GREMLIN Database
YTLI - HTH-type transcriptional regulator YtlI
UniProt: O35038 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (284)
Sequences: 79678 (58280)
Seq/√Len: 3458.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_D73_Q3.6141.00
15_F24_I3.4601.00
157_H288_T2.7601.00
95_G140_I2.6561.00
66_R80_N2.4431.00
230_V237_S2.3611.00
163_T241_S2.3101.00
172_H188_E2.2661.00
111_D290_R2.2641.00
11_T24_I2.2121.00
161_Y264_P2.1921.00
91_I122_N2.1881.00
158_P161_Y2.1861.00
20_K23_E2.1661.00
14_K68_G2.1661.00
91_I120_T2.1141.00
227_E247_P2.0711.00
181_H184_D2.0651.00
158_P264_P2.0571.00
8_T35_R2.0371.00
45_V59_A2.0371.00
10_H64_Y2.0301.00
93_N122_N2.0071.00
161_Y262_T1.9891.00
66_R73_Q1.9681.00
111_D286_R1.9611.00
10_H68_G1.9311.00
70_L74_Y1.9291.00
191_I235_G1.9201.00
8_T32_I1.9201.00
11_T14_K1.9181.00
18_F36_M1.9151.00
13_V56_L1.9041.00
11_T15_F1.8861.00
10_H14_K1.8771.00
64_Y68_G1.8291.00
165_N241_S1.8211.00
231_R247_P1.7971.00
63_F77_L1.7541.00
49_E55_Q1.7311.00
189_R217_K1.7101.00
177_K184_D1.6811.00
62_L80_N1.6731.00
112_F283_L1.6681.00
156_Y266_G1.6411.00
14_K24_I1.6291.00
134_K139_T1.6191.00
9_F64_Y1.6151.00
13_V64_Y1.5981.00
10_H67_T1.5871.00
8_T27_Y1.5791.00
15_F20_K1.5661.00
112_F119_I1.5551.00
19_Y29_Q1.5471.00
87_E118_K1.5291.00
58_K61_K1.5201.00
5_S35_R1.5121.00
133_Q137_D1.5101.00
28_S31_T1.4791.00
155_Y272_K1.4761.00
10_H71_L1.4611.00
200_R204_E1.4581.00
5_S42_D1.4531.00
157_H269_T1.4501.00
46_L49_E1.4501.00
276_F280_T1.4451.00
17_S20_K1.4401.00
5_S38_Q1.4281.00
66_R69_D1.4201.00
11_T25_L1.4151.00
168_V254_I1.4131.00
284_I288_T1.4081.00
145_C268_L1.3991.00
70_L77_L1.3891.00
155_Y269_T1.3871.00
66_R76_A1.3731.00
147_E266_G1.3611.00
136_L153_E1.3541.00
111_D115_D1.3511.00
102_S224_M1.3441.00
142_F280_T1.3421.00
93_N124_K1.3351.00
89_A118_K1.3341.00
267_L284_I1.3241.00
42_D78_K1.3101.00
135_L143_A1.3061.00
282_D285_A1.2991.00
134_K140_I1.2931.00
63_F78_K1.2851.00
162_D242_T1.2841.00
168_V236_I1.2811.00
188_E236_I1.2791.00
3_L74_Y1.2741.00
226_H237_S1.2541.00
113_L217_K1.2531.00
142_F267_L1.2441.00
61_K65_E1.2351.00
170_D250_G1.2341.00
269_T284_I1.2341.00
37_K41_Q1.2321.00
115_D286_R1.2101.00
73_Q76_A1.2091.00
228_Y231_R1.2011.00
241_S245_S1.1981.00
65_E69_D1.1961.00
62_L65_E1.1931.00
207_L212_G1.1921.00
66_R77_L1.1901.00
191_I226_H1.1891.00
113_L189_R1.1871.00
111_D114_M1.1861.00
110_K114_M1.1751.00
9_F48_F1.1721.00
173_P188_E1.1551.00
92_I283_L1.1501.00
158_P266_G1.1491.00
170_D252_K1.1491.00
156_Y268_L1.1431.00
270_N273_E1.1411.00
165_N255_P1.1401.00
9_F47_L1.1381.00
251_T255_P1.1361.00
27_Y31_T1.1291.00
9_F13_V1.1291.00
33_S37_K1.1221.00
122_N219_E1.1181.00
34_M37_K1.1171.00
7_K75_E1.1141.00
110_K232_E1.1001.00
34_M38_Q1.0991.00
189_R215_Y1.0981.00
220_L226_H1.0971.00
241_S255_P1.0971.00
12_I21_A1.0971.00
285_A288_T1.0921.00
112_F286_R1.0911.00
126_D134_K1.0901.00
18_F54_L1.0871.00
116_Y282_D1.0761.00
245_S249_N1.0721.00
6_I67_T1.0711.00
69_D76_A1.0681.00
101_A125_V1.0661.00
286_R290_R1.0611.00
70_L73_Q1.0561.00
56_L60_G1.0521.00
281_K285_A1.0501.00
108_I287_I1.0491.00
169_S233_N1.0491.00
11_T21_A1.0441.00
231_R252_K1.0431.00
227_E231_R1.0391.00
4_R7_K1.0311.00
35_R38_Q1.0291.00
178_K254_I1.0191.00
180_V184_D1.0191.00
62_L66_R1.0191.00
157_H284_I1.0061.00
228_Y232_E1.0051.00
166_V236_I1.0001.00
107_E232_E0.9971.00
75_E79_H0.9951.00
136_L151_I0.9911.00
167_I244_H0.9911.00
8_T25_L0.9911.00
163_T255_P0.9901.00
78_K82_S0.9791.00
13_V48_F0.9761.00
112_F116_Y0.9751.00
163_T262_T0.9731.00
75_E78_K0.9711.00
27_Y32_I0.9641.00
115_D289_K0.9621.00
270_N274_V0.9561.00
9_F56_L0.9541.00
168_V172_H0.9541.00
172_H175_A0.9521.00
12_I18_F0.9501.00
63_F67_T0.9481.00
48_F54_L0.9451.00
72_M76_A0.9401.00
172_H189_R0.9331.00
201_L204_E0.9281.00
220_L229_Y0.9231.00
134_K137_D0.9231.00
108_I286_R0.9211.00
277_D280_T0.9201.00
201_L205_Q0.9201.00
286_R289_K0.9171.00
13_V60_G0.9151.00
9_F39_L0.9151.00
45_V81_L0.9151.00
231_R250_G0.9141.00
21_A32_I0.9031.00
168_V173_P0.9011.00
124_K134_K0.8991.00
95_G143_A0.8951.00
140_I143_A0.8831.00
192_F216_K0.8811.00
38_Q41_Q0.8801.00
120_T215_Y0.8801.00
172_H176_E0.8781.00
153_E272_K0.8731.00
95_G145_C0.8701.00
251_T254_I0.8701.00
20_K24_I0.8641.00
119_I279_A0.8591.00
65_E68_G0.8591.00
94_I142_F0.8571.00
285_A289_K0.8561.00
154_N268_L0.8551.00
248_F251_T0.8531.00
184_D187_E0.8531.00
19_Y23_E0.8481.00
147_E264_P0.8481.00
16_G55_Q0.8431.00
190_F214_R0.8421.00
132_S136_L0.8411.00
98_E222_S0.8401.00
167_I237_S0.8361.00
244_H247_P0.8321.00
176_E189_R0.8311.00
12_I36_M0.8301.00
167_I253_V0.8271.00
25_L32_I0.8231.00
173_P178_K0.8201.00
179_A257_L0.8191.00
247_P250_G0.8171.00
247_P252_K0.8151.00
69_D72_M0.8141.00
124_K140_I0.8081.00
246_K250_G0.8011.00
203_I207_L0.7991.00
12_I48_F0.7981.00
9_F63_F0.7971.00
13_V16_G0.7941.00
37_K46_L0.7921.00
155_Y158_P0.7921.00
189_R216_K0.7911.00
16_G61_K0.7901.00
59_A81_L0.7861.00
276_F281_K0.7861.00
171_Q175_A0.7851.00
90_G119_I0.7801.00
206_H210_E0.7781.00
90_G279_A0.7741.00
110_K234_I0.7721.00
88_E116_Y0.7711.00
74_Y77_L0.7681.00
29_Q33_S0.7681.00
169_S234_I0.7671.00
174_L188_E0.7661.00
200_R219_E0.7651.00
183_S186_A0.7651.00
73_Q77_L0.7651.00
14_K64_Y0.7631.00
163_T260_D0.7591.00
82_S85_K0.7521.00
15_F21_A0.7501.00
4_R35_R0.7471.00
142_F283_L0.7421.00
229_Y234_I0.7401.00
62_L84_L0.7401.00
278_R282_D0.7381.00
56_L61_K0.7361.00
59_A84_L0.7331.00
76_A80_N0.7311.00
115_D282_D0.7311.00
165_N253_V0.7311.00
3_L71_L0.7301.00
16_G53_S0.7301.00
136_L154_N0.7291.00
113_L234_I0.7251.00
59_A62_L0.7241.00
111_D289_K0.7201.00
31_T35_R0.7171.00
167_I239_F0.7171.00
55_Q61_K0.7141.00
144_V287_I0.7131.00
67_T70_L0.7121.00
93_N140_I0.7111.00
205_Q209_R0.7111.00
108_I290_R0.7081.00
5_S8_T0.7071.00
244_H248_F0.7051.00
74_Y78_K0.7041.00
169_S172_H0.7041.00
174_L177_K0.7011.00
77_L81_L0.7011.00
112_F282_D0.6981.00
7_K11_T0.6961.00
12_I32_I0.6941.00
167_I248_F0.6931.00
18_F32_I0.6901.00
240_T243_A0.6871.00
49_E57_T0.6871.00
40_E45_V0.6861.00
96_V101_A0.6851.00
18_F53_S0.6841.00
182_L258_N0.6831.00
183_S210_E0.6821.00
206_H209_R0.6821.00
222_S225_S0.6811.00
186_A212_G0.6811.00
187_E215_Y0.6781.00
205_Q208_H0.6771.00
92_I279_A0.6731.00
59_A63_F0.6731.00
96_V105_F0.6711.00
93_N141_D0.6711.00
218_M229_Y0.6621.00
252_K255_P0.6611.00
68_G72_M0.6601.00
49_E53_S0.6601.00
193_T226_H0.6591.00
141_D280_T0.6581.00
194_P219_E0.6571.00
72_M75_E0.6531.00
181_H258_N0.6521.00
76_A79_H0.6511.00
168_V174_L0.6511.00
202_Q206_H0.6481.00
67_T71_L0.6461.00
135_L268_L0.6431.00
251_T257_L0.6431.00
40_E50_R0.6391.00
21_A25_L0.6371.00
58_K62_L0.6361.00
203_I206_H0.6351.00
282_D286_R0.6351.00
61_K64_Y0.6341.00
120_T219_E0.6331.00
63_F81_L0.6291.00
89_A120_T0.6271.00
12_I17_S0.6201.00
246_K249_N0.6181.00
36_M40_E0.6181.00
171_Q233_N0.6181.00
23_E26_N0.6141.00
171_Q174_L0.6121.00
138_G270_N0.6111.00
173_P177_K0.6111.00
201_L206_H0.6101.00
98_E127_D0.6061.00
166_V185_L0.6061.00
66_R70_L0.6051.00
102_S228_Y0.6051.00
7_K10_H0.6041.00
173_P176_E0.6031.00
190_F236_I0.6011.00
207_L214_R0.5991.00
142_F284_I0.5981.00
62_L81_L0.5981.00
4_R38_Q0.5971.00
166_V190_F0.5971.00
166_V238_I0.5931.00
283_L287_I0.5921.00
125_V221_T0.5911.00
92_I142_F0.5911.00
204_E208_H0.5911.00
174_L180_V0.5901.00
278_R281_K0.5891.00
125_V222_S0.5881.00
229_Y235_G0.5871.00
160_F265_I0.5861.00
226_H230_V0.5841.00
56_L64_Y0.5811.00
30_P34_M0.5781.00
95_G126_D0.5771.00
79_H83_D0.5731.00
31_T34_M0.5731.00
274_V277_D0.5701.00
135_L154_N0.5681.00
107_E111_D0.5681.00
164_L238_I0.5671.00
194_P221_T0.5631.00
48_F56_L0.5621.00
45_V49_E0.5611.00
28_S34_M0.5601.00
105_F108_I0.5591.00
155_Y273_E0.5551.00
109_L121_V0.5521.00
146_G263_P0.5511.00
43_L81_L0.5501.00
186_A213_N0.5471.00
43_L63_F0.5441.00
204_E207_L0.5411.00
4_R8_T0.5411.00
202_Q205_Q0.5391.00
220_L225_S0.5381.00
195_A219_E0.5361.00
162_D263_P0.5351.00
65_E80_N0.5351.00
251_T256_I0.5341.00
100_T104_I0.5341.00
179_A184_D0.5341.00
95_G124_K0.5331.00
107_E110_K0.5321.00
269_T281_K0.5301.00
8_T36_M0.5301.00
36_M48_F0.5291.00
168_V175_A0.5281.00
71_L74_Y0.5271.00
67_T74_Y0.5251.00
239_F244_H0.5251.00
43_L46_L0.5211.00
90_G118_K0.5201.00
172_H236_I0.5151.00
7_K71_L0.5141.00
66_R81_L0.5131.00
18_F50_R0.5131.00
116_Y119_I0.5121.00
159_F267_L0.5121.00
71_L75_E0.5111.00
144_V267_L0.5111.00
223_S240_T0.5071.00
102_S222_S0.5041.00
200_R206_H0.5031.00
114_M175_A0.5031.00
46_L59_A0.5021.00
8_T21_A0.5021.00
147_E156_Y0.5021.00
181_H257_L0.5021.00
90_G116_Y0.5021.00
175_A252_K0.5001.00
27_Y35_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ixcA 4 0.9448 100 0.112 Contact Map
3fzvA 4 0.9253 100 0.123 Contact Map
2esnA 3 0.9416 100 0.126 Contact Map
1uthA 2 0.7305 100 0.127 Contact Map
4x6gA 4 0.974 100 0.128 Contact Map
1al3A 1 0.724 100 0.129 Contact Map
2h98A 2 0.6883 100 0.129 Contact Map
2h9bA 2 0.6916 100 0.131 Contact Map
3fxqA 3 0.9383 100 0.137 Contact Map
3szpA 3 0.9318 100 0.15 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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