GREMLIN Database
SSPC - Small, acid-soluble spore protein C
UniProt: P02958 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 72 (62)
Sequences: 494 (180)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_T59_L3.6491.00
50_S54_E2.7450.99
48_N51_V2.6680.99
23_A27_M2.4300.98
56_T60_V2.0890.95
31_I58_R2.0550.94
35_F54_E1.9640.93
27_M31_I1.9610.93
54_E57_K1.9100.92
55_I59_L1.8900.91
37_V43_T1.6000.83
61_R65_Q1.5810.82
24_I55_I1.5630.81
45_S48_N1.5460.80
21_A25_E1.5000.78
31_I51_V1.4410.75
40_G43_T1.4380.75
39_L50_S1.3980.73
44_T47_A1.3970.73
39_L42_E1.3860.72
29_L34_E1.3160.68
62_L65_Q1.3110.68
50_S57_K1.3040.68
31_I54_E1.2670.65
55_I69_G1.1690.59
35_F40_G1.1200.56
62_L66_N1.1040.55
37_V51_V1.0500.51
46_R51_V1.0480.51
20_A23_A1.0220.49
22_S38_Q1.0000.47
37_V57_K0.9650.45
20_A27_M0.9560.44
55_I58_R0.9520.44
29_L55_I0.9480.44
54_E58_R0.9360.43
43_T48_N0.9330.43
25_E29_L0.9310.43
10_N14_D0.9100.41
13_N67_M0.8960.40
45_S69_G0.8700.39
20_A33_S0.8570.38
14_D45_S0.8380.36
40_G45_S0.7930.34
39_L43_T0.7910.33
17_I66_N0.7890.33
66_N69_G0.7870.33
20_A67_M0.7680.32
40_G48_N0.7590.32
10_N23_A0.7460.31
51_V54_E0.7440.31
39_L48_N0.7420.31
23_A38_Q0.7380.30
9_S68_G0.7340.30
36_G70_Q0.6770.27
54_E61_R0.6750.27
33_S44_T0.6690.26
14_D17_I0.6650.26
37_V40_G0.6630.26
19_Q61_R0.6600.26
63_A70_Q0.6560.26
16_L24_I0.6510.25
56_T64_Q0.6470.25
41_A60_V0.6400.25
46_R61_R0.6370.25
15_L41_A0.6330.24
35_F50_S0.6300.24
17_I62_L0.6120.23
11_N50_S0.6090.23
60_V63_A0.6060.23
21_A63_A0.5960.23
15_L18_P0.5940.23
15_L19_Q0.5930.22
37_V42_E0.5720.21
39_L47_A0.5690.21
27_M63_A0.5650.21
33_S47_A0.5580.21
47_A63_A0.5570.21
42_E66_N0.5520.21
61_R66_N0.5440.20
11_N70_Q0.5390.20
13_N26_Q0.5310.20
50_S69_G0.5230.19
9_S12_N0.5210.19
13_N63_A0.5120.19
13_N16_L0.5090.19
40_G47_A0.5090.19
25_E67_M0.5080.19
61_R67_M0.5040.18
27_M41_A0.5040.18
26_Q61_R0.5030.18
41_A44_T0.5030.18
40_G54_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z3xA 3 0.7778 99.9 0.3 Contact Map
4bzjA 2 0 5.9 0.926 Contact Map
3frrA 1 0.6528 5.6 0.927 Contact Map
3sjrA 2 0.8333 4.7 0.929 Contact Map
2wshA 4 0.5694 4.3 0.93 Contact Map
3pm9A 5 0.9722 4 0.932 Contact Map
3h0gA 2 0.9861 3.8 0.932 Contact Map
3k44A 1 0.5 3.7 0.933 Contact Map
2bcqA 1 0.6944 3.7 0.933 Contact Map
2qb7A 1 0.4028 3.7 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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