GREMLIN Database
MNTC - Manganese transport system membrane protein MntC
UniProt: O35024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 435 (346)
Sequences: 304 (223)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_T137_A3.7170.99
58_A62_T3.5000.98
168_L186_L3.3620.98
53_P111_G3.3050.98
170_T282_L3.1690.97
242_S269_L3.0100.96
222_R231_M2.9940.96
226_E279_K2.9460.95
50_S53_P2.8990.95
241_V269_L2.8680.94
110_V235_A2.8510.94
109_G195_V2.6790.92
224_W273_S2.6710.92
50_S111_G2.6470.91
138_A239_G2.4180.87
21_T239_G2.4100.87
298_R338_D2.3980.87
245_A272_F2.3910.86
107_F175_F2.3740.86
42_L53_P2.3030.84
47_M100_I2.1720.80
223_Y270_F2.1230.79
48_A96_E2.0350.76
188_G223_Y2.0320.76
88_I301_V1.9860.74
24_L224_W1.9830.74
50_S194_I1.9830.74
134_F137_A1.9810.74
309_Y360_I1.9590.73
303_L367_A1.9580.73
234_I238_T1.9520.73
61_F80_L1.9390.72
52_L59_F1.9180.71
50_S207_V1.9070.71
234_I237_I1.8950.70
146_I193_L1.8350.68
30_V232_I1.8320.68
215_I249_L1.8210.67
148_I201_G1.8070.66
163_F270_F1.8060.66
76_L349_E1.7880.66
238_T273_S1.7770.65
146_I149_A1.7550.64
225_T231_M1.7440.64
39_K345_I1.7430.64
304_A308_Q1.7390.63
45_D52_L1.7310.63
154_V350_N1.6980.61
55_V304_A1.6930.61
168_L181_I1.6670.60
28_S210_M1.6520.59
167_T228_L1.6250.58
304_A315_C1.6230.58
191_A210_M1.6050.57
175_F179_L1.5890.56
134_F212_A1.5510.54
218_A265_S1.5450.54
162_F342_E1.5350.53
218_A262_M1.5310.53
275_I283_A1.5220.53
111_G178_G1.5210.53
80_L85_I1.5200.53
95_K215_I1.4920.51
192_C318_V1.4910.51
118_I129_L1.4910.51
36_L208_I1.4760.51
42_L260_P1.4740.50
21_T138_A1.4660.50
29_G202_L1.4640.50
305_I353_W1.4590.50
45_D101_G1.4580.50
208_I212_A1.4560.50
71_L288_R1.4490.49
157_L161_V1.4450.49
100_I139_S1.4390.49
38_R83_F1.4370.49
208_I267_T1.4340.48
290_M364_Y1.4340.48
284_A321_V1.4290.48
57_L163_F1.4280.48
342_E362_K1.4270.48
36_L145_I1.4100.47
42_L178_G1.4030.47
58_A70_F1.3990.47
152_S275_I1.3830.46
51_A63_G1.3710.45
42_L111_G1.3630.45
237_I283_A1.3620.45
245_A361_E1.3600.45
118_I126_Q1.3580.45
25_G115_L1.3560.45
33_S232_I1.3550.44
132_F203_Q1.3550.44
151_I185_F1.3530.44
61_F241_V1.3490.44
58_A195_V1.3430.44
178_G242_S1.3360.44
161_V272_F1.3220.43
61_F181_I1.3120.42
116_T339_L1.3000.42
118_I136_Q1.2970.42
59_F235_A1.2910.41
104_L128_G1.2880.41
65_K195_V1.2880.41
165_E225_T1.2760.41
163_F229_T1.2740.41
95_K102_I1.2670.40
103_V283_A1.2650.40
59_F127_S1.2600.40
237_I287_I1.2590.40
58_A325_R1.2520.39
146_I150_G1.2480.39
65_K109_G1.2360.39
20_G140_L1.2230.38
301_V339_L1.2190.38
47_M164_K1.2140.38
104_L259_G1.2130.38
50_S363_G1.2080.37
189_L318_V1.2010.37
76_L154_V1.2000.37
220_T273_S1.1970.37
157_L275_I1.1940.37
31_L202_L1.1940.37
357_S364_Y1.1900.37
287_I291_R1.1860.36
168_L305_I1.1820.36
235_A248_L1.1790.36
179_L293_R1.1770.36
90_R94_T1.1690.36
56_C219_I1.1680.36
226_E363_G1.1600.35
79_L192_C1.1580.35
42_L325_R1.1540.35
277_A280_R1.1500.35
151_I358_K1.1430.34
134_F216_T1.1390.34
191_A270_F1.1380.34
153_A349_E1.1340.34
77_A111_G1.1340.34
275_I355_I1.1320.34
52_L70_F1.1320.34
44_G211_A1.1230.33
315_C324_K1.1200.33
75_A151_I1.1190.33
64_Q67_L1.1170.33
100_I112_I1.1170.33
172_D246_G1.1140.33
52_L58_A1.1080.33
134_F260_P1.1050.33
136_Q258_T1.1040.33
34_F52_L1.1000.32
58_A69_F1.1000.32
154_V268_L1.0910.32
75_A204_T1.0850.32
25_G29_G1.0820.32
52_L191_A1.0780.31
88_I274_M1.0760.31
245_A268_L1.0720.31
113_I133_L1.0700.31
233_I240_G1.0660.31
56_C215_I1.0630.31
157_L245_A1.0620.31
124_G191_A1.0620.31
299_E339_L1.0620.31
72_L168_L1.0560.31
38_R101_G1.0520.30
102_I321_V1.0460.30
25_G202_L1.0450.30
41_S117_Y1.0400.30
201_G223_Y1.0380.30
42_L77_A1.0340.30
61_F150_G1.0320.30
306_Y363_G1.0320.30
72_L156_L1.0310.29
159_C215_I1.0300.29
31_L35_V1.0300.29
109_G148_I1.0290.29
216_T256_M1.0280.29
45_D59_F1.0280.29
158_L345_I1.0250.29
23_L154_V1.0170.29
137_A280_R1.0090.29
192_C208_I1.0070.29
337_N358_K1.0040.28
159_C170_T1.0020.28
129_L144_D1.0020.28
321_V336_L0.9940.28
25_G259_G0.9910.28
19_A233_I0.9850.28
51_A81_G0.9830.28
305_I345_I0.9810.27
241_V268_L0.9800.27
202_L260_P0.9780.27
100_I215_I0.9760.27
176_A183_V0.9750.27
84_C266_A0.9700.27
36_L101_G0.9530.26
41_S253_M0.9520.26
119_Q144_D0.9520.26
34_F101_G0.9490.26
101_G292_L0.9470.26
96_E109_G0.9420.26
216_T270_F0.9420.26
104_L260_P0.9400.26
80_L90_R0.9340.26
197_A207_V0.9330.26
100_I136_Q0.9330.26
83_F345_I0.9330.26
41_S248_L0.9280.25
201_G210_M0.9280.25
50_S220_T0.9260.25
38_R170_T0.9260.25
191_A204_T0.9250.25
40_Q187_N0.9230.25
163_F231_M0.9220.25
76_L334_K0.9200.25
326_R352_I0.9170.25
275_I341_Q0.9150.25
283_A292_L0.9120.25
126_Q140_L0.9110.25
68_P327_L0.9100.25
241_V271_L0.9090.25
40_Q175_F0.9090.25
205_V239_G0.9050.25
126_Q223_Y0.9040.24
221_A231_M0.8980.24
159_C219_I0.8950.24
27_A356_T0.8940.24
201_G222_R0.8930.24
46_A85_I0.8920.24
55_V153_A0.8900.24
146_I159_C0.8900.24
50_S77_A0.8860.24
52_L130_D0.8860.24
134_F339_L0.8820.24
56_C211_A0.8790.24
133_L209_L0.8780.24
239_G291_R0.8750.23
132_F182_P0.8730.23
271_L357_S0.8730.23
115_L144_D0.8720.23
77_A164_K0.8700.23
175_F358_K0.8690.23
186_L238_T0.8690.23
50_S147_L0.8650.23
341_Q349_E0.8640.23
47_M167_T0.8640.23
88_I162_F0.8610.23
282_L319_E0.8590.23
283_A346_E0.8580.23
199_V283_A0.8580.23
137_A258_T0.8580.23
48_A208_I0.8570.23
60_L66_S0.8550.23
126_Q260_P0.8520.23
287_I323_K0.8480.22
105_S300_Q0.8470.22
298_R342_E0.8470.22
145_I198_V0.8440.22
136_Q213_M0.8420.22
319_E333_L0.8420.22
184_R357_S0.8420.22
85_I178_G0.8390.22
90_R280_R0.8370.22
333_L349_E0.8330.22
233_I253_M0.8310.22
272_F276_C0.8300.22
237_I241_V0.8290.22
245_A330_S0.8270.22
156_L351_G0.8270.22
40_Q222_R0.8260.22
118_I134_F0.8240.22
104_L201_G0.8240.22
37_L108_F0.8210.22
161_V239_G0.8190.21
245_A265_S0.8180.21
145_I366_T0.8160.21
112_I261_L0.8160.21
89_P116_T0.8150.21
81_G208_I0.8140.21
310_E367_A0.8050.21
306_Y360_I0.8050.21
128_G202_L0.8010.21
274_M319_E0.8000.21
55_V70_F0.7960.21
239_G280_R0.7950.21
197_A270_F0.7940.21
119_Q250_S0.7910.21
52_L101_G0.7890.20
103_V224_W0.7870.20
166_F192_C0.7860.20
17_V345_I0.7820.20
58_A176_A0.7780.20
144_D207_V0.7780.20
175_F183_V0.7770.20
137_A260_P0.7740.20
57_L291_R0.7730.20
145_I355_I0.7720.20
93_K127_S0.7720.20
60_L119_Q0.7700.20
35_V210_M0.7700.20
133_L141_V0.7690.20
213_M243_G0.7670.20
40_Q353_W0.7660.20
140_L149_A0.7650.20
101_G170_T0.7650.20
39_K227_R0.7640.20
157_L280_R0.7590.20
187_N270_F0.7570.19
321_V339_L0.7570.19
237_I268_L0.7550.19
50_S161_V0.7530.19
271_L351_G0.7530.19
196_C337_N0.7510.19
231_M239_G0.7500.19
31_L232_I0.7490.19
50_S107_F0.7480.19
249_L276_C0.7470.19
227_R274_M0.7450.19
277_A284_A0.7440.19
152_S159_C0.7440.19
42_L216_T0.7390.19
156_L298_R0.7380.19
295_R299_E0.7380.19
76_L338_D0.7370.19
53_P134_F0.7360.19
286_A290_M0.7330.19
111_G242_S0.7330.19
115_L128_G0.7290.19
154_V241_V0.7230.18
198_V207_V0.7230.18
41_S179_L0.7200.18
72_L241_V0.7200.18
228_L345_I0.7190.18
102_I269_L0.7160.18
25_G201_G0.7150.18
150_G333_L0.7140.18
279_K333_L0.7130.18
98_S194_I0.7130.18
227_R240_G0.7120.18
198_V204_T0.7100.18
162_F321_V0.7090.18
23_L85_I0.7080.18
168_L343_R0.7070.18
237_I337_N0.7040.18
81_G105_S0.7030.18
71_L173_L0.7030.18
74_A78_G0.7030.18
105_S128_G0.7020.18
85_I163_F0.7010.18
234_I288_R0.7010.18
41_S223_Y0.7000.18
44_G214_L0.6990.18
35_V81_G0.6990.18
105_S201_G0.6980.18
227_R230_G0.6970.18
81_G222_R0.6950.18
63_G271_L0.6920.17
47_M188_G0.6850.17
263_I273_S0.6840.17
283_A294_R0.6810.17
82_T99_A0.6810.17
45_D128_G0.6810.17
47_M78_G0.6810.17
48_A219_I0.6800.17
304_A324_K0.6770.17
90_R185_F0.6760.17
170_T241_V0.6750.17
234_I267_T0.6740.17
150_G200_I0.6730.17
123_A243_G0.6730.17
29_G253_M0.6720.17
61_F67_L0.6680.17
186_L207_V0.6680.17
146_I345_I0.6660.17
164_K181_I0.6630.17
178_G286_A0.6580.17
81_G104_L0.6550.16
28_S113_I0.6540.16
103_V205_V0.6540.16
96_E194_I0.6500.16
24_L128_G0.6490.16
296_T310_E0.6460.16
88_I233_I0.6460.16
28_S31_L0.6440.16
173_L271_L0.6440.16
154_V349_E0.6440.16
357_S361_E0.6440.16
103_V272_F0.6420.16
77_A173_L0.6400.16
153_A313_N0.6390.16
60_L190_L0.6360.16
140_L353_W0.6360.16
31_L159_C0.6340.16
216_T266_A0.6330.16
257_A260_P0.6320.16
165_E181_I0.6320.16
86_Q304_A0.6310.16
87_L248_L0.6280.16
99_A137_A0.6280.16
323_K357_S0.6270.16
105_S141_V0.6270.16
150_G361_E0.6250.16
148_I270_F0.6240.16
80_L98_S0.6240.16
154_V357_S0.6240.16
84_C367_A0.6240.16
55_V198_V0.6240.16
128_G260_P0.6230.16
94_T275_I0.6200.16
20_G137_A0.6190.15
26_T236_G0.6180.15
96_E214_L0.6180.15
178_G196_C0.6170.15
40_Q107_F0.6150.15
238_T269_L0.6150.15
116_T203_Q0.6120.15
270_F296_T0.6120.15
56_C187_N0.6110.15
58_A358_K0.6100.15
111_G207_V0.6060.15
137_A207_V0.6050.15
24_L200_I0.6050.15
95_K99_A0.6030.15
41_S66_S0.6030.15
55_V164_K0.6020.15
131_S138_A0.6020.15
201_G224_W0.6010.15
319_E334_K0.6000.15
46_A100_I0.6000.15
31_L59_F0.5990.15
56_C125_S0.5980.15
26_T358_K0.5970.15
56_C126_Q0.5960.15
66_S241_V0.5960.15
81_G195_V0.5950.15
100_I114_L0.5920.15
173_L272_F0.5900.15
236_G284_A0.5890.15
24_L56_C0.5880.15
134_F138_A0.5870.15
34_F45_D0.5870.15
107_F200_I0.5860.15
45_D126_Q0.5860.15
245_A323_K0.5860.15
349_E357_S0.5850.15
157_L362_K0.5850.15
257_A300_Q0.5830.15
109_G225_T0.5830.15
233_I349_E0.5820.15
99_A205_V0.5820.15
31_L82_T0.5760.14
88_I296_T0.5750.14
118_I260_P0.5720.14
104_L257_A0.5700.14
140_L191_A0.5650.14
50_S259_G0.5650.14
301_V326_R0.5630.14
41_S213_M0.5620.14
207_V260_P0.5620.14
267_T327_L0.5620.14
309_Y363_G0.5610.14
84_C249_L0.5600.14
35_V41_S0.5590.14
53_P106_V0.5580.14
52_L115_L0.5570.14
205_V231_M0.5560.14
128_G201_G0.5550.14
188_G222_R0.5550.14
71_L76_L0.5540.14
115_L203_Q0.5520.14
49_H171_F0.5510.14
163_F331_L0.5510.14
98_S212_A0.5500.14
128_G144_D0.5480.14
184_R351_G0.5470.14
137_A277_A0.5460.14
25_G128_G0.5460.14
80_L349_E0.5460.14
45_D306_Y0.5450.14
216_T261_L0.5410.14
31_L148_I0.5410.14
22_L328_S0.5400.14
24_L40_Q0.5400.14
18_L247_T0.5380.13
109_G214_L0.5380.13
237_I354_Q0.5360.13
226_E242_S0.5350.13
26_T237_I0.5340.13
161_V220_T0.5320.13
138_A262_M0.5320.13
60_L175_F0.5320.13
110_V341_Q0.5240.13
18_L244_V0.5230.13
116_T259_G0.5230.13
44_G182_P0.5220.13
107_F183_V0.5220.13
46_A243_G0.5170.13
222_R273_S0.5170.13
304_A367_A0.5170.13
182_P215_I0.5170.13
43_I360_I0.5160.13
52_L296_T0.5150.13
30_V237_I0.5130.13
128_G195_V0.5120.13
57_L361_E0.5120.13
101_G126_Q0.5110.13
220_T335_A0.5100.13
30_V35_V0.5090.13
194_I207_V0.5080.13
102_I204_T0.5080.13
31_L345_I0.5070.13
162_F274_M0.5060.13
65_K128_G0.5050.13
85_I150_G0.5040.13
72_L354_Q0.5030.13
272_F311_K0.5030.13
319_E350_N0.5000.13
26_T331_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.5954 100 0.789 Contact Map
2qi9A 2 0.6184 100 0.791 Contact Map
4g1uA 2 0.577 100 0.803 Contact Map
1fx7A 4 0.331 99.9 0.866 Contact Map
3hrsA 2 0.3218 99.9 0.867 Contact Map
2qq9A 2 0.3149 99.9 0.867 Contact Map
4o5vA 2 0.3241 99.8 0.871 Contact Map
2x4hA 3 0.2989 99.5 0.901 Contact Map
1on2A 2 0.308 99.4 0.907 Contact Map
2p8tA 1 0.2897 99.1 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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