GREMLIN Database
COABC - Probable coenzyme A biosynthesis bifunctional protein CoaBC
UniProt: O35033 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (387)
Sequences: 3593 (2443)
Seq/√Len: 124.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
260_R312_E3.4961.00
191_H231_R3.4681.00
202_A255_S3.3081.00
135_R143_D2.8991.00
186_P228_L2.8921.00
216_K363_D2.8901.00
6_N33_N2.8741.00
219_Y236_S2.8401.00
338_K342_A2.7151.00
290_H330_Q2.6391.00
367_V387_V2.5061.00
43_C61_T2.4121.00
12_S93_V2.4001.00
135_R139_V2.3861.00
24_T55_S2.3851.00
228_L393_Q2.3801.00
225_A392_L2.3341.00
228_L392_L2.3241.00
191_H233_I2.3031.00
9_L24_T2.2951.00
283_T304_K2.2871.00
285_K302_E2.2681.00
10_C106_L2.2611.00
257_A261_E2.2471.00
35_K57_H2.2101.00
377_R394_E2.2041.00
151_S170_N2.1681.00
333_E370_F2.1181.00
331_D334_H2.1111.00
349_V367_V2.0991.00
26_K29_Q2.0621.00
195_T263_V2.0551.00
85_I175_A2.0211.00
79_D159_Y2.0081.00
223_E385_L1.9961.00
21_C54_L1.9901.00
4_N32_A1.9841.00
192_V272_I1.9841.00
249_E266_V1.9661.00
193_V270_S1.9651.00
243_Q250_F1.9641.00
21_C50_T1.9621.00
97_L119_I1.9621.00
83_L175_A1.9561.00
148_I166_E1.9351.00
11_V51_F1.9251.00
194_I221_L1.8561.00
37_I109_T1.8481.00
198_P238_P1.8451.00
84_I113_A1.8431.00
95_G133_V1.8031.00
40_E44_R1.7821.00
260_R264_L1.7771.00
231_R249_E1.7741.00
329_T353_V1.7581.00
233_I251_I1.7571.00
264_L312_E1.7521.00
33_N57_H1.7391.00
369_I394_E1.7331.00
283_T306_T1.7321.00
311_K315_E1.7211.00
35_K80_W1.7191.00
84_I110_L1.7141.00
129_D162_K1.7111.00
195_T235_I1.6911.00
336_A350_A1.6871.00
224_A389_F1.6481.00
285_K304_K1.6411.00
202_A212_K1.6341.00
30_A176_E1.6231.00
97_L110_L1.6191.00
263_V313_L1.6051.00
198_P237_G1.5981.00
219_Y241_L1.5911.00
226_V247_L1.5721.00
137_I147_F1.5701.00
14_G90_T1.5671.00
118_W178_H1.5651.00
221_L391_I1.5401.00
94_I119_I1.5371.00
128_Y137_I1.5221.00
138_S142_Q1.5201.00
253_V259_M1.5141.00
262_A265_S1.5131.00
272_I395_I1.5111.00
243_Q252_P1.5021.00
214_T361_G1.4881.00
203_I209_F1.4871.00
257_A307_V1.4851.00
347_L371_F1.4821.00
86_V110_L1.4801.00
149_E162_K1.4771.00
38_M42_A1.4761.00
251_I266_V1.4741.00
190_K271_D1.4731.00
332_I350_A1.4571.00
149_E166_E1.4571.00
364_T381_I1.4471.00
46_V51_F1.4111.00
93_V107_T1.3861.00
200_R210_T1.3731.00
93_V104_D1.3721.00
192_V225_A1.3671.00
202_A254_Q1.3651.00
135_R142_Q1.3591.00
132_A143_D1.3481.00
274_I392_L1.3371.00
314_G322_L1.3311.00
273_V313_L1.3291.00
119_I145_Y1.3261.00
200_R254_Q1.3251.00
324_G345_L1.3251.00
22_A26_K1.3211.00
219_Y239_V1.3211.00
120_A148_I1.3081.00
390_E393_Q1.3051.00
205_P290_H1.3021.00
257_A283_T1.3021.00
23_L172_V1.3001.00
203_I284_P1.2981.00
96_K101_I1.2951.00
221_L274_I1.2951.00
9_L20_A1.2941.00
98_A139_V1.2881.00
37_I106_L1.2861.00
95_G111_L1.2791.00
349_V391_I1.2781.00
138_S141_Y1.2691.00
196_A219_Y1.2611.00
382_M390_E1.2581.00
275_K310_L1.2561.00
139_V143_D1.2561.00
337_R341_A1.2541.00
335_Y338_K1.2531.00
21_C46_V1.2521.00
83_L118_W1.2511.00
334_H338_K1.2481.00
254_Q258_D1.2370.99
219_Y243_Q1.2370.99
358_A364_T1.2310.99
114_T126_H1.2310.99
128_Y150_P1.2260.99
36_V55_S1.2230.99
235_I263_V1.2200.99
124_N157_C1.2190.99
313_L322_L1.1970.99
256_A279_V1.1920.99
96_K103_D1.1820.99
151_S166_E1.1800.99
22_A169_E1.1790.99
186_P396_A1.1780.99
236_S250_F1.1770.99
92_N103_D1.1640.99
298_G302_E1.1630.99
186_P393_Q1.1580.99
244_P247_L1.1480.99
126_H159_Y1.1480.99
312_E315_E1.1410.99
185_A188_E1.1380.99
366_I381_I1.1370.99
104_D107_T1.1360.99
257_A260_R1.1360.99
120_A166_E1.1290.99
233_I266_V1.1260.99
341_A372_K1.1260.99
371_F375_H1.1250.99
7_V83_L1.1230.99
193_V266_V1.1200.99
39_T106_L1.1180.99
310_L324_G1.1140.99
382_M387_V1.1070.99
227_Q389_F1.1040.99
26_K172_V1.0990.99
95_G101_I1.0980.99
38_M43_C1.0960.99
193_V235_I1.0890.99
151_S167_E1.0880.99
24_T51_F1.0860.99
262_A266_V1.0840.99
267_Y273_V1.0810.99
97_L145_Y1.0800.99
111_L133_V1.0800.99
40_E62_D1.0760.99
323_V395_I1.0740.99
258_D261_E1.0730.99
257_A306_T1.0690.98
267_Y320_Q1.0660.98
255_S258_D1.0600.98
141_Y149_E1.0570.98
120_A165_L1.0530.98
316_K320_Q1.0510.98
99_N139_V1.0510.98
233_I249_E1.0510.98
212_K361_G1.0410.98
212_K254_Q1.0400.98
367_V391_I1.0390.98
200_R208_F1.0160.98
5_R82_D1.0150.98
44_R64_F1.0090.98
147_F166_E1.0070.98
225_A274_I1.0040.98
259_M309_I1.0020.98
233_I270_S1.0020.98
89_A94_I0.9990.98
60_Y105_M0.9950.98
110_L117_V0.9930.98
203_I301_L0.9900.97
146_C178_H0.9890.97
125_V155_L0.9880.97
95_G99_N0.9810.97
92_N101_I0.9800.97
130_H145_Y0.9800.97
260_R307_V0.9780.97
226_V246_G0.9720.97
236_S239_V0.9700.97
366_I378_E0.9670.97
7_V32_A0.9670.97
27_L172_V0.9660.97
340_L372_K0.9650.97
192_V274_I0.9630.97
165_L168_P0.9630.97
345_L348_I0.9610.97
41_S92_N0.9600.97
148_I174_L0.9600.97
224_A227_Q0.9560.97
194_I225_A0.9550.97
311_K342_A0.9520.97
186_P389_F0.9510.97
333_E337_R0.9500.97
166_E170_N0.9490.97
224_A228_L0.9490.97
209_F303_L0.9480.97
118_W148_I0.9460.97
30_A172_V0.9460.97
314_G344_N0.9420.97
6_N80_W0.9420.97
23_L87_A0.9410.97
382_M386_D0.9410.97
10_C84_I0.9410.97
273_V322_L0.9400.97
40_E43_C0.9390.97
394_E397_A0.9330.96
284_P301_L0.9330.96
5_R32_A0.9320.96
119_I147_F0.9320.96
120_A171_I0.9280.96
26_K168_P0.9280.96
331_D335_Y0.9230.96
321_I395_I0.9220.96
314_G345_L0.9200.96
196_A234_L0.9190.96
321_I347_L0.9180.96
228_L389_F0.9110.96
358_A366_I0.9070.96
219_Y250_F0.9050.96
24_T36_V0.9040.96
383_S386_D0.9010.96
113_A117_V0.9000.96
355_A366_I0.8980.96
191_H270_S0.8940.95
53_A72_I0.8940.95
371_F374_G0.8930.95
251_I262_A0.8860.95
86_V97_L0.8850.95
25_S154_Y0.8830.95
76_D80_W0.8740.95
267_Y313_L0.8700.95
347_L369_I0.8680.95
317_K320_Q0.8630.94
21_C51_F0.8590.94
377_R390_E0.8510.94
152_E162_K0.8500.94
326_A336_A0.8450.94
297_G305_R0.8440.94
28_V56_R0.8420.94
91_A111_L0.8420.94
6_N35_K0.8400.94
117_V145_Y0.8390.94
118_W175_A0.8380.94
149_E165_L0.8330.93
110_L130_H0.8330.93
379_L390_E0.8320.93
275_K313_L0.8300.93
125_V129_D0.8300.93
286_T302_E0.8290.93
21_C24_T0.8250.93
219_Y252_P0.8250.93
33_N80_W0.8240.93
327_A353_V0.8220.93
22_A168_P0.8220.93
8_L81_A0.8210.93
187_L396_A0.8170.93
27_L175_A0.8170.93
23_L85_I0.8130.93
43_C48_P0.8110.92
141_Y147_F0.8090.92
26_K30_A0.8070.92
11_V17_V0.8060.92
261_E265_S0.8030.92
288_F292_M0.7990.92
221_L388_S0.7950.92
338_K341_A0.7950.92
337_R370_F0.7930.92
333_E368_T0.7920.92
194_I274_I0.7900.91
379_L382_M0.7850.91
96_K107_T0.7840.91
139_V142_Q0.7820.91
151_S164_R0.7810.91
236_S241_L0.7800.91
282_F299_M0.7800.91
228_L396_A0.7790.91
196_A218_G0.7790.91
198_P210_T0.7780.91
10_C86_V0.7780.91
272_I321_I0.7760.91
205_P329_T0.7760.91
110_L145_Y0.7730.91
85_I171_I0.7730.91
79_D126_H0.7700.90
20_A23_L0.7610.90
337_R340_L0.7610.90
330_Q335_Y0.7570.90
293_K328_E0.7530.89
368_T378_E0.7520.89
359_G365_N0.7500.89
99_N136_N0.7490.89
392_L395_I0.7460.89
75_I157_C0.7460.89
358_A381_I0.7450.89
358_A362_A0.7450.89
192_V392_L0.7440.89
49_L53_A0.7430.89
166_E174_L0.7430.89
116_P146_C0.7410.89
310_L345_L0.7410.89
193_V263_V0.7410.89
27_L85_I0.7400.89
117_V130_H0.7390.88
348_I370_F0.7380.88
154_Y160_V0.7370.88
349_V369_I0.7360.88
20_A51_F0.7330.88
20_A165_L0.7330.88
166_E171_I0.7330.88
9_L87_A0.7320.88
290_H331_D0.7300.88
226_V243_Q0.7280.88
125_V157_C0.7260.88
195_T275_K0.7240.87
173_K177_K0.7230.87
98_A135_R0.7220.87
97_L130_H0.7210.87
263_V275_K0.7190.87
236_S243_Q0.7190.87
390_E394_E0.7190.87
36_V51_F0.7180.87
173_K176_E0.7170.87
236_S252_P0.7160.87
359_G362_A0.7160.87
220_A223_E0.7150.87
89_A140_L0.7140.87
187_L190_K0.7120.87
12_S90_T0.7110.86
63_T105_M0.7110.86
93_V110_L0.7100.86
40_E104_D0.7100.86
371_F394_E0.7090.86
125_V159_Y0.7090.86
94_I137_I0.7060.86
219_Y234_L0.7030.86
337_R375_H0.7020.86
298_G305_R0.6990.86
227_Q385_L0.6910.85
241_L244_P0.6900.85
357_G366_I0.6880.85
352_D355_A0.6860.84
32_A176_E0.6860.84
322_L345_L0.6820.84
293_K335_Y0.6820.84
78_A115_A0.6820.84
385_L389_F0.6810.84
223_E227_Q0.6790.84
193_V273_V0.6790.84
95_G136_N0.6770.84
87_A165_L0.6750.84
118_W146_C0.6750.84
327_A352_D0.6740.83
118_W174_L0.6740.83
47_S50_T0.6730.83
283_T307_V0.6730.83
12_S86_V0.6730.83
267_Y270_S0.6670.83
355_A358_A0.6660.83
367_V379_L0.6640.83
102_A111_L0.6640.83
24_T28_V0.6640.83
11_V20_A0.6640.83
316_K319_E0.6620.82
294_K310_L0.6620.82
28_V33_N0.6600.82
336_A348_I0.6600.82
72_I157_C0.6590.82
8_L77_A0.6590.82
38_M59_V0.6580.82
368_T375_H0.6570.82
275_K322_L0.6550.82
235_I259_M0.6540.82
387_V390_E0.6540.82
256_A280_A0.6490.81
264_L313_L0.6470.81
41_S44_R0.6470.81
134_K138_S0.6450.81
25_S29_Q0.6440.81
15_I50_T0.6440.81
333_E378_E0.6420.80
284_P287_V0.6410.80
253_V258_D0.6410.80
124_N159_Y0.6410.80
237_G259_M0.6400.80
294_K305_R0.6390.80
191_H269_A0.6370.80
256_A306_T0.6360.80
69_P73_S0.6350.80
365_N387_V0.6350.80
200_R238_P0.6340.80
267_Y316_K0.6330.79
268_D318_K0.6310.79
386_D389_F0.6300.79
221_L392_L0.6290.79
214_T276_T0.6270.79
26_K169_E0.6260.79
187_L392_L0.6220.78
295_Q298_G0.6200.78
5_R179_F0.6170.78
25_S157_C0.6160.78
47_S51_F0.6160.78
200_R212_K0.6150.77
198_P239_V0.6150.77
132_A139_V0.6140.77
118_W179_F0.6130.77
352_D358_A0.6130.77
364_T383_S0.6130.77
266_V269_A0.6090.77
37_I105_M0.6090.77
174_L177_K0.6090.77
261_E264_L0.6080.77
70_S76_D0.6060.76
370_F375_H0.6060.76
270_S273_V0.6060.76
13_G41_S0.6040.76
128_Y149_E0.6030.76
35_K60_Y0.6030.76
308_D343_K0.6030.76
314_G320_Q0.6030.76
23_L165_L0.6010.76
205_P288_F0.6000.76
379_L387_V0.5990.76
112_A124_N0.5980.75
96_K104_D0.5980.75
38_M48_P0.5970.75
29_Q154_Y0.5950.75
247_L250_F0.5950.75
71_V76_D0.5940.75
38_M51_F0.5940.75
286_T289_D0.5930.75
110_L119_I0.5910.75
353_V359_G0.5900.75
85_I120_A0.5900.75
78_A126_H0.5870.74
87_A171_I0.5860.74
201_E306_T0.5860.74
253_V262_A0.5850.74
181_E185_A0.5840.74
389_F393_Q0.5830.74
369_I391_I0.5820.74
234_L241_L0.5820.74
296_D305_R0.5820.74
38_M46_V0.5810.73
344_N372_K0.5780.73
116_P178_H0.5780.73
219_Y240_S0.5770.73
84_I109_T0.5740.73
110_L113_A0.5720.72
23_L26_K0.5720.72
263_V309_I0.5710.72
224_A392_L0.5710.72
125_V162_K0.5710.72
191_H266_V0.5710.72
27_L32_A0.5710.72
23_L171_I0.5690.72
187_L192_V0.5690.72
8_L84_I0.5680.72
354_K358_A0.5680.72
22_A167_E0.5680.72
266_V270_S0.5670.72
201_E256_A0.5660.71
28_V55_S0.5660.71
97_L111_L0.5660.71
354_K357_G0.5650.71
10_C39_T0.5650.71
164_R167_E0.5640.71
267_Y322_L0.5640.71
198_P236_S0.5630.71
99_N135_R0.5600.71
114_T129_D0.5600.71
292_M299_M0.5580.70
13_G17_V0.5570.70
93_V106_L0.5570.70
58_E67_Q0.5570.70
366_I387_V0.5570.70
251_I265_S0.5560.70
101_I108_T0.5560.70
11_V36_V0.5550.70
137_I141_Y0.5540.70
307_V312_E0.5540.70
332_I335_Y0.5530.70
43_C47_S0.5530.70
89_A119_I0.5510.69
391_I395_I0.5510.69
334_H337_R0.5500.69
85_I118_W0.5500.69
92_N96_K0.5490.69
355_A359_G0.5490.69
13_G42_A0.5480.69
18_Y22_A0.5470.69
65_K68_N0.5460.69
21_C38_M0.5460.69
44_R49_L0.5450.69
224_A385_L0.5440.68
6_N82_D0.5440.68
323_V347_L0.5440.68
135_R138_S0.5420.68
13_G45_F0.5420.68
168_P172_V0.5410.68
283_T287_V0.5410.68
200_R361_G0.5410.68
83_L179_F0.5400.68
120_A147_F0.5400.68
274_I395_I0.5400.68
333_E375_H0.5390.68
104_D108_T0.5380.68
28_V57_H0.5360.67
239_V243_Q0.5360.67
86_V93_V0.5360.67
187_L225_A0.5320.67
241_L250_F0.5320.67
73_S76_D0.5310.67
24_T54_L0.5310.67
349_V387_V0.5310.67
347_L394_E0.5300.66
154_Y157_C0.5300.66
78_A109_T0.5300.66
190_K272_I0.5260.66
326_A339_K0.5260.66
340_L348_I0.5260.66
87_A120_A0.5260.66
79_D125_V0.5220.65
267_Y317_K0.5220.65
72_I79_D0.5210.65
147_F171_I0.5210.65
192_V221_L0.5200.65
131_P143_D0.5200.65
11_V24_T0.5190.65
25_S28_V0.5180.65
157_C160_V0.5180.65
238_P241_L0.5170.65
22_A29_Q0.5150.64
17_V51_F0.5140.64
263_V270_S0.5120.64
170_N174_L0.5110.64
216_K220_A0.5110.64
125_V164_R0.5090.63
284_P288_F0.5090.63
72_I75_I0.5090.63
97_L117_V0.5080.63
17_V46_V0.5070.63
260_R263_V0.5070.63
42_A51_F0.5000.62
75_I124_N0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjiA 2 0.5025 100 0.533 Contact Map
1p9oA 2 0.532 100 0.595 Contact Map
1p3y1 6 0.4138 100 0.632 Contact Map
2gk4A 2 0.5049 100 0.633 Contact Map
1mvlA 3 0.4113 100 0.636 Contact Map
3qjgA 5 0.4089 100 0.641 Contact Map
1qzuA 3 0.3768 100 0.645 Contact Map
1u7zA 2 0.5419 100 0.648 Contact Map
1g63A 6 0.4187 100 0.659 Contact Map
3mcuA 5 0.4409 100 0.668 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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