_A0.8761.00
116_I206_A0.8761.00
56_I260_E0.8761.00
156_V168_S0.8751.00
116_I120_T0.8741.00
70_I74_Q0.8701.00
59_L63_S0.8681.00
7_I11_N0.8681.00
85_A88_Q0.8641.00
37_N41_D0.8631.00
9_A13_L0.8631.00
63_S249_L0.8540.99
156_V166_Q0.8540.99
171_I175_G0.8420.99
271_E274_E0.8420.99
163_A219_K0.8390.99
74_Q239_Q0.8380.99
27_M275_F0.8320.99
53_R57_R0.8280.99
16_L286_Q0.8210.99
225_I229_S0.8170.99
274_E278_N0.8110.99
119_L122_E0.8080.99
20_N282_S0.8050.99
16_L282_S0.8010.99
279_N283_Q0.7970.99
243_E247_N0.7940.99
127_S138_L0.7920.99
25_K28_E0.7920.99
94_V116_I0.7890.99
22_A25_K0.7880.99
162_N165_Q0.7860.99
206_A209_T0.7810.99
95_V98_G0.7800.99
171_I176_A0.7800.99
170_N173_D0.7750.99
8_A295_Q0.7750.99
93_L96_Q0.7740.99
4_N34_L0.7690.99
19_N23_S0.7680.99
103_Q109_L0.7660.99
179_L183_E0.7660.99
286_Q289_L0.7660.99
207_A210_A0.7630.99
29_K266_V0.7630.99
11_N14_N0.7630.99
219_K222_D0.7630.99
98_G103_Q0.7610.99
18_S21_S0.7600.99
103_Q111_S0.7560.99
13_L273_S0.7550.99
4_N7_I0.7540.99
69_G242_L0.7530.99
165_Q175_G0.7520.99
159_I165_Q0.7490.99
155_L158_Q0.7480.99
120_T127_S0.7450.99
14_N254_E0.7450.99
97_A109_L0.7410.99
177_D183_E0.7390.99
245_T249_L0.7380.99
94_V217_Q0.7360.99
95_V222_D0.7230.98
114_D117_S0.7230.98
206_A217_Q0.7180.98
44_A48_I0.7080.98
116_I208_D0.7070.98
76_A235_L0.7060.98
252_S256_L0.7050.98
283_Q287_A0.6960.98
88_Q92_E0.6920.98
277_K281_L0.6920.98
173_D177_D0.6880.98
122_E241_R0.6870.98
131_E135_K0.6860.98
230_S234_K0.6810.98
93_L119_L0.6790.97
79_A138_L0.6780.97
105_K111_S0.6760.97
23_S279_N0.6740.97
172_E175_G0.6720.97
168_S171_I0.6700.97
9_A12_T0.6680.97
124_D127_S0.6680.97
24_Q27_M0.6670.97
239_Q243_E0.6610.97
82_E244_H0.6600.97
2_R261_S0.6580.97
21_S25_K0.6560.97
73_I238_V0.6550.97
174_M231_Q0.6540.97
161_A164_T0.6500.97
84_H232_R0.6490.97
94_V98_G0.6490.97
139_D142_Y0.6470.97
174_M181_I0.6440.97
114_D233_A0.6390.96
120_T176_A0.6370.96
73_I242_L0.6370.96
250_S253_G0.6370.96
226_N230_S0.6340.96
155_L171_I0.6330.96
22_A274_E0.6330.96
16_L285_S0.6310.96
174_M180_G0.6310.96
157_F169_V0.6300.96
176_A179_L0.6300.96
154_N171_I0.6300.96
98_G214_F0.6200.96
213_G217_Q0.6180.96
19_N282_S0.6150.96
66_S245_T0.6150.96
19_N278_N0.6150.96
214_F217_Q0.6150.96
101_G211_D0.6140.95
174_M179_L0.6140.95
174_M177_D0.6120.95
254_E258_A0.6110.95
165_Q168_S0.6090.95
2_R295_Q0.6080.95
215_D219_K0.6080.95
68_D71_S0.6070.95
63_S246_I0.6060.95
97_A113_Q0.6060.95
113_Q209_T0.6050.95
35_R45_G0.6050.95
76_A79_A0.6040.95
220_V223_E0.6040.95
246_I250_S0.5950.95
55_Q58_G0.5950.95
7_I10_L0.5930.95
208_D211_D0.5930.95
98_G218_L0.5910.94
121_D125_G0.5840.94
287_A290_A0.5840.94
97_A214_F0.5830.94
175_G181_I0.5820.94
52_M56_I0.5800.94
205_N210_A0.5780.94
63_S67_Q0.5770.94
80_L232_R0.5770.94
71_S74_Q0.5770.94
21_S24_Q0.5750.94
115_E119_L0.5730.94
26_N29_K0.5710.93
83_T87_L0.5710.93
179_L182_K0.5710.93
47_A133_N0.5660.93
118_A241_R0.5650.93
216_A219_K0.5650.93
163_A171_I0.5630.93
30_L272_M0.5620.93
109_L214_F0.5610.93
170_N175_G0.5590.93
113_Q120_T0.5580.93
288_M291_Q0.5560.92
168_S172_E0.5550.92
54_G134_G0.5540.92
251_A255_N0.5540.92
105_K134_G0.5530.92
120_T123_I0.5490.92
34_L37_N0.5470.92
34_L265_D0.5460.92
217_Q221_V0.5460.92
275_F282_S0.5440.92
212_I215_D0.5440.92
285_S288_M0.5440.92
20_N24_Q0.5420.92
159_I175_G0.5400.91
72_L171_I0.5400.91
24_Q295_Q0.5370.91
208_D217_Q0.5370.91
126_I130_T0.5360.91
279_N291_Q0.5350.91
79_A83_T0.5330.91
111_S233_A0.5320.91
15_R28_E0.5320.91
56_I253_G0.5300.91
208_D212_I0.5300.91
73_I239_Q0.5280.90
168_S173_D0.5280.90
47_A111_S0.5280.90
251_A254_E0.5270.90
254_E257_T0.5260.90
50_E264_R0.5250.90
114_D118_A0.5240.90
284_A287_A0.5240.90
23_S282_S0.5230.90
78_G255_N0.5220.90
98_G109_L0.5210.90
261_S264_R0.5190.90
77_E235_L0.5190.90
227_Q230_S0.5190.90
23_S26_N0.5180.90
155_L169_V0.5180.90
237_A240_N0.5170.90
222_D225_I0.5170.90
57_R88_Q0.5160.89
135_K155_L0.5150.89
279_N286_Q0.5130.89
5_H260_E0.5130.89
276_T280_I0.5130.89
160_G164_T0.5120.89
83_T138_L0.5120.89
76_A137_L0.5120.89
50_E229_S0.5100.89
78_G251_A0.5090.89
119_L244_H0.5080.89
175_G179_L0.5070.89
80_L138_L0.5060.89
75_T132_F0.5030.88
158_Q163_A0.5010.88
12_T15_R0.5000.88
67_Q71_S0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ucuA 1 0.9572 100 0.158 Contact Map
3pwxA 2 0.727 100 0.387 Contact Map
2d4xA 1 0.648 100 0.406 Contact Map
3k8wA 1 0.6809 100 0.416 Contact Map
4nx9A 1 0.6053 100 0.549 Contact Map
3v47C 1 0.5757 100 0.574 Contact Map
4cfiA 1 0.5362 99.9 0.644 Contact Map
1io1A 1 0.5855 99.8 0.666 Contact Map
3k1iC 1 0.3947 99.5 0.754 Contact Map
1oryB 2 0.1316 98.6 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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