MNTC - BACSU - GREMLIN Contacts

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MNTC - Manganese transport system membrane protein MntC

UniProt:	O35024	Sequences: MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIGDAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGIVLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCIVFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPAITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMICAPKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLKALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDYFDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	435 (346)
Sequences:	304 (223)
Seq/√Len:	12.0

BACSU - MNTC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
21_T	137_A	3.717	0.99
58_A	62_T	3.500	0.98
168_L	186_L	3.362	0.98
53_P	111_G	3.305	0.98
170_T	282_L	3.169	0.97
242_S	269_L	3.010	0.96
222_R	231_M	2.994	0.96
226_E	279_K	2.946	0.95
50_S	53_P	2.899	0.95
241_V	269_L	2.868	0.94
110_V	235_A	2.851	0.94
109_G	195_V	2.679	0.92
224_W	273_S	2.671	0.92
50_S	111_G	2.647	0.91
138_A	239_G	2.418	0.87
21_T	239_G	2.410	0.87
298_R	338_D	2.398	0.87
245_A	272_F	2.391	0.86
107_F	175_F	2.374	0.86
42_L	53_P	2.303	0.84
47_M	100_I	2.172	0.80
223_Y	270_F	2.123	0.79
48_A	96_E	2.035	0.76
188_G	223_Y	2.032	0.76
88_I	301_V	1.986	0.74
24_L	224_W	1.983	0.74
50_S	194_I	1.983	0.74
134_F	137_A	1.981	0.74
309_Y	360_I	1.959	0.73
303_L	367_A	1.958	0.73
234_I	238_T	1.952	0.73
61_F	80_L	1.939	0.72
52_L	59_F	1.918	0.71
50_S	207_V	1.907	0.71
234_I	237_I	1.895	0.70
146_I	193_L	1.835	0.68
30_V	232_I	1.832	0.68
215_I	249_L	1.821	0.67
148_I	201_G	1.807	0.66
163_F	270_F	1.806	0.66
76_L	349_E	1.788	0.66
238_T	273_S	1.777	0.65
146_I	149_A	1.755	0.64
225_T	231_M	1.744	0.64
39_K	345_I	1.743	0.64
304_A	308_Q	1.739	0.63
45_D	52_L	1.731	0.63
154_V	350_N	1.698	0.61
55_V	304_A	1.693	0.61
168_L	181_I	1.667	0.60
28_S	210_M	1.652	0.59
167_T	228_L	1.625	0.58
304_A	315_C	1.623	0.58
191_A	210_M	1.605	0.57
175_F	179_L	1.589	0.56
134_F	212_A	1.551	0.54
218_A	265_S	1.545	0.54
162_F	342_E	1.535	0.53
218_A	262_M	1.531	0.53
275_I	283_A	1.522	0.53
111_G	178_G	1.521	0.53
80_L	85_I	1.520	0.53
95_K	215_I	1.492	0.51
192_C	318_V	1.491	0.51
118_I	129_L	1.491	0.51
36_L	208_I	1.476	0.51
42_L	260_P	1.474	0.50
21_T	138_A	1.466	0.50
29_G	202_L	1.464	0.50
305_I	353_W	1.459	0.50
45_D	101_G	1.458	0.50
208_I	212_A	1.456	0.50
71_L	288_R	1.449	0.49
157_L	161_V	1.445	0.49
100_I	139_S	1.439	0.49
38_R	83_F	1.437	0.49
208_I	267_T	1.434	0.48
290_M	364_Y	1.434	0.48
284_A	321_V	1.429	0.48
57_L	163_F	1.428	0.48
342_E	362_K	1.427	0.48
36_L	145_I	1.410	0.47
42_L	178_G	1.403	0.47
58_A	70_F	1.399	0.47
152_S	275_I	1.383	0.46
51_A	63_G	1.371	0.45
42_L	111_G	1.363	0.45
237_I	283_A	1.362	0.45
245_A	361_E	1.360	0.45
118_I	126_Q	1.358	0.45
25_G	115_L	1.356	0.45
33_S	232_I	1.355	0.44
132_F	203_Q	1.355	0.44
151_I	185_F	1.353	0.44
61_F	241_V	1.349	0.44
58_A	195_V	1.343	0.44
178_G	242_S	1.336	0.44
161_V	272_F	1.322	0.43
61_F	181_I	1.312	0.42
116_T	339_L	1.300	0.42
118_I	136_Q	1.297	0.42
59_F	235_A	1.291	0.41
104_L	128_G	1.288	0.41
65_K	195_V	1.288	0.41
165_E	225_T	1.276	0.41
163_F	229_T	1.274	0.41
95_K	102_I	1.267	0.40
103_V	283_A	1.265	0.40
59_F	127_S	1.260	0.40
237_I	287_I	1.259	0.40
58_A	325_R	1.252	0.39
146_I	150_G	1.248	0.39
65_K	109_G	1.236	0.39
20_G	140_L	1.223	0.38
301_V	339_L	1.219	0.38
47_M	164_K	1.214	0.38
104_L	259_G	1.213	0.38
50_S	363_G	1.208	0.37
189_L	318_V	1.201	0.37
76_L	154_V	1.200	0.37
220_T	273_S	1.197	0.37
157_L	275_I	1.194	0.37
31_L	202_L	1.194	0.37
357_S	364_Y	1.190	0.37
287_I	291_R	1.186	0.36
168_L	305_I	1.182	0.36
235_A	248_L	1.179	0.36
179_L	293_R	1.177	0.36
90_R	94_T	1.169	0.36
56_C	219_I	1.168	0.36
226_E	363_G	1.160	0.35
79_L	192_C	1.158	0.35
42_L	325_R	1.154	0.35
277_A	280_R	1.150	0.35
151_I	358_K	1.143	0.34
134_F	216_T	1.139	0.34
191_A	270_F	1.138	0.34
153_A	349_E	1.134	0.34
77_A	111_G	1.134	0.34
275_I	355_I	1.132	0.34
52_L	70_F	1.132	0.34
44_G	211_A	1.123	0.33
315_C	324_K	1.120	0.33
75_A	151_I	1.119	0.33
64_Q	67_L	1.117	0.33
100_I	112_I	1.117	0.33
172_D	246_G	1.114	0.33
52_L	58_A	1.108	0.33
134_F	260_P	1.105	0.33
136_Q	258_T	1.104	0.33
34_F	52_L	1.100	0.32
58_A	69_F	1.100	0.32
154_V	268_L	1.091	0.32
75_A	204_T	1.085	0.32
25_G	29_G	1.082	0.32
52_L	191_A	1.078	0.31
88_I	274_M	1.076	0.31
245_A	268_L	1.072	0.31
113_I	133_L	1.070	0.31
233_I	240_G	1.066	0.31
56_C	215_I	1.063	0.31
157_L	245_A	1.062	0.31
124_G	191_A	1.062	0.31
299_E	339_L	1.062	0.31
72_L	168_L	1.056	0.31
38_R	101_G	1.052	0.30
102_I	321_V	1.046	0.30
25_G	202_L	1.045	0.30
41_S	117_Y	1.040	0.30
201_G	223_Y	1.038	0.30
42_L	77_A	1.034	0.30
61_F	150_G	1.032	0.30
306_Y	363_G	1.032	0.30
72_L	156_L	1.031	0.29
159_C	215_I	1.030	0.29
31_L	35_V	1.030	0.29
109_G	148_I	1.029	0.29
216_T	256_M	1.028	0.29
45_D	59_F	1.028	0.29
158_L	345_I	1.025	0.29
23_L	154_V	1.017	0.29
137_A	280_R	1.009	0.29
192_C	208_I	1.007	0.29
337_N	358_K	1.004	0.28
159_C	170_T	1.002	0.28
129_L	144_D	1.002	0.28
321_V	336_L	0.994	0.28
25_G	259_G	0.991	0.28
19_A	233_I	0.985	0.28
51_A	81_G	0.983	0.28
305_I	345_I	0.981	0.27
241_V	268_L	0.980	0.27
202_L	260_P	0.978	0.27
100_I	215_I	0.976	0.27
176_A	183_V	0.975	0.27
84_C	266_A	0.970	0.27
36_L	101_G	0.953	0.26
41_S	253_M	0.952	0.26
119_Q	144_D	0.952	0.26
34_F	101_G	0.949	0.26
101_G	292_L	0.947	0.26
96_E	109_G	0.942	0.26
216_T	270_F	0.942	0.26
104_L	260_P	0.940	0.26
80_L	90_R	0.934	0.26
197_A	207_V	0.933	0.26
100_I	136_Q	0.933	0.26
83_F	345_I	0.933	0.26
41_S	248_L	0.928	0.25
201_G	210_M	0.928	0.25
50_S	220_T	0.926	0.25
38_R	170_T	0.926	0.25
191_A	204_T	0.925	0.25
40_Q	187_N	0.923	0.25
163_F	231_M	0.922	0.25
76_L	334_K	0.920	0.25
326_R	352_I	0.917	0.25
275_I	341_Q	0.915	0.25
283_A	292_L	0.912	0.25
126_Q	140_L	0.911	0.25
68_P	327_L	0.910	0.25
241_V	271_L	0.909	0.25
40_Q	175_F	0.909	0.25
205_V	239_G	0.905	0.25
126_Q	223_Y	0.904	0.24
221_A	231_M	0.898	0.24
159_C	219_I	0.895	0.24
27_A	356_T	0.894	0.24
201_G	222_R	0.893	0.24
46_A	85_I	0.892	0.24
55_V	153_A	0.890	0.24
146_I	159_C	0.890	0.24
50_S	77_A	0.886	0.24
52_L	130_D	0.886	0.24
134_F	339_L	0.882	0.24
56_C	211_A	0.879	0.24
133_L	209_L	0.878	0.24
239_G	291_R	0.875	0.23
132_F	182_P	0.873	0.23
271_L	357_S	0.873	0.23
115_L	144_D	0.872	0.23
77_A	164_K	0.870	0.23
175_F	358_K	0.869	0.23
186_L	238_T	0.869	0.23
50_S	147_L	0.865	0.23
341_Q	349_E	0.864	0.23
47_M	167_T	0.864	0.23
88_I	162_F	0.861	0.23
282_L	319_E	0.859	0.23
283_A	346_E	0.858	0.23
199_V	283_A	0.858	0.23
137_A	258_T	0.858	0.23
48_A	208_I	0.857	0.23
60_L	66_S	0.855	0.23
126_Q	260_P	0.852	0.23
287_I	323_K	0.848	0.22
105_S	300_Q	0.847	0.22
298_R	342_E	0.847	0.22
145_I	198_V	0.844	0.22
136_Q	213_M	0.842	0.22
319_E	333_L	0.842	0.22
184_R	357_S	0.842	0.22
85_I	178_G	0.839	0.22
90_R	280_R	0.837	0.22
333_L	349_E	0.833	0.22
233_I	253_M	0.831	0.22
272_F	276_C	0.830	0.22
237_I	241_V	0.829	0.22
245_A	330_S	0.827	0.22
156_L	351_G	0.827	0.22
40_Q	222_R	0.826	0.22
118_I	134_F	0.824	0.22
104_L	201_G	0.824	0.22
37_L	108_F	0.821	0.22
161_V	239_G	0.819	0.21
245_A	265_S	0.818	0.21
145_I	366_T	0.816	0.21
112_I	261_L	0.816	0.21
89_P	116_T	0.815	0.21
81_G	208_I	0.814	0.21
310_E	367_A	0.805	0.21
306_Y	360_I	0.805	0.21
128_G	202_L	0.801	0.21
274_M	319_E	0.800	0.21
55_V	70_F	0.796	0.21
239_G	280_R	0.795	0.21
197_A	270_F	0.794	0.21
119_Q	250_S	0.791	0.21
52_L	101_G	0.789	0.20
103_V	224_W	0.787	0.20
166_F	192_C	0.786	0.20
17_V	345_I	0.782	0.20
58_A	176_A	0.778	0.20
144_D	207_V	0.778	0.20
175_F	183_V	0.777	0.20
137_A	260_P	0.774	0.20
57_L	291_R	0.773	0.20
145_I	355_I	0.772	0.20
93_K	127_S	0.772	0.20
60_L	119_Q	0.770	0.20
35_V	210_M	0.770	0.20
133_L	141_V	0.769	0.20
213_M	243_G	0.767	0.20
40_Q	353_W	0.766	0.20
140_L	149_A	0.765	0.20
101_G	170_T	0.765	0.20
39_K	227_R	0.764	0.20
157_L	280_R	0.759	0.20
187_N	270_F	0.757	0.19
321_V	339_L	0.757	0.19
237_I	268_L	0.755	0.19
50_S	161_V	0.753	0.19
271_L	351_G	0.753	0.19
196_C	337_N	0.751	0.19
231_M	239_G	0.750	0.19
31_L	232_I	0.749	0.19
50_S	107_F	0.748	0.19
249_L	276_C	0.747	0.19
227_R	274_M	0.745	0.19
277_A	284_A	0.744	0.19
152_S	159_C	0.744	0.19
42_L	216_T	0.739	0.19
156_L	298_R	0.738	0.19
295_R	299_E	0.738	0.19
76_L	338_D	0.737	0.19
53_P	134_F	0.736	0.19
286_A	290_M	0.733	0.19
111_G	242_S	0.733	0.19
115_L	128_G	0.729	0.19
154_V	241_V	0.723	0.18
198_V	207_V	0.723	0.18
41_S	179_L	0.720	0.18
72_L	241_V	0.720	0.18
228_L	345_I	0.719	0.18
102_I	269_L	0.716	0.18
25_G	201_G	0.715	0.18
150_G	333_L	0.714	0.18
279_K	333_L	0.713	0.18
98_S	194_I	0.713	0.18
227_R	240_G	0.712	0.18
198_V	204_T	0.710	0.18
162_F	321_V	0.709	0.18
23_L	85_I	0.708	0.18
168_L	343_R	0.707	0.18
237_I	337_N	0.704	0.18
81_G	105_S	0.703	0.18
71_L	173_L	0.703	0.18
74_A	78_G	0.703	0.18
105_S	128_G	0.702	0.18
85_I	163_F	0.701	0.18
234_I	288_R	0.701	0.18
41_S	223_Y	0.700	0.18
44_G	214_L	0.699	0.18
35_V	81_G	0.699	0.18
105_S	201_G	0.698	0.18
227_R	230_G	0.697	0.18
81_G	222_R	0.695	0.18
63_G	271_L	0.692	0.17
47_M	188_G	0.685	0.17
263_I	273_S	0.684	0.17
283_A	294_R	0.681	0.17
82_T	99_A	0.681	0.17
45_D	128_G	0.681	0.17
47_M	78_G	0.681	0.17
48_A	219_I	0.680	0.17
304_A	324_K	0.677	0.17
90_R	185_F	0.676	0.17
170_T	241_V	0.675	0.17
234_I	267_T	0.674	0.17
150_G	200_I	0.673	0.17
123_A	243_G	0.673	0.17
29_G	253_M	0.672	0.17
61_F	67_L	0.668	0.17
186_L	207_V	0.668	0.17
146_I	345_I	0.666	0.17
164_K	181_I	0.663	0.17
178_G	286_A	0.658	0.17
81_G	104_L	0.655	0.16
28_S	113_I	0.654	0.16
103_V	205_V	0.654	0.16
96_E	194_I	0.650	0.16
24_L	128_G	0.649	0.16
296_T	310_E	0.646	0.16
88_I	233_I	0.646	0.16
28_S	31_L	0.644	0.16
173_L	271_L	0.644	0.16
154_V	349_E	0.644	0.16
357_S	361_E	0.644	0.16
103_V	272_F	0.642	0.16
77_A	173_L	0.640	0.16
153_A	313_N	0.639	0.16
60_L	190_L	0.636	0.16
140_L	353_W	0.636	0.16
31_L	159_C	0.634	0.16
216_T	266_A	0.633	0.16
257_A	260_P	0.632	0.16
165_E	181_I	0.632	0.16
86_Q	304_A	0.631	0.16
87_L	248_L	0.628	0.16
99_A	137_A	0.628	0.16
323_K	357_S	0.627	0.16
105_S	141_V	0.627	0.16
150_G	361_E	0.625	0.16
148_I	270_F	0.624	0.16
80_L	98_S	0.624	0.16
154_V	357_S	0.624	0.16
84_C	367_A	0.624	0.16
55_V	198_V	0.624	0.16
128_G	260_P	0.623	0.16
94_T	275_I	0.620	0.16
20_G	137_A	0.619	0.15
26_T	236_G	0.618	0.15
96_E	214_L	0.618	0.15
178_G	196_C	0.617	0.15
40_Q	107_F	0.615	0.15
238_T	269_L	0.615	0.15
116_T	203_Q	0.612	0.15
270_F	296_T	0.612	0.15
56_C	187_N	0.611	0.15
58_A	358_K	0.610	0.15
111_G	207_V	0.606	0.15
137_A	207_V	0.605	0.15
24_L	200_I	0.605	0.15
95_K	99_A	0.603	0.15
41_S	66_S	0.603	0.15
55_V	164_K	0.602	0.15
131_S	138_A	0.602	0.15
201_G	224_W	0.601	0.15
319_E	334_K	0.600	0.15
46_A	100_I	0.600	0.15
31_L	59_F	0.599	0.15
56_C	125_S	0.598	0.15
26_T	358_K	0.597	0.15
56_C	126_Q	0.596	0.15
66_S	241_V	0.596	0.15
81_G	195_V	0.595	0.15
100_I	114_L	0.592	0.15
173_L	272_F	0.590	0.15
236_G	284_A	0.589	0.15
24_L	56_C	0.588	0.15
134_F	138_A	0.587	0.15
34_F	45_D	0.587	0.15
107_F	200_I	0.586	0.15
45_D	126_Q	0.586	0.15
245_A	323_K	0.586	0.15
349_E	357_S	0.585	0.15
157_L	362_K	0.585	0.15
257_A	300_Q	0.583	0.15
109_G	225_T	0.583	0.15
233_I	349_E	0.582	0.15
99_A	205_V	0.582	0.15
31_L	82_T	0.576	0.14
88_I	296_T	0.575	0.14
118_I	260_P	0.572	0.14
104_L	257_A	0.570	0.14
140_L	191_A	0.565	0.14
50_S	259_G	0.565	0.14
301_V	326_R	0.563	0.14
41_S	213_M	0.562	0.14
207_V	260_P	0.562	0.14
267_T	327_L	0.562	0.14
309_Y	363_G	0.561	0.14
84_C	249_L	0.560	0.14
35_V	41_S	0.559	0.14
53_P	106_V	0.558	0.14
52_L	115_L	0.557	0.14
205_V	231_M	0.556	0.14
128_G	201_G	0.555	0.14
188_G	222_R	0.555	0.14
71_L	76_L	0.554	0.14
115_L	203_Q	0.552	0.14
49_H	171_F	0.551	0.14
163_F	331_L	0.551	0.14
98_S	212_A	0.550	0.14
128_G	144_D	0.548	0.14
184_R	351_G	0.547	0.14
137_A	277_A	0.546	0.14
25_G	128_G	0.546	0.14
80_L	349_E	0.546	0.14
45_D	306_Y	0.545	0.14
216_T	261_L	0.541	0.14
31_L	148_I	0.541	0.14
22_L	328_S	0.540	0.14
24_L	40_Q	0.540	0.14
18_L	247_T	0.538	0.13
109_G	214_L	0.538	0.13
237_I	354_Q	0.536	0.13
226_E	242_S	0.535	0.13
26_T	237_I	0.534	0.13
161_V	220_T	0.532	0.13
138_A	262_M	0.532	0.13
60_L	175_F	0.532	0.13
110_V	341_Q	0.524	0.13
18_L	244_V	0.523	0.13
116_T	259_G	0.523	0.13
44_G	182_P	0.522	0.13
107_F	183_V	0.522	0.13
46_A	243_G	0.517	0.13
222_R	273_S	0.517	0.13
304_A	367_A	0.517	0.13
182_P	215_I	0.517	0.13
43_I	360_I	0.516	0.13
52_L	296_T	0.515	0.13
30_V	237_I	0.513	0.13
128_G	195_V	0.512	0.13
57_L	361_E	0.512	0.13
101_G	126_Q	0.511	0.13
220_T	335_A	0.510	0.13
30_V	35_V	0.509	0.13
194_I	207_V	0.508	0.13
102_I	204_T	0.508	0.13
31_L	345_I	0.507	0.13
162_F	274_M	0.506	0.13
65_K	128_G	0.505	0.13
85_I	150_G	0.504	0.13
72_L	354_Q	0.503	0.13
272_F	311_K	0.503	0.13
319_E	350_N	0.500	0.13
26_T	331_L	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.5954	100	0.789	Contact Map
2qi9A	2	0.6184	100	0.791	Contact Map
4g1uA	2	0.577	100	0.803	Contact Map
1fx7A	4	0.331	99.9	0.866	Contact Map
3hrsA	2	0.3218	99.9	0.867	Contact Map
2qq9A	2	0.3149	99.9	0.867	Contact Map
4o5vA	2	0.3241	99.8	0.871	Contact Map
2x4hA	3	0.2989	99.5	0.901	Contact Map
1on2A	2	0.308	99.4	0.907	Contact Map
2p8tA	1	0.2897	99.1	0.919	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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