GREMLIN Database
YJMD - Uncharacterized zinc-type alcohol dehydrogenase-like protein YjmD
UniProt: O35045 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (302)
Sequences: 52930 (36430)
Seq/√Len: 2096.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_D319_H2.9601.00
33_K138_W2.9061.00
31_K67_E2.8381.00
33_K65_Q2.7791.00
29_L67_E2.6211.00
28_V129_L2.5231.00
7_R15_A2.5201.00
137_P140_E2.4761.00
182_K207_D2.4101.00
77_K80_D2.3921.00
81_H132_V2.3591.00
80_D131_A2.3541.00
220_R223_E2.3241.00
312_F323_F2.3021.00
199_A203_E2.2841.00
62_V117_G2.2451.00
31_K65_Q2.2341.00
19_K121_Y2.2131.00
164_T187_A2.1891.00
139_E311_T2.1711.00
170_A190_M2.1621.00
160_E163_D2.1431.00
31_K121_Y2.1361.00
295_E299_G2.1161.00
165_V181_A2.1001.00
310_H323_F2.0851.00
7_R13_V2.0821.00
198_L202_K2.0741.00
75_S126_E2.0371.00
155_W184_A2.0211.00
25_D71_A2.0201.00
313_S316_D2.0001.00
24_K27_E1.9811.00
25_D72_N1.9591.00
5_Q15_A1.9531.00
135_D298_N1.9511.00
178_L206_A1.9481.00
62_V84_I1.9221.00
26_D72_N1.9111.00
322_Q326_E1.8871.00
81_H138_W1.8811.00
63_T138_W1.8331.00
21_V68_A1.8211.00
29_L123_V1.8041.00
67_E121_Y1.7981.00
147_Y176_C1.7941.00
326_E329_D1.7881.00
155_W292_K1.7841.00
199_A202_K1.7631.00
195_N199_A1.7331.00
319_H322_Q1.7271.00
166_L191_T1.7241.00
166_L230_A1.7191.00
231_N251_S1.7001.00
46_H325_K1.6951.00
163_D255_H1.6591.00
255_H279_T1.6551.00
198_L209_V1.6321.00
183_L301_R1.6311.00
132_V138_W1.6261.00
192_D198_L1.6241.00
319_H323_F1.6221.00
312_F320_A1.6141.00
189_M230_A1.6121.00
195_N214_A1.5571.00
200_F203_E1.5461.00
70_G73_V1.5441.00
208_A224_W1.5421.00
76_L131_A1.5331.00
168_Q246_S1.5251.00
255_H281_T1.5251.00
215_E220_R1.5111.00
195_N211_N1.5071.00
69_V78_P1.5031.00
250_V256_V1.4921.00
187_A208_A1.4831.00
29_L121_Y1.4781.00
68_A78_P1.4751.00
250_V278_V1.4731.00
211_N214_A1.4721.00
4_V317_V1.4721.00
157_G232_V1.4671.00
76_L80_D1.4571.00
216_H219_E1.4501.00
27_E125_P1.4461.00
118_M321_F1.4171.00
32_V62_V1.4171.00
65_Q81_H1.4151.00
250_V254_G1.4081.00
26_D125_P1.4031.00
81_H134_K1.3861.00
318_H322_Q1.3741.00
132_V141_A1.3661.00
22_L123_V1.3631.00
233_V250_V1.3611.00
34_R139_E1.3591.00
27_E123_V1.3581.00
233_V246_S1.3441.00
22_L29_L1.3421.00
309_T323_F1.3321.00
29_L68_A1.3211.00
66_V76_L1.3201.00
323_F329_D1.3111.00
219_E223_E1.3071.00
28_V76_L1.3021.00
295_E298_N1.2811.00
187_A207_D1.2751.00
45_Y321_F1.2641.00
178_L190_M1.2521.00
164_T189_M1.2501.00
65_Q138_W1.2431.00
193_L212_V1.2411.00
177_V234_I1.2371.00
151_A155_W1.2211.00
168_Q191_T1.2201.00
183_L296_L1.2141.00
202_K209_V1.1881.00
33_K81_H1.1741.00
76_L129_L1.1731.00
193_L198_L1.1721.00
159_V186_A1.1601.00
4_V14_T1.1581.00
19_K29_L1.1461.00
195_N198_L1.1431.00
292_K295_E1.1201.00
26_D126_E1.1161.00
8_K11_D1.1151.00
32_V122_I1.1081.00
164_T231_N1.1021.00
179_K303_M1.0961.00
220_R224_W1.0941.00
22_L27_E1.0921.00
198_L211_N1.0881.00
124_L129_L1.0861.00
67_E78_P1.0751.00
163_D231_N1.0741.00
37_I320_A1.0431.00
155_W289_Q1.0431.00
30_V64_G1.0421.00
157_G257_V1.0401.00
190_M206_A1.0351.00
216_H220_R1.0261.00
14_T315_D1.0211.00
200_F331_V1.0211.00
214_A220_R1.0201.00
203_E306_G1.0201.00
140_E303_M1.0181.00
291_P295_E1.0161.00
189_M208_A1.0131.00
317_V336_I1.0131.00
152_Q289_Q1.0131.00
202_K208_A1.0111.00
248_E272_P1.0081.00
30_V82_V1.0071.00
296_L301_R1.0061.00
45_Y325_K1.0051.00
237_V242_T1.0021.00
218_A248_E0.9961.00
34_R138_W0.9951.00
4_V314_V0.9901.00
150_G177_V0.9891.00
150_G180_M0.9771.00
35_V118_M0.9761.00
303_M306_G0.9631.00
5_Q17_V0.9631.00
33_K63_T0.9621.00
136_L141_A0.9541.00
118_M317_V0.9451.00
323_F334_A0.9381.00
38_C61_E0.9341.00
244_A248_E0.9251.00
245_L248_E0.9241.00
322_Q325_K0.9221.00
225_T229_G0.9211.00
153_A259_L0.9151.00
218_A245_L0.9141.00
159_V163_D0.9131.00
19_K68_A0.9131.00
167_I177_V0.9091.00
73_V126_E0.9081.00
34_R335_V0.9071.00
170_A192_D0.9071.00
147_Y293_V0.9071.00
151_A292_K0.9061.00
181_A186_A0.9041.00
35_V117_G0.9041.00
178_L188_V0.8991.00
74_Q126_E0.8961.00
225_T228_E0.8931.00
38_C60_H0.8891.00
7_R11_D0.8861.00
42_M324_I0.8851.00
31_K120_E0.8821.00
191_T212_V0.8811.00
193_L213_Q0.8801.00
69_V73_V0.8781.00
56_R115_D0.8771.00
5_Q57_V0.8761.00
167_I181_A0.8761.00
166_L249_A0.8731.00
168_Q233_V0.8731.00
235_D238_C0.8721.00
17_V115_D0.8701.00
272_P276_K0.8701.00
170_A201_A0.8681.00
273_I280_I0.8671.00
197_R331_V0.8671.00
77_K131_A0.8661.00
180_M293_V0.8651.00
218_A222_L0.8651.00
26_D70_G0.8641.00
153_A234_I0.8591.00
189_M210_V0.8491.00
196_E199_A0.8481.00
221_V230_A0.8481.00
62_V122_I0.8461.00
118_M336_I0.8441.00
175_I200_F0.8421.00
170_A178_L0.8401.00
194_N197_R0.8371.00
19_K67_E0.8371.00
190_M201_A0.8341.00
164_T230_A0.8321.00
21_V29_L0.8321.00
143_M297_L0.8311.00
36_G61_E0.8311.00
192_D209_V0.8241.00
292_K296_L0.8241.00
83_V294_V0.8241.00
288_N292_K0.8191.00
312_F316_D0.8191.00
253_A277_E0.8171.00
194_N211_N0.8141.00
163_D232_V0.8051.00
37_I324_I0.8021.00
324_I334_A0.7921.00
4_V12_L0.7921.00
288_N291_P0.7881.00
217_V245_L0.7801.00
219_E222_L0.7791.00
180_M296_L0.7761.00
154_V181_A0.7741.00
134_K298_N0.7741.00
148_T289_Q0.7731.00
82_V129_L0.7701.00
201_A206_A0.7671.00
241_E245_L0.7641.00
14_T314_V0.7621.00
168_Q242_T0.7621.00
24_K123_V0.7581.00
218_A249_A0.7541.00
130_H291_P0.7541.00
233_V256_V0.7521.00
184_A292_K0.7511.00
150_G176_C0.7511.00
38_C41_D0.7501.00
189_M224_W0.7471.00
216_H245_L0.7441.00
69_V77_K0.7411.00
244_A265_A0.7411.00
159_V232_V0.7391.00
153_A177_V0.7361.00
136_L297_L0.7351.00
189_M221_V0.7351.00
269_S272_P0.7351.00
158_Q255_H0.7351.00
246_S256_V0.7331.00
226_G229_G0.7331.00
265_A269_S0.7331.00
84_I124_L0.7321.00
165_V186_A0.7311.00
193_L201_A0.7291.00
28_V126_E0.7281.00
40_S60_H0.7271.00
296_L299_G0.7251.00
310_H319_H0.7241.00
26_D71_A0.7211.00
181_A188_V0.7191.00
137_P141_A0.7161.00
308_V311_T0.7151.00
236_A259_L0.7141.00
323_F326_E0.7121.00
155_W180_M0.7121.00
188_V207_D0.7101.00
296_L300_G0.7051.00
152_Q277_E0.7051.00
273_I278_V0.7031.00
133_S298_N0.7021.00
203_E303_M0.6961.00
150_G173_I0.6951.00
63_T142_V0.6951.00
17_V57_V0.6921.00
83_V132_V0.6921.00
312_F336_I0.6901.00
34_R311_T0.6891.00
186_A232_V0.6861.00
312_F334_A0.6821.00
252_P276_K0.6801.00
258_V280_I0.6781.00
167_I190_M0.6741.00
232_V257_V0.6731.00
117_G122_I0.6701.00
228_E251_S0.6701.00
230_A233_V0.6701.00
310_H334_A0.6701.00
164_T228_E0.6671.00
37_I118_M0.6671.00
294_V298_N0.6661.00
61_E145_E0.6661.00
151_A293_V0.6611.00
38_C145_E0.6591.00
323_F330_Q0.6591.00
130_H290_F0.6581.00
38_C146_P0.6541.00
200_F204_N0.6521.00
158_Q281_T0.6501.00
130_H294_V0.6501.00
81_H135_D0.6491.00
150_G154_V0.6491.00
178_L204_N0.6481.00
221_V249_A0.6481.00
4_V318_H0.6471.00
158_Q279_T0.6471.00
83_V144_A0.6471.00
222_L225_T0.6471.00
28_V66_V0.6471.00
145_E149_I0.6471.00
22_L70_G0.6451.00
10_Y322_Q0.6451.00
26_D127_R0.6441.00
151_A296_L0.6441.00
162_G187_A0.6401.00
6_V11_D0.6371.00
34_R63_T0.6351.00
75_S131_A0.6341.00
60_H145_E0.6341.00
156_R279_T0.6341.00
243_F256_V0.6331.00
63_T132_V0.6331.00
22_L68_A0.6301.00
146_P172_P0.6301.00
157_G255_H0.6291.00
20_P123_V0.6291.00
75_S78_P0.6211.00
80_D134_K0.6191.00
273_I282_G0.6181.00
235_D256_V0.6181.00
149_I173_I0.6161.00
39_G43_H0.6161.00
9_A322_Q0.6141.00
30_V84_I0.6111.00
40_S44_I0.6111.00
19_K22_L0.6101.00
85_E130_H0.6091.00
244_A272_P0.6091.00
32_V35_V0.6091.00
179_K204_N0.6071.00
191_T210_V0.6071.00
230_A249_A0.6061.00
192_D212_V0.6041.00
232_V255_H0.6041.00
63_T81_H0.6031.00
244_A267_Q0.6031.00
177_V259_L0.6011.00
192_D201_A0.5991.00
242_T246_S0.5991.00
192_D211_N0.5971.00
42_M325_K0.5901.00
321_F325_K0.5881.00
330_Q334_A0.5881.00
180_M184_A0.5871.00
210_V224_W0.5861.00
208_A220_R0.5861.00
146_P176_C0.5851.00
138_W141_A0.5841.00
84_I129_L0.5811.00
182_K188_V0.5811.00
8_K13_V0.5791.00
206_A209_V0.5771.00
151_A289_Q0.5771.00
165_V232_V0.5761.00
233_V249_A0.5751.00
235_D260_G0.5741.00
217_V221_V0.5731.00
241_E244_A0.5731.00
198_L201_A0.5731.00
20_P121_Y0.5711.00
38_C333_K0.5691.00
52_A56_R0.5671.00
278_V282_G0.5661.00
210_V220_R0.5641.00
74_Q77_K0.5641.00
222_L229_G0.5641.00
164_T225_T0.5641.00
257_V283_S0.5641.00
166_L233_V0.5621.00
40_S43_H0.5621.00
161_K185_G0.5611.00
55_P59_G0.5581.00
153_A283_S0.5581.00
149_I259_L0.5571.00
326_E330_Q0.5571.00
43_H48_T0.5551.00
69_V80_D0.5501.00
59_G118_M0.5491.00
39_G171_G0.5491.00
272_P278_V0.5481.00
198_L212_V0.5481.00
18_K21_V0.5471.00
42_M46_H0.5471.00
178_L201_A0.5411.00
156_R289_Q0.5391.00
201_A209_V0.5371.00
35_V336_I0.5341.00
175_I307_L0.5341.00
76_L126_E0.5331.00
152_Q156_R0.5321.00
14_T317_V0.5321.00
19_K123_V0.5321.00
63_T141_A0.5301.00
200_F307_L0.5301.00
20_P27_E0.5291.00
300_G303_M0.5281.00
310_H331_V0.5271.00
289_Q292_K0.5271.00
57_V116_G0.5271.00
161_K184_A0.5251.00
126_E129_L0.5251.00
309_T332_R0.5241.00
176_C180_M0.5221.00
125_P128_Q0.5221.00
272_P275_K0.5201.00
32_V84_I0.5191.00
154_V180_M0.5191.00
37_I336_I0.5161.00
84_I117_G0.5151.00
192_D197_R0.5141.00
61_E333_K0.5141.00
12_L321_F0.5101.00
275_K284_R0.5091.00
202_K206_A0.5081.00
53_T56_R0.5071.00
137_P311_T0.5061.00
223_E226_G0.5051.00
131_A134_K0.5041.00
20_P29_L0.5041.00
310_H316_D0.5021.00
158_Q163_D0.5021.00
182_K206_A0.5011.00
229_G251_S0.5011.00
36_G142_V0.5011.00
175_I204_N0.5001.00
146_P333_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ej6A 1 0.9853 100 0.128 Contact Map
4ilkA 2 0.9823 100 0.128 Contact Map
2dq4A 4 0.9823 100 0.138 Contact Map
4oh1A 4 0.9705 100 0.15 Contact Map
3m6iA 4 0.9912 100 0.152 Contact Map
2d8aA 3 0.9499 100 0.156 Contact Map
1f8fA 4 0.9794 100 0.156 Contact Map
3ip1A 4 0.9794 100 0.156 Contact Map
4cpdA 2 0.9882 100 0.156 Contact Map
3ukoA 4 0.9853 100 0.157 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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