GREMLIN Database
ACYP - Acylphosphatase
UniProt: O35031 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 91 (84)
Sequences: 1986 (1587)
Seq/√Len: 173.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_F59_A2.8541.00
46_A56_F2.7411.00
24_E27_K2.7341.00
7_I41_R2.6931.00
16_G19_Y2.5651.00
9_D41_R2.4181.00
9_D71_D2.2081.00
37_R43_E2.1331.00
6_I57_V1.7901.00
6_I60_V1.7401.00
5_R43_E1.7391.00
47_E82_G1.7341.00
37_R41_R1.7161.00
22_Q26_D1.6751.00
21_V56_F1.5791.00
64_S67_S1.5501.00
44_I60_V1.5151.00
6_I44_I1.4871.00
6_I46_A1.4141.00
6_I74_V1.3911.00
47_E81_E1.3281.00
35_K43_E1.3201.00
9_D73_S1.3201.00
49_P52_A1.3091.00
46_A53_L1.3061.00
31_A85_R1.2631.00
57_V74_V1.2621.00
4_Y76_E1.2591.00
46_A60_V1.2401.00
50_E54_Q1.2181.00
21_V60_V1.1891.00
45_L77_S1.1581.00
19_Y22_Q1.1341.00
30_L48_G1.1291.00
5_R33_W1.1151.00
45_L83_H1.1081.00
19_Y23_M1.0841.00
24_E59_A1.0771.00
8_V60_V1.0521.00
33_W45_L1.0210.99
61_K72_I1.0200.99
8_V72_I1.0060.99
8_V44_I0.9740.99
28_R59_A0.9730.99
16_G66_F0.9640.99
28_R55_S0.9630.99
47_E79_S0.9490.99
7_I37_R0.9470.99
34_V44_I0.9430.99
28_R56_F0.9430.99
24_E28_R0.9240.99
54_Q58_E0.9230.99
52_A55_S0.9200.99
22_Q88_I0.9190.99
44_I56_F0.9160.99
57_V61_K0.9060.99
33_W43_E0.9020.98
5_R77_S0.8940.98
29_K52_A0.8920.98
33_W44_I0.8810.98
7_I43_E0.8640.98
58_E61_K0.8540.98
50_E76_E0.8430.98
20_F67_S0.8400.98
16_G20_F0.8330.97
16_G23_M0.8270.97
45_L82_G0.8240.97
21_V46_A0.8240.97
4_Y74_V0.8210.97
79_S83_H0.8200.97
20_F24_E0.8200.97
4_Y57_V0.8100.97
31_A47_E0.8090.97
30_L46_A0.8070.97
20_F63_G0.8030.97
4_Y53_L0.7960.97
21_V34_V0.7790.96
23_M26_D0.7750.96
84_H87_S0.7660.96
31_A83_H0.7630.96
63_G67_S0.7600.96
47_E83_H0.7570.96
17_F60_V0.7530.95
5_R75_T0.7530.95
16_G65_P0.7530.95
4_Y46_A0.7430.95
48_G52_A0.7340.95
28_R52_A0.7270.94
5_R45_L0.6780.92
79_S82_G0.6740.92
11_R68_K0.6670.92
22_Q34_V0.6500.90
83_H87_S0.6400.90
7_I39_D0.6180.88
33_W37_R0.6130.88
53_L57_V0.6060.87
54_Q74_V0.6030.87
21_V59_A0.6000.87
20_F64_S0.5950.86
55_S59_A0.5950.86
45_L81_E0.5940.86
6_I72_I0.5880.86
26_D85_R0.5780.85
19_Y66_F0.5690.84
11_R16_G0.5610.83
55_S58_E0.5510.82
70_T87_S0.5490.81
12_V42_V0.5460.81
27_K51_N0.5450.81
77_S83_H0.5430.81
7_I73_S0.5410.80
35_K79_S0.5400.80
8_V63_G0.5370.80
26_D78_R0.5300.79
8_V21_V0.5250.78
17_F21_V0.5210.78
52_A56_F0.5140.77
49_P76_E0.5110.77
70_T75_T0.5100.76
7_I38_D0.5080.76
16_G21_V0.5060.76
58_E62_N0.5060.76
63_G69_V0.5060.76
33_W48_G0.5010.75
23_M27_K0.5000.75
47_E77_S0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g9iA 1 0.989 100 0.152 Contact Map
2lxfA 1 0.978 100 0.156 Contact Map
2fhmA 1 1 100 0.157 Contact Map
2bjdA 1 0.978 100 0.172 Contact Map
3trgA 1 0.967 100 0.175 Contact Map
1ulrA 1 0.956 100 0.176 Contact Map
1w2iA 2 0.978 100 0.177 Contact Map
1urrA 1 0.989 100 0.177 Contact Map
3vthA 1 0.978 100 0.18 Contact Map
4hi1A 3 0.967 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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