GREMLIN Database
RL7 - 50S ribosomal protein L7/L12
UniProt: P02394 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (119)
Sequences: 2751 (1203)
Seq/√Len: 110.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_K30_E3.1451.00
84_K88_E3.0851.00
7_E11_S2.9941.00
78_I109_L2.9271.00
110_K114_E2.9121.00
113_L118_A2.6411.00
62_A121_E2.5861.00
62_A119_S2.5641.00
108_E112_K2.5621.00
63_G119_S2.4791.00
67_Q70_K2.4481.00
74_V77_E2.2891.00
60_I96_P2.2691.00
111_A115_E2.2421.00
77_E112_K2.1511.00
64_A91_D1.7201.00
5_I15_A1.6981.00
58_D100_G1.6651.00
88_E92_N1.6031.00
10_A14_E1.5491.00
8_I11_S1.5461.00
53_E103_K1.5401.00
21_N25_K1.5231.00
102_A105_E1.5201.00
110_K120_V1.4831.00
9_I27_I1.4681.00
17_V20_L1.4511.00
75_V90_V1.4401.00
105_E108_E1.4371.00
70_K116_V1.4341.00
13_K31_F1.4321.00
10_A13_K1.4091.00
107_E111_A1.3391.00
108_E111_A1.2990.99
98_K105_E1.2760.99
7_E10_A1.2430.99
54_Q57_F1.2320.99
6_E26_A1.2200.99
5_I26_A1.2090.99
25_K28_E1.1960.99
6_E10_A1.1890.99
74_V115_E1.1830.99
11_S14_E1.1780.99
98_K109_L1.1660.99
63_G66_S1.1550.99
104_E108_E1.1230.98
12_V31_F1.1150.98
111_A114_E1.1020.98
60_I121_E1.0980.98
92_N95_K1.0830.98
114_E119_S1.0660.98
57_F103_K1.0590.98
56_E100_G1.0410.97
5_I11_S1.0370.97
54_Q58_D1.0320.97
67_Q116_V1.0260.97
101_I122_V1.0230.97
8_I23_L1.0220.97
12_V27_I1.0200.97
104_E107_E1.0130.97
68_K90_V1.0100.97
9_I26_A0.9980.97
11_S15_A0.9940.96
110_K122_V0.9920.96
74_V112_K0.9860.96
85_E88_E0.9800.96
9_I13_K0.9630.96
69_I76_R0.9620.96
18_L21_N0.9580.96
103_K107_E0.9550.96
58_D96_P0.9530.96
75_V97_L0.9480.95
61_L93_T0.9370.95
5_I9_I0.9360.95
78_I112_K0.9210.95
105_E109_L0.9180.94
101_I109_L0.9170.94
9_I31_F0.9080.94
20_L27_I0.9020.94
101_I105_E0.8810.93
88_E95_K0.8760.93
59_L106_A0.8680.93
16_T19_E0.8550.92
28_E35_A0.8450.92
89_L95_K0.8260.91
5_I8_I0.8040.90
112_K115_E0.7940.89
54_Q100_G0.7920.89
8_I26_A0.7910.89
62_A94_P0.7710.88
90_V93_T0.7700.87
28_E34_T0.7580.87
58_D99_E0.7570.87
8_I12_V0.7560.86
21_N27_I0.7550.86
89_L97_L0.7350.85
15_A31_F0.7350.85
45_A49_G0.7320.85
82_G85_E0.7220.84
76_R79_T0.7190.84
96_P99_E0.7170.83
47_A51_A0.7100.83
59_L109_L0.7090.83
46_A49_G0.7060.82
114_E122_V0.7040.82
76_R81_L0.7020.82
62_A123_K0.6890.81
114_E120_V0.6830.80
72_I76_R0.6820.80
26_A30_E0.6810.80
23_L27_I0.6790.80
69_I72_I0.6730.79
78_I113_L0.6730.79
9_I30_E0.6730.79
15_A27_I0.6720.79
55_S122_V0.6720.79
90_V94_P0.6680.79
54_Q102_A0.6570.78
8_I27_I0.6560.78
80_G98_K0.6510.77
12_V34_T0.6460.77
76_R82_G0.6450.76
92_N96_P0.6410.76
79_T97_L0.6360.75
24_V31_F0.6340.75
12_V23_L0.6340.75
41_V44_G0.6330.75
53_E57_F0.6280.75
79_T98_K0.6280.75
57_F122_V0.6210.74
38_P41_V0.6200.74
39_V42_A0.6180.73
62_A93_T0.6160.73
65_G71_V0.6080.72
54_Q103_K0.6060.72
13_K27_I0.6060.72
48_G51_A0.6010.71
47_A50_A0.5990.71
79_T82_G0.5950.71
107_E122_V0.5890.70
61_L68_K0.5870.70
21_N24_V0.5830.69
19_E22_D0.5790.69
81_L89_L0.5750.68
113_L120_V0.5690.67
74_V78_I0.5670.67
60_I123_K0.5640.66
43_G46_A0.5640.66
89_L96_P0.5610.66
69_I91_D0.5570.66
46_A51_A0.5550.65
28_E33_V0.5550.65
12_V17_V0.5470.64
25_K29_E0.5450.64
70_K74_V0.5370.63
25_K32_G0.5370.63
113_L116_V0.5360.63
65_G118_A0.5320.62
20_L23_L0.5280.61
12_V30_E0.5240.61
6_E30_E0.5230.61
12_V15_A0.5230.61
61_L118_A0.5200.60
28_E31_F0.5190.60
8_I15_A0.5160.60
45_A48_G0.5150.60
44_G47_A0.5140.59
101_I106_A0.5130.59
7_E15_A0.5130.59
58_D123_K0.5110.59
5_I20_L0.5090.59
66_S119_S0.5080.59
68_K93_T0.5070.58
5_I30_E0.5060.58
34_T37_A0.5060.58
15_A20_L0.5050.58
61_L64_A0.5000.57
56_E102_A0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kix6 1 0.2439 100 0.053 Contact Map
2zjq5 1 0.5772 100 0.062 Contact Map
1dd3A 6 0.9837 100 0.08 Contact Map
2ftcE 2 0.9837 100 0.112 Contact Map
1ctfA 2 0.5528 99.9 0.338 Contact Map
4qs1e 1 0.5854 99.9 0.379 Contact Map
4kcze 1 0.5854 99.9 0.382 Contact Map
1dd4C 7 0.3252 98.3 0.752 Contact Map
1zavU 5 0.2439 97.1 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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