PUR1 - BACSU - GREMLIN Contacts

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PUR1 - Amidophosphoribosyltransferase

UniProt:	P00497	Sequences: MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGIVATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRSQNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKNSLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLREVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKMLAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQGVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHPCFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLACFTGKYPTEIYQDTVLPHVKEAVLTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	476 (433)
Sequences:	5600 (2751)
Seq/√Len:	132.2

ECOLI - PUR1 GLMS
BACSU - PUR1 GLMS
HALSA - Q9HPS4 GLMS
SULSO - Q7LXR4 Q7LXR3 Q980D3 Q97YQ6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
125_Q	164_M	5.248	1.00
181_V	202_V	4.517	1.00
27_T	78_A	3.757	1.00
413_E	416_R	3.612	1.00
279_Q	305_A	3.563	1.00
255_S	258_D	3.423	1.00
129_Q	148_R	3.390	1.00
272_N	275_K	3.323	1.00
281_S	425_S	3.096	1.00
280_E	431_G	3.070	1.00
276_M	434_K	3.034	1.00
146_I	161_S	3.024	1.00
411_S	414_E	3.005	1.00
193_I	220_V	2.871	1.00
45_V	54_A	2.810	1.00
149_S	160_N	2.713	1.00
45_V	52_L	2.666	1.00
15_F	30_G	2.547	1.00
153_T	156_D	2.524	1.00
58_Q	90_G	2.516	1.00
280_E	428_S	2.504	1.00
195_M	215_T	2.485	1.00
344_R	348_E	2.331	1.00
237_R	241_N	2.326	1.00
202_V	228_I	2.322	1.00
401_T	404_E	2.317	1.00
299_A	350_K	2.309	1.00
429_V	453_T	2.267	1.00
276_M	279_Q	2.249	1.00
271_K	275_K	2.243	1.00
32_H	65_F	2.234	1.00
77_G	174_M	2.119	1.00
351_R	379_E	2.115	1.00
428_S	431_G	2.115	1.00
260_N	265_N	2.072	1.00
449_L	453_T	2.058	1.00
229_N	232_G	2.042	1.00
57_G	92_Y	2.040	1.00
19_G	23_A	2.023	1.00
193_I	226_L	2.023	1.00
142_L	165_L	2.015	1.00
284_E	351_R	2.014	1.00
124_Q	128_N	2.006	1.00
193_I	202_V	1.989	1.00
275_K	305_A	1.987	1.00
370_T	374_E	1.970	1.00
218_R	235_S	1.967	1.00
46_A	75_G	1.958	1.00
158_I	183_L	1.953	1.00
303_A	313_G	1.874	1.00
281_S	285_A	1.850	1.00
229_N	234_K	1.849	1.00
196_M	199_A	1.847	1.00
276_M	431_G	1.841	1.00
433_L	449_L	1.832	1.00
221_E	237_R	1.830	1.00
41_G	95_V	1.825	1.00
121_Q	166_K	1.806	1.00
45_V	109_A	1.806	1.00
347_V	377_A	1.791	1.00
336_V	363_T	1.790	1.00
415_I	426_F	1.783	1.00
200_Y	233_M	1.778	1.00
324_F	327_P	1.758	1.00
406_I	415_I	1.751	1.00
285_A	289_T	1.750	1.00
149_S	164_M	1.745	1.00
155_K	236_E	1.727	1.00
142_L	171_F	1.711	1.00
209_F	214_A	1.705	1.00
100_F	105_N	1.695	1.00
131_S	147_K	1.679	1.00
131_S	144_H	1.647	1.00
154_L	175_T	1.644	1.00
27_T	80_G	1.642	1.00
66_Q	69_E	1.627	1.00
192_S	206_T	1.594	1.00
192_S	209_F	1.580	1.00
159_K	236_E	1.576	1.00
111_A	172_L	1.574	1.00
203_A	208_A	1.570	1.00
146_I	158_I	1.557	1.00
224_E	244_R	1.551	1.00
323_T	327_P	1.528	1.00
393_C	448_C	1.520	1.00
416_R	424_L	1.517	1.00
178_E	229_N	1.517	1.00
287_V	352_V	1.509	1.00
220_V	226_L	1.495	1.00
158_I	173_I	1.489	1.00
282_A	285_A	1.485	1.00
101_R	147_K	1.482	1.00
11_E	14_V	1.480	1.00
131_S	148_R	1.471	1.00
252_I	258_D	1.469	1.00
184_D	226_L	1.467	1.00
155_K	227_I	1.465	1.00
299_A	348_E	1.459	1.00
123_K	133_F	1.457	1.00
178_E	181_V	1.445	1.00
383_K	425_S	1.425	1.00
216_Y	248_S	1.412	1.00
184_D	202_V	1.407	1.00
264_I	269_A	1.397	1.00
321_G	327_P	1.395	1.00
283_V	383_K	1.394	1.00
371_M	374_E	1.391	1.00
18_W	230_D	1.389	1.00
325_I	328_S	1.389	1.00
195_M	200_Y	1.382	1.00
381_H	423_T	1.381	1.00
413_E	417_Q	1.378	1.00
281_S	284_E	1.366	1.00
271_K	304_E	1.364	1.00
57_G	67_N	1.361	1.00
324_F	328_S	1.360	1.00
162_L	165_L	1.357	1.00
187_G	223_G	1.356	1.00
416_R	421_A	1.352	1.00
154_L	183_L	1.351	1.00
193_I	218_R	1.350	1.00
124_Q	127_E	1.344	1.00
169_Y	185_P	1.330	1.00
327_P	332_R	1.330	1.00
285_A	353_V	1.326	1.00
269_A	273_L	1.319	1.00
180_I	227_I	1.318	1.00
24_P	75_G	1.314	1.00
46_A	78_A	1.307	1.00
107_S	176_E	1.303	1.00
169_Y	238_F	1.301	1.00
22_E	25_Q	1.300	1.00
410_H	418_E	1.300	1.00
175_T	178_E	1.299	1.00
202_V	226_L	1.287	1.00
412_V	416_R	1.286	1.00
210_D	341_S	1.281	1.00
365_S	382_V	1.277	1.00
389_I	399_T	1.269	1.00
155_K	225_M	1.261	1.00
41_G	58_Q	1.258	1.00
58_Q	91_G	1.252	1.00
395_Y	450_A	1.242	1.00
275_K	304_E	1.237	1.00
107_S	177_T	1.233	1.00
18_W	77_G	1.229	1.00
57_G	64_V	1.225	1.00
181_V	227_I	1.222	1.00
181_V	226_L	1.222	1.00
382_V	419_I	1.216	1.00
178_E	227_I	1.215	1.00
15_F	27_T	1.212	1.00
382_V	421_A	1.206	1.00
101_R	131_S	1.206	1.00
13_G	82_V	1.201	0.99
62_T	66_Q	1.198	0.99
12_C	113_N	1.192	0.99
155_K	234_K	1.189	0.99
268_S	345_G	1.189	0.99
123_K	127_E	1.169	0.99
285_A	288_V	1.168	0.99
56_K	92_Y	1.168	0.99
431_G	434_K	1.162	0.99
448_C	451_C	1.158	0.99
248_S	436_I	1.158	0.99
149_S	157_Q	1.149	0.99
193_I	228_I	1.147	0.99
48_D	51_K	1.145	0.99
160_N	163_S	1.145	0.99
100_F	131_S	1.144	0.99
19_G	199_A	1.142	0.99
17_I	26_I	1.142	0.99
29_Y	211_V	1.141	0.99
125_Q	129_Q	1.131	0.99
252_I	256_R	1.131	0.99
227_I	234_K	1.130	0.99
200_Y	228_I	1.128	0.99
116_L	165_L	1.126	0.99
68_G	72_K	1.123	0.99
165_L	169_Y	1.120	0.99
17_I	199_A	1.120	0.99
347_V	372_L	1.119	0.99
373_R	422_D	1.117	0.99
63_E	66_Q	1.116	0.99
62_T	65_F	1.115	0.99
191_L	220_V	1.114	0.99
149_S	161_S	1.110	0.99
172_L	202_V	1.106	0.99
333_E	363_T	1.103	0.99
248_S	447_Q	1.099	0.99
289_T	313_G	1.096	0.99
388_P	407_A	1.093	0.99
16_G	172_L	1.091	0.99
46_A	53_T	1.089	0.99
391_H	402_H	1.086	0.99
303_A	306_T	1.083	0.99
393_C	450_A	1.079	0.99
267_H	297_S	1.074	0.99
414_E	417_Q	1.074	0.99
281_S	286_D	1.072	0.99
290_G	294_S	1.069	0.99
370_T	420_G	1.068	0.99
171_F	182_A	1.063	0.99
151_H	156_D	1.063	0.99
168_A	188_L	1.062	0.99
282_A	425_S	1.059	0.99
328_S	332_R	1.056	0.99
252_I	257_P	1.042	0.99
200_Y	232_G	1.042	0.99
429_V	449_L	1.041	0.99
52_L	109_A	1.040	0.99
335_G	343_V	1.040	0.99
321_G	326_Q	1.036	0.98
436_I	447_Q	1.034	0.98
112_H	139_T	1.019	0.98
99_L	109_A	1.015	0.98
195_M	233_M	1.010	0.98
54_A	99_L	1.009	0.98
368_I	372_L	1.009	0.98
55_H	69_E	1.004	0.98
31_L	80_G	1.003	0.98
146_I	173_I	0.994	0.98
193_I	233_M	0.990	0.98
252_I	255_S	0.990	0.98
283_V	286_D	0.989	0.98
338_M	341_S	0.988	0.98
407_A	415_I	0.987	0.98
278_A	305_A	0.984	0.98
221_E	224_E	0.967	0.98
16_G	202_V	0.965	0.98
366_R	418_E	0.964	0.98
253_Y	258_D	0.960	0.98
155_K	159_K	0.958	0.97
170_A	188_L	0.954	0.97
285_A	290_G	0.954	0.97
15_F	203_A	0.953	0.97
21_E	199_A	0.953	0.97
227_I	236_E	0.952	0.97
221_E	244_R	0.950	0.97
24_P	46_A	0.949	0.97
261_I	266_V	0.949	0.97
253_Y	256_R	0.949	0.97
268_S	272_N	0.946	0.97
272_N	276_M	0.945	0.97
286_D	289_T	0.939	0.97
154_L	158_I	0.934	0.97
26_I	212_V	0.934	0.97
24_P	44_I	0.932	0.97
323_T	335_G	0.928	0.97
412_V	424_L	0.928	0.97
162_L	182_A	0.927	0.97
200_Y	217_L	0.924	0.97
108_L	175_T	0.924	0.97
195_M	218_R	0.919	0.97
98_L	135_T	0.915	0.97
46_A	73_V	0.915	0.97
201_V	209_F	0.911	0.97
218_R	224_E	0.911	0.97
351_R	378_T	0.911	0.97
86_T	113_N	0.910	0.97
85_A	90_G	0.906	0.96
172_L	182_A	0.905	0.96
207_C	210_D	0.903	0.96
157_Q	161_S	0.902	0.96
116_L	142_L	0.898	0.96
48_D	53_T	0.897	0.96
58_Q	89_G	0.892	0.96
206_T	216_Y	0.890	0.96
433_L	447_Q	0.887	0.96
133_F	140_E	0.878	0.96
132_I	144_H	0.877	0.96
271_K	311_E	0.875	0.96
110_L	143_A	0.873	0.96
323_T	326_Q	0.871	0.96
321_G	324_F	0.870	0.96
125_Q	148_R	0.870	0.96
313_G	355_V	0.868	0.95
47_T	174_M	0.865	0.95
321_G	325_I	0.863	0.95
151_H	160_N	0.863	0.95
100_F	107_S	0.863	0.95
291_V	294_S	0.862	0.95
334_Q	338_M	0.862	0.95
312_L	318_R	0.862	0.95
325_I	332_R	0.860	0.95
371_M	375_A	0.860	0.95
283_V	425_S	0.859	0.95
282_A	286_D	0.857	0.95
206_T	219_E	0.855	0.95
284_E	288_V	0.851	0.95
126_L	133_F	0.851	0.95
237_R	240_M	0.850	0.95
288_V	292_P	0.849	0.95
388_P	412_V	0.849	0.95
210_D	344_R	0.845	0.95
108_L	154_L	0.844	0.95
12_C	86_T	0.841	0.95
117_V	166_K	0.836	0.94
193_I	200_Y	0.830	0.94
289_T	354_M	0.829	0.94
13_G	42_A	0.829	0.94
351_R	354_M	0.828	0.94
292_P	295_S	0.828	0.94
142_L	161_S	0.827	0.94
152_F	160_N	0.827	0.94
28_Y	65_F	0.826	0.94
126_L	145_L	0.823	0.94
67_N	71_S	0.819	0.94
118_N	122_L	0.818	0.94
66_Q	70_L	0.818	0.94
260_N	263_G	0.818	0.94
430_E	433_L	0.815	0.94
349_G	378_T	0.814	0.94
17_I	23_A	0.812	0.94
285_A	291_V	0.806	0.93
300_I	333_E	0.804	0.93
273_L	432_L	0.803	0.93
159_K	163_S	0.803	0.93
251_Y	256_R	0.803	0.93
290_G	296_I	0.799	0.93
172_L	181_V	0.798	0.93
55_H	72_K	0.797	0.93
110_L	139_T	0.796	0.93
196_M	201_V	0.795	0.93
392_P	401_T	0.794	0.93
206_T	210_D	0.793	0.93
407_A	426_F	0.791	0.93
87_A	136_S	0.787	0.93
135_T	140_E	0.787	0.93
296_I	312_L	0.785	0.92
290_G	293_D	0.784	0.92
319_Y	323_T	0.784	0.92
285_A	308_I	0.783	0.92
194_G	214_A	0.782	0.92
32_H	62_T	0.779	0.92
282_A	383_K	0.778	0.92
348_E	351_R	0.777	0.92
274_G	278_A	0.776	0.92
24_P	73_V	0.775	0.92
20_H	230_D	0.774	0.92
120_T	124_Q	0.774	0.92
101_R	132_I	0.772	0.92
286_D	290_G	0.771	0.92
180_I	225_M	0.771	0.92
87_A	115_N	0.769	0.92
58_Q	92_Y	0.768	0.92
79_I	174_M	0.767	0.92
402_H	408_S	0.766	0.91
302_Y	340_L	0.764	0.91
28_Y	44_I	0.764	0.91
370_T	373_R	0.763	0.91
219_E	247_C	0.763	0.91
286_D	291_V	0.762	0.91
253_Y	257_P	0.761	0.91
322_R	344_R	0.761	0.91
26_I	196_M	0.757	0.91
156_D	159_K	0.754	0.91
390_A	454_G	0.753	0.91
220_V	233_M	0.753	0.91
383_K	423_T	0.753	0.91
265_N	268_S	0.753	0.91
83_R	86_T	0.751	0.91
40_E	85_A	0.751	0.91
369_V	372_L	0.749	0.91
133_F	141_V	0.745	0.90
17_I	201_V	0.743	0.90
352_V	372_L	0.743	0.90
150_G	153_T	0.742	0.90
393_C	451_C	0.741	0.90
254_F	257_P	0.739	0.90
281_S	287_V	0.739	0.90
282_A	288_V	0.738	0.90
182_A	238_F	0.737	0.90
109_A	174_M	0.734	0.90
47_T	77_G	0.734	0.90
354_M	382_V	0.733	0.90
323_T	328_S	0.730	0.89
248_S	251_Y	0.730	0.89
25_Q	29_Y	0.729	0.89
145_L	165_L	0.727	0.89
273_L	385_S	0.722	0.89
315_I	318_R	0.721	0.89
158_I	180_I	0.721	0.89
192_S	216_Y	0.720	0.89
368_I	371_M	0.719	0.89
362_G	366_R	0.719	0.89
319_Y	322_R	0.719	0.89
27_T	46_A	0.718	0.89
322_R	325_I	0.717	0.89
55_H	67_N	0.713	0.88
100_F	147_K	0.712	0.88
287_V	291_V	0.709	0.88
267_H	271_K	0.708	0.88
42_A	82_V	0.707	0.88
127_E	130_G	0.707	0.88
386_S	452_F	0.707	0.88
130_G	133_F	0.706	0.88
370_T	376_G	0.705	0.88
61_I	68_G	0.703	0.88
283_V	287_V	0.702	0.88
321_G	328_S	0.701	0.87
219_E	262_D	0.700	0.87
265_N	269_A	0.700	0.87
292_P	296_I	0.698	0.87
16_G	179_M	0.696	0.87
234_K	242_I	0.696	0.87
274_G	277_L	0.695	0.87
363_T	366_R	0.695	0.87
144_H	147_K	0.691	0.87
350_K	354_M	0.690	0.87
359_I	382_V	0.690	0.87
83_R	113_N	0.688	0.86
25_Q	67_N	0.687	0.86
162_L	169_Y	0.686	0.86
177_T	230_D	0.686	0.86
30_G	201_V	0.683	0.86
195_M	217_L	0.681	0.86
57_G	61_I	0.680	0.86
282_A	287_V	0.680	0.86
433_L	438_R	0.679	0.86
347_V	352_V	0.678	0.86
14_V	172_L	0.678	0.86
101_R	107_S	0.677	0.86
56_K	93_E	0.676	0.85
123_K	141_V	0.674	0.85
286_D	292_P	0.673	0.85
416_R	423_T	0.671	0.85
275_K	279_Q	0.669	0.85
119_A	123_K	0.668	0.85
363_T	367_R	0.666	0.85
79_I	172_L	0.666	0.85
431_G	435_G	0.662	0.84
284_E	289_T	0.662	0.84
377_A	380_V	0.661	0.84
434_K	437_G	0.661	0.84
330_A	334_Q	0.661	0.84
187_G	222_P	0.659	0.84
181_V	228_I	0.659	0.84
300_I	303_A	0.658	0.84
275_K	278_A	0.658	0.84
201_V	212_V	0.657	0.84
129_Q	150_G	0.657	0.84
195_M	216_Y	0.655	0.84
249_M	256_R	0.654	0.84
366_R	417_Q	0.653	0.83
430_E	434_K	0.653	0.83
186_N	245_S	0.651	0.83
391_H	454_G	0.651	0.83
266_V	269_A	0.650	0.83
259_S	263_G	0.650	0.83
273_L	427_L	0.649	0.83
447_Q	450_A	0.648	0.83
389_I	397_I	0.644	0.83
340_L	347_V	0.644	0.83
83_R	88_G	0.644	0.83
76_K	230_D	0.643	0.83
412_V	425_S	0.642	0.82
253_Y	324_F	0.641	0.82
95_V	157_Q	0.640	0.82
197_G	215_T	0.640	0.82
125_Q	128_N	0.639	0.82
324_F	332_R	0.638	0.82
295_S	298_A	0.637	0.82
372_L	377_A	0.637	0.82
159_K	225_M	0.636	0.82
110_L	142_L	0.636	0.82
281_S	289_T	0.636	0.82
169_Y	187_G	0.635	0.82
298_A	385_S	0.634	0.82
79_I	111_A	0.633	0.82
183_L	187_G	0.633	0.82
429_V	432_L	0.633	0.82
13_G	34_L	0.632	0.81
333_E	336_V	0.631	0.81
251_Y	262_D	0.631	0.81
20_H	198_D	0.629	0.81
47_T	50_E	0.627	0.81
246_I	262_D	0.626	0.81
184_D	193_I	0.623	0.81
385_S	391_H	0.623	0.81
434_K	438_R	0.623	0.81
99_L	106_G	0.622	0.80
326_Q	332_R	0.622	0.80
193_I	235_S	0.622	0.80
228_I	233_M	0.621	0.80
248_S	252_I	0.620	0.80
180_I	230_D	0.619	0.80
87_A	119_A	0.619	0.80
90_G	94_N	0.619	0.80
127_E	132_I	0.617	0.80
276_M	435_G	0.616	0.80
416_R	419_I	0.616	0.80
29_Y	32_H	0.614	0.80
89_G	93_E	0.614	0.80
56_K	59_G	0.614	0.80
283_V	289_T	0.613	0.79
248_S	449_L	0.611	0.79
101_R	144_H	0.608	0.79
118_N	167_G	0.606	0.79
360_V	363_T	0.606	0.79
311_E	314_L	0.606	0.79
248_S	432_L	0.604	0.78
316_K	320_V	0.603	0.78
320_V	324_F	0.603	0.78
401_T	408_S	0.602	0.78
433_L	439_K	0.601	0.78
432_L	435_G	0.598	0.78
359_I	362_G	0.598	0.78
411_S	417_Q	0.598	0.78
33_S	211_V	0.597	0.78
392_P	399_T	0.596	0.78
438_R	447_Q	0.596	0.78
365_S	368_I	0.595	0.77
98_L	137_S	0.595	0.77
339_K	342_A	0.595	0.77
121_Q	164_M	0.595	0.77
247_C	250_E	0.594	0.77
284_E	287_V	0.594	0.77
390_A	453_T	0.594	0.77
399_T	405_L	0.592	0.77
284_E	290_G	0.591	0.77
249_M	253_Y	0.590	0.77
93_E	136_S	0.588	0.77
276_M	280_E	0.586	0.76
362_G	367_R	0.585	0.76
299_A	302_Y	0.585	0.76
65_F	69_E	0.584	0.76
433_L	437_G	0.583	0.76
65_F	75_G	0.583	0.76
359_I	363_T	0.581	0.76
272_N	279_Q	0.579	0.76
411_S	416_R	0.579	0.76
173_I	183_L	0.577	0.75
274_G	292_P	0.576	0.75
22_E	74_K	0.575	0.75
368_I	376_G	0.575	0.75
450_A	453_T	0.574	0.75
100_F	143_A	0.573	0.75
126_L	130_G	0.573	0.75
319_Y	325_I	0.569	0.74
64_V	69_E	0.568	0.74
60_L	63_E	0.565	0.74
179_M	228_I	0.565	0.74
287_V	290_G	0.564	0.74
404_E	407_A	0.564	0.74
193_I	217_L	0.563	0.73
382_V	390_A	0.562	0.73
235_S	244_R	0.560	0.73
181_V	200_Y	0.560	0.73
55_H	65_F	0.559	0.73
354_M	372_L	0.558	0.73
273_L	277_L	0.558	0.73
273_L	436_I	0.558	0.73
417_Q	420_G	0.557	0.73
432_L	436_I	0.556	0.73
325_I	344_R	0.556	0.73
399_T	408_S	0.555	0.72
93_E	134_Q	0.555	0.72
380_V	383_K	0.555	0.72
415_I	419_I	0.554	0.72
86_T	112_H	0.552	0.72
53_T	57_G	0.552	0.72
281_S	383_K	0.552	0.72
388_P	451_C	0.549	0.72
162_L	225_M	0.549	0.72
15_F	201_V	0.549	0.72
400_S	404_E	0.548	0.71
61_I	65_F	0.547	0.71
287_V	294_S	0.547	0.71
264_I	272_N	0.545	0.71
376_G	380_V	0.545	0.71
331_L	334_Q	0.545	0.71
264_I	268_S	0.543	0.71
269_A	436_I	0.542	0.71
21_E	26_I	0.541	0.71
345_G	348_E	0.539	0.70
303_A	308_I	0.537	0.70
294_S	298_A	0.537	0.70
149_S	152_F	0.536	0.70
415_I	418_E	0.536	0.70
123_K	126_L	0.535	0.70
437_G	449_L	0.534	0.70
376_G	379_E	0.532	0.69
195_M	199_A	0.532	0.69
317_N	333_E	0.530	0.69
418_E	421_A	0.529	0.69
53_T	74_K	0.529	0.69
208_A	336_V	0.529	0.69
264_I	437_G	0.528	0.69
224_E	235_S	0.528	0.69
81_H	113_N	0.527	0.69
283_V	288_V	0.527	0.69
375_A	379_E	0.527	0.69
55_H	71_S	0.526	0.68
293_D	296_I	0.526	0.68
86_T	115_N	0.526	0.68
196_M	200_Y	0.526	0.68
417_Q	455_K	0.525	0.68
434_K	439_K	0.524	0.68
281_S	288_V	0.522	0.68
298_A	301_G	0.522	0.68
15_F	212_V	0.521	0.68
385_S	388_P	0.521	0.68
342_A	347_V	0.521	0.68
25_Q	70_L	0.520	0.68
282_A	292_P	0.520	0.68
42_A	65_F	0.520	0.68
433_L	453_T	0.520	0.68
57_G	66_Q	0.519	0.67
86_T	139_T	0.519	0.67
292_P	322_R	0.518	0.67
32_H	338_M	0.518	0.67
181_V	229_N	0.516	0.67
12_C	81_H	0.516	0.67
438_R	449_L	0.514	0.67
57_G	63_E	0.514	0.67
280_E	425_S	0.513	0.67
262_D	269_A	0.513	0.67
150_G	160_N	0.512	0.66
362_G	365_S	0.511	0.66
336_V	339_K	0.511	0.66
447_Q	452_F	0.511	0.66
410_H	413_E	0.511	0.66
83_R	138_D	0.511	0.66
81_H	364_T	0.511	0.66
319_Y	324_F	0.510	0.66
175_T	183_L	0.510	0.66
51_K	176_E	0.509	0.66
61_I	207_C	0.508	0.66
366_R	401_T	0.507	0.66
302_Y	306_T	0.507	0.66
23_A	78_A	0.507	0.66
196_M	214_A	0.507	0.66
390_A	408_S	0.506	0.65
263_G	266_V	0.506	0.65
403_E	409_S	0.505	0.65
358_S	362_G	0.505	0.65
81_H	112_H	0.505	0.65
264_I	436_I	0.505	0.65
48_D	75_G	0.504	0.65
18_W	229_N	0.504	0.65
289_T	292_P	0.503	0.65
28_Y	32_H	0.503	0.65
295_S	340_L	0.503	0.65
403_E	407_A	0.503	0.65
392_P	402_H	0.503	0.65
323_T	332_R	0.503	0.65
88_G	113_N	0.502	0.65
170_A	189_R	0.500	0.65
282_A	290_G	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ecfA	4	0.9706	100	0.343	Contact Map
1ao0A	3	0.9538	100	0.352	Contact Map
4amvA	2	0.9391	100	0.519	Contact Map
1ct9A	2	0.8508	100	0.578	Contact Map
1xffA	2	0.4874	100	0.622	Contact Map
1jgtA	2	0.8046	100	0.652	Contact Map
1te5A	2	0.4517	100	0.664	Contact Map
3mdnA	4	0.4202	100	0.666	Contact Map
1ofdA	1	0.813	100	0.69	Contact Map
1ea0A	1	0.8172	100	0.696	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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