GREMLIN Database
YTHQ - Putative transporter YthQ
UniProt: O35029 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (364)
Sequences: 540 (458)
Seq/√Len: 24.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
328_C370_F7.6471.00
259_R264_Y5.0401.00
298_M366_L4.4261.00
288_M362_C3.8411.00
264_Y286_K3.3901.00
84_F110_Y3.3341.00
306_T373_C3.1671.00
287_V339_V2.7100.99
302_L328_C2.6680.99
82_R110_Y2.6570.99
98_E181_I2.5180.99
120_L149_F2.3940.98
69_Y73_V2.3820.98
46_Y128_P2.3210.98
267_S289_L2.3150.98
339_V344_F2.2440.97
94_L100_I2.2410.97
27_D79_G2.2280.97
316_L320_A2.1650.96
300_M331_I2.1390.96
302_L370_F2.0420.95
281_K361_S2.0190.95
72_C144_L2.0180.95
75_I122_L2.0100.94
245_S349_D1.9920.94
245_S331_I1.9320.93
7_F110_Y1.9310.93
28_W40_A1.9220.93
27_D30_V1.9040.93
49_L363_I1.9010.93
5_T9_R1.8840.92
284_F355_Y1.8750.92
34_I289_L1.8520.92
28_W286_K1.8470.91
35_V258_R1.8430.91
329_R367_H1.8230.91
24_A29_T1.8200.91
204_L273_R1.8170.91
300_M349_D1.8100.91
14_Y110_Y1.8080.91
309_I312_S1.7990.90
305_F374_C1.7970.90
309_I313_P1.7740.90
75_I113_L1.7720.90
82_R230_E1.7620.89
11_L173_I1.7420.89
21_V331_I1.7110.88
22_L163_I1.7090.88
288_M366_L1.6900.87
168_S369_A1.6700.87
85_L104_K1.6640.86
155_F183_F1.6630.86
115_T152_H1.6550.86
89_D290_R1.6470.86
25_V237_L1.6450.86
28_W33_Y1.6160.85
7_F14_Y1.6120.85
48_D284_F1.6110.85
87_E231_K1.6000.84
26_I33_Y1.5880.84
198_L368_Y1.5780.83
86_M344_F1.5710.83
205_F369_A1.5470.82
103_L245_S1.5310.81
270_I281_K1.5290.81
137_T369_A1.5240.81
27_D32_L1.5150.81
214_L217_T1.5100.80
21_V24_A1.5050.80
109_L113_L1.4990.80
70_A380_V1.4970.80
248_A331_I1.4910.80
21_V29_T1.4840.79
97_K280_Y1.4690.78
83_T103_L1.4630.78
77_F183_F1.4610.78
28_W49_L1.4570.78
23_H239_G1.4570.78
340_M355_Y1.4570.78
43_I241_V1.4460.77
9_R299_Y1.4430.77
261_P264_Y1.4370.77
260_K263_L1.4340.77
201_F372_A1.4300.77
28_W32_L1.4300.77
24_A35_V1.4280.76
160_Q179_R1.4230.76
230_E283_L1.4210.76
83_T94_L1.4200.76
277_C354_E1.4180.76
177_L188_I1.4170.76
325_T367_H1.4140.76
124_F127_L1.4050.75
267_S286_K1.4010.75
103_L331_I1.3970.75
296_R300_M1.3940.75
11_L110_Y1.3920.75
244_M326_G1.3730.74
24_A246_Q1.3710.73
26_I41_F1.3690.73
303_S380_V1.3470.72
141_S319_I1.3350.71
21_V300_M1.3320.71
245_S300_M1.3230.71
127_L131_S1.3200.71
184_A203_I1.3150.70
84_F345_L1.3100.70
260_K300_M1.2940.69
7_F107_A1.2900.69
278_T281_K1.2860.68
130_I141_S1.2820.68
331_I349_D1.2700.67
68_L72_C1.2670.67
77_F155_F1.2630.67
347_G355_Y1.2600.67
113_L357_R1.2570.67
31_A332_L1.2560.67
16_K126_V1.2500.66
27_D244_M1.2500.66
150_G376_L1.2470.66
112_F289_L1.2440.66
221_T226_E1.2400.66
152_H348_T1.2330.65
237_L370_F1.2320.65
211_I214_L1.2270.65
366_L369_A1.2260.65
273_R278_T1.2250.65
243_M247_E1.2210.64
76_M204_L1.2140.64
28_W336_F1.2120.64
97_K223_F1.2060.63
185_G318_V1.1960.63
28_W264_Y1.1920.62
120_L124_F1.1920.62
227_V319_I1.1910.62
32_L35_V1.1830.62
83_T247_E1.1810.62
67_W357_R1.1800.62
94_L97_K1.1640.61
40_A82_R1.1590.60
308_L314_I1.1570.60
107_A357_R1.1560.60
33_Y295_A1.1510.60
116_L178_V1.1500.60
39_I157_S1.1460.59
200_L369_A1.1440.59
60_S129_L1.1410.59
130_I226_E1.1400.59
239_G315_W1.1350.59
295_A315_W1.1330.58
137_T186_S1.1320.58
237_L358_A1.1290.58
217_T357_R1.1270.58
146_C196_H1.1270.58
82_R297_Q1.1260.58
125_I277_C1.1190.57
27_D40_A1.1180.57
27_D330_Y1.0920.56
27_D34_I1.0910.55
56_L207_F1.0810.55
237_L242_M1.0780.55
48_D323_V1.0700.54
19_F34_I1.0700.54
113_L146_C1.0670.54
7_F106_Y1.0660.54
25_V242_M1.0510.53
31_A341_D1.0480.52
104_K257_M1.0480.52
18_Q24_A1.0420.52
233_S334_L1.0400.52
56_L299_Y1.0380.52
282_E286_K1.0350.52
42_V232_K1.0230.51
32_L38_A1.0210.51
75_I212_R1.0180.50
351_E372_A1.0160.50
194_E201_F1.0140.50
182_L207_F1.0120.50
227_V263_L1.0090.50
22_L246_Q1.0070.50
144_L293_E1.0050.49
56_L142_T1.0030.49
205_F227_V1.0010.49
47_I51_N1.0010.49
305_F324_Y1.0010.49
150_G327_V0.9910.48
82_R233_S0.9900.48
67_W144_L0.9890.48
21_V247_E0.9880.48
24_A32_L0.9860.48
116_L149_F0.9840.48
58_E153_I0.9820.48
99_I373_C0.9780.47
6_L24_A0.9750.47
163_I222_A0.9750.47
294_Y335_I0.9720.47
56_L253_V0.9710.47
161_D204_L0.9690.47
142_T181_I0.9690.47
77_F243_M0.9670.47
200_L218_A0.9670.47
87_E90_K0.9660.47
147_Y198_L0.9630.46
153_I200_L0.9610.46
259_R286_K0.9500.46
317_K358_A0.9460.45
43_I125_I0.9460.45
82_R162_R0.9440.45
97_K331_I0.9410.45
194_E206_L0.9380.45
12_F145_L0.9370.45
11_L84_F0.9370.45
227_V375_F0.9330.44
223_F300_M0.9320.44
14_Y230_E0.9290.44
79_G297_Q0.9280.44
67_W341_D0.9230.44
298_M370_F0.9220.44
61_E226_E0.9190.43
21_V245_S0.9180.43
18_Q291_N0.9140.43
10_R89_D0.9130.43
84_F206_L0.9120.43
181_I375_F0.9110.43
79_G115_T0.9100.43
312_S320_A0.9090.43
245_S282_E0.9060.42
95_Q246_Q0.9030.42
6_L10_R0.8960.42
168_S372_A0.8940.42
26_I233_S0.8910.41
18_Q242_M0.8910.41
61_E242_M0.8910.41
5_T372_A0.8890.41
300_M335_I0.8890.41
17_Y234_R0.8880.41
313_P380_V0.8850.41
83_T100_I0.8790.41
127_L239_G0.8780.41
109_L120_L0.8760.40
297_Q334_L0.8750.40
274_R344_F0.8750.40
12_F180_A0.8710.40
123_F127_L0.8710.40
243_M301_L0.8660.40
151_L206_L0.8640.40
265_R289_L0.8600.39
275_T299_Y0.8580.39
8_F207_F0.8560.39
83_T241_V0.8560.39
152_H296_R0.8500.39
260_K283_L0.8480.38
177_L351_E0.8470.38
51_N100_I0.8460.38
198_L201_F0.8450.38
74_L209_S0.8440.38
187_A309_I0.8440.38
25_V80_S0.8430.38
14_Y165_K0.8410.38
168_S206_L0.8410.38
339_V348_T0.8400.38
14_Y235_L0.8390.38
150_G306_T0.8380.38
94_L246_Q0.8380.38
40_A259_R0.8370.38
327_V330_Y0.8360.38
119_W148_L0.8360.38
21_V248_A0.8360.38
202_G377_A0.8320.37
129_L291_N0.8310.37
27_D78_T0.8310.37
105_R196_H0.8300.37
35_V233_S0.8290.37
341_D346_I0.8290.37
203_I214_L0.8280.37
264_Y267_S0.8270.37
10_R290_R0.8220.37
152_H355_Y0.8200.37
152_H284_F0.8190.37
154_F298_M0.8190.37
112_F116_L0.8160.36
188_I372_A0.8150.36
97_K301_L0.8140.36
343_P346_I0.8140.36
200_L352_S0.8130.36
247_E331_I0.8100.36
79_G152_H0.8090.36
91_V95_Q0.8050.36
25_V328_C0.8040.36
27_D41_F0.8040.36
143_A373_C0.8030.35
100_I373_C0.8030.35
127_L141_S0.7990.35
301_L324_Y0.7980.35
88_A92_F0.7900.35
76_M251_P0.7850.34
68_L130_I0.7850.34
27_D33_Y0.7840.34
21_V238_A0.7820.34
118_K152_H0.7790.34
87_E270_I0.7780.34
178_V262_L0.7780.34
150_G368_Y0.7770.34
120_L173_I0.7770.34
16_K267_S0.7760.34
27_D334_L0.7750.34
24_A270_I0.7750.34
56_L326_G0.7740.34
262_L286_K0.7740.34
20_K82_R0.7710.33
9_R41_F0.7670.33
291_N338_K0.7670.33
245_S248_A0.7650.33
326_G374_C0.7640.33
123_F145_L0.7620.33
26_I40_A0.7620.33
5_T39_I0.7610.33
27_D293_E0.7610.33
143_A200_L0.7590.33
134_V317_K0.7570.33
81_I289_L0.7570.33
143_A262_L0.7530.32
262_L359_R0.7520.32
40_A264_Y0.7450.32
296_R324_Y0.7450.32
57_Y82_R0.7420.32
368_Y372_A0.7410.32
306_T316_L0.7360.31
172_W205_F0.7330.31
284_F336_F0.7320.31
13_D362_C0.7310.31
74_L277_C0.7310.31
12_F184_A0.7310.31
306_T377_A0.7290.31
7_F11_L0.7280.31
223_F227_V0.7280.31
21_V103_L0.7280.31
199_A202_G0.7280.31
52_G100_I0.7240.31
11_L27_D0.7220.30
190_I319_I0.7210.30
184_A241_V0.7170.30
71_V265_R0.7160.30
111_S156_L0.7150.30
269_R284_F0.7140.30
14_Y18_Q0.7140.30
207_F275_T0.7140.30
278_T361_S0.7120.30
145_L200_L0.7120.30
19_F23_H0.7110.30
68_L204_L0.7080.30
67_W335_I0.7070.30
9_R200_L0.7050.29
126_V173_I0.6980.29
223_F226_E0.6950.29
25_V344_F0.6940.29
7_F253_V0.6900.29
75_I88_A0.6890.28
9_R278_T0.6870.28
22_L222_A0.6870.28
70_A251_P0.6860.28
104_K221_T0.6850.28
30_V42_V0.6840.28
131_S332_L0.6840.28
109_L137_T0.6840.28
102_Q353_D0.6820.28
282_E331_I0.6800.28
323_V326_G0.6800.28
225_A365_I0.6780.28
358_A376_L0.6770.28
158_L208_F0.6750.28
109_L206_L0.6750.28
70_A298_M0.6750.28
20_K57_Y0.6730.28
127_L145_L0.6730.28
95_Q331_I0.6720.27
82_R234_R0.6710.27
193_T241_V0.6690.27
87_E317_K0.6690.27
121_L257_M0.6680.27
235_L285_F0.6670.27
206_L357_R0.6670.27
154_F242_M0.6660.27
32_L47_I0.6650.27
167_R311_V0.6650.27
31_A320_A0.6630.27
85_L227_V0.6630.27
302_L373_C0.6620.27
163_I254_K0.6620.27
107_A301_L0.6590.27
31_A42_V0.6580.27
263_L303_S0.6560.27
280_Y298_M0.6540.26
327_V367_H0.6540.26
273_R367_H0.6510.26
171_R225_A0.6510.26
203_I220_F0.6500.26
354_E357_R0.6500.26
71_V85_L0.6490.26
43_I297_Q0.6490.26
237_L291_N0.6470.26
84_F243_M0.6470.26
40_A286_K0.6460.26
181_I325_T0.6450.26
126_V183_F0.6450.26
21_V260_K0.6440.26
212_R371_A0.6420.26
76_M320_A0.6400.26
212_R368_Y0.6390.26
7_F328_C0.6390.26
29_T237_L0.6360.26
29_T242_M0.6360.26
18_Q34_I0.6350.25
137_T184_A0.6320.25
28_W330_Y0.6300.25
113_L196_H0.6300.25
83_T321_L0.6280.25
299_Y318_V0.6270.25
71_V184_A0.6260.25
306_T357_R0.6250.25
311_V314_I0.6250.25
223_F284_F0.6240.25
147_Y350_K0.6230.25
280_Y348_T0.6230.25
103_L349_D0.6220.25
191_V352_S0.6220.25
279_G350_K0.6210.25
102_Q285_F0.6200.25
184_A361_S0.6160.24
267_S282_E0.6150.24
299_Y304_A0.6150.24
9_R178_V0.6150.24
28_W267_S0.6140.24
70_A180_A0.6130.24
150_G372_A0.6130.24
27_D162_R0.6120.24
269_R369_A0.6110.24
165_K236_A0.6090.24
266_N331_I0.6070.24
76_M207_F0.6060.24
51_N153_I0.6040.24
23_H98_E0.6040.24
33_Y264_Y0.6040.24
29_T38_A0.6040.24
232_K299_Y0.6010.24
70_A214_L0.6000.24
69_Y359_R0.6000.24
281_K362_C0.5990.24
127_L313_P0.5990.24
160_Q223_F0.5980.24
144_L319_I0.5970.23
94_L300_M0.5960.23
182_L205_F0.5960.23
200_L211_I0.5940.23
4_R146_C0.5940.23
137_T146_C0.5900.23
115_T155_F0.5900.23
11_L14_Y0.5880.23
164_R214_L0.5850.23
72_C120_L0.5850.23
17_Y238_A0.5840.23
39_I279_G0.5840.23
5_T102_Q0.5830.23
40_A233_S0.5830.23
106_Y337_D0.5810.23
121_L266_N0.5810.23
94_L243_M0.5800.23
105_R146_C0.5800.23
29_T33_Y0.5790.23
40_A244_M0.5780.23
73_V175_D0.5780.23
146_C310_F0.5770.22
88_A178_V0.5770.22
204_L366_L0.5760.22
117_A211_I0.5750.22
125_I284_F0.5740.22
206_L210_V0.5740.22
274_R282_E0.5730.22
115_T294_Y0.5720.22
56_L59_W0.5700.22
175_D178_V0.5700.22
233_S244_M0.5680.22
71_V380_V0.5680.22
196_H361_S0.5680.22
210_V309_I0.5680.22
238_A331_I0.5680.22
16_K303_S0.5670.22
251_P331_I0.5660.22
268_K273_R0.5630.22
49_L366_L0.5610.22
234_R238_A0.5610.22
195_R203_I0.5610.22
116_L202_G0.5590.22
17_Y61_E0.5570.21
49_L52_G0.5560.21
179_R262_L0.5560.21
86_M220_F0.5560.21
263_L295_A0.5550.21
121_L143_A0.5520.21
143_A202_G0.5510.21
97_K300_M0.5510.21
70_A184_A0.5500.21
22_L211_I0.5490.21
146_C353_D0.5480.21
237_L330_Y0.5460.21
82_R237_L0.5450.21
5_T139_A0.5440.21
50_M331_I0.5440.21
122_L361_S0.5440.21
13_D366_L0.5430.21
79_G264_Y0.5390.21
83_T256_R0.5380.21
227_V329_R0.5380.21
281_K365_I0.5370.21
207_F211_I0.5370.21
142_T204_L0.5360.20
270_I273_R0.5330.20
231_K373_C0.5310.20
230_E281_K0.5280.20
22_L32_L0.5280.20
195_R199_A0.5240.20
113_L124_F0.5230.20
145_L276_I0.5220.20
40_A258_R0.5220.20
291_N322_L0.5180.20
206_L244_M0.5170.20
304_A363_I0.5140.19
238_A323_V0.5130.19
246_Q264_Y0.5120.19
217_T376_L0.5120.19
197_L202_G0.5120.19
284_F340_M0.5110.19
193_T200_L0.5100.19
152_H349_D0.5100.19
45_Q100_I0.5100.19
101_Y181_I0.5100.19
16_K235_L0.5080.19
47_I242_M0.5080.19
39_I110_Y0.5080.19
111_S349_D0.5080.19
135_L295_A0.5070.19
106_Y150_G0.5060.19
116_L376_L0.5050.19
95_Q223_F0.5030.19
44_Y104_K0.5010.19
171_R282_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 0.561 32.1 0.963 Contact Map
3l1lA 2 0.5714 17 0.967 Contact Map
4ev6A 3 0.2052 11.2 0.97 Contact Map
4i0uA 4 0.2 9.6 0.971 Contact Map
3nuhB 1 0.1013 8.9 0.971 Contact Map
3mktA 1 0.5792 6.3 0.973 Contact Map
3w4tA 1 0.5506 5.1 0.974 Contact Map
4aq5C 1 0.1455 4 0.975 Contact Map
4humA 1 0.5792 3.1 0.977 Contact Map
1nvpB 1 0.0312 2.8 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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