GREMLIN Database
YKOQ - Uncharacterized metallophosphoesterase YkoQ
UniProt: O35040 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (255)
Sequences: 4173 (3229)
Seq/√Len: 202.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_H81_T5.5331.00
79_A185_L4.0511.00
47_N269_Q3.5931.00
36_Q181_Y3.3941.00
46_L108_Y3.2331.00
78_I104_L3.1001.00
49_L267_F2.8211.00
234_K248_E2.8201.00
73_Q267_F2.8051.00
33_S269_Q2.7711.00
111_Y157_I2.5251.00
245_Y266_T2.4561.00
139_I146_V2.4541.00
130_K142_Q2.4261.00
238_Y243_P2.3601.00
31_T269_Q2.2801.00
49_L70_T2.2731.00
142_Q161_D2.2621.00
112_A140_T2.2601.00
236_L243_P2.2591.00
149_E154_P2.2221.00
49_L75_V2.1191.00
52_S247_S2.0261.00
51_L70_T2.0201.00
47_N267_F1.9681.00
158_I182_H1.9611.00
64_E103_K1.9571.00
110_M138_C1.9351.00
48_I77_I1.9081.00
203_L242_K1.9041.00
31_T73_Q1.8711.00
50_H204_L1.8441.00
80_L84_F1.8241.00
32_I245_Y1.8181.00
156_N180_G1.8141.00
69_L73_Q1.8051.00
79_A204_L1.7981.00
147_R156_N1.7791.00
169_N172_G1.7261.00
67_Y71_K1.7021.00
237_H246_I1.6851.00
145_H176_S1.6541.00
26_D262_R1.6421.00
204_L268_H1.6401.00
156_N182_H1.6301.00
38_D201_D1.6201.00
114_F130_K1.6171.00
186_T205_S1.5931.00
64_E68_H1.5821.00
139_I144_E1.5621.00
45_K269_Q1.5331.00
49_L73_Q1.5281.00
111_Y146_V1.5141.00
157_I183_L1.5001.00
147_R154_P1.4891.00
145_H156_N1.4621.00
238_Y241_D1.4541.00
50_H247_S1.4381.00
32_I266_T1.4231.00
81_T185_L1.4101.00
79_A157_I1.3981.00
149_E152_A1.3841.00
192_I244_F1.3831.00
42_A153_G1.3831.00
40_L43_R1.3791.00
81_T204_L1.3771.00
174_Y200_Y1.3761.00
22_R26_D1.3751.00
43_R150_T1.3721.00
31_T267_F1.3491.00
51_L54_L1.3401.00
19_K23_N1.3371.00
47_N73_Q1.3341.00
132_V135_E1.3321.00
52_S81_T1.3291.00
30_N248_E1.3171.00
232_M237_H1.3131.00
147_R180_G1.3121.00
71_K107_A1.3041.00
162_D188_D1.2911.00
106_P109_G1.2901.00
160_I186_T1.2861.00
158_I200_Y1.2581.00
192_I242_K1.2461.00
64_E100_A1.2301.00
130_K134_E1.2271.00
192_I239_H1.2191.00
145_H158_I1.2171.00
236_L245_Y1.2041.00
148_I157_I1.1951.00
43_R155_V1.1831.00
81_T247_S1.1821.00
66_L250_L1.1781.00
150_T153_G1.1601.00
29_V73_Q1.1581.00
156_N177_L1.1561.00
245_Y268_H1.1551.00
247_S266_T1.1331.00
184_V200_Y1.1291.00
18_Y22_R1.1291.00
131_R135_E1.1141.00
80_L138_C1.1091.00
56_L63_P1.1021.00
51_L80_L1.1011.00
28_K262_R1.0961.00
30_N264_E1.0911.00
69_L72_D1.0911.00
77_I111_Y1.0851.00
154_P180_G1.0841.00
39_G270_I1.0791.00
36_Q39_G1.0791.00
130_K140_T1.0651.00
29_V265_V1.0591.00
74_P107_A1.0531.00
42_A45_K1.0421.00
119_Y161_D1.0411.00
173_S176_S1.0221.00
143_N161_D1.0201.00
131_R134_E1.0171.00
70_T104_L1.0111.00
155_V181_Y1.0051.00
48_I79_A1.0031.00
50_H268_H1.0001.00
67_Y100_A0.9991.00
127_Q131_R0.9991.00
60_S63_P0.9971.00
182_H200_Y0.9931.00
50_H79_A0.9891.00
25_K57_E0.9831.00
134_E140_T0.9791.00
34_I236_L0.9781.00
32_I236_L0.9741.00
71_K108_Y0.9711.00
237_H244_F0.9660.99
71_K105_K0.9620.99
233_I237_H0.9610.99
20_A24_T0.9570.99
77_I148_I0.9570.99
170_I184_V0.9520.99
174_Y177_L0.9490.99
184_V195_M0.9470.99
112_A138_C0.9470.99
112_A133_L0.9460.99
145_H173_S0.9450.99
18_Y24_T0.9420.99
55_H209_H0.9390.99
98_L132_V0.9380.99
102_Q136_N0.9370.99
177_L182_H0.9300.99
19_K24_T0.9180.99
71_K106_P0.9170.99
145_H177_L0.9160.99
98_L135_E0.9150.99
35_D243_P0.9150.99
78_I106_P0.9140.99
43_R46_L0.9120.99
19_K259_V0.9100.99
158_I174_Y0.9090.99
32_I268_H0.9070.99
54_L250_L0.9070.99
106_P110_M0.9030.99
210_G248_E0.9030.99
129_L133_L0.9010.99
223_K230_M0.8990.99
30_N266_T0.8940.99
133_L138_C0.8930.99
216_P219_Y0.8890.99
50_H245_Y0.8890.99
186_T191_I0.8880.99
69_L265_V0.8880.99
19_K22_R0.8810.99
81_T113_V0.8800.99
24_T252_Q0.8770.99
80_L110_M0.8730.99
20_A23_N0.8680.99
202_Y268_H0.8670.99
27_V69_L0.8660.99
248_E261_S0.8600.99
105_K109_G0.8560.99
158_I173_S0.8500.99
68_H103_K0.8500.99
210_G262_R0.8470.99
57_E86_D0.8390.99
100_A103_K0.8380.99
183_L202_Y0.8370.99
17_L21_N0.8340.98
78_I110_M0.8270.98
210_G233_I0.8260.98
43_R153_G0.8250.98
62_S66_L0.8240.98
232_M244_F0.8220.98
108_Y150_T0.8220.98
84_F133_L0.8150.98
15_P19_K0.7930.98
196_K239_H0.7870.98
116_N209_H0.7820.98
118_D129_L0.7790.98
171_T175_Q0.7790.98
192_I203_L0.7790.98
10_I14_V0.7770.98
49_L265_V0.7730.98
251_G258_R0.7720.98
164_S188_D0.7710.97
116_N207_H0.7710.97
234_K266_T0.7710.97
29_V267_F0.7710.97
210_G234_K0.7650.97
48_I268_H0.7580.97
36_Q201_D0.7560.97
40_L45_K0.7560.97
193_L232_M0.7530.97
127_Q130_K0.7500.97
34_I202_Y0.7490.97
117_H209_H0.7480.97
158_I177_L0.7420.97
216_P260_G0.7390.97
239_H242_K0.7340.97
193_L231_N0.7320.97
54_L66_L0.7310.97
248_E263_P0.7280.96
163_Y188_D0.7270.96
141_L144_E0.7230.96
143_N160_I0.7220.96
55_H117_H0.7180.96
193_L197_D0.7140.96
188_D208_F0.7120.96
50_H266_T0.7090.96
102_Q137_G0.7080.96
56_L97_Y0.7080.96
185_L204_L0.7050.96
65_E69_L0.7020.96
169_N173_S0.7000.96
205_S244_F0.6980.96
23_N26_D0.6950.95
99_N102_Q0.6890.95
84_F112_A0.6880.95
24_T27_V0.6880.95
170_I200_Y0.6860.95
46_L150_T0.6840.95
132_V136_N0.6830.95
86_D253_T0.6780.95
98_L136_N0.6770.95
114_F118_D0.6740.95
71_K103_K0.6680.94
203_L244_F0.6660.94
83_D209_H0.6640.94
146_V150_T0.6620.94
39_G45_K0.6590.94
172_G175_Q0.6570.94
149_E153_G0.6570.94
20_A259_V0.6550.94
160_I173_S0.6540.94
39_G43_R0.6540.94
146_V157_I0.6530.94
210_G261_S0.6510.94
30_N245_Y0.6500.93
75_V108_Y0.6500.93
66_L70_T0.6470.93
195_M203_L0.6450.93
114_F161_D0.6430.93
21_N24_T0.6430.93
54_L80_L0.6420.93
42_A152_A0.6400.93
160_I191_I0.6350.93
220_H223_K0.6340.93
16_F20_A0.6330.93
114_F126_F0.6300.92
184_V203_L0.6290.92
238_Y242_K0.6290.92
85_L257_I0.6280.92
39_G44_K0.6270.92
158_I184_V0.6260.92
39_G181_Y0.6240.92
23_N263_P0.6240.92
46_L148_I0.6230.92
134_E142_Q0.6220.92
49_L81_T0.6200.92
55_H116_N0.6170.92
171_T197_D0.6170.92
133_L140_T0.6170.92
200_Y203_L0.6150.91
163_Y191_I0.6150.91
114_F129_L0.6140.91
252_Q256_N0.6130.91
248_E264_E0.6130.91
181_Y201_D0.6100.91
183_L204_L0.6080.91
27_V250_L0.6050.91
172_G176_S0.6050.91
67_Y73_Q0.6040.91
30_N234_K0.6030.91
34_I268_H0.6030.91
122_K126_F0.6020.91
120_V254_G0.6010.91
17_L20_A0.6010.91
36_Q202_Y0.5960.90
73_Q265_V0.5920.90
196_K242_K0.5920.90
36_Q243_P0.5900.90
190_N229_R0.5900.90
80_L101_L0.5880.90
80_L112_A0.5880.90
68_H72_D0.5870.89
71_K78_I0.5840.89
55_H83_D0.5830.89
21_N25_K0.5780.89
231_N239_H0.5780.89
23_N262_R0.5780.89
143_N173_S0.5760.89
97_Y101_L0.5750.89
191_I194_D0.5710.88
220_H261_S0.5700.88
95_A99_N0.5700.88
134_E144_E0.5670.88
40_L181_Y0.5670.88
59_I252_Q0.5660.88
96_G99_N0.5640.88
26_D259_V0.5640.88
248_E266_T0.5640.88
7_S11_L0.5640.88
216_P248_E0.5630.87
54_L62_S0.5560.87
252_Q257_I0.5550.87
98_L102_Q0.5520.86
8_L12_V0.5520.86
229_R232_M0.5520.86
196_K199_H0.5510.86
42_A270_I0.5500.86
213_I255_V0.5490.86
181_Y202_Y0.5480.86
65_E68_H0.5480.86
111_Y139_I0.5460.86
117_H120_V0.5460.86
46_L76_D0.5450.86
93_K96_G0.5430.86
120_V247_S0.5420.85
234_K247_S0.5410.85
7_S15_P0.5410.85
223_K233_I0.5400.85
192_I232_M0.5390.85
67_Y104_L0.5360.85
14_V18_Y0.5360.85
112_A118_D0.5320.84
51_L81_T0.5320.84
195_M200_Y0.5310.84
118_D188_D0.5280.84
162_D212_Q0.5260.84
37_K241_D0.5260.84
177_L180_G0.5250.84
11_L17_L0.5250.84
75_V267_F0.5230.83
57_E252_Q0.5220.83
114_F140_T0.5210.83
29_V69_L0.5210.83
86_D188_D0.5200.83
68_H71_K0.5200.83
126_F130_K0.5200.83
175_Q198_V0.5190.83
143_N168_S0.5180.83
182_H201_D0.5180.83
171_T179_N0.5180.83
171_T198_V0.5180.83
113_V185_L0.5180.83
85_L118_D0.5180.83
32_I35_D0.5170.83
146_V149_E0.5150.82
46_L77_I0.5130.82
62_S250_L0.5130.82
217_K260_G0.5130.82
18_Y23_N0.5120.82
81_T245_Y0.5100.82
25_K252_Q0.5100.82
188_D253_T0.5090.82
216_P220_H0.5090.82
80_L113_V0.5060.81
128_R131_R0.5050.81
160_I163_Y0.5050.81
103_K106_P0.5050.81
220_H224_M0.5030.81
157_I185_L0.5020.81
143_N186_T0.5000.81
48_I270_I0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rl5A 1 0.8444 100 0.623 Contact Map
4fbkA 2 0.9111 100 0.63 Contact Map
4fbwA 2 0.8222 100 0.631 Contact Map
3t1iA 2 0.8444 99.9 0.653 Contact Map
4ykeA 2 0.8407 99.9 0.662 Contact Map
3d03A 5 0.7111 99.9 0.678 Contact Map
4nzvA 1 0.8593 99.9 0.685 Contact Map
1ii7A 2 0.7963 99.9 0.686 Contact Map
2wdcA 1 0.8111 99.9 0.687 Contact Map
1uf3A 6 0.7 99.9 0.689 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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