BCES - BACSU - GREMLIN Contacts

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BCES - Sensor protein BceS

UniProt:	O35044	Sequences: MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYLCILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLKQTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLLDQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDAKWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGFTSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	334 (285)
Sequences:	72600 (59154)
Seq/√Len:	3504.0

ECOLI - TORS BARA RCSD RCSC GLRK ARCB PHOQ BAES RSTB CUSS CPXA CREC ENVZ BASS EVGS QSEC YEDV ZRAS ATOS KDPD PHOR DPIB DCUS NARQ NARX UHPB YPDA NTRB
BACSU - BCES YCLK YVRG YXDK KINB YVCQ YKOH CSSS KINE YCBM PHOR RESE GLNK YYCG KINA KIND DCTS CITS KINC LYTS MALK NATK YRKQ YBDK LIAS YESM YFIJ YDFH COMP YXJM DEGS YWPD YVFT YHCY DESK
HALSA - Q9HQG5 Q9HQ15 Q9HQ16 Q9HRE4 Q9HQE9 Q9HR10 O51970 Q9HNM2 Q9HRG1 BAT Q9HQB9 Q9HNA6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
258_D	262_G	3.463	1.00
181_I	216_S	3.176	1.00
257_K	317_V	3.160	1.00
307_D	319_T	2.911	1.00
251_Q	321_T	2.859	1.00
296_K	300_A	2.834	1.00
137_I	149_L	2.832	1.00
216_S	302_L	2.669	1.00
255_Q	317_V	2.506	1.00
268_V	310_S	2.501	1.00
141_E	150_S	2.332	1.00
244_K	255_Q	2.307	1.00
255_Q	319_T	2.290	1.00
180_F	215_L	2.272	1.00
236_S	259_C	2.270	1.00
206_D	242_E	2.249	1.00
264_D	267_D	2.214	1.00
134_H	154_L	2.192	1.00
308_V	318_F	2.167	1.00
253_Q	321_T	2.157	1.00
224_I	299_A	2.157	1.00
253_Q	319_T	2.130	1.00
246_F	253_Q	2.110	1.00
311_E	314_A	2.095	1.00
208_Q	244_K	2.092	1.00
272_F	306_I	2.089	1.00
295_A	306_I	2.087	1.00
63_F	66_S	2.079	1.00
268_V	308_V	2.068	1.00
206_D	240_E	2.062	1.00
242_E	257_K	2.035	1.00
134_H	153_W	2.033	1.00
240_E	259_C	2.019	1.00
141_E	147_S	2.011	1.00
180_F	213_E	2.000	1.00
299_A	304_I	1.991	1.00
246_F	255_Q	1.966	1.00
244_K	257_K	1.925	1.00
179_E	218_A	1.862	1.00
189_K	222_A	1.856	1.00
309_E	319_T	1.841	1.00
309_E	317_V	1.841	1.00
263_I	271_I	1.816	1.00
310_S	316_T	1.773	1.00
305_H	321_T	1.758	1.00
182_Q	185_P	1.754	1.00
299_A	320_L	1.752	1.00
239_S	259_C	1.723	1.00
270_R	273_D	1.720	1.00
194_L	226_R	1.704	1.00
204_G	240_E	1.694	1.00
133_M	153_W	1.675	1.00
270_R	276_F	1.675	1.00
208_Q	242_E	1.658	1.00
134_H	157_H	1.654	1.00
267_D	270_R	1.641	1.00
265_P	268_V	1.640	1.00
224_I	298_A	1.636	1.00
216_S	221_L	1.623	1.00
230_T	234_K	1.618	1.00
263_I	267_D	1.591	1.00
157_H	161_D	1.586	1.00
224_I	295_A	1.573	1.00
178_V	215_L	1.556	1.00
138_D	150_S	1.544	1.00
247_Q	324_I	1.531	1.00
198_C	233_V	1.530	1.00
267_D	276_F	1.508	1.00
298_A	302_L	1.504	1.00
236_S	239_S	1.504	1.00
112_L	115_E	1.460	1.00
300_A	305_H	1.453	1.00
263_I	316_T	1.453	1.00
105_A	108_H	1.440	1.00
272_F	308_V	1.430	1.00
307_D	321_T	1.424	1.00
267_D	278_S	1.422	1.00
60_E	63_F	1.409	1.00
136_I	145_L	1.388	1.00
113_E	117_D	1.369	1.00
125_E	223_F	1.363	1.00
248_K	253_Q	1.358	1.00
225_I	254_L	1.336	1.00
137_I	150_S	1.334	1.00
254_L	320_L	1.306	1.00
220_W	223_F	1.299	1.00
217_D	220_W	1.278	1.00
150_S	154_L	1.278	1.00
117_D	121_A	1.273	1.00
227_Q	295_A	1.272	1.00
66_S	70_W	1.272	1.00
140_M	146_K	1.267	1.00
133_M	149_L	1.262	1.00
310_S	314_A	1.249	1.00
80_N	84_T	1.248	1.00
184_Q	188_F	1.241	1.00
104_T	108_H	1.236	1.00
98_T	102_K	1.203	1.00
195_Q	199_I	1.200	1.00
242_E	259_C	1.196	1.00
105_A	109_R	1.192	1.00
134_H	150_S	1.187	1.00
95_A	98_T	1.184	1.00
193_D	222_A	1.182	1.00
115_E	119_L	1.177	1.00
182_Q	213_E	1.175	1.00
264_D	312_F	1.168	1.00
273_D	276_F	1.164	1.00
251_Q	305_H	1.163	1.00
121_A	274_K	1.146	1.00
189_K	218_A	1.141	1.00
310_S	313_G	1.136	1.00
87_E	90_V	1.131	1.00
184_Q	245_S	1.122	1.00
54_W	58_R	1.119	1.00
94_I	98_T	1.112	1.00
137_I	153_W	1.104	1.00
271_I	308_V	1.100	1.00
218_A	222_A	1.097	1.00
209_L	245_S	1.097	1.00
252_T	324_I	1.087	1.00
258_D	315_G	1.085	1.00
158_L	219_K	1.082	1.00
109_R	113_E	1.080	1.00
136_I	148_Q	1.078	1.00
297_K	300_A	1.069	1.00
220_W	298_A	1.068	1.00
91_E	95_A	1.060	1.00
224_I	320_L	1.057	1.00
221_L	302_L	1.056	1.00
132_A	152_E	1.056	1.00
77_T	80_N	1.054	1.00
137_I	141_E	1.052	1.00
63_F	71_E	1.046	1.00
176_L	217_D	1.045	1.00
191_I	207_I	1.043	1.00
91_E	94_I	1.040	1.00
304_I	322_F	1.038	1.00
87_E	91_E	1.037	1.00
117_D	274_K	1.036	1.00
90_V	94_I	1.036	1.00
277_T	285_Q	1.033	1.00
178_V	302_L	1.031	1.00
90_V	95_A	1.027	1.00
220_W	301_P	1.023	1.00
258_D	316_T	1.019	1.00
299_A	306_I	1.017	1.00
71_E	75_D	1.013	1.00
272_F	318_F	1.008	1.00
236_S	241_I	1.006	1.00
304_I	320_L	0.995	1.00
107_R	110_L	0.995	1.00
94_I	97_Q	0.981	1.00
53_L	57_Y	0.979	1.00
187_I	245_S	0.977	1.00
92_R	95_A	0.977	1.00
59_K	66_S	0.976	1.00
235_Y	277_T	0.973	1.00
147_S	151_Y	0.971	1.00
184_Q	209_L	0.966	1.00
103_Q	107_R	0.966	1.00
84_T	87_E	0.964	1.00
188_F	207_I	0.963	1.00
110_L	114_N	0.957	1.00
152_E	155_R	0.955	1.00
277_T	287_S	0.953	1.00
132_A	136_I	0.947	1.00
86_F	90_V	0.946	1.00
197_W	200_Q	0.945	1.00
308_V	316_T	0.940	1.00
268_V	272_F	0.938	1.00
190_E	222_A	0.929	1.00
135_L	139_R	0.929	1.00
181_I	186_L	0.927	1.00
80_N	83_E	0.927	1.00
186_L	216_S	0.926	1.00
137_I	146_K	0.921	1.00
272_F	296_K	0.920	1.00
162_Q	220_W	0.917	1.00
190_E	226_R	0.916	1.00
262_G	316_T	0.910	1.00
209_L	212_K	0.907	1.00
257_K	311_E	0.906	1.00
111_A	115_E	0.904	1.00
127_K	161_D	0.900	1.00
95_A	99_E	0.894	1.00
104_T	107_R	0.894	1.00
97_Q	101_L	0.892	1.00
166_Q	293_Y	0.883	1.00
85_P	88_A	0.879	1.00
177_S	217_D	0.877	1.00
186_L	190_E	0.877	1.00
263_I	269_P	0.876	1.00
193_D	226_R	0.867	1.00
98_T	101_L	0.863	1.00
63_F	70_W	0.859	1.00
126_V	156_I	0.850	1.00
148_Q	152_E	0.850	1.00
190_E	194_L	0.842	1.00
118_E	122_W	0.840	1.00
144_A	148_Q	0.839	1.00
97_Q	100_H	0.838	1.00
112_L	116_K	0.836	1.00
68_K	71_E	0.832	1.00
161_D	165_H	0.829	1.00
297_K	301_P	0.828	1.00
299_A	322_F	0.826	1.00
194_L	229_L	0.825	1.00
134_H	138_D	0.825	1.00
76_V	80_N	0.818	1.00
197_W	230_T	0.815	1.00
106_A	110_L	0.815	1.00
151_Y	189_K	0.812	1.00
61_T	66_S	0.808	1.00
225_I	256_V	0.808	1.00
250_E	324_I	0.801	1.00
232_A	241_I	0.800	1.00
153_W	157_H	0.799	1.00
210_E	246_F	0.798	1.00
77_T	83_E	0.793	1.00
178_V	216_S	0.793	1.00
143_K	147_S	0.793	1.00
57_Y	61_T	0.785	1.00
149_L	153_W	0.785	1.00
225_I	229_L	0.781	1.00
132_A	135_L	0.780	1.00
76_V	79_I	0.775	1.00
228_L	318_F	0.774	1.00
235_Y	261_R	0.771	1.00
271_I	318_F	0.769	1.00
191_I	205_F	0.766	1.00
101_L	104_T	0.760	1.00
162_Q	223_F	0.756	1.00
165_H	223_F	0.755	1.00
56_R	60_E	0.753	1.00
248_K	251_Q	0.750	1.00
141_E	146_K	0.745	1.00
148_Q	151_Y	0.743	1.00
178_V	303_L	0.741	1.00
107_R	111_A	0.740	1.00
265_P	310_S	0.737	1.00
181_I	218_A	0.737	1.00
227_Q	230_T	0.736	1.00
93_S	97_Q	0.736	1.00
155_R	222_A	0.735	1.00
128_T	132_A	0.735	1.00
57_Y	60_E	0.735	1.00
191_I	195_Q	0.733	1.00
110_L	113_E	0.732	1.00
84_T	90_V	0.732	1.00
116_K	170_S	0.730	1.00
263_I	308_V	0.723	1.00
102_K	105_A	0.722	1.00
295_A	299_A	0.720	1.00
67_L	71_E	0.720	1.00
90_V	93_S	0.719	1.00
184_Q	211_A	0.717	1.00
183_L	254_L	0.716	1.00
219_K	222_A	0.716	1.00
103_Q	106_A	0.714	1.00
185_P	189_K	0.712	1.00
222_A	226_R	0.712	1.00
198_C	205_F	0.708	1.00
202_G	238_A	0.708	1.00
263_I	268_V	0.707	1.00
279_T	283_H	0.705	1.00
176_L	220_W	0.702	1.00
251_Q	323_P	0.701	1.00
70_W	74_L	0.701	1.00
290_M	294_L	0.699	1.00
263_I	310_S	0.696	1.00
226_R	230_T	0.692	1.00
210_E	245_S	0.691	1.00
144_A	147_S	0.688	1.00
96_G	100_H	0.685	1.00
258_D	261_R	0.685	1.00
90_V	98_T	0.684	1.00
154_L	157_H	0.682	1.00
100_H	103_Q	0.682	1.00
63_F	67_L	0.681	1.00
194_L	230_T	0.681	1.00
203_I	207_I	0.677	1.00
228_L	295_A	0.677	1.00
130_L	160_L	0.675	1.00
176_L	301_P	0.673	1.00
248_K	321_T	0.671	1.00
198_C	241_I	0.669	1.00
77_T	81_E	0.668	1.00
223_F	298_A	0.668	1.00
147_S	150_S	0.666	1.00
79_I	83_E	0.665	1.00
136_I	152_E	0.663	1.00
261_R	285_Q	0.661	1.00
158_L	162_Q	0.656	1.00
196_S	199_I	0.655	1.00
113_E	116_K	0.652	1.00
71_E	74_L	0.652	1.00
188_F	192_K	0.650	1.00
228_L	306_I	0.649	1.00
187_I	225_I	0.649	1.00
234_K	287_S	0.649	1.00
101_L	105_A	0.649	1.00
274_K	297_K	0.646	1.00
234_K	285_Q	0.646	1.00
253_Q	307_D	0.644	1.00
307_D	320_L	0.644	1.00
228_L	320_L	0.643	1.00
165_H	220_W	0.643	1.00
192_K	195_Q	0.639	1.00
152_E	193_D	0.638	1.00
127_K	157_H	0.635	1.00
268_V	309_E	0.634	1.00
229_L	243_I	0.634	1.00
68_K	72_N	0.634	1.00
296_K	305_H	0.633	1.00
203_I	233_V	0.633	1.00
220_W	302_L	0.633	1.00
203_I	236_S	0.632	1.00
255_Q	309_E	0.628	1.00
90_V	97_Q	0.628	1.00
265_P	311_E	0.626	1.00
203_I	241_I	0.625	1.00
111_A	114_N	0.625	1.00
181_I	215_L	0.624	1.00
83_E	88_A	0.620	1.00
60_E	64_Y	0.619	1.00
69_T	73_N	0.618	1.00
183_L	252_T	0.618	1.00
56_R	59_K	0.616	1.00
186_L	221_L	0.615	1.00
55_F	59_K	0.614	1.00
201_K	233_V	0.612	1.00
109_R	112_L	0.612	1.00
117_D	297_K	0.610	1.00
108_H	112_L	0.609	1.00
243_I	256_V	0.607	1.00
268_V	318_F	0.605	1.00
187_I	243_I	0.605	1.00
91_E	98_T	0.604	1.00
139_R	145_L	0.603	1.00
138_D	142_E	0.603	1.00
190_E	229_L	0.603	1.00
194_L	233_V	0.602	1.00
145_L	148_Q	0.601	1.00
92_R	96_G	0.600	1.00
199_I	202_G	0.599	1.00
102_K	106_A	0.599	1.00
140_M	145_L	0.596	1.00
164_L	168_R	0.596	1.00
61_T	65_K	0.591	1.00
234_K	279_T	0.590	1.00
224_I	302_L	0.589	1.00
185_P	218_A	0.585	1.00
122_W	163_Q	0.584	1.00
70_W	73_N	0.578	1.00
84_T	91_E	0.578	1.00
81_E	84_T	0.578	1.00
198_C	202_G	0.577	1.00
304_I	323_P	0.576	1.00
67_L	70_W	0.575	1.00
63_F	68_K	0.574	1.00
77_T	84_T	0.572	1.00
264_D	278_S	0.570	1.00
229_L	241_I	0.567	1.00
267_D	280_T	0.565	1.00
271_I	293_Y	0.557	1.00
126_V	160_L	0.557	1.00
232_A	256_V	0.557	1.00
83_E	87_E	0.555	1.00
108_H	111_A	0.555	1.00
277_T	286_A	0.554	1.00
136_I	149_L	0.553	1.00
203_I	259_C	0.552	1.00
146_K	150_S	0.552	1.00
204_G	207_I	0.550	1.00
100_H	104_T	0.549	1.00
80_N	90_V	0.549	1.00
82_P	85_P	0.548	1.00
78_A	81_E	0.548	1.00
91_E	97_Q	0.542	1.00
188_F	209_L	0.541	1.00
132_A	148_Q	0.541	1.00
196_S	200_Q	0.539	1.00
186_L	222_A	0.534	1.00
174_N	220_W	0.532	1.00
84_T	88_A	0.531	1.00
65_K	68_K	0.528	1.00
154_L	158_L	0.528	1.00
241_I	256_V	0.527	1.00
83_E	90_V	0.527	1.00
119_L	123_I	0.526	1.00
125_E	129_P	0.524	1.00
228_L	299_A	0.524	1.00
86_F	89_M	0.524	1.00
187_I	190_E	0.523	1.00
208_Q	246_F	0.521	1.00
265_P	269_P	0.521	1.00
99_E	103_Q	0.520	1.00
76_V	81_E	0.518	1.00
114_N	117_D	0.518	1.00
131_T	135_L	0.517	1.00
58_R	63_F	0.516	1.00
87_E	93_S	0.516	1.00
257_K	313_G	0.515	1.00
251_Q	324_I	0.515	1.00
170_S	297_K	0.515	1.00
184_Q	212_K	0.515	1.00
223_F	226_R	0.514	1.00
125_E	227_Q	0.514	1.00
237_E	261_R	0.513	1.00
89_M	93_S	0.511	1.00
39_L	42_V	0.511	1.00
50_I	54_W	0.511	1.00
198_C	201_K	0.511	1.00
306_I	318_F	0.510	1.00
162_Q	219_K	0.509	1.00
76_V	83_E	0.509	1.00
245_S	252_T	0.508	1.00
59_K	63_F	0.508	1.00
78_A	82_P	0.507	1.00
237_E	259_C	0.506	1.00
61_T	64_Y	0.505	1.00
247_Q	250_E	0.505	1.00
259_C	314_A	0.505	1.00
63_F	74_L	0.504	1.00
198_C	203_I	0.504	1.00
191_I	243_I	0.501	1.00
39_L	43_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.7964	100	0.327	Contact Map
4bixA	2	0.6677	100	0.354	Contact Map
4ctiA	2	0.6796	100	0.38	Contact Map
4q20A	2	0.6647	100	0.387	Contact Map
3jz3A	2	0.4581	100	0.403	Contact Map
4e01A	3	0.8503	100	0.405	Contact Map
4mpcA	2	0.8772	100	0.407	Contact Map
2c2aA	2	0.6677	100	0.409	Contact Map
3d36A	2	0.6347	100	0.416	Contact Map
2q8gA	2	0.8982	100	0.418	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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