YTHQ - BACSU - GREMLIN Contacts

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YTHQ - Putative transporter YthQ

UniProt:	O35029	Sequences: MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIYQYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQLKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQDRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTASFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTICTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTLIFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	385 (364)
Sequences:	540 (458)
Seq/√Len:	24.0

BACSU - YTHQ ECSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
328_C	370_F	7.647	1.00
259_R	264_Y	5.040	1.00
298_M	366_L	4.426	1.00
288_M	362_C	3.841	1.00
264_Y	286_K	3.390	1.00
84_F	110_Y	3.334	1.00
306_T	373_C	3.167	1.00
287_V	339_V	2.710	0.99
302_L	328_C	2.668	0.99
82_R	110_Y	2.657	0.99
98_E	181_I	2.518	0.99
120_L	149_F	2.394	0.98
69_Y	73_V	2.382	0.98
46_Y	128_P	2.321	0.98
267_S	289_L	2.315	0.98
339_V	344_F	2.244	0.97
94_L	100_I	2.241	0.97
27_D	79_G	2.228	0.97
316_L	320_A	2.165	0.96
300_M	331_I	2.139	0.96
302_L	370_F	2.042	0.95
281_K	361_S	2.019	0.95
72_C	144_L	2.018	0.95
75_I	122_L	2.010	0.94
245_S	349_D	1.992	0.94
245_S	331_I	1.932	0.93
7_F	110_Y	1.931	0.93
28_W	40_A	1.922	0.93
27_D	30_V	1.904	0.93
49_L	363_I	1.901	0.93
5_T	9_R	1.884	0.92
284_F	355_Y	1.875	0.92
34_I	289_L	1.852	0.92
28_W	286_K	1.847	0.91
35_V	258_R	1.843	0.91
329_R	367_H	1.823	0.91
24_A	29_T	1.820	0.91
204_L	273_R	1.817	0.91
300_M	349_D	1.810	0.91
14_Y	110_Y	1.808	0.91
309_I	312_S	1.799	0.90
305_F	374_C	1.797	0.90
309_I	313_P	1.774	0.90
75_I	113_L	1.772	0.90
82_R	230_E	1.762	0.89
11_L	173_I	1.742	0.89
21_V	331_I	1.711	0.88
22_L	163_I	1.709	0.88
288_M	366_L	1.690	0.87
168_S	369_A	1.670	0.87
85_L	104_K	1.664	0.86
155_F	183_F	1.663	0.86
115_T	152_H	1.655	0.86
89_D	290_R	1.647	0.86
25_V	237_L	1.645	0.86
28_W	33_Y	1.616	0.85
7_F	14_Y	1.612	0.85
48_D	284_F	1.611	0.85
87_E	231_K	1.600	0.84
26_I	33_Y	1.588	0.84
198_L	368_Y	1.578	0.83
86_M	344_F	1.571	0.83
205_F	369_A	1.547	0.82
103_L	245_S	1.531	0.81
270_I	281_K	1.529	0.81
137_T	369_A	1.524	0.81
27_D	32_L	1.515	0.81
214_L	217_T	1.510	0.80
21_V	24_A	1.505	0.80
109_L	113_L	1.499	0.80
70_A	380_V	1.497	0.80
248_A	331_I	1.491	0.80
21_V	29_T	1.484	0.79
97_K	280_Y	1.469	0.78
83_T	103_L	1.463	0.78
77_F	183_F	1.461	0.78
28_W	49_L	1.457	0.78
23_H	239_G	1.457	0.78
340_M	355_Y	1.457	0.78
43_I	241_V	1.446	0.77
9_R	299_Y	1.443	0.77
261_P	264_Y	1.437	0.77
260_K	263_L	1.434	0.77
201_F	372_A	1.430	0.77
28_W	32_L	1.430	0.77
24_A	35_V	1.428	0.76
160_Q	179_R	1.423	0.76
230_E	283_L	1.421	0.76
83_T	94_L	1.420	0.76
277_C	354_E	1.418	0.76
177_L	188_I	1.417	0.76
325_T	367_H	1.414	0.76
124_F	127_L	1.405	0.75
267_S	286_K	1.401	0.75
103_L	331_I	1.397	0.75
296_R	300_M	1.394	0.75
11_L	110_Y	1.392	0.75
244_M	326_G	1.373	0.74
24_A	246_Q	1.371	0.73
26_I	41_F	1.369	0.73
303_S	380_V	1.347	0.72
141_S	319_I	1.335	0.71
21_V	300_M	1.332	0.71
245_S	300_M	1.323	0.71
127_L	131_S	1.320	0.71
184_A	203_I	1.315	0.70
84_F	345_L	1.310	0.70
260_K	300_M	1.294	0.69
7_F	107_A	1.290	0.69
278_T	281_K	1.286	0.68
130_I	141_S	1.282	0.68
331_I	349_D	1.270	0.67
68_L	72_C	1.267	0.67
77_F	155_F	1.263	0.67
347_G	355_Y	1.260	0.67
113_L	357_R	1.257	0.67
31_A	332_L	1.256	0.67
16_K	126_V	1.250	0.66
27_D	244_M	1.250	0.66
150_G	376_L	1.247	0.66
112_F	289_L	1.244	0.66
221_T	226_E	1.240	0.66
152_H	348_T	1.233	0.65
237_L	370_F	1.232	0.65
211_I	214_L	1.227	0.65
366_L	369_A	1.226	0.65
273_R	278_T	1.225	0.65
243_M	247_E	1.221	0.64
76_M	204_L	1.214	0.64
28_W	336_F	1.212	0.64
97_K	223_F	1.206	0.63
185_G	318_V	1.196	0.63
28_W	264_Y	1.192	0.62
120_L	124_F	1.192	0.62
227_V	319_I	1.191	0.62
32_L	35_V	1.183	0.62
83_T	247_E	1.181	0.62
67_W	357_R	1.180	0.62
94_L	97_K	1.164	0.61
40_A	82_R	1.159	0.60
308_L	314_I	1.157	0.60
107_A	357_R	1.156	0.60
33_Y	295_A	1.151	0.60
116_L	178_V	1.150	0.60
39_I	157_S	1.146	0.59
200_L	369_A	1.144	0.59
60_S	129_L	1.141	0.59
130_I	226_E	1.140	0.59
239_G	315_W	1.135	0.59
295_A	315_W	1.133	0.58
137_T	186_S	1.132	0.58
237_L	358_A	1.129	0.58
217_T	357_R	1.127	0.58
146_C	196_H	1.127	0.58
82_R	297_Q	1.126	0.58
125_I	277_C	1.119	0.57
27_D	40_A	1.118	0.57
27_D	330_Y	1.092	0.56
27_D	34_I	1.091	0.55
56_L	207_F	1.081	0.55
237_L	242_M	1.078	0.55
48_D	323_V	1.070	0.54
19_F	34_I	1.070	0.54
113_L	146_C	1.067	0.54
7_F	106_Y	1.066	0.54
25_V	242_M	1.051	0.53
31_A	341_D	1.048	0.52
104_K	257_M	1.048	0.52
18_Q	24_A	1.042	0.52
233_S	334_L	1.040	0.52
56_L	299_Y	1.038	0.52
282_E	286_K	1.035	0.52
42_V	232_K	1.023	0.51
32_L	38_A	1.021	0.51
75_I	212_R	1.018	0.50
351_E	372_A	1.016	0.50
194_E	201_F	1.014	0.50
182_L	207_F	1.012	0.50
227_V	263_L	1.009	0.50
22_L	246_Q	1.007	0.50
144_L	293_E	1.005	0.49
56_L	142_T	1.003	0.49
205_F	227_V	1.001	0.49
47_I	51_N	1.001	0.49
305_F	324_Y	1.001	0.49
150_G	327_V	0.991	0.48
82_R	233_S	0.990	0.48
67_W	144_L	0.989	0.48
21_V	247_E	0.988	0.48
24_A	32_L	0.986	0.48
116_L	149_F	0.984	0.48
58_E	153_I	0.982	0.48
99_I	373_C	0.978	0.47
6_L	24_A	0.975	0.47
163_I	222_A	0.975	0.47
294_Y	335_I	0.972	0.47
56_L	253_V	0.971	0.47
161_D	204_L	0.969	0.47
142_T	181_I	0.969	0.47
77_F	243_M	0.967	0.47
200_L	218_A	0.967	0.47
87_E	90_K	0.966	0.47
147_Y	198_L	0.963	0.46
153_I	200_L	0.961	0.46
259_R	286_K	0.950	0.46
317_K	358_A	0.946	0.45
43_I	125_I	0.946	0.45
82_R	162_R	0.944	0.45
97_K	331_I	0.941	0.45
194_E	206_L	0.938	0.45
12_F	145_L	0.937	0.45
11_L	84_F	0.937	0.45
227_V	375_F	0.933	0.44
223_F	300_M	0.932	0.44
14_Y	230_E	0.929	0.44
79_G	297_Q	0.928	0.44
67_W	341_D	0.923	0.44
298_M	370_F	0.922	0.44
61_E	226_E	0.919	0.43
21_V	245_S	0.918	0.43
18_Q	291_N	0.914	0.43
10_R	89_D	0.913	0.43
84_F	206_L	0.912	0.43
181_I	375_F	0.911	0.43
79_G	115_T	0.910	0.43
312_S	320_A	0.909	0.43
245_S	282_E	0.906	0.42
95_Q	246_Q	0.903	0.42
6_L	10_R	0.896	0.42
168_S	372_A	0.894	0.42
26_I	233_S	0.891	0.41
18_Q	242_M	0.891	0.41
61_E	242_M	0.891	0.41
5_T	372_A	0.889	0.41
300_M	335_I	0.889	0.41
17_Y	234_R	0.888	0.41
313_P	380_V	0.885	0.41
83_T	100_I	0.879	0.41
127_L	239_G	0.878	0.41
109_L	120_L	0.876	0.40
297_Q	334_L	0.875	0.40
274_R	344_F	0.875	0.40
12_F	180_A	0.871	0.40
123_F	127_L	0.871	0.40
243_M	301_L	0.866	0.40
151_L	206_L	0.864	0.40
265_R	289_L	0.860	0.39
275_T	299_Y	0.858	0.39
8_F	207_F	0.856	0.39
83_T	241_V	0.856	0.39
152_H	296_R	0.850	0.39
260_K	283_L	0.848	0.38
177_L	351_E	0.847	0.38
51_N	100_I	0.846	0.38
198_L	201_F	0.845	0.38
74_L	209_S	0.844	0.38
187_A	309_I	0.844	0.38
25_V	80_S	0.843	0.38
14_Y	165_K	0.841	0.38
168_S	206_L	0.841	0.38
339_V	348_T	0.840	0.38
14_Y	235_L	0.839	0.38
150_G	306_T	0.838	0.38
94_L	246_Q	0.838	0.38
40_A	259_R	0.837	0.38
327_V	330_Y	0.836	0.38
119_W	148_L	0.836	0.38
21_V	248_A	0.836	0.38
202_G	377_A	0.832	0.37
129_L	291_N	0.831	0.37
27_D	78_T	0.831	0.37
105_R	196_H	0.830	0.37
35_V	233_S	0.829	0.37
341_D	346_I	0.829	0.37
203_I	214_L	0.828	0.37
264_Y	267_S	0.827	0.37
10_R	290_R	0.822	0.37
152_H	355_Y	0.820	0.37
152_H	284_F	0.819	0.37
154_F	298_M	0.819	0.37
112_F	116_L	0.816	0.36
188_I	372_A	0.815	0.36
97_K	301_L	0.814	0.36
343_P	346_I	0.814	0.36
200_L	352_S	0.813	0.36
247_E	331_I	0.810	0.36
79_G	152_H	0.809	0.36
91_V	95_Q	0.805	0.36
25_V	328_C	0.804	0.36
27_D	41_F	0.804	0.36
143_A	373_C	0.803	0.35
100_I	373_C	0.803	0.35
127_L	141_S	0.799	0.35
301_L	324_Y	0.798	0.35
88_A	92_F	0.790	0.35
76_M	251_P	0.785	0.34
68_L	130_I	0.785	0.34
27_D	33_Y	0.784	0.34
21_V	238_A	0.782	0.34
118_K	152_H	0.779	0.34
87_E	270_I	0.778	0.34
178_V	262_L	0.778	0.34
150_G	368_Y	0.777	0.34
120_L	173_I	0.777	0.34
16_K	267_S	0.776	0.34
27_D	334_L	0.775	0.34
24_A	270_I	0.775	0.34
56_L	326_G	0.774	0.34
262_L	286_K	0.774	0.34
20_K	82_R	0.771	0.33
9_R	41_F	0.767	0.33
291_N	338_K	0.767	0.33
245_S	248_A	0.765	0.33
326_G	374_C	0.764	0.33
123_F	145_L	0.762	0.33
26_I	40_A	0.762	0.33
5_T	39_I	0.761	0.33
27_D	293_E	0.761	0.33
143_A	200_L	0.759	0.33
134_V	317_K	0.757	0.33
81_I	289_L	0.757	0.33
143_A	262_L	0.753	0.32
262_L	359_R	0.752	0.32
40_A	264_Y	0.745	0.32
296_R	324_Y	0.745	0.32
57_Y	82_R	0.742	0.32
368_Y	372_A	0.741	0.32
306_T	316_L	0.736	0.31
172_W	205_F	0.733	0.31
284_F	336_F	0.732	0.31
13_D	362_C	0.731	0.31
74_L	277_C	0.731	0.31
12_F	184_A	0.731	0.31
306_T	377_A	0.729	0.31
7_F	11_L	0.728	0.31
223_F	227_V	0.728	0.31
21_V	103_L	0.728	0.31
199_A	202_G	0.728	0.31
52_G	100_I	0.724	0.31
11_L	27_D	0.722	0.30
190_I	319_I	0.721	0.30
184_A	241_V	0.717	0.30
71_V	265_R	0.716	0.30
111_S	156_L	0.715	0.30
269_R	284_F	0.714	0.30
14_Y	18_Q	0.714	0.30
207_F	275_T	0.714	0.30
278_T	361_S	0.712	0.30
145_L	200_L	0.712	0.30
19_F	23_H	0.711	0.30
68_L	204_L	0.708	0.30
67_W	335_I	0.707	0.30
9_R	200_L	0.705	0.29
126_V	173_I	0.698	0.29
223_F	226_E	0.695	0.29
25_V	344_F	0.694	0.29
7_F	253_V	0.690	0.29
75_I	88_A	0.689	0.28
9_R	278_T	0.687	0.28
22_L	222_A	0.687	0.28
70_A	251_P	0.686	0.28
104_K	221_T	0.685	0.28
30_V	42_V	0.684	0.28
131_S	332_L	0.684	0.28
109_L	137_T	0.684	0.28
102_Q	353_D	0.682	0.28
282_E	331_I	0.680	0.28
323_V	326_G	0.680	0.28
225_A	365_I	0.678	0.28
358_A	376_L	0.677	0.28
158_L	208_F	0.675	0.28
109_L	206_L	0.675	0.28
70_A	298_M	0.675	0.28
20_K	57_Y	0.673	0.28
127_L	145_L	0.673	0.28
95_Q	331_I	0.672	0.27
82_R	234_R	0.671	0.27
193_T	241_V	0.669	0.27
87_E	317_K	0.669	0.27
121_L	257_M	0.668	0.27
235_L	285_F	0.667	0.27
206_L	357_R	0.667	0.27
154_F	242_M	0.666	0.27
32_L	47_I	0.665	0.27
167_R	311_V	0.665	0.27
31_A	320_A	0.663	0.27
85_L	227_V	0.663	0.27
302_L	373_C	0.662	0.27
163_I	254_K	0.662	0.27
107_A	301_L	0.659	0.27
31_A	42_V	0.658	0.27
263_L	303_S	0.656	0.27
280_Y	298_M	0.654	0.26
327_V	367_H	0.654	0.26
273_R	367_H	0.651	0.26
171_R	225_A	0.651	0.26
203_I	220_F	0.650	0.26
354_E	357_R	0.650	0.26
71_V	85_L	0.649	0.26
43_I	297_Q	0.649	0.26
237_L	291_N	0.647	0.26
84_F	243_M	0.647	0.26
40_A	286_K	0.646	0.26
181_I	325_T	0.645	0.26
126_V	183_F	0.645	0.26
21_V	260_K	0.644	0.26
212_R	371_A	0.642	0.26
76_M	320_A	0.640	0.26
212_R	368_Y	0.639	0.26
7_F	328_C	0.639	0.26
29_T	237_L	0.636	0.26
29_T	242_M	0.636	0.26
18_Q	34_I	0.635	0.25
137_T	184_A	0.632	0.25
28_W	330_Y	0.630	0.25
113_L	196_H	0.630	0.25
83_T	321_L	0.628	0.25
299_Y	318_V	0.627	0.25
71_V	184_A	0.626	0.25
306_T	357_R	0.625	0.25
311_V	314_I	0.625	0.25
223_F	284_F	0.624	0.25
147_Y	350_K	0.623	0.25
280_Y	348_T	0.623	0.25
103_L	349_D	0.622	0.25
191_V	352_S	0.622	0.25
279_G	350_K	0.621	0.25
102_Q	285_F	0.620	0.25
184_A	361_S	0.616	0.24
267_S	282_E	0.615	0.24
299_Y	304_A	0.615	0.24
9_R	178_V	0.615	0.24
28_W	267_S	0.614	0.24
70_A	180_A	0.613	0.24
150_G	372_A	0.613	0.24
27_D	162_R	0.612	0.24
269_R	369_A	0.611	0.24
165_K	236_A	0.609	0.24
266_N	331_I	0.607	0.24
76_M	207_F	0.606	0.24
51_N	153_I	0.604	0.24
23_H	98_E	0.604	0.24
33_Y	264_Y	0.604	0.24
29_T	38_A	0.604	0.24
232_K	299_Y	0.601	0.24
70_A	214_L	0.600	0.24
69_Y	359_R	0.600	0.24
281_K	362_C	0.599	0.24
127_L	313_P	0.599	0.24
160_Q	223_F	0.598	0.24
144_L	319_I	0.597	0.23
94_L	300_M	0.596	0.23
182_L	205_F	0.596	0.23
200_L	211_I	0.594	0.23
4_R	146_C	0.594	0.23
137_T	146_C	0.590	0.23
115_T	155_F	0.590	0.23
11_L	14_Y	0.588	0.23
164_R	214_L	0.585	0.23
72_C	120_L	0.585	0.23
17_Y	238_A	0.584	0.23
39_I	279_G	0.584	0.23
5_T	102_Q	0.583	0.23
40_A	233_S	0.583	0.23
106_Y	337_D	0.581	0.23
121_L	266_N	0.581	0.23
94_L	243_M	0.580	0.23
105_R	146_C	0.580	0.23
29_T	33_Y	0.579	0.23
40_A	244_M	0.578	0.23
73_V	175_D	0.578	0.23
146_C	310_F	0.577	0.22
88_A	178_V	0.577	0.22
204_L	366_L	0.576	0.22
117_A	211_I	0.575	0.22
125_I	284_F	0.574	0.22
206_L	210_V	0.574	0.22
274_R	282_E	0.573	0.22
115_T	294_Y	0.572	0.22
56_L	59_W	0.570	0.22
175_D	178_V	0.570	0.22
233_S	244_M	0.568	0.22
71_V	380_V	0.568	0.22
196_H	361_S	0.568	0.22
210_V	309_I	0.568	0.22
238_A	331_I	0.568	0.22
16_K	303_S	0.567	0.22
251_P	331_I	0.566	0.22
268_K	273_R	0.563	0.22
49_L	366_L	0.561	0.22
234_R	238_A	0.561	0.22
195_R	203_I	0.561	0.22
116_L	202_G	0.559	0.22
17_Y	61_E	0.557	0.21
49_L	52_G	0.556	0.21
179_R	262_L	0.556	0.21
86_M	220_F	0.556	0.21
263_L	295_A	0.555	0.21
121_L	143_A	0.552	0.21
143_A	202_G	0.551	0.21
97_K	300_M	0.551	0.21
70_A	184_A	0.550	0.21
22_L	211_I	0.549	0.21
146_C	353_D	0.548	0.21
237_L	330_Y	0.546	0.21
82_R	237_L	0.545	0.21
5_T	139_A	0.544	0.21
50_M	331_I	0.544	0.21
122_L	361_S	0.544	0.21
13_D	366_L	0.543	0.21
79_G	264_Y	0.539	0.21
83_T	256_R	0.538	0.21
227_V	329_R	0.538	0.21
281_K	365_I	0.537	0.21
207_F	211_I	0.537	0.21
142_T	204_L	0.536	0.20
270_I	273_R	0.533	0.20
231_K	373_C	0.531	0.20
230_E	281_K	0.528	0.20
22_L	32_L	0.528	0.20
195_R	199_A	0.524	0.20
113_L	124_F	0.523	0.20
145_L	276_I	0.522	0.20
40_A	258_R	0.522	0.20
291_N	322_L	0.518	0.20
206_L	244_M	0.517	0.20
304_A	363_I	0.514	0.19
238_A	323_V	0.513	0.19
246_Q	264_Y	0.512	0.19
217_T	376_L	0.512	0.19
197_L	202_G	0.512	0.19
284_F	340_M	0.511	0.19
193_T	200_L	0.510	0.19
152_H	349_D	0.510	0.19
45_Q	100_I	0.510	0.19
101_Y	181_I	0.510	0.19
16_K	235_L	0.508	0.19
47_I	242_M	0.508	0.19
39_I	110_Y	0.508	0.19
111_S	349_D	0.508	0.19
135_L	295_A	0.507	0.19
106_Y	150_G	0.506	0.19
116_L	376_L	0.505	0.19
95_Q	223_F	0.503	0.19
44_Y	104_K	0.501	0.19
171_R	282_E	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3giaA	1	0.561	32.1	0.963	Contact Map
3l1lA	2	0.5714	17	0.967	Contact Map
4ev6A	3	0.2052	11.2	0.97	Contact Map
4i0uA	4	0.2	9.6	0.971	Contact Map
3nuhB	1	0.1013	8.9	0.971	Contact Map
3mktA	1	0.5792	6.3	0.973	Contact Map
3w4tA	1	0.5506	5.1	0.974	Contact Map
4aq5C	1	0.1455	4	0.975	Contact Map
4humA	1	0.5792	3.1	0.977	Contact Map
1nvpB	1	0.0312	2.8	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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