GREMLIN Database
BCES - Sensor protein BceS
UniProt: O35044 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (285)
Sequences: 72600 (59154)
Seq/√Len: 3504.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_D262_G3.4631.00
181_I216_S3.1761.00
257_K317_V3.1601.00
307_D319_T2.9111.00
251_Q321_T2.8591.00
296_K300_A2.8341.00
137_I149_L2.8321.00
216_S302_L2.6691.00
255_Q317_V2.5061.00
268_V310_S2.5011.00
141_E150_S2.3321.00
244_K255_Q2.3071.00
255_Q319_T2.2901.00
180_F215_L2.2721.00
236_S259_C2.2701.00
206_D242_E2.2491.00
264_D267_D2.2141.00
134_H154_L2.1921.00
308_V318_F2.1671.00
253_Q321_T2.1571.00
224_I299_A2.1571.00
253_Q319_T2.1301.00
246_F253_Q2.1101.00
311_E314_A2.0951.00
208_Q244_K2.0921.00
272_F306_I2.0891.00
295_A306_I2.0871.00
63_F66_S2.0791.00
268_V308_V2.0681.00
206_D240_E2.0621.00
242_E257_K2.0351.00
134_H153_W2.0331.00
240_E259_C2.0191.00
141_E147_S2.0111.00
180_F213_E2.0001.00
299_A304_I1.9911.00
246_F255_Q1.9661.00
244_K257_K1.9251.00
179_E218_A1.8621.00
189_K222_A1.8561.00
309_E319_T1.8411.00
309_E317_V1.8411.00
263_I271_I1.8161.00
310_S316_T1.7731.00
305_H321_T1.7581.00
182_Q185_P1.7541.00
299_A320_L1.7521.00
239_S259_C1.7231.00
270_R273_D1.7201.00
194_L226_R1.7041.00
204_G240_E1.6941.00
133_M153_W1.6751.00
270_R276_F1.6751.00
208_Q242_E1.6581.00
134_H157_H1.6541.00
267_D270_R1.6411.00
265_P268_V1.6401.00
224_I298_A1.6361.00
216_S221_L1.6231.00
230_T234_K1.6181.00
263_I267_D1.5911.00
157_H161_D1.5861.00
224_I295_A1.5731.00
178_V215_L1.5561.00
138_D150_S1.5441.00
247_Q324_I1.5311.00
198_C233_V1.5301.00
267_D276_F1.5081.00
298_A302_L1.5041.00
236_S239_S1.5041.00
112_L115_E1.4601.00
300_A305_H1.4531.00
263_I316_T1.4531.00
105_A108_H1.4401.00
272_F308_V1.4301.00
307_D321_T1.4241.00
267_D278_S1.4221.00
60_E63_F1.4091.00
136_I145_L1.3881.00
113_E117_D1.3691.00
125_E223_F1.3631.00
248_K253_Q1.3581.00
225_I254_L1.3361.00
137_I150_S1.3341.00
254_L320_L1.3061.00
220_W223_F1.2991.00
217_D220_W1.2781.00
150_S154_L1.2781.00
117_D121_A1.2731.00
227_Q295_A1.2721.00
66_S70_W1.2721.00
140_M146_K1.2671.00
133_M149_L1.2621.00
310_S314_A1.2491.00
80_N84_T1.2481.00
184_Q188_F1.2411.00
104_T108_H1.2361.00
98_T102_K1.2031.00
195_Q199_I1.2001.00
242_E259_C1.1961.00
105_A109_R1.1921.00
134_H150_S1.1871.00
95_A98_T1.1841.00
193_D222_A1.1821.00
115_E119_L1.1771.00
182_Q213_E1.1751.00
264_D312_F1.1681.00
273_D276_F1.1641.00
251_Q305_H1.1631.00
121_A274_K1.1461.00
189_K218_A1.1411.00
310_S313_G1.1361.00
87_E90_V1.1311.00
184_Q245_S1.1221.00
54_W58_R1.1191.00
94_I98_T1.1121.00
137_I153_W1.1041.00
271_I308_V1.1001.00
218_A222_A1.0971.00
209_L245_S1.0971.00
252_T324_I1.0871.00
258_D315_G1.0851.00
158_L219_K1.0821.00
109_R113_E1.0801.00
136_I148_Q1.0781.00
297_K300_A1.0691.00
220_W298_A1.0681.00
91_E95_A1.0601.00
224_I320_L1.0571.00
221_L302_L1.0561.00
132_A152_E1.0561.00
77_T80_N1.0541.00
137_I141_E1.0521.00
63_F71_E1.0461.00
176_L217_D1.0451.00
191_I207_I1.0431.00
91_E94_I1.0401.00
304_I322_F1.0381.00
87_E91_E1.0371.00
117_D274_K1.0361.00
90_V94_I1.0361.00
277_T285_Q1.0331.00
178_V302_L1.0311.00
90_V95_A1.0271.00
220_W301_P1.0231.00
258_D316_T1.0191.00
299_A306_I1.0171.00
71_E75_D1.0131.00
272_F318_F1.0081.00
236_S241_I1.0061.00
304_I320_L0.9951.00
107_R110_L0.9951.00
94_I97_Q0.9811.00
53_L57_Y0.9791.00
187_I245_S0.9771.00
92_R95_A0.9771.00
59_K66_S0.9761.00
235_Y277_T0.9731.00
147_S151_Y0.9711.00
184_Q209_L0.9661.00
103_Q107_R0.9661.00
84_T87_E0.9641.00
188_F207_I0.9631.00
110_L114_N0.9571.00
152_E155_R0.9551.00
277_T287_S0.9531.00
132_A136_I0.9471.00
86_F90_V0.9461.00
197_W200_Q0.9451.00
308_V316_T0.9401.00
268_V272_F0.9381.00
190_E222_A0.9291.00
135_L139_R0.9291.00
181_I186_L0.9271.00
80_N83_E0.9271.00
186_L216_S0.9261.00
137_I146_K0.9211.00
272_F296_K0.9201.00
162_Q220_W0.9171.00
190_E226_R0.9161.00
262_G316_T0.9101.00
209_L212_K0.9071.00
257_K311_E0.9061.00
111_A115_E0.9041.00
127_K161_D0.9001.00
95_A99_E0.8941.00
104_T107_R0.8941.00
97_Q101_L0.8921.00
166_Q293_Y0.8831.00
85_P88_A0.8791.00
177_S217_D0.8771.00
186_L190_E0.8771.00
263_I269_P0.8761.00
193_D226_R0.8671.00
98_T101_L0.8631.00
63_F70_W0.8591.00
126_V156_I0.8501.00
148_Q152_E0.8501.00
190_E194_L0.8421.00
118_E122_W0.8401.00
144_A148_Q0.8391.00
97_Q100_H0.8381.00
112_L116_K0.8361.00
68_K71_E0.8321.00
161_D165_H0.8291.00
297_K301_P0.8281.00
299_A322_F0.8261.00
194_L229_L0.8251.00
134_H138_D0.8251.00
76_V80_N0.8181.00
197_W230_T0.8151.00
106_A110_L0.8151.00
151_Y189_K0.8121.00
61_T66_S0.8081.00
225_I256_V0.8081.00
250_E324_I0.8011.00
232_A241_I0.8001.00
153_W157_H0.7991.00
210_E246_F0.7981.00
77_T83_E0.7931.00
178_V216_S0.7931.00
143_K147_S0.7931.00
57_Y61_T0.7851.00
149_L153_W0.7851.00
225_I229_L0.7811.00
132_A135_L0.7801.00
76_V79_I0.7751.00
228_L318_F0.7741.00
235_Y261_R0.7711.00
271_I318_F0.7691.00
191_I205_F0.7661.00
101_L104_T0.7601.00
162_Q223_F0.7561.00
165_H223_F0.7551.00
56_R60_E0.7531.00
248_K251_Q0.7501.00
141_E146_K0.7451.00
148_Q151_Y0.7431.00
178_V303_L0.7411.00
107_R111_A0.7401.00
265_P310_S0.7371.00
181_I218_A0.7371.00
227_Q230_T0.7361.00
93_S97_Q0.7361.00
155_R222_A0.7351.00
128_T132_A0.7351.00
57_Y60_E0.7351.00
191_I195_Q0.7331.00
110_L113_E0.7321.00
84_T90_V0.7321.00
116_K170_S0.7301.00
263_I308_V0.7231.00
102_K105_A0.7221.00
295_A299_A0.7201.00
67_L71_E0.7201.00
90_V93_S0.7191.00
184_Q211_A0.7171.00
183_L254_L0.7161.00
219_K222_A0.7161.00
103_Q106_A0.7141.00
185_P189_K0.7121.00
222_A226_R0.7121.00
198_C205_F0.7081.00
202_G238_A0.7081.00
263_I268_V0.7071.00
279_T283_H0.7051.00
176_L220_W0.7021.00
251_Q323_P0.7011.00
70_W74_L0.7011.00
290_M294_L0.6991.00
263_I310_S0.6961.00
226_R230_T0.6921.00
210_E245_S0.6911.00
144_A147_S0.6881.00
96_G100_H0.6851.00
258_D261_R0.6851.00
90_V98_T0.6841.00
154_L157_H0.6821.00
100_H103_Q0.6821.00
63_F67_L0.6811.00
194_L230_T0.6811.00
203_I207_I0.6771.00
228_L295_A0.6771.00
130_L160_L0.6751.00
176_L301_P0.6731.00
248_K321_T0.6711.00
198_C241_I0.6691.00
77_T81_E0.6681.00
223_F298_A0.6681.00
147_S150_S0.6661.00
79_I83_E0.6651.00
136_I152_E0.6631.00
261_R285_Q0.6611.00
158_L162_Q0.6561.00
196_S199_I0.6551.00
113_E116_K0.6521.00
71_E74_L0.6521.00
188_F192_K0.6501.00
228_L306_I0.6491.00
187_I225_I0.6491.00
234_K287_S0.6491.00
101_L105_A0.6491.00
274_K297_K0.6461.00
234_K285_Q0.6461.00
253_Q307_D0.6441.00
307_D320_L0.6441.00
228_L320_L0.6431.00
165_H220_W0.6431.00
192_K195_Q0.6391.00
152_E193_D0.6381.00
127_K157_H0.6351.00
268_V309_E0.6341.00
229_L243_I0.6341.00
68_K72_N0.6341.00
296_K305_H0.6331.00
203_I233_V0.6331.00
220_W302_L0.6331.00
203_I236_S0.6321.00
255_Q309_E0.6281.00
90_V97_Q0.6281.00
265_P311_E0.6261.00
203_I241_I0.6251.00
111_A114_N0.6251.00
181_I215_L0.6241.00
83_E88_A0.6201.00
60_E64_Y0.6191.00
69_T73_N0.6181.00
183_L252_T0.6181.00
56_R59_K0.6161.00
186_L221_L0.6151.00
55_F59_K0.6141.00
201_K233_V0.6121.00
109_R112_L0.6121.00
117_D297_K0.6101.00
108_H112_L0.6091.00
243_I256_V0.6071.00
268_V318_F0.6051.00
187_I243_I0.6051.00
91_E98_T0.6041.00
139_R145_L0.6031.00
138_D142_E0.6031.00
190_E229_L0.6031.00
194_L233_V0.6021.00
145_L148_Q0.6011.00
92_R96_G0.6001.00
199_I202_G0.5991.00
102_K106_A0.5991.00
140_M145_L0.5961.00
164_L168_R0.5961.00
61_T65_K0.5911.00
234_K279_T0.5901.00
224_I302_L0.5891.00
185_P218_A0.5851.00
122_W163_Q0.5841.00
70_W73_N0.5781.00
84_T91_E0.5781.00
81_E84_T0.5781.00
198_C202_G0.5771.00
304_I323_P0.5761.00
67_L70_W0.5751.00
63_F68_K0.5741.00
77_T84_T0.5721.00
264_D278_S0.5701.00
229_L241_I0.5671.00
267_D280_T0.5651.00
271_I293_Y0.5571.00
126_V160_L0.5571.00
232_A256_V0.5571.00
83_E87_E0.5551.00
108_H111_A0.5551.00
277_T286_A0.5541.00
136_I149_L0.5531.00
203_I259_C0.5521.00
146_K150_S0.5521.00
204_G207_I0.5501.00
100_H104_T0.5491.00
80_N90_V0.5491.00
82_P85_P0.5481.00
78_A81_E0.5481.00
91_E97_Q0.5421.00
188_F209_L0.5411.00
132_A148_Q0.5411.00
196_S200_Q0.5391.00
186_L222_A0.5341.00
174_N220_W0.5321.00
84_T88_A0.5311.00
65_K68_K0.5281.00
154_L158_L0.5281.00
241_I256_V0.5271.00
83_E90_V0.5271.00
119_L123_I0.5261.00
125_E129_P0.5241.00
228_L299_A0.5241.00
86_F89_M0.5241.00
187_I190_E0.5231.00
208_Q246_F0.5211.00
265_P269_P0.5211.00
99_E103_Q0.5201.00
76_V81_E0.5181.00
114_N117_D0.5181.00
131_T135_L0.5171.00
58_R63_F0.5161.00
87_E93_S0.5161.00
257_K313_G0.5151.00
251_Q324_I0.5151.00
170_S297_K0.5151.00
184_Q212_K0.5151.00
223_F226_R0.5141.00
125_E227_Q0.5141.00
237_E261_R0.5131.00
89_M93_S0.5111.00
39_L42_V0.5111.00
50_I54_W0.5111.00
198_C201_K0.5111.00
306_I318_F0.5101.00
162_Q219_K0.5091.00
76_V83_E0.5091.00
245_S252_T0.5081.00
59_K63_F0.5081.00
78_A82_P0.5071.00
237_E259_C0.5061.00
61_T64_Y0.5051.00
247_Q250_E0.5051.00
259_C314_A0.5051.00
63_F74_L0.5041.00
198_C203_I0.5041.00
191_I243_I0.5011.00
39_L43_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.7964 100 0.327 Contact Map
4bixA 2 0.6677 100 0.354 Contact Map
4ctiA 2 0.6796 100 0.38 Contact Map
4q20A 2 0.6647 100 0.387 Contact Map
3jz3A 2 0.4581 100 0.403 Contact Map
4e01A 3 0.8503 100 0.405 Contact Map
4mpcA 2 0.8772 100 0.407 Contact Map
2c2aA 2 0.6677 100 0.409 Contact Map
3d36A 2 0.6347 100 0.416 Contact Map
2q8gA 2 0.8982 100 0.418 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.