GREMLIN Database
YOCD - Putative carboxypeptidase YocD
UniProt: O35046 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (293)
Sequences: 2945 (2277)
Seq/√Len: 133.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_E310_R4.7611.00
10_D77_K4.0471.00
13_R70_A3.8831.00
11_E42_R3.6431.00
18_A88_S3.5401.00
51_E62_S3.1391.00
59_S62_S3.1161.00
221_E253_H3.0031.00
60_I90_Q2.9641.00
11_E44_T2.9411.00
16_S82_T2.8651.00
44_T73_D2.8481.00
41_Y155_A2.8131.00
197_E308_T2.7461.00
12_I41_Y2.5151.00
14_I82_T2.3611.00
68_H99_K2.2141.00
64_V94_Y2.2081.00
222_H255_K2.1941.00
246_I283_L2.1941.00
200_L303_F2.1911.00
33_K37_E2.1651.00
224_I309_C2.1401.00
195_Y312_E2.1261.00
256_A311_I2.1131.00
195_Y310_R2.1101.00
44_T76_V2.0981.00
65_H69_A2.0881.00
78_A106_I2.0751.00
199_T223_T2.0631.00
217_F250_A2.0401.00
48_H66_D2.0401.00
48_H51_E1.9601.00
254_V257_I1.9121.00
74_P103_H1.8521.00
227_I259_I1.8501.00
37_E42_R1.8291.00
257_I286_I1.8191.00
64_V68_H1.7991.00
4_S77_K1.7841.00
13_R76_V1.7801.00
225_L254_V1.7671.00
39_L151_L1.7301.00
32_A134_F1.7061.00
34_T38_R1.6891.00
148_E152_S1.6881.00
258_L292_I1.6681.00
34_T37_E1.6631.00
45_I49_A1.6441.00
193_E314_I1.6421.00
15_V70_A1.6071.00
68_H72_F1.6021.00
41_Y151_L1.5931.00
33_K45_I1.5911.00
11_E75_G1.5881.00
61_E94_Y1.5711.00
226_L305_I1.5611.00
67_L71_F1.5441.00
145_Y301_A1.5401.00
127_V307_G1.5281.00
47_E69_A1.5271.00
200_L309_C1.5231.00
143_L299_P1.5141.00
11_E76_V1.5051.00
72_F99_K1.5001.00
258_L311_I1.4891.00
33_K43_V1.4761.00
199_T308_T1.4121.00
16_S49_A1.4071.00
272_L275_A1.4001.00
61_E65_H1.3851.00
225_L251_F1.3751.00
220_T250_A1.3701.00
117_C128_T1.3671.00
151_L155_A1.3651.00
212_Q248_L1.3601.00
77_K103_H1.3501.00
130_S204_N1.3371.00
226_L303_F1.3361.00
251_F286_I1.3101.00
13_R44_T1.3101.00
71_F100_I1.3051.00
190_V313_A1.2971.00
110_Y136_T1.2971.00
48_H62_S1.2961.00
97_Y119_A1.2851.00
257_I281_K1.2811.00
121_Y305_I1.2781.00
243_Q280_K1.2761.00
71_F126_L1.2661.00
26_N30_I1.2651.00
80_L108_C1.2641.00
130_S300_I1.2641.00
117_C305_I1.2571.00
106_I129_Y1.2511.00
196_A256_A1.2431.00
129_Y302_T1.2341.00
254_V286_I1.2301.00
117_C130_S1.2161.00
88_S116_L1.2101.00
261_R293_N1.2091.00
93_R247_H1.2041.00
150_F154_C1.1950.99
120_I124_T1.1860.99
15_V95_L1.1840.99
7_K10_D1.1780.99
30_I33_K1.1730.99
35_A39_L1.1730.99
212_Q217_F1.1610.99
259_I262_F1.1550.99
17_P113_I1.1540.99
46_A66_D1.1470.99
45_I50_N1.1370.99
202_G226_L1.1210.99
209_N212_Q1.1200.99
274_K290_A1.1130.99
312_E315_S1.1130.99
100_I124_T1.1080.99
92_L115_A1.1020.99
13_R46_A1.1000.99
235_I276_M1.0890.99
161_E319_R1.0850.99
90_Q239_D1.0790.99
189_V290_A1.0770.99
37_E43_V1.0710.99
117_C121_Y1.0710.99
108_C131_G1.0700.99
98_E101_K1.0680.99
14_I134_F1.0610.99
233_S237_M1.0580.99
229_D262_F1.0510.99
107_L120_I1.0470.99
108_C302_T1.0460.99
216_Y247_H1.0290.98
81_T113_I1.0230.98
233_S241_D1.0140.98
120_I128_T1.0040.98
261_R297_T1.0020.98
64_V95_L0.9990.98
226_L294_A0.9990.98
310_R319_R0.9980.98
312_E318_S0.9970.98
123_K215_E0.9950.98
30_I34_T0.9920.98
71_F103_H0.9900.98
115_A207_T0.9850.98
11_E43_V0.9800.98
64_V91_L0.9790.98
62_S65_H0.9750.98
212_Q244_S0.9710.98
46_A70_A0.9670.98
148_E151_L0.9660.98
208_L227_I0.9590.98
220_T253_H0.9560.97
118_N208_L0.9530.97
83_L87_N0.9500.97
248_L251_F0.9490.97
257_I288_I0.9360.97
107_L113_I0.9350.97
136_T300_I0.9350.97
224_I256_A0.9320.97
281_K288_I0.9270.97
42_R75_G0.9240.97
12_I43_V0.9220.97
289_I313_A0.9190.97
127_V304_P0.9180.97
68_H95_L0.9170.97
44_T75_G0.9170.97
99_K103_H0.9160.97
294_A303_F0.9150.97
152_S156_S0.9100.97
206_C233_S0.9090.97
39_L147_E0.9070.97
217_F220_T0.9060.97
212_Q245_L0.9020.96
12_I78_A0.8980.96
14_I33_K0.8950.96
89_N247_H0.8880.96
149_Y302_T0.8850.96
250_A253_H0.8850.96
195_Y314_I0.8840.96
201_I223_T0.8800.96
206_C229_D0.8800.96
210_L244_S0.8750.96
87_N239_D0.8750.96
289_I311_I0.8730.96
196_A311_I0.8730.96
21_M82_T0.8720.96
153_C302_T0.8690.96
309_C320_I0.8680.96
52_C58_S0.8670.96
220_T223_T0.8650.95
60_I239_D0.8610.95
18_A113_I0.8600.95
204_N262_F0.8600.95
86_F236_H0.8590.95
205_L245_L0.8580.95
232_M264_K0.8570.95
83_L133_H0.8510.95
36_L80_L0.8490.95
229_D233_S0.8480.95
152_S157_D0.8470.95
189_V274_K0.8470.95
29_K33_K0.8460.95
121_Y201_I0.8330.94
67_L95_L0.8320.94
60_I64_V0.8300.94
89_N207_T0.8300.94
205_L241_D0.8280.94
73_D105_K0.8250.94
87_N90_Q0.8150.94
209_N244_S0.8140.94
15_V66_D0.8110.94
209_N241_D0.8100.94
259_I290_A0.8090.94
47_E65_H0.8090.94
39_L155_A0.8060.93
201_I218_P0.8060.93
233_S236_H0.8050.93
278_E282_E0.8040.93
206_C210_L0.8040.93
71_F107_L0.8020.93
53_N59_S0.8020.93
149_Y153_C0.7990.93
68_H97_Y0.7950.93
214_T244_S0.7940.93
93_R216_Y0.7910.93
96_D100_I0.7900.93
256_A313_A0.7900.93
218_P250_A0.7840.92
30_I50_N0.7820.92
4_S7_K0.7820.92
104_P126_L0.7810.92
243_Q279_T0.7790.92
15_V79_I0.7760.92
100_I126_L0.7760.92
149_Y152_S0.7760.92
234_D237_M0.7750.92
32_A36_L0.7750.92
110_Y300_I0.7690.92
31_Q34_T0.7670.92
6_L10_D0.7640.92
119_A216_Y0.7630.91
81_T107_L0.7620.91
68_H96_D0.7610.91
11_E77_K0.7600.91
89_N210_L0.7530.91
115_A211_L0.7450.90
194_G313_A0.7450.90
238_F273_V0.7430.90
95_L100_I0.7430.90
92_L216_Y0.7410.90
83_L231_Y0.7390.90
304_P307_G0.7380.90
60_I87_N0.7370.90
246_I280_K0.7360.90
30_I37_E0.7330.90
89_N243_Q0.7330.90
274_K278_E0.7330.90
219_E223_T0.7330.90
67_L91_L0.7320.90
67_L107_L0.7320.90
45_I48_H0.7320.90
207_T210_L0.7300.90
192_Q278_E0.7280.89
312_E316_G0.7270.89
281_K284_S0.7260.89
78_A154_C0.7210.89
12_I80_L0.7190.89
121_Y128_T0.7190.89
17_P116_L0.7180.89
236_H239_D0.7180.89
54_E58_S0.7130.88
26_N50_N0.7130.88
227_I242_L0.7070.88
246_I252_S0.7050.88
106_I127_V0.7020.88
19_T83_L0.6980.87
110_Y130_S0.6980.87
97_Y124_T0.6960.87
8_K151_L0.6920.87
33_K134_F0.6890.87
190_V289_I0.6890.87
29_K45_I0.6890.87
214_T217_F0.6890.87
206_C241_D0.6850.86
100_I120_I0.6840.86
113_I116_L0.6840.86
261_R291_N0.6790.86
36_L43_V0.6760.86
227_I257_I0.6710.85
225_L250_A0.6670.85
214_T247_H0.6660.85
70_A76_V0.6650.85
205_L238_F0.6620.84
11_E73_D0.6590.84
244_S248_L0.6580.84
92_L119_A0.6580.84
199_T222_H0.6570.84
152_S160_F0.6550.84
245_L250_A0.6520.84
144_D148_E0.6510.83
313_A318_S0.6490.83
106_I154_C0.6480.83
189_V291_N0.6480.83
32_A138_A0.6440.83
119_A124_T0.6440.83
49_A82_T0.6430.83
17_P67_L0.6430.83
147_E151_L0.6420.83
60_I91_L0.6390.82
97_Y100_I0.6390.82
188_P293_N0.6360.82
243_Q247_H0.6350.82
151_L154_C0.6330.82
192_Q286_I0.6320.82
101_K124_T0.6310.82
146_T299_P0.6300.81
88_S115_A0.6280.81
87_N229_D0.6280.81
69_A73_D0.6260.81
27_E31_Q0.6250.81
238_F265_A0.6240.81
136_T139_M0.6230.81
108_C150_F0.6230.81
93_R246_I0.6220.81
96_D104_P0.6210.81
118_N218_P0.6200.80
246_I279_T0.6190.80
13_R73_D0.6190.80
152_S158_D0.6190.80
193_E313_A0.6170.80
206_C237_M0.6160.80
73_D76_V0.6160.80
68_H100_I0.6160.80
129_Y304_P0.6140.80
56_D90_Q0.6130.80
22_S28_A0.6130.80
88_S107_L0.6120.80
233_S238_F0.6120.80
14_I45_I0.6080.79
237_M241_D0.6040.79
134_F138_A0.6010.78
246_I284_S0.6010.78
5_K157_D0.5990.78
8_K42_R0.5970.78
136_T146_T0.5970.78
312_E317_T0.5950.78
98_E102_R0.5950.78
242_L280_K0.5940.78
86_F239_D0.5940.78
312_E319_R0.5930.77
7_K77_K0.5920.77
228_E260_G0.5890.77
128_T305_I0.5890.77
106_I302_T0.5880.77
12_I155_A0.5880.77
14_I32_A0.5870.77
311_I320_I0.5860.77
252_S284_S0.5850.76
87_N236_H0.5830.76
235_I265_A0.5830.76
6_L106_I0.5820.76
205_L239_D0.5810.76
88_S113_I0.5790.76
16_S261_R0.5790.76
315_S319_R0.5730.75
246_I251_F0.5720.75
208_L245_L0.5710.75
238_F241_D0.5690.74
273_V277_I0.5690.74
161_E317_T0.5670.74
114_T245_L0.5650.74
90_Q236_H0.5630.74
9_G78_A0.5630.74
135_S139_M0.5620.74
56_D87_N0.5620.74
185_N188_P0.5620.74
275_A278_E0.5610.73
311_I314_I0.5610.73
68_H94_Y0.5600.73
68_H91_L0.5560.73
196_A313_A0.5550.73
224_I311_I0.5500.72
250_A254_V0.5490.72
162_I301_A0.5480.72
87_N231_Y0.5480.72
91_L94_Y0.5460.71
211_L218_P0.5460.71
231_Y237_M0.5440.71
262_F273_V0.5440.71
121_Y306_G0.5430.71
81_T88_S0.5420.71
83_L236_H0.5340.70
21_M29_K0.5340.70
204_N229_D0.5330.70
69_A102_R0.5330.70
201_I220_T0.5330.70
205_L266_S0.5310.69
219_E253_H0.5310.69
31_Q35_A0.5310.69
153_C160_F0.5300.69
6_L77_K0.5290.69
91_L95_L0.5290.69
121_Y223_T0.5270.69
10_D41_Y0.5270.69
210_L240_R0.5240.68
72_F100_I0.5240.68
86_F233_S0.5240.68
15_V46_A0.5230.68
140_K143_L0.5220.68
227_I247_H0.5190.68
132_P302_T0.5180.67
191_I194_G0.5150.67
239_D280_K0.5150.67
119_A214_T0.5130.67
201_I254_V0.5120.67
183_Y186_N0.5110.66
194_G256_A0.5110.66
68_H128_T0.5100.66
56_D60_I0.5090.66
273_V276_M0.5080.66
10_D78_A0.5070.66
16_S57_S0.5070.66
192_Q285_G0.5070.66
46_A49_A0.5070.66
204_N241_D0.5070.66
81_T133_H0.5070.66
239_D279_T0.5060.66
89_N136_T0.5050.66
149_Y301_A0.5050.66
61_E93_R0.5030.65
123_K216_Y0.5030.65
21_M32_A0.5030.65
229_D239_D0.5020.65
47_E62_S0.5020.65
162_I185_N0.5020.65
35_A147_E0.5010.65
118_N201_I0.5010.65
309_C318_S0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e5sA 2 0.9969 100 0.061 Contact Map
3tlaA 2 0.9938 100 0.07 Contact Map
4injA 2 0.9815 100 0.074 Contact Map
4jvoA 2 0.9908 100 0.089 Contact Map
1zl0A 1 0.92 100 0.137 Contact Map
4eysA 3 0.9538 100 0.155 Contact Map
3g23A 2 0.8031 100 0.21 Contact Map
2csuA 2 0.4369 90.4 0.946 Contact Map
4z0nA 1 0.5354 84 0.951 Contact Map
3mwdA 2 0.4246 81.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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