GREMLIN Database
YFKC - Uncharacterized MscS family protein YfkC
UniProt: O35043 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (243)
Sequences: 11371 (8413)
Seq/√Len: 539.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_V263_Y3.7231.00
126_T132_N3.3331.00
186_D260_R3.2871.00
25_L70_F3.1561.00
136_E146_R3.1291.00
189_Y256_R2.9241.00
226_A235_E2.9121.00
261_Q264_Q2.8241.00
193_E197_D2.7061.00
261_Q265_N2.6871.00
187_R265_N2.6101.00
124_Y132_N2.5261.00
184_D187_R2.5161.00
190_S194_E2.4821.00
178_L233_G2.3311.00
225_T237_T2.3171.00
194_E261_Q2.3041.00
228_N235_E2.2921.00
101_Q105_K2.2731.00
199_L253_A2.2381.00
176_S237_T2.1721.00
187_R190_S2.1681.00
187_R191_V1.9831.00
137_E144_Q1.9821.00
124_Y134_T1.9771.00
176_S235_E1.9581.00
251_S255_R1.9101.00
180_S268_Q1.8691.00
257_V260_R1.8491.00
189_Y193_E1.7921.00
191_V261_Q1.7841.00
179_I188_V1.7581.00
194_E198_M1.7451.00
126_T166_Y1.7111.00
116_E141_R1.7071.00
253_A257_V1.7061.00
240_G254_V1.7021.00
183_E268_Q1.6941.00
136_E152_L1.6901.00
178_L235_E1.6781.00
198_M257_V1.6681.00
128_N162_Q1.6591.00
126_T164_E1.6501.00
25_L29_V1.6431.00
147_E153_L1.6241.00
224_I234_V1.6181.00
260_R264_Q1.5861.00
174_T237_T1.5791.00
191_V265_N1.5731.00
159_E162_Q1.5581.00
102_S105_K1.5221.00
14_K17_D1.5131.00
126_T129_N1.5131.00
203_L216_T1.5061.00
243_K246_D1.4861.00
186_D256_R1.4741.00
124_Y148_W1.4631.00
198_M261_Q1.4601.00
195_A261_Q1.4411.00
119_L143_L1.4251.00
143_L157_N1.4051.00
262_L267_V1.3711.00
94_I97_G1.3541.00
144_Q152_L1.3531.00
123_D168_I1.3431.00
246_D249_S1.3411.00
27_I31_I1.3271.00
133_G145_I1.3211.00
256_R260_R1.3161.00
153_L164_E1.3151.00
199_L257_V1.3081.00
186_D190_S1.3061.00
192_L258_L1.3051.00
125_V135_V1.3031.00
22_A26_W1.2771.00
247_Y251_S1.2761.00
249_S253_A1.2751.00
26_W30_F1.2691.00
191_V194_E1.2611.00
66_A70_F1.2611.00
196_C238_V1.2481.00
173_I240_G1.2451.00
33_N63_Q1.2411.00
177_F258_L1.2381.00
37_Q59_R1.2371.00
191_V195_A1.2361.00
242_V250_A1.2341.00
74_V78_F1.2131.00
257_V261_Q1.2061.00
29_V33_N1.2051.00
120_H168_I1.2031.00
151_K164_E1.2001.00
18_I78_F1.1981.00
127_V130_L1.1901.00
188_V236_F1.1721.00
22_A25_L1.1671.00
171_M247_Y1.1651.00
186_D189_Y1.1651.00
63_Q67_T1.1391.00
194_E265_N1.1351.00
147_E151_K1.1341.00
190_S193_E1.1291.00
127_V160_V1.1181.00
182_K259_V1.1141.00
182_K271_E1.1061.00
88_G91_V1.1041.00
183_E188_V1.0911.00
182_K268_Q1.0831.00
180_S183_E1.0811.00
195_A257_V1.0751.00
194_E197_D1.0691.00
18_I22_A1.0531.00
178_L228_N1.0491.00
152_L168_I1.0361.00
226_A255_R1.0341.00
75_I80_H1.0231.00
179_I183_E1.0211.00
21_V25_L1.0201.00
178_L230_I1.0151.00
222_H238_V1.0151.00
84_K87_A1.0051.00
196_C200_N1.0011.00
229_K235_E0.9991.00
195_A198_M0.9981.00
201_E253_A0.9941.00
139_G144_Q0.9781.00
172_R241_M0.9771.00
193_E222_H0.9771.00
176_S225_T0.9661.00
18_I74_V0.9621.00
14_K18_I0.9601.00
173_I251_S0.9601.00
30_F34_R0.9551.00
176_S226_A0.9531.00
185_P236_F0.9461.00
183_E187_R0.9381.00
86_L90_G0.9331.00
225_T235_E0.9241.00
185_P189_Y0.9201.00
142_S154_T0.9181.00
230_I271_E0.9081.00
100_A108_L0.9081.00
37_Q41_K0.9071.00
125_V145_I0.9021.00
70_F74_V0.9001.00
150_G241_M0.9001.00
223_G252_L0.8971.00
92_A96_I0.8961.00
99_G104_I0.8911.00
184_D188_V0.8901.00
192_L262_L0.8861.00
174_T239_K0.8851.00
105_K158_G0.8721.00
179_I236_F0.8671.00
181_F227_L0.8661.00
254_V258_L0.8661.00
181_F269_M0.8631.00
13_N16_V0.8591.00
17_D77_L0.8571.00
248_F252_L0.8541.00
33_N37_Q0.8471.00
52_K56_S0.8451.00
192_L238_V0.8441.00
262_L269_M0.8421.00
195_A199_L0.8411.00
216_T219_F0.8401.00
201_E246_D0.8401.00
230_I233_G0.8351.00
128_N159_E0.8311.00
88_G92_A0.8261.00
135_V145_I0.8201.00
191_V267_V0.8191.00
268_Q273_A0.8181.00
196_C240_G0.8181.00
180_S270_L0.8161.00
179_I262_L0.8141.00
178_L229_K0.8121.00
152_L169_D0.8101.00
185_P259_V0.8101.00
199_L254_V0.8061.00
91_V100_A0.8041.00
116_E142_S0.8031.00
146_R152_L0.8021.00
225_T251_S0.8021.00
103_L109_A0.8011.00
252_L256_R0.8001.00
117_R120_H0.7991.00
16_V20_L0.7941.00
199_L202_E0.7921.00
188_V192_L0.7911.00
227_L234_V0.7891.00
229_K272_E0.7881.00
181_F271_E0.7851.00
39_F43_T0.7851.00
92_A95_V0.7841.00
179_I267_V0.7831.00
190_S265_N0.7701.00
76_S81_D0.7651.00
253_A256_R0.7641.00
198_M202_E0.7611.00
229_K233_G0.7601.00
86_L95_V0.7521.00
201_E250_A0.7521.00
67_T71_I0.7481.00
33_N59_R0.7461.00
21_V70_F0.7431.00
193_E220_Q0.7411.00
56_S60_S0.7411.00
32_I62_T0.7401.00
230_I273_A0.7401.00
40_F44_D0.7401.00
59_R63_Q0.7401.00
146_R150_G0.7371.00
195_A254_V0.7321.00
190_S197_D0.7301.00
134_T146_R0.7291.00
73_Y77_L0.7231.00
227_L255_R0.7201.00
224_I255_R0.7191.00
35_L39_F0.7181.00
175_E255_R0.7171.00
173_I242_V0.7161.00
18_I25_L0.7141.00
18_I29_V0.7091.00
21_V26_W0.7081.00
119_L160_V0.7081.00
172_R239_K0.7071.00
223_G237_T0.7051.00
177_F192_L0.7051.00
30_F33_N0.7051.00
31_I35_L0.7031.00
185_P234_V0.7011.00
53_T57_L0.7001.00
189_Y252_L0.7001.00
89_A93_G0.6991.00
70_F73_Y0.6981.00
175_E240_G0.6981.00
178_L181_F0.6951.00
21_V77_L0.6941.00
187_R194_E0.6901.00
178_L271_E0.6881.00
115_Y118_Q0.6841.00
106_D158_G0.6841.00
248_F251_S0.6841.00
52_K55_E0.6791.00
96_I104_I0.6781.00
146_R169_D0.6771.00
15_I18_I0.6701.00
116_E144_Q0.6681.00
87_A90_G0.6671.00
127_V155_I0.6641.00
25_L28_G0.6631.00
139_G142_S0.6611.00
234_V259_V0.6601.00
16_V19_L0.6531.00
27_I30_F0.6481.00
29_V63_Q0.6481.00
188_V191_V0.6481.00
185_P260_R0.6451.00
88_G93_G0.6441.00
119_L125_V0.6411.00
226_A251_S0.6401.00
51_E54_I0.6341.00
228_N233_G0.6321.00
238_V258_L0.6321.00
53_T56_S0.6311.00
227_L259_V0.6311.00
68_I72_F0.6311.00
109_A158_G0.6231.00
149_S172_R0.6221.00
173_I247_Y0.6221.00
14_K21_V0.6201.00
25_L66_A0.6191.00
132_N166_Y0.6191.00
81_D84_K0.6191.00
180_S269_M0.6181.00
20_L23_V0.6151.00
181_F234_V0.6141.00
192_L195_A0.6131.00
91_V95_V0.6131.00
202_E257_V0.6121.00
144_Q154_T0.6101.00
102_S158_G0.6091.00
29_V66_A0.6091.00
54_I57_L0.6091.00
195_A265_N0.6081.00
101_Q158_G0.6031.00
96_I108_L0.6031.00
38_L42_R0.6021.00
20_L24_I0.6001.00
90_G93_G0.5981.00
192_L196_C0.5951.00
197_D216_T0.5941.00
130_L164_E0.5941.00
221_I239_K0.5911.00
193_E196_C0.5901.00
83_G87_A0.5870.99
119_L163_I0.5820.99
60_S63_Q0.5820.99
113_L119_L0.5800.99
230_I272_E0.5800.99
196_C254_V0.5760.99
17_D21_V0.5740.99
134_T148_W0.5690.99
191_V198_M0.5680.99
134_T245_D0.5660.99
183_E234_V0.5650.99
125_V160_V0.5620.99
23_V27_I0.5620.99
36_V39_F0.5600.99
13_N17_D0.5580.99
29_V67_T0.5570.99
40_F43_T0.5530.99
98_F103_L0.5520.99
224_I227_L0.5510.99
180_S273_A0.5510.99
104_I108_L0.5510.99
201_E249_S0.5500.99
189_Y236_F0.5500.99
103_L112_F0.5490.99
181_F230_I0.5480.99
93_G99_G0.5460.99
233_G271_E0.5450.99
255_R258_L0.5440.99
180_S271_E0.5430.99
227_L258_L0.5400.99
53_T114_I0.5400.99
15_I19_L0.5390.99
221_I225_T0.5360.99
184_D190_S0.5320.99
177_F227_L0.5300.99
60_S64_Y0.5270.99
98_F101_Q0.5260.99
132_N148_W0.5250.99
151_K166_Y0.5250.99
262_L265_N0.5230.99
90_G101_Q0.5220.99
260_R263_Y0.5210.99
55_E59_R0.5200.99
94_I102_S0.5200.99
33_N38_L0.5200.99
36_V42_R0.5200.99
196_C222_H0.5190.99
185_P224_I0.5180.99
196_C202_E0.5180.99
136_E144_Q0.5180.99
184_D260_R0.5180.99
259_V269_M0.5180.99
51_E120_H0.5170.99
269_M273_A0.5140.99
64_Y68_I0.5120.99
26_W29_V0.5110.99
32_I35_L0.5100.99
203_L218_P0.5100.99
90_G94_I0.5100.99
177_F236_F0.5080.99
88_G95_V0.5070.99
185_P188_V0.5060.99
188_V195_A0.5060.99
56_S137_E0.5030.98
22_A74_V0.5030.98
189_Y222_H0.5020.98
237_T252_L0.5010.98
217_E220_Q0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3udcA 3 0.9286 100 0.168 Contact Map
5ajiA 3 0.9071 100 0.175 Contact Map
4hw9A 3 0.8857 100 0.183 Contact Map
1nz9A 1 0.175 38.5 0.939 Contact Map
2e6zA 1 0.1857 24.7 0.945 Contact Map
4l5gA 1 0.5 23.1 0.946 Contact Map
2mi6A 1 0.1857 21.6 0.946 Contact Map
3mlqE 1 0.1429 17.5 0.949 Contact Map
1mwwA 3 0.3536 14.4 0.95 Contact Map
2aalA 3 0.3357 12.3 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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