YKOQ - BACSU - GREMLIN Contacts

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YKOQ - Uncharacterized metallophosphoesterase YkoQ

UniProt:	O35040	Sequences: MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARKKLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQKLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGIDDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKPYHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	270 (255)
Sequences:	4173 (3229)
Seq/√Len:	202.2

ECOLI - YAEI
BACSU - YKOQ YKUE YPBG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_H	81_T	5.533	1.00
79_A	185_L	4.051	1.00
47_N	269_Q	3.593	1.00
36_Q	181_Y	3.394	1.00
46_L	108_Y	3.233	1.00
78_I	104_L	3.100	1.00
49_L	267_F	2.821	1.00
234_K	248_E	2.820	1.00
73_Q	267_F	2.805	1.00
33_S	269_Q	2.771	1.00
111_Y	157_I	2.525	1.00
245_Y	266_T	2.456	1.00
139_I	146_V	2.454	1.00
130_K	142_Q	2.426	1.00
238_Y	243_P	2.360	1.00
31_T	269_Q	2.280	1.00
49_L	70_T	2.273	1.00
142_Q	161_D	2.262	1.00
112_A	140_T	2.260	1.00
236_L	243_P	2.259	1.00
149_E	154_P	2.222	1.00
49_L	75_V	2.119	1.00
52_S	247_S	2.026	1.00
51_L	70_T	2.020	1.00
47_N	267_F	1.968	1.00
158_I	182_H	1.961	1.00
64_E	103_K	1.957	1.00
110_M	138_C	1.935	1.00
48_I	77_I	1.908	1.00
203_L	242_K	1.904	1.00
31_T	73_Q	1.871	1.00
50_H	204_L	1.844	1.00
80_L	84_F	1.824	1.00
32_I	245_Y	1.818	1.00
156_N	180_G	1.814	1.00
69_L	73_Q	1.805	1.00
79_A	204_L	1.798	1.00
147_R	156_N	1.779	1.00
169_N	172_G	1.726	1.00
67_Y	71_K	1.702	1.00
237_H	246_I	1.685	1.00
145_H	176_S	1.654	1.00
26_D	262_R	1.642	1.00
204_L	268_H	1.640	1.00
156_N	182_H	1.630	1.00
38_D	201_D	1.620	1.00
114_F	130_K	1.617	1.00
186_T	205_S	1.593	1.00
64_E	68_H	1.582	1.00
139_I	144_E	1.562	1.00
45_K	269_Q	1.533	1.00
49_L	73_Q	1.528	1.00
111_Y	146_V	1.514	1.00
157_I	183_L	1.500	1.00
147_R	154_P	1.489	1.00
145_H	156_N	1.462	1.00
238_Y	241_D	1.454	1.00
50_H	247_S	1.438	1.00
32_I	266_T	1.423	1.00
81_T	185_L	1.410	1.00
79_A	157_I	1.398	1.00
149_E	152_A	1.384	1.00
192_I	244_F	1.383	1.00
42_A	153_G	1.383	1.00
40_L	43_R	1.379	1.00
81_T	204_L	1.377	1.00
174_Y	200_Y	1.376	1.00
22_R	26_D	1.375	1.00
43_R	150_T	1.372	1.00
31_T	267_F	1.349	1.00
51_L	54_L	1.340	1.00
19_K	23_N	1.337	1.00
47_N	73_Q	1.334	1.00
132_V	135_E	1.332	1.00
52_S	81_T	1.329	1.00
30_N	248_E	1.317	1.00
232_M	237_H	1.313	1.00
147_R	180_G	1.312	1.00
71_K	107_A	1.304	1.00
162_D	188_D	1.291	1.00
106_P	109_G	1.290	1.00
160_I	186_T	1.286	1.00
158_I	200_Y	1.258	1.00
192_I	242_K	1.246	1.00
64_E	100_A	1.230	1.00
130_K	134_E	1.227	1.00
192_I	239_H	1.219	1.00
145_H	158_I	1.217	1.00
236_L	245_Y	1.204	1.00
148_I	157_I	1.195	1.00
43_R	155_V	1.183	1.00
81_T	247_S	1.182	1.00
66_L	250_L	1.178	1.00
150_T	153_G	1.160	1.00
29_V	73_Q	1.158	1.00
156_N	177_L	1.156	1.00
245_Y	268_H	1.155	1.00
247_S	266_T	1.133	1.00
184_V	200_Y	1.129	1.00
18_Y	22_R	1.129	1.00
131_R	135_E	1.114	1.00
80_L	138_C	1.109	1.00
56_L	63_P	1.102	1.00
51_L	80_L	1.101	1.00
28_K	262_R	1.096	1.00
30_N	264_E	1.091	1.00
69_L	72_D	1.091	1.00
77_I	111_Y	1.085	1.00
154_P	180_G	1.084	1.00
39_G	270_I	1.079	1.00
36_Q	39_G	1.079	1.00
130_K	140_T	1.065	1.00
29_V	265_V	1.059	1.00
74_P	107_A	1.053	1.00
42_A	45_K	1.042	1.00
119_Y	161_D	1.041	1.00
173_S	176_S	1.022	1.00
143_N	161_D	1.020	1.00
131_R	134_E	1.017	1.00
70_T	104_L	1.011	1.00
155_V	181_Y	1.005	1.00
48_I	79_A	1.003	1.00
50_H	268_H	1.000	1.00
67_Y	100_A	0.999	1.00
127_Q	131_R	0.999	1.00
60_S	63_P	0.997	1.00
182_H	200_Y	0.993	1.00
50_H	79_A	0.989	1.00
25_K	57_E	0.983	1.00
134_E	140_T	0.979	1.00
34_I	236_L	0.978	1.00
32_I	236_L	0.974	1.00
71_K	108_Y	0.971	1.00
237_H	244_F	0.966	0.99
71_K	105_K	0.962	0.99
233_I	237_H	0.961	0.99
20_A	24_T	0.957	0.99
77_I	148_I	0.957	0.99
170_I	184_V	0.952	0.99
174_Y	177_L	0.949	0.99
184_V	195_M	0.947	0.99
112_A	138_C	0.947	0.99
112_A	133_L	0.946	0.99
145_H	173_S	0.945	0.99
18_Y	24_T	0.942	0.99
55_H	209_H	0.939	0.99
98_L	132_V	0.938	0.99
102_Q	136_N	0.937	0.99
177_L	182_H	0.930	0.99
19_K	24_T	0.918	0.99
71_K	106_P	0.917	0.99
145_H	177_L	0.916	0.99
98_L	135_E	0.915	0.99
35_D	243_P	0.915	0.99
78_I	106_P	0.914	0.99
43_R	46_L	0.912	0.99
19_K	259_V	0.910	0.99
158_I	174_Y	0.909	0.99
32_I	268_H	0.907	0.99
54_L	250_L	0.907	0.99
106_P	110_M	0.903	0.99
210_G	248_E	0.903	0.99
129_L	133_L	0.901	0.99
223_K	230_M	0.899	0.99
30_N	266_T	0.894	0.99
133_L	138_C	0.893	0.99
216_P	219_Y	0.889	0.99
50_H	245_Y	0.889	0.99
186_T	191_I	0.888	0.99
69_L	265_V	0.888	0.99
19_K	22_R	0.881	0.99
81_T	113_V	0.880	0.99
24_T	252_Q	0.877	0.99
80_L	110_M	0.873	0.99
20_A	23_N	0.868	0.99
202_Y	268_H	0.867	0.99
27_V	69_L	0.866	0.99
248_E	261_S	0.860	0.99
105_K	109_G	0.856	0.99
158_I	173_S	0.850	0.99
68_H	103_K	0.850	0.99
210_G	262_R	0.847	0.99
57_E	86_D	0.839	0.99
100_A	103_K	0.838	0.99
183_L	202_Y	0.837	0.99
17_L	21_N	0.834	0.98
78_I	110_M	0.827	0.98
210_G	233_I	0.826	0.98
43_R	153_G	0.825	0.98
62_S	66_L	0.824	0.98
232_M	244_F	0.822	0.98
108_Y	150_T	0.822	0.98
84_F	133_L	0.815	0.98
15_P	19_K	0.793	0.98
196_K	239_H	0.787	0.98
116_N	209_H	0.782	0.98
118_D	129_L	0.779	0.98
171_T	175_Q	0.779	0.98
192_I	203_L	0.779	0.98
10_I	14_V	0.777	0.98
49_L	265_V	0.773	0.98
251_G	258_R	0.772	0.98
164_S	188_D	0.771	0.97
116_N	207_H	0.771	0.97
234_K	266_T	0.771	0.97
29_V	267_F	0.771	0.97
210_G	234_K	0.765	0.97
48_I	268_H	0.758	0.97
36_Q	201_D	0.756	0.97
40_L	45_K	0.756	0.97
193_L	232_M	0.753	0.97
127_Q	130_K	0.750	0.97
34_I	202_Y	0.749	0.97
117_H	209_H	0.748	0.97
158_I	177_L	0.742	0.97
216_P	260_G	0.739	0.97
239_H	242_K	0.734	0.97
193_L	231_N	0.732	0.97
54_L	66_L	0.731	0.97
248_E	263_P	0.728	0.96
163_Y	188_D	0.727	0.96
141_L	144_E	0.723	0.96
143_N	160_I	0.722	0.96
55_H	117_H	0.718	0.96
193_L	197_D	0.714	0.96
188_D	208_F	0.712	0.96
50_H	266_T	0.709	0.96
102_Q	137_G	0.708	0.96
56_L	97_Y	0.708	0.96
185_L	204_L	0.705	0.96
65_E	69_L	0.702	0.96
169_N	173_S	0.700	0.96
205_S	244_F	0.698	0.96
23_N	26_D	0.695	0.95
99_N	102_Q	0.689	0.95
84_F	112_A	0.688	0.95
24_T	27_V	0.688	0.95
170_I	200_Y	0.686	0.95
46_L	150_T	0.684	0.95
132_V	136_N	0.683	0.95
86_D	253_T	0.678	0.95
98_L	136_N	0.677	0.95
114_F	118_D	0.674	0.95
71_K	103_K	0.668	0.94
203_L	244_F	0.666	0.94
83_D	209_H	0.664	0.94
146_V	150_T	0.662	0.94
39_G	45_K	0.659	0.94
172_G	175_Q	0.657	0.94
149_E	153_G	0.657	0.94
20_A	259_V	0.655	0.94
160_I	173_S	0.654	0.94
39_G	43_R	0.654	0.94
146_V	157_I	0.653	0.94
210_G	261_S	0.651	0.94
30_N	245_Y	0.650	0.93
75_V	108_Y	0.650	0.93
66_L	70_T	0.647	0.93
195_M	203_L	0.645	0.93
114_F	161_D	0.643	0.93
21_N	24_T	0.643	0.93
54_L	80_L	0.642	0.93
42_A	152_A	0.640	0.93
160_I	191_I	0.635	0.93
220_H	223_K	0.634	0.93
16_F	20_A	0.633	0.93
114_F	126_F	0.630	0.92
184_V	203_L	0.629	0.92
238_Y	242_K	0.629	0.92
85_L	257_I	0.628	0.92
39_G	44_K	0.627	0.92
158_I	184_V	0.626	0.92
39_G	181_Y	0.624	0.92
23_N	263_P	0.624	0.92
46_L	148_I	0.623	0.92
134_E	142_Q	0.622	0.92
49_L	81_T	0.620	0.92
55_H	116_N	0.617	0.92
171_T	197_D	0.617	0.92
133_L	140_T	0.617	0.92
200_Y	203_L	0.615	0.91
163_Y	191_I	0.615	0.91
114_F	129_L	0.614	0.91
252_Q	256_N	0.613	0.91
248_E	264_E	0.613	0.91
181_Y	201_D	0.610	0.91
183_L	204_L	0.608	0.91
27_V	250_L	0.605	0.91
172_G	176_S	0.605	0.91
67_Y	73_Q	0.604	0.91
30_N	234_K	0.603	0.91
34_I	268_H	0.603	0.91
122_K	126_F	0.602	0.91
120_V	254_G	0.601	0.91
17_L	20_A	0.601	0.91
36_Q	202_Y	0.596	0.90
73_Q	265_V	0.592	0.90
196_K	242_K	0.592	0.90
36_Q	243_P	0.590	0.90
190_N	229_R	0.590	0.90
80_L	101_L	0.588	0.90
80_L	112_A	0.588	0.90
68_H	72_D	0.587	0.89
71_K	78_I	0.584	0.89
55_H	83_D	0.583	0.89
21_N	25_K	0.578	0.89
231_N	239_H	0.578	0.89
23_N	262_R	0.578	0.89
143_N	173_S	0.576	0.89
97_Y	101_L	0.575	0.89
191_I	194_D	0.571	0.88
220_H	261_S	0.570	0.88
95_A	99_N	0.570	0.88
134_E	144_E	0.567	0.88
40_L	181_Y	0.567	0.88
59_I	252_Q	0.566	0.88
96_G	99_N	0.564	0.88
26_D	259_V	0.564	0.88
248_E	266_T	0.564	0.88
7_S	11_L	0.564	0.88
216_P	248_E	0.563	0.87
54_L	62_S	0.556	0.87
252_Q	257_I	0.555	0.87
98_L	102_Q	0.552	0.86
8_L	12_V	0.552	0.86
229_R	232_M	0.552	0.86
196_K	199_H	0.551	0.86
42_A	270_I	0.550	0.86
213_I	255_V	0.549	0.86
181_Y	202_Y	0.548	0.86
65_E	68_H	0.548	0.86
111_Y	139_I	0.546	0.86
117_H	120_V	0.546	0.86
46_L	76_D	0.545	0.86
93_K	96_G	0.543	0.86
120_V	247_S	0.542	0.85
234_K	247_S	0.541	0.85
7_S	15_P	0.541	0.85
223_K	233_I	0.540	0.85
192_I	232_M	0.539	0.85
67_Y	104_L	0.536	0.85
14_V	18_Y	0.536	0.85
112_A	118_D	0.532	0.84
51_L	81_T	0.532	0.84
195_M	200_Y	0.531	0.84
118_D	188_D	0.528	0.84
162_D	212_Q	0.526	0.84
37_K	241_D	0.526	0.84
177_L	180_G	0.525	0.84
11_L	17_L	0.525	0.84
75_V	267_F	0.523	0.83
57_E	252_Q	0.522	0.83
114_F	140_T	0.521	0.83
29_V	69_L	0.521	0.83
86_D	188_D	0.520	0.83
68_H	71_K	0.520	0.83
126_F	130_K	0.520	0.83
175_Q	198_V	0.519	0.83
143_N	168_S	0.518	0.83
182_H	201_D	0.518	0.83
171_T	179_N	0.518	0.83
171_T	198_V	0.518	0.83
113_V	185_L	0.518	0.83
85_L	118_D	0.518	0.83
32_I	35_D	0.517	0.83
146_V	149_E	0.515	0.82
46_L	77_I	0.513	0.82
62_S	250_L	0.513	0.82
217_K	260_G	0.513	0.82
18_Y	23_N	0.512	0.82
81_T	245_Y	0.510	0.82
25_K	252_Q	0.510	0.82
188_D	253_T	0.509	0.82
216_P	220_H	0.509	0.82
80_L	113_V	0.506	0.81
128_R	131_R	0.505	0.81
160_I	163_Y	0.505	0.81
103_K	106_P	0.505	0.81
220_H	224_M	0.503	0.81
157_I	185_L	0.502	0.81
143_N	186_T	0.500	0.81
48_I	270_I	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rl5A	1	0.8444	100	0.623	Contact Map
4fbkA	2	0.9111	100	0.63	Contact Map
4fbwA	2	0.8222	100	0.631	Contact Map
3t1iA	2	0.8444	99.9	0.653	Contact Map
4ykeA	2	0.8407	99.9	0.662	Contact Map
3d03A	5	0.7111	99.9	0.678	Contact Map
4nzvA	1	0.8593	99.9	0.685	Contact Map
1ii7A	2	0.7963	99.9	0.686	Contact Map
2wdcA	1	0.8111	99.9	0.687	Contact Map
1uf3A	6	0.7	99.9	0.689	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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