FLA - BACSU - GREMLIN Contacts

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FLA - Flagellin

UniProt:	P02968	Sequences: MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAAGLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGTQDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIGANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQLKVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFTKNNILSQASQAMLAQANQQPQNVLQLLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	304 (262)
Sequences:	6164 (4194)
Seq/√Len:	259.1

ECOLI - FLIC FLGL
BACSU - FLA FLGL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_R	222_D	4.611	1.00
113_Q	117_S	3.639	1.00
83_T	123_I	3.361	1.00
90_V	116_I	3.274	1.00
89_R	115_E	3.022	1.00
29_K	271_E	2.793	1.00
261_S	265_D	2.768	1.00
105_K	108_D	2.707	1.00
131_E	136_K	2.681	1.00
35_R	42_D	2.553	1.00
270_K	274_E	2.483	1.00
63_S	250_S	2.419	1.00
53_R	260_E	2.399	1.00
60_E	253_G	2.391	1.00
19_N	285_S	2.347	1.00
118_A	121_D	2.330	1.00
86_I	123_I	2.290	1.00
122_E	125_G	2.280	1.00
34_L	264_R	2.268	1.00
266_V	271_E	2.265	1.00
86_I	119_L	2.260	1.00
260_E	264_R	2.226	1.00
36_I	45_G	2.202	1.00
66_S	246_I	2.111	1.00
89_R	93_L	2.092	1.00
26_N	278_N	2.073	1.00
73_I	235_L	2.055	1.00
77_E	232_R	2.028	1.00
61_M	64_K	2.006	1.00
25_K	29_K	1.995	1.00
106_A	110_Q	1.918	1.00
57_R	92_E	1.900	1.00
87_L	221_V	1.817	1.00
90_V	119_L	1.784	1.00
94_V	218_L	1.769	1.00
131_E	134_G	1.744	1.00
28_E	38_R	1.722	1.00
53_R	264_R	1.711	1.00
79_A	130_T	1.709	1.00
49_S	264_R	1.702	1.00
208_D	214_F	1.676	1.00
93_L	115_E	1.662	1.00
110_Q	114_D	1.650	1.00
112_I	116_I	1.630	1.00
82_E	85_A	1.605	1.00
142_Y	155_L	1.594	1.00
231_Q	234_K	1.574	1.00
108_D	111_S	1.558	1.00
89_R	92_E	1.547	1.00
87_L	225_I	1.535	1.00
45_G	263_I	1.533	1.00
117_S	121_D	1.525	1.00
70_I	243_E	1.523	1.00
42_D	45_G	1.511	1.00
87_L	228_V	1.494	1.00
90_V	221_V	1.476	1.00
93_L	112_I	1.459	1.00
83_T	228_V	1.456	1.00
86_I	126_I	1.423	1.00
107_T	110_Q	1.422	1.00
36_I	49_S	1.413	1.00
114_D	234_K	1.377	1.00
59_L	249_L	1.375	1.00
175_G	178_A	1.368	1.00
107_T	226_N	1.362	1.00
79_A	126_I	1.352	1.00
247_N	250_S	1.348	1.00
86_I	122_E	1.346	1.00
97_A	112_I	1.342	1.00
113_Q	116_I	1.339	1.00
210_A	213_G	1.337	1.00
26_N	274_E	1.337	1.00
276_T	279_N	1.325	1.00
99_N	102_T	1.319	1.00
117_S	120_T	1.315	1.00
14_N	18_S	1.305	1.00
111_S	114_D	1.295	1.00
222_D	226_N	1.292	1.00
171_I	174_M	1.288	1.00
80_L	228_V	1.287	1.00
253_G	257_T	1.272	1.00
120_T	124_D	1.265	1.00
272_M	276_T	1.262	1.00
80_L	83_T	1.255	1.00
103_Q	108_D	1.254	1.00
91_R	95_V	1.252	1.00
84_H	225_I	1.237	1.00
69_G	157_F	1.236	1.00
83_T	86_I	1.226	1.00
98_G	215_D	1.226	1.00
30_L	271_E	1.225	1.00
112_I	208_D	1.222	1.00
81_T	85_A	1.220	1.00
56_I	257_T	1.181	1.00
125_G	129_R	1.168	1.00
50_E	53_R	1.162	1.00
66_S	249_L	1.160	1.00
67_Q	246_I	1.153	1.00
82_E	126_I	1.148	1.00
88_Q	91_R	1.147	1.00
26_N	271_E	1.143	1.00
83_T	126_I	1.142	1.00
84_H	229_S	1.141	1.00
136_K	139_D	1.140	1.00
36_I	41_D	1.130	1.00
275_F	279_N	1.122	1.00
127_S	175_G	1.113	1.00
103_Q	112_I	1.107	1.00
96_Q	112_I	1.106	1.00
258_A	262_R	1.100	1.00
124_D	176_A	1.083	1.00
84_H	88_Q	1.077	1.00
51_K	108_D	1.070	1.00
70_I	246_I	1.070	1.00
219_K	223_E	1.063	1.00
209_T	213_G	1.058	1.00
160_G	165_Q	1.055	1.00
207_A	213_G	1.049	1.00
216_A	220_V	1.048	1.00
206_A	210_A	1.045	1.00
131_E	165_Q	1.041	1.00
22_A	278_N	1.037	1.00
18_S	22_A	1.036	1.00
88_Q	225_I	1.029	1.00
287_A	291_Q	1.024	1.00
99_N	103_Q	1.020	1.00
118_A	238_V	1.020	1.00
272_M	275_F	1.019	1.00
268_M	272_M	1.016	1.00
63_S	253_G	1.012	1.00
56_I	256_L	1.011	1.00
124_D	128_N	1.009	1.00
165_Q	171_I	1.007	1.00
223_E	226_N	1.004	1.00
128_N	139_D	1.000	1.00
60_E	63_S	0.995	1.00
28_E	32_S	0.994	1.00
26_N	266_V	0.991	1.00
95_V	218_L	0.988	1.00
8_A	24_Q	0.984	1.00
62_A	249_L	0.983	1.00
234_K	238_V	0.981	1.00
61_M	92_E	0.978	1.00
66_S	242_L	0.973	1.00
64_K	68_D	0.972	1.00
59_L	253_G	0.971	1.00
94_V	221_V	0.968	1.00
282_S	286_Q	0.966	1.00
90_V	120_T	0.965	1.00
211_D	215_D	0.960	1.00
142_Y	171_I	0.960	1.00
210_A	214_F	0.959	1.00
173_D	178_A	0.958	1.00
91_R	218_L	0.956	1.00
34_L	266_V	0.951	1.00
212_I	216_A	0.949	1.00
159_I	167_I	0.948	1.00
223_E	227_Q	0.944	1.00
49_S	260_E	0.944	1.00
208_D	213_G	0.939	1.00
161_A	165_Q	0.926	1.00
19_N	22_A	0.919	1.00
28_E	37_N	0.917	1.00
177_D	182_K	0.915	1.00
70_I	239_Q	0.912	1.00
180_G	183_E	0.911	1.00
23_S	27_M	0.909	1.00
61_M	65_N	0.908	1.00
84_H	228_V	0.908	1.00
154_N	158_Q	0.905	1.00
32_S	37_N	0.905	1.00
81_T	232_R	0.903	1.00
274_E	277_K	0.895	1.00
15_R	32_S	0.894	1.00
89_R	119_L	0.891	1.00
13_L	17_S	0.887	1.00
94_V	214_F	0.885	1.00
114_D	230_S	0.883	1.00
71_S	132_F	0.877	1.00
158_Q	161_A	0.876	1.00
116_I	206_A	0.876	1.00
56_I	260_E	0.876	1.00
156_V	168_S	0.875	1.00
116_I	120_T	0.874	1.00
70_I	74_Q	0.870	1.00
59_L	63_S	0.868	1.00
7_I	11_N	0.868	1.00
85_A	88_Q	0.864	1.00
37_N	41_D	0.863	1.00
9_A	13_L	0.863	1.00
63_S	249_L	0.854	0.99
156_V	166_Q	0.854	0.99
171_I	175_G	0.842	0.99
271_E	274_E	0.842	0.99
163_A	219_K	0.839	0.99
74_Q	239_Q	0.838	0.99
27_M	275_F	0.832	0.99
53_R	57_R	0.828	0.99
16_L	286_Q	0.821	0.99
225_I	229_S	0.817	0.99
274_E	278_N	0.811	0.99
119_L	122_E	0.808	0.99
20_N	282_S	0.805	0.99
16_L	282_S	0.801	0.99
279_N	283_Q	0.797	0.99
243_E	247_N	0.794	0.99
127_S	138_L	0.792	0.99
25_K	28_E	0.792	0.99
94_V	116_I	0.789	0.99
22_A	25_K	0.788	0.99
162_N	165_Q	0.786	0.99
206_A	209_T	0.781	0.99
95_V	98_G	0.780	0.99
171_I	176_A	0.780	0.99
170_N	173_D	0.775	0.99
8_A	295_Q	0.775	0.99
93_L	96_Q	0.774	0.99
4_N	34_L	0.769	0.99
19_N	23_S	0.768	0.99
103_Q	109_L	0.766	0.99
179_L	183_E	0.766	0.99
286_Q	289_L	0.766	0.99
207_A	210_A	0.763	0.99
29_K	266_V	0.763	0.99
11_N	14_N	0.763	0.99
219_K	222_D	0.763	0.99
98_G	103_Q	0.761	0.99
18_S	21_S	0.760	0.99
103_Q	111_S	0.756	0.99
13_L	273_S	0.755	0.99
4_N	7_I	0.754	0.99
69_G	242_L	0.753	0.99
165_Q	175_G	0.752	0.99
159_I	165_Q	0.749	0.99
155_L	158_Q	0.748	0.99
120_T	127_S	0.745	0.99
14_N	254_E	0.745	0.99
97_A	109_L	0.741	0.99
177_D	183_E	0.739	0.99
245_T	249_L	0.738	0.99
94_V	217_Q	0.736	0.99
95_V	222_D	0.723	0.98
114_D	117_S	0.723	0.98
206_A	217_Q	0.718	0.98
44_A	48_I	0.708	0.98
116_I	208_D	0.707	0.98
76_A	235_L	0.706	0.98
252_S	256_L	0.705	0.98
283_Q	287_A	0.696	0.98
88_Q	92_E	0.692	0.98
277_K	281_L	0.692	0.98
173_D	177_D	0.688	0.98
122_E	241_R	0.687	0.98
131_E	135_K	0.686	0.98
230_S	234_K	0.681	0.98
93_L	119_L	0.679	0.97
79_A	138_L	0.678	0.97
105_K	111_S	0.676	0.97
23_S	279_N	0.674	0.97
172_E	175_G	0.672	0.97
168_S	171_I	0.670	0.97
9_A	12_T	0.668	0.97
124_D	127_S	0.668	0.97
24_Q	27_M	0.667	0.97
239_Q	243_E	0.661	0.97
82_E	244_H	0.660	0.97
2_R	261_S	0.658	0.97
21_S	25_K	0.656	0.97
73_I	238_V	0.655	0.97
174_M	231_Q	0.654	0.97
161_A	164_T	0.650	0.97
84_H	232_R	0.649	0.97
94_V	98_G	0.649	0.97
139_D	142_Y	0.647	0.97
174_M	181_I	0.644	0.97
114_D	233_A	0.639	0.96
120_T	176_A	0.637	0.96
73_I	242_L	0.637	0.96
250_S	253_G	0.637	0.96
226_N	230_S	0.634	0.96
155_L	171_I	0.633	0.96
22_A	274_E	0.633	0.96
16_L	285_S	0.631	0.96
174_M	180_G	0.631	0.96
157_F	169_V	0.630	0.96
176_A	179_L	0.630	0.96
154_N	171_I	0.630	0.96
98_G	214_F	0.620	0.96
213_G	217_Q	0.618	0.96
19_N	282_S	0.615	0.96
66_S	245_T	0.615	0.96
19_N	278_N	0.615	0.96
214_F	217_Q	0.615	0.96
101_G	211_D	0.614	0.95
174_M	179_L	0.614	0.95
174_M	177_D	0.612	0.95
254_E	258_A	0.611	0.95
165_Q	168_S	0.609	0.95
2_R	295_Q	0.608	0.95
215_D	219_K	0.608	0.95
68_D	71_S	0.607	0.95
63_S	246_I	0.606	0.95
97_A	113_Q	0.606	0.95
113_Q	209_T	0.605	0.95
35_R	45_G	0.605	0.95
76_A	79_A	0.604	0.95
220_V	223_E	0.604	0.95
246_I	250_S	0.595	0.95
55_Q	58_G	0.595	0.95
7_I	10_L	0.593	0.95
208_D	211_D	0.593	0.95
98_G	218_L	0.591	0.94
121_D	125_G	0.584	0.94
287_A	290_A	0.584	0.94
97_A	214_F	0.583	0.94
175_G	181_I	0.582	0.94
52_M	56_I	0.580	0.94
205_N	210_A	0.578	0.94
63_S	67_Q	0.577	0.94
80_L	232_R	0.577	0.94
71_S	74_Q	0.577	0.94
21_S	24_Q	0.575	0.94
115_E	119_L	0.573	0.94
26_N	29_K	0.571	0.93
83_T	87_L	0.571	0.93
179_L	182_K	0.571	0.93
47_A	133_N	0.566	0.93
118_A	241_R	0.565	0.93
216_A	219_K	0.565	0.93
163_A	171_I	0.563	0.93
30_L	272_M	0.562	0.93
109_L	214_F	0.561	0.93
170_N	175_G	0.559	0.93
113_Q	120_T	0.558	0.93
288_M	291_Q	0.556	0.92
168_S	172_E	0.555	0.92
54_G	134_G	0.554	0.92
251_A	255_N	0.554	0.92
105_K	134_G	0.553	0.92
120_T	123_I	0.549	0.92
34_L	37_N	0.547	0.92
34_L	265_D	0.546	0.92
217_Q	221_V	0.546	0.92
275_F	282_S	0.544	0.92
212_I	215_D	0.544	0.92
285_S	288_M	0.544	0.92
20_N	24_Q	0.542	0.92
159_I	175_G	0.540	0.91
72_L	171_I	0.540	0.91
24_Q	295_Q	0.537	0.91
208_D	217_Q	0.537	0.91
126_I	130_T	0.536	0.91
279_N	291_Q	0.535	0.91
79_A	83_T	0.533	0.91
111_S	233_A	0.532	0.91
15_R	28_E	0.532	0.91
56_I	253_G	0.530	0.91
208_D	212_I	0.530	0.91
73_I	239_Q	0.528	0.90
168_S	173_D	0.528	0.90
47_A	111_S	0.528	0.90
251_A	254_E	0.527	0.90
254_E	257_T	0.526	0.90
50_E	264_R	0.525	0.90
114_D	118_A	0.524	0.90
284_A	287_A	0.524	0.90
23_S	282_S	0.523	0.90
78_G	255_N	0.522	0.90
98_G	109_L	0.521	0.90
261_S	264_R	0.519	0.90
77_E	235_L	0.519	0.90
227_Q	230_S	0.519	0.90
23_S	26_N	0.518	0.90
155_L	169_V	0.518	0.90
237_A	240_N	0.517	0.90
222_D	225_I	0.517	0.90
57_R	88_Q	0.516	0.89
135_K	155_L	0.515	0.89
279_N	286_Q	0.513	0.89
5_H	260_E	0.513	0.89
276_T	280_I	0.513	0.89
160_G	164_T	0.512	0.89
83_T	138_L	0.512	0.89
76_A	137_L	0.512	0.89
50_E	229_S	0.510	0.89
78_G	251_A	0.509	0.89
119_L	244_H	0.508	0.89
175_G	179_L	0.507	0.89
80_L	138_L	0.506	0.89
75_T	132_F	0.503	0.88
158_Q	163_A	0.501	0.88
12_T	15_R	0.500	0.88
67_Q	71_S	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ucuA	1	0.9572	100	0.158	Contact Map
3pwxA	2	0.727	100	0.387	Contact Map
2d4xA	1	0.648	100	0.406	Contact Map
3k8wA	1	0.6809	100	0.416	Contact Map
4nx9A	1	0.6053	100	0.549	Contact Map
3v47C	1	0.5757	100	0.574	Contact Map
4cfiA	1	0.5362	99.9	0.644	Contact Map
1io1A	1	0.5855	99.8	0.666	Contact Map
3k1iC	1	0.3947	99.5	0.754	Contact Map
1oryB	2	0.1316	98.6	0.833	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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