GREMLIN Database
YEFC - Resolvase homolog YefC
UniProt: O35034 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 111 (97)
Sequences: 2527 (1680)
Seq/√Len: 170.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_T32_A3.1971.00
24_I35_E2.9091.00
11_I14_K2.9071.00
25_L36_F2.6871.00
37_E44_R2.5441.00
57_D60_E2.2331.00
42_V46_Q2.2331.00
78_L86_V2.2211.00
49_K60_E2.1111.00
24_I39_D2.0731.00
25_L32_A1.9451.00
51_L55_N1.9251.00
84_K94_V1.8241.00
78_L101_K1.8071.00
77_L89_M1.7971.00
84_K88_D1.7681.00
45_T49_K1.7211.00
81_H89_M1.7181.00
87_E97_L1.7021.00
20_Y23_K1.6761.00
77_L81_H1.6111.00
28_T39_D1.5751.00
74_A97_L1.5321.00
86_V90_T1.5251.00
92_I97_L1.4611.00
26_I30_F1.3991.00
81_H85_Q1.3891.00
38_R41_I1.3281.00
73_H76_T1.3141.00
30_F33_F1.3131.00
78_L83_Y1.2841.00
83_Y98_V1.2701.00
43_E47_E1.2521.00
13_S47_E1.2301.00
8_P19_I1.2021.00
100_A103_K1.1801.00
67_T70_Q1.1701.00
53_K60_E1.1471.00
82_S85_Q1.1391.00
29_I32_A1.1371.00
35_E39_D1.1351.00
46_Q49_K1.1321.00
77_L86_V1.0861.00
28_T31_S1.0841.00
74_A100_A1.0791.00
85_Q89_M1.0550.99
74_A86_V1.0490.99
71_I100_A1.0430.99
26_I29_I1.0380.99
75_L79_E1.0290.99
22_E36_F1.0150.99
42_V45_T1.0140.99
68_K72_N1.0060.99
94_V98_V1.0040.99
50_M54_Q1.0020.99
74_A90_T1.0000.99
70_Q73_H0.9640.99
73_H89_M0.9420.99
48_G52_A0.9140.99
96_T99_R0.9130.99
22_E30_F0.9100.98
66_F70_Q0.8980.98
33_F36_F0.8940.98
83_Y94_V0.8860.98
10_A15_P0.8520.98
71_I74_A0.8430.98
22_E26_I0.8390.97
70_Q90_T0.8370.97
73_H77_L0.8300.97
25_L28_T0.8290.97
78_L97_L0.8190.97
71_I103_K0.8150.97
85_Q88_D0.8050.97
46_Q50_M0.7960.96
66_F71_I0.7940.96
95_S99_R0.7920.96
25_L33_F0.7740.96
22_E25_L0.7670.96
54_Q57_D0.7670.96
38_R42_V0.7560.95
25_L29_I0.7530.95
87_E94_V0.7460.95
95_S98_V0.7420.95
73_H90_T0.7410.95
39_D42_V0.7260.94
36_F40_M0.7200.94
92_I96_T0.7180.94
72_N76_T0.7140.94
77_L90_T0.7130.94
16_F32_A0.7080.93
21_S39_D0.7030.93
9_L18_A0.6930.93
42_V49_K0.6860.92
66_F74_A0.6820.92
76_T79_E0.6780.92
17_P23_K0.6700.91
26_I33_F0.6670.91
69_Q85_Q0.6570.91
65_K70_Q0.6470.90
68_K71_I0.6470.90
20_Y27_F0.6360.89
30_F36_F0.6200.88
66_F90_T0.6190.88
76_T89_M0.6140.87
72_N79_E0.6100.87
97_L101_K0.6100.87
28_T35_E0.6100.87
11_I16_F0.6080.87
31_S34_A0.6070.87
87_E90_T0.6020.86
75_L101_K0.5900.85
9_L32_A0.5820.84
28_T33_F0.5800.84
64_K100_A0.5790.84
93_S99_R0.5740.84
53_K57_D0.5690.83
69_Q73_H0.5690.83
71_I75_L0.5690.83
82_S86_V0.5660.83
7_N16_F0.5630.82
10_A17_P0.5600.82
83_Y97_L0.5570.82
21_S43_E0.5530.81
71_I97_L0.5500.81
54_Q103_K0.5450.80
14_K41_I0.5430.80
9_L15_P0.5420.80
29_I33_F0.5380.80
8_P18_A0.5320.79
75_L103_K0.5280.78
49_K58_F0.5270.78
64_K103_K0.5220.78
53_K58_F0.5200.77
87_E92_I0.5200.77
66_F96_T0.5170.77
18_A23_K0.5170.77
16_F27_F0.5130.76
75_L100_A0.5120.76
41_I46_Q0.5100.76
58_F64_K0.5090.76
81_H86_V0.5090.76
28_T36_F0.5080.76
99_R103_K0.5070.76
22_E41_I0.5040.75
55_N60_E0.5030.75
97_L100_A0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uj3X 2 0.4234 99.9 0.392 Contact Map
1gdtA 2 0.9189 99.9 0.423 Contact Map
2r0qC 3 0.9369 99.8 0.468 Contact Map
3g13A 2 0.5495 99.5 0.608 Contact Map
4bqqA 2 0.9369 99.4 0.618 Contact Map
2lvsA 1 0.8288 99.3 0.643 Contact Map
3guvA 2 0.4775 99.3 0.643 Contact Map
2gm5A 4 0.4234 99.2 0.668 Contact Map
3vw4A 1 0.7568 99.1 0.68 Contact Map
3ilxA 2 0.4685 98.8 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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