GREMLIN Database
PUR1 - Amidophosphoribosyltransferase
UniProt: P00497 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 476 (433)
Sequences: 5600 (2751)
Seq/√Len: 132.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_Q164_M5.2481.00
181_V202_V4.5171.00
27_T78_A3.7571.00
413_E416_R3.6121.00
279_Q305_A3.5631.00
255_S258_D3.4231.00
129_Q148_R3.3901.00
272_N275_K3.3231.00
281_S425_S3.0961.00
280_E431_G3.0701.00
276_M434_K3.0341.00
146_I161_S3.0241.00
411_S414_E3.0051.00
193_I220_V2.8711.00
45_V54_A2.8101.00
149_S160_N2.7131.00
45_V52_L2.6661.00
15_F30_G2.5471.00
153_T156_D2.5241.00
58_Q90_G2.5161.00
280_E428_S2.5041.00
195_M215_T2.4851.00
344_R348_E2.3311.00
237_R241_N2.3261.00
202_V228_I2.3221.00
401_T404_E2.3171.00
299_A350_K2.3091.00
429_V453_T2.2671.00
276_M279_Q2.2491.00
271_K275_K2.2431.00
32_H65_F2.2341.00
77_G174_M2.1191.00
351_R379_E2.1151.00
428_S431_G2.1151.00
260_N265_N2.0721.00
449_L453_T2.0581.00
229_N232_G2.0421.00
57_G92_Y2.0401.00
19_G23_A2.0231.00
193_I226_L2.0231.00
142_L165_L2.0151.00
284_E351_R2.0141.00
124_Q128_N2.0061.00
193_I202_V1.9891.00
275_K305_A1.9871.00
370_T374_E1.9701.00
218_R235_S1.9671.00
46_A75_G1.9581.00
158_I183_L1.9531.00
303_A313_G1.8741.00
281_S285_A1.8501.00
229_N234_K1.8491.00
196_M199_A1.8471.00
276_M431_G1.8411.00
433_L449_L1.8321.00
221_E237_R1.8301.00
41_G95_V1.8251.00
121_Q166_K1.8061.00
45_V109_A1.8061.00
347_V377_A1.7911.00
336_V363_T1.7901.00
415_I426_F1.7831.00
200_Y233_M1.7781.00
324_F327_P1.7581.00
406_I415_I1.7511.00
285_A289_T1.7501.00
149_S164_M1.7451.00
155_K236_E1.7271.00
142_L171_F1.7111.00
209_F214_A1.7051.00
100_F105_N1.6951.00
131_S147_K1.6791.00
131_S144_H1.6471.00
154_L175_T1.6441.00
27_T80_G1.6421.00
66_Q69_E1.6271.00
192_S206_T1.5941.00
192_S209_F1.5801.00
159_K236_E1.5761.00
111_A172_L1.5741.00
203_A208_A1.5701.00
146_I158_I1.5571.00
224_E244_R1.5511.00
323_T327_P1.5281.00
393_C448_C1.5201.00
416_R424_L1.5171.00
178_E229_N1.5171.00
287_V352_V1.5091.00
220_V226_L1.4951.00
158_I173_I1.4891.00
282_A285_A1.4851.00
101_R147_K1.4821.00
11_E14_V1.4801.00
131_S148_R1.4711.00
252_I258_D1.4691.00
184_D226_L1.4671.00
155_K227_I1.4651.00
299_A348_E1.4591.00
123_K133_F1.4571.00
178_E181_V1.4451.00
383_K425_S1.4251.00
216_Y248_S1.4121.00
184_D202_V1.4071.00
264_I269_A1.3971.00
321_G327_P1.3951.00
283_V383_K1.3941.00
371_M374_E1.3911.00
18_W230_D1.3891.00
325_I328_S1.3891.00
195_M200_Y1.3821.00
381_H423_T1.3811.00
413_E417_Q1.3781.00
281_S284_E1.3661.00
271_K304_E1.3641.00
57_G67_N1.3611.00
324_F328_S1.3601.00
162_L165_L1.3571.00
187_G223_G1.3561.00
416_R421_A1.3521.00
154_L183_L1.3511.00
193_I218_R1.3501.00
124_Q127_E1.3441.00
169_Y185_P1.3301.00
327_P332_R1.3301.00
285_A353_V1.3261.00
269_A273_L1.3191.00
180_I227_I1.3181.00
24_P75_G1.3141.00
46_A78_A1.3071.00
107_S176_E1.3031.00
169_Y238_F1.3011.00
22_E25_Q1.3001.00
410_H418_E1.3001.00
175_T178_E1.2991.00
202_V226_L1.2871.00
412_V416_R1.2861.00
210_D341_S1.2811.00
365_S382_V1.2771.00
389_I399_T1.2691.00
155_K225_M1.2611.00
41_G58_Q1.2581.00
58_Q91_G1.2521.00
395_Y450_A1.2421.00
275_K304_E1.2371.00
107_S177_T1.2331.00
18_W77_G1.2291.00
57_G64_V1.2251.00
181_V227_I1.2221.00
181_V226_L1.2221.00
382_V419_I1.2161.00
178_E227_I1.2151.00
15_F27_T1.2121.00
382_V421_A1.2061.00
101_R131_S1.2061.00
13_G82_V1.2010.99
62_T66_Q1.1980.99
12_C113_N1.1920.99
155_K234_K1.1890.99
268_S345_G1.1890.99
123_K127_E1.1690.99
285_A288_V1.1680.99
56_K92_Y1.1680.99
431_G434_K1.1620.99
448_C451_C1.1580.99
248_S436_I1.1580.99
149_S157_Q1.1490.99
193_I228_I1.1470.99
48_D51_K1.1450.99
160_N163_S1.1450.99
100_F131_S1.1440.99
19_G199_A1.1420.99
17_I26_I1.1420.99
29_Y211_V1.1410.99
125_Q129_Q1.1310.99
252_I256_R1.1310.99
227_I234_K1.1300.99
200_Y228_I1.1280.99
116_L165_L1.1260.99
68_G72_K1.1230.99
165_L169_Y1.1200.99
17_I199_A1.1200.99
347_V372_L1.1190.99
373_R422_D1.1170.99
63_E66_Q1.1160.99
62_T65_F1.1150.99
191_L220_V1.1140.99
149_S161_S1.1100.99
172_L202_V1.1060.99
333_E363_T1.1030.99
248_S447_Q1.0990.99
289_T313_G1.0960.99
388_P407_A1.0930.99
16_G172_L1.0910.99
46_A53_T1.0890.99
391_H402_H1.0860.99
303_A306_T1.0830.99
393_C450_A1.0790.99
267_H297_S1.0740.99
414_E417_Q1.0740.99
281_S286_D1.0720.99
290_G294_S1.0690.99
370_T420_G1.0680.99
171_F182_A1.0630.99
151_H156_D1.0630.99
168_A188_L1.0620.99
282_A425_S1.0590.99
328_S332_R1.0560.99
252_I257_P1.0420.99
200_Y232_G1.0420.99
429_V449_L1.0410.99
52_L109_A1.0400.99
335_G343_V1.0400.99
321_G326_Q1.0360.98
436_I447_Q1.0340.98
112_H139_T1.0190.98
99_L109_A1.0150.98
195_M233_M1.0100.98
54_A99_L1.0090.98
368_I372_L1.0090.98
55_H69_E1.0040.98
31_L80_G1.0030.98
146_I173_I0.9940.98
193_I233_M0.9900.98
252_I255_S0.9900.98
283_V286_D0.9890.98
338_M341_S0.9880.98
407_A415_I0.9870.98
278_A305_A0.9840.98
221_E224_E0.9670.98
16_G202_V0.9650.98
366_R418_E0.9640.98
253_Y258_D0.9600.98
155_K159_K0.9580.97
170_A188_L0.9540.97
285_A290_G0.9540.97
15_F203_A0.9530.97
21_E199_A0.9530.97
227_I236_E0.9520.97
221_E244_R0.9500.97
24_P46_A0.9490.97
261_I266_V0.9490.97
253_Y256_R0.9490.97
268_S272_N0.9460.97
272_N276_M0.9450.97
286_D289_T0.9390.97
154_L158_I0.9340.97
26_I212_V0.9340.97
24_P44_I0.9320.97
323_T335_G0.9280.97
412_V424_L0.9280.97
162_L182_A0.9270.97
200_Y217_L0.9240.97
108_L175_T0.9240.97
195_M218_R0.9190.97
98_L135_T0.9150.97
46_A73_V0.9150.97
201_V209_F0.9110.97
218_R224_E0.9110.97
351_R378_T0.9110.97
86_T113_N0.9100.97
85_A90_G0.9060.96
172_L182_A0.9050.96
207_C210_D0.9030.96
157_Q161_S0.9020.96
116_L142_L0.8980.96
48_D53_T0.8970.96
58_Q89_G0.8920.96
206_T216_Y0.8900.96
433_L447_Q0.8870.96
133_F140_E0.8780.96
132_I144_H0.8770.96
271_K311_E0.8750.96
110_L143_A0.8730.96
323_T326_Q0.8710.96
321_G324_F0.8700.96
125_Q148_R0.8700.96
313_G355_V0.8680.95
47_T174_M0.8650.95
321_G325_I0.8630.95
151_H160_N0.8630.95
100_F107_S0.8630.95
291_V294_S0.8620.95
334_Q338_M0.8620.95
312_L318_R0.8620.95
325_I332_R0.8600.95
371_M375_A0.8600.95
283_V425_S0.8590.95
282_A286_D0.8570.95
206_T219_E0.8550.95
284_E288_V0.8510.95
126_L133_F0.8510.95
237_R240_M0.8500.95
288_V292_P0.8490.95
388_P412_V0.8490.95
210_D344_R0.8450.95
108_L154_L0.8440.95
12_C86_T0.8410.95
117_V166_K0.8360.94
193_I200_Y0.8300.94
289_T354_M0.8290.94
13_G42_A0.8290.94
351_R354_M0.8280.94
292_P295_S0.8280.94
142_L161_S0.8270.94
152_F160_N0.8270.94
28_Y65_F0.8260.94
126_L145_L0.8230.94
67_N71_S0.8190.94
118_N122_L0.8180.94
66_Q70_L0.8180.94
260_N263_G0.8180.94
430_E433_L0.8150.94
349_G378_T0.8140.94
17_I23_A0.8120.94
285_A291_V0.8060.93
300_I333_E0.8040.93
273_L432_L0.8030.93
159_K163_S0.8030.93
251_Y256_R0.8030.93
290_G296_I0.7990.93
172_L181_V0.7980.93
55_H72_K0.7970.93
110_L139_T0.7960.93
196_M201_V0.7950.93
392_P401_T0.7940.93
206_T210_D0.7930.93
407_A426_F0.7910.93
87_A136_S0.7870.93
135_T140_E0.7870.93
296_I312_L0.7850.92
290_G293_D0.7840.92
319_Y323_T0.7840.92
285_A308_I0.7830.92
194_G214_A0.7820.92
32_H62_T0.7790.92
282_A383_K0.7780.92
348_E351_R0.7770.92
274_G278_A0.7760.92
24_P73_V0.7750.92
20_H230_D0.7740.92
120_T124_Q0.7740.92
101_R132_I0.7720.92
286_D290_G0.7710.92
180_I225_M0.7710.92
87_A115_N0.7690.92
58_Q92_Y0.7680.92
79_I174_M0.7670.92
402_H408_S0.7660.91
302_Y340_L0.7640.91
28_Y44_I0.7640.91
370_T373_R0.7630.91
219_E247_C0.7630.91
286_D291_V0.7620.91
253_Y257_P0.7610.91
322_R344_R0.7610.91
26_I196_M0.7570.91
156_D159_K0.7540.91
390_A454_G0.7530.91
220_V233_M0.7530.91
383_K423_T0.7530.91
265_N268_S0.7530.91
83_R86_T0.7510.91
40_E85_A0.7510.91
369_V372_L0.7490.91
133_F141_V0.7450.90
17_I201_V0.7430.90
352_V372_L0.7430.90
150_G153_T0.7420.90
393_C451_C0.7410.90
254_F257_P0.7390.90
281_S287_V0.7390.90
282_A288_V0.7380.90
182_A238_F0.7370.90
109_A174_M0.7340.90
47_T77_G0.7340.90
354_M382_V0.7330.90
323_T328_S0.7300.89
248_S251_Y0.7300.89
25_Q29_Y0.7290.89
145_L165_L0.7270.89
273_L385_S0.7220.89
315_I318_R0.7210.89
158_I180_I0.7210.89
192_S216_Y0.7200.89
368_I371_M0.7190.89
362_G366_R0.7190.89
319_Y322_R0.7190.89
27_T46_A0.7180.89
322_R325_I0.7170.89
55_H67_N0.7130.88
100_F147_K0.7120.88
287_V291_V0.7090.88
267_H271_K0.7080.88
42_A82_V0.7070.88
127_E130_G0.7070.88
386_S452_F0.7070.88
130_G133_F0.7060.88
370_T376_G0.7050.88
61_I68_G0.7030.88
283_V287_V0.7020.88
321_G328_S0.7010.87
219_E262_D0.7000.87
265_N269_A0.7000.87
292_P296_I0.6980.87
16_G179_M0.6960.87
234_K242_I0.6960.87
274_G277_L0.6950.87
363_T366_R0.6950.87
144_H147_K0.6910.87
350_K354_M0.6900.87
359_I382_V0.6900.87
83_R113_N0.6880.86
25_Q67_N0.6870.86
162_L169_Y0.6860.86
177_T230_D0.6860.86
30_G201_V0.6830.86
195_M217_L0.6810.86
57_G61_I0.6800.86
282_A287_V0.6800.86
433_L438_R0.6790.86
347_V352_V0.6780.86
14_V172_L0.6780.86
101_R107_S0.6770.86
56_K93_E0.6760.85
123_K141_V0.6740.85
286_D292_P0.6730.85
416_R423_T0.6710.85
275_K279_Q0.6690.85
119_A123_K0.6680.85
363_T367_R0.6660.85
79_I172_L0.6660.85
431_G435_G0.6620.84
284_E289_T0.6620.84
377_A380_V0.6610.84
434_K437_G0.6610.84
330_A334_Q0.6610.84
187_G222_P0.6590.84
181_V228_I0.6590.84
300_I303_A0.6580.84
275_K278_A0.6580.84
201_V212_V0.6570.84
129_Q150_G0.6570.84
195_M216_Y0.6550.84
249_M256_R0.6540.84
366_R417_Q0.6530.83
430_E434_K0.6530.83
186_N245_S0.6510.83
391_H454_G0.6510.83
266_V269_A0.6500.83
259_S263_G0.6500.83
273_L427_L0.6490.83
447_Q450_A0.6480.83
389_I397_I0.6440.83
340_L347_V0.6440.83
83_R88_G0.6440.83
76_K230_D0.6430.83
412_V425_S0.6420.82
253_Y324_F0.6410.82
95_V157_Q0.6400.82
197_G215_T0.6400.82
125_Q128_N0.6390.82
324_F332_R0.6380.82
295_S298_A0.6370.82
372_L377_A0.6370.82
159_K225_M0.6360.82
110_L142_L0.6360.82
281_S289_T0.6360.82
169_Y187_G0.6350.82
298_A385_S0.6340.82
79_I111_A0.6330.82
183_L187_G0.6330.82
429_V432_L0.6330.82
13_G34_L0.6320.81
333_E336_V0.6310.81
251_Y262_D0.6310.81
20_H198_D0.6290.81
47_T50_E0.6270.81
246_I262_D0.6260.81
184_D193_I0.6230.81
385_S391_H0.6230.81
434_K438_R0.6230.81
99_L106_G0.6220.80
326_Q332_R0.6220.80
193_I235_S0.6220.80
228_I233_M0.6210.80
248_S252_I0.6200.80
180_I230_D0.6190.80
87_A119_A0.6190.80
90_G94_N0.6190.80
127_E132_I0.6170.80
276_M435_G0.6160.80
416_R419_I0.6160.80
29_Y32_H0.6140.80
89_G93_E0.6140.80
56_K59_G0.6140.80
283_V289_T0.6130.79
248_S449_L0.6110.79
101_R144_H0.6080.79
118_N167_G0.6060.79
360_V363_T0.6060.79
311_E314_L0.6060.79
248_S432_L0.6040.78
316_K320_V0.6030.78
320_V324_F0.6030.78
401_T408_S0.6020.78
433_L439_K0.6010.78
432_L435_G0.5980.78
359_I362_G0.5980.78
411_S417_Q0.5980.78
33_S211_V0.5970.78
392_P399_T0.5960.78
438_R447_Q0.5960.78
365_S368_I0.5950.77
98_L137_S0.5950.77
339_K342_A0.5950.77
121_Q164_M0.5950.77
247_C250_E0.5940.77
284_E287_V0.5940.77
390_A453_T0.5940.77
399_T405_L0.5920.77
284_E290_G0.5910.77
249_M253_Y0.5900.77
93_E136_S0.5880.77
276_M280_E0.5860.76
362_G367_R0.5850.76
299_A302_Y0.5850.76
65_F69_E0.5840.76
433_L437_G0.5830.76
65_F75_G0.5830.76
359_I363_T0.5810.76
272_N279_Q0.5790.76
411_S416_R0.5790.76
173_I183_L0.5770.75
274_G292_P0.5760.75
22_E74_K0.5750.75
368_I376_G0.5750.75
450_A453_T0.5740.75
100_F143_A0.5730.75
126_L130_G0.5730.75
319_Y325_I0.5690.74
64_V69_E0.5680.74
60_L63_E0.5650.74
179_M228_I0.5650.74
287_V290_G0.5640.74
404_E407_A0.5640.74
193_I217_L0.5630.73
382_V390_A0.5620.73
235_S244_R0.5600.73
181_V200_Y0.5600.73
55_H65_F0.5590.73
354_M372_L0.5580.73
273_L277_L0.5580.73
273_L436_I0.5580.73
417_Q420_G0.5570.73
432_L436_I0.5560.73
325_I344_R0.5560.73
399_T408_S0.5550.72
93_E134_Q0.5550.72
380_V383_K0.5550.72
415_I419_I0.5540.72
86_T112_H0.5520.72
53_T57_G0.5520.72
281_S383_K0.5520.72
388_P451_C0.5490.72
162_L225_M0.5490.72
15_F201_V0.5490.72
400_S404_E0.5480.71
61_I65_F0.5470.71
287_V294_S0.5470.71
264_I272_N0.5450.71
376_G380_V0.5450.71
331_L334_Q0.5450.71
264_I268_S0.5430.71
269_A436_I0.5420.71
21_E26_I0.5410.71
345_G348_E0.5390.70
303_A308_I0.5370.70
294_S298_A0.5370.70
149_S152_F0.5360.70
415_I418_E0.5360.70
123_K126_L0.5350.70
437_G449_L0.5340.70
376_G379_E0.5320.69
195_M199_A0.5320.69
317_N333_E0.5300.69
418_E421_A0.5290.69
53_T74_K0.5290.69
208_A336_V0.5290.69
264_I437_G0.5280.69
224_E235_S0.5280.69
81_H113_N0.5270.69
283_V288_V0.5270.69
375_A379_E0.5270.69
55_H71_S0.5260.68
293_D296_I0.5260.68
86_T115_N0.5260.68
196_M200_Y0.5260.68
417_Q455_K0.5250.68
434_K439_K0.5240.68
281_S288_V0.5220.68
298_A301_G0.5220.68
15_F212_V0.5210.68
385_S388_P0.5210.68
342_A347_V0.5210.68
25_Q70_L0.5200.68
282_A292_P0.5200.68
42_A65_F0.5200.68
433_L453_T0.5200.68
57_G66_Q0.5190.67
86_T139_T0.5190.67
292_P322_R0.5180.67
32_H338_M0.5180.67
181_V229_N0.5160.67
12_C81_H0.5160.67
438_R449_L0.5140.67
57_G63_E0.5140.67
280_E425_S0.5130.67
262_D269_A0.5130.67
150_G160_N0.5120.66
362_G365_S0.5110.66
336_V339_K0.5110.66
447_Q452_F0.5110.66
410_H413_E0.5110.66
83_R138_D0.5110.66
81_H364_T0.5110.66
319_Y324_F0.5100.66
175_T183_L0.5100.66
51_K176_E0.5090.66
61_I207_C0.5080.66
366_R401_T0.5070.66
302_Y306_T0.5070.66
23_A78_A0.5070.66
196_M214_A0.5070.66
390_A408_S0.5060.65
263_G266_V0.5060.65
403_E409_S0.5050.65
358_S362_G0.5050.65
81_H112_H0.5050.65
264_I436_I0.5050.65
48_D75_G0.5040.65
18_W229_N0.5040.65
289_T292_P0.5030.65
28_Y32_H0.5030.65
295_S340_L0.5030.65
403_E407_A0.5030.65
392_P402_H0.5030.65
323_T332_R0.5030.65
88_G113_N0.5020.65
170_A189_R0.5000.65
282_A290_G0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ecfA 4 0.9706 100 0.343 Contact Map
1ao0A 3 0.9538 100 0.352 Contact Map
4amvA 2 0.9391 100 0.519 Contact Map
1ct9A 2 0.8508 100 0.578 Contact Map
1xffA 2 0.4874 100 0.622 Contact Map
1jgtA 2 0.8046 100 0.652 Contact Map
1te5A 2 0.4517 100 0.664 Contact Map
3mdnA 4 0.4202 100 0.666 Contact Map
1ofdA 1 0.813 100 0.69 Contact Map
1ea0A 1 0.8172 100 0.696 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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