GREMLIN Database
SODF - Probable superoxide dismutase [Fe]
UniProt: O35023 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (218)
Sequences: 305 (234)
Seq/√Len: 15.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_M178_S4.3471.00
171_L267_E4.1871.00
100_I245_Q3.9761.00
249_D252_S3.9321.00
123_L142_L3.8961.00
97_S245_Q3.6021.00
97_S100_I3.4980.99
232_L266_A3.2990.99
246_Y256_H3.2490.99
122_E125_K3.1800.99
110_Q114_D2.7550.97
99_D247_K2.6560.96
185_F189_F2.6560.96
166_R183_S2.6300.96
172_F176_D2.5770.95
160_H262_D2.5650.95
108_H243_Y2.3720.93
191_Q194_K2.1890.89
158_S265_E2.1670.89
252_S255_D2.1650.89
100_I247_K2.1430.88
157_F265_E2.0450.86
115_G145_H2.0180.85
135_I142_L1.9790.84
103_L246_Y1.9060.82
123_L135_I1.8500.80
98_R102_I1.8440.79
105_H149_H1.8080.78
184_A187_E1.7140.74
148_G221_H1.6820.72
174_M270_F1.6430.71
170_A274_K1.5860.68
152_H236_D1.5650.67
202_A254_V1.5170.64
265_E268_K1.5150.64
189_F235_L1.4960.63
109_H156_W1.4720.62
159_M257_W1.4620.61
178_S213_L1.4610.61
101_M148_G1.4590.61
80_H120_E1.4570.61
144_F197_E1.4440.60
147_A222_Q1.4320.60
193_S235_L1.4320.60
151_L203_I1.4280.59
107_K248_N1.4250.59
167_P182_Y1.4170.59
237_V250_R1.3980.58
82_L112_Y1.3940.58
160_H264_R1.3900.57
149_H153_S1.3790.57
90_S98_R1.3680.56
233_L266_A1.3540.55
104_H152_H1.3480.55
165_R250_R1.3360.54
164_K182_Y1.3160.53
106_T110_Q1.3000.52
221_H234_P1.2890.52
107_K110_Q1.2860.51
109_H149_H1.2720.51
59_Y62_I1.2700.50
193_S202_A1.2590.50
147_A234_P1.2440.49
143_A221_H1.2430.49
243_Y248_N1.2290.48
193_S254_V1.2270.48
104_H236_D1.2270.48
187_E191_Q1.2170.47
95_Y259_N1.2010.46
251_A255_D1.1970.46
203_I227_W1.1930.46
89_Y101_M1.1920.46
101_M155_F1.1810.45
204_L213_L1.1800.45
103_L247_K1.1740.45
178_S212_R1.1670.45
147_A225_S1.1650.44
194_K251_A1.1620.44
96_I101_M1.1610.44
97_S158_S1.1440.43
100_I199_V1.1240.42
108_H241_A1.1220.42
207_A210_S1.1200.42
197_E224_F1.1090.41
195_K245_Q1.0990.41
112_Y236_D1.0910.40
146_G154_I1.0890.40
97_S195_K1.0860.40
82_L109_H1.0860.40
225_S229_V1.0800.40
147_A221_H1.0740.39
143_A222_Q1.0660.39
71_R173_Q1.0610.39
160_H163_G1.0520.38
235_L254_V1.0480.38
166_R176_D1.0480.38
194_K254_V1.0420.38
105_H153_S1.0350.37
104_H112_Y1.0330.37
119_A148_G1.0310.37
112_Y152_H1.0240.37
83_P149_H1.0200.36
165_R182_Y1.0150.36
235_L257_W1.0080.36
159_M261_V1.0010.35
111_S115_G0.9970.35
97_S247_K0.9970.35
218_A229_V0.9920.35
82_L156_W0.9900.35
196_V219_E0.9850.35
70_E74_Y0.9790.34
145_H250_R0.9760.34
151_L221_H0.9730.34
82_L113_V0.9680.34
144_F224_F0.9650.33
165_R266_A0.9620.33
220_K254_V0.9590.33
147_A229_V0.9560.33
174_M262_D0.9540.33
166_R173_Q0.9370.32
125_K129_T0.9340.32
168_T251_A0.9330.32
108_H111_S0.9320.32
88_K91_A0.9190.31
89_Y260_V0.9180.31
154_I265_E0.9180.31
96_I119_A0.9130.31
150_Y195_K0.9100.31
111_S251_A0.9080.31
174_M177_L0.9060.31
190_T194_K0.9030.30
220_K223_L0.8960.30
268_K272_Q0.8930.30
100_I103_L0.8880.30
137_H140_R0.8810.29
87_Y93_E0.8790.29
158_S234_P0.8740.29
94_P156_W0.8660.29
199_V220_K0.8640.28
245_Q260_V0.8610.28
209_R228_D0.8590.28
99_D246_Y0.8570.28
196_V237_V0.8530.28
187_E272_Q0.8510.28
59_Y66_D0.8470.28
227_W251_A0.8430.28
105_H113_V0.8380.27
205_V235_L0.8370.27
166_R172_F0.8340.27
64_E128_A0.8300.27
108_H248_N0.8290.27
119_A146_G0.8270.27
71_R271_E0.8240.27
71_R162_N0.8210.27
80_H116_L0.8200.26
97_S199_V0.8190.26
143_A226_Q0.8160.26
63_T66_D0.8160.26
93_E269_R0.8110.26
64_E251_A0.8080.26
84_K166_R0.8070.26
61_D64_E0.8070.26
218_A222_Q0.8040.26
112_Y148_G0.8030.26
97_S223_L0.8000.26
65_S187_E0.7970.25
139_E142_L0.7940.25
96_I244_L0.7920.25
179_F213_L0.7750.24
207_A214_E0.7730.24
122_E126_A0.7600.24
108_H112_Y0.7600.24
143_A148_G0.7590.24
79_K121_S0.7580.24
183_S187_E0.7500.23
173_Q176_D0.7480.23
147_A223_L0.7480.23
256_H259_N0.7470.23
72_R271_E0.7470.23
181_S198_G0.7460.23
62_I69_S0.7450.23
205_V228_D0.7430.23
83_P258_W0.7360.23
114_D228_D0.7310.23
170_A252_S0.7290.23
104_H108_H0.7280.23
101_M119_A0.7230.22
123_L217_T0.7180.22
92_L269_R0.7140.22
211_G247_K0.7110.22
85_L89_Y0.7110.22
67_D71_R0.7030.22
154_I245_Q0.7000.21
65_S175_I0.6980.21
66_D72_R0.6960.21
147_A218_A0.6900.21
170_A270_F0.6890.21
176_D181_S0.6870.21
217_T226_Q0.6850.21
252_S259_N0.6840.21
83_P113_V0.6780.21
154_I234_P0.6780.21
201_W241_A0.6770.21
87_Y92_L0.6760.21
100_I250_R0.6720.20
199_V243_Y0.6700.20
99_D103_L0.6700.20
70_E183_S0.6690.20
83_P153_S0.6670.20
123_L144_F0.6640.20
245_Q256_H0.6600.20
152_H240_H0.6590.20
112_Y185_F0.6580.20
153_S276_V0.6530.20
199_V223_L0.6500.20
97_S131_N0.6480.19
147_A220_K0.6470.19
185_F227_W0.6460.19
138_W146_G0.6440.19
60_R63_T0.6430.19
62_I72_R0.6430.19
170_A174_M0.6430.19
108_H156_W0.6420.19
76_P215_I0.6420.19
151_L220_K0.6410.19
123_L126_A0.6410.19
216_L226_Q0.6400.19
61_D268_K0.6390.19
63_T73_A0.6380.19
90_S162_N0.6340.19
97_S250_R0.6320.19
237_V254_V0.6310.19
67_D172_F0.6310.19
108_H250_R0.6300.19
78_G85_L0.6250.19
179_F235_L0.6240.19
219_E226_Q0.6220.19
64_E170_A0.6190.18
148_G222_Q0.6180.18
101_M221_H0.6170.18
167_P172_F0.6130.18
133_D195_K0.6130.18
173_Q271_E0.6100.18
63_T168_T0.6080.18
95_Y275_E0.6080.18
157_F266_A0.6060.18
203_I234_P0.6060.18
193_S196_V0.6060.18
204_L231_P0.6020.18
246_Y254_V0.6000.18
173_Q183_S0.5950.18
232_L235_L0.5930.18
211_G249_D0.5920.18
126_A267_E0.5920.18
68_T255_D0.5890.17
238_W243_Y0.5890.17
154_I221_H0.5880.17
109_H131_N0.5840.17
113_V149_H0.5830.17
90_S183_S0.5830.17
86_P175_I0.5790.17
112_Y243_Y0.5720.17
61_D67_D0.5710.17
154_I249_D0.5700.17
63_T68_T0.5700.17
185_F235_L0.5680.17
77_I81_V0.5680.17
151_L197_E0.5660.17
196_V224_F0.5650.17
83_P109_H0.5630.17
218_A225_S0.5610.17
151_L222_Q0.5610.17
272_Q275_E0.5600.16
59_Y69_S0.5590.16
91_A244_L0.5570.16
254_V260_V0.5570.16
131_N262_D0.5550.16
167_P171_L0.5540.16
87_Y244_L0.5540.16
104_H243_Y0.5530.16
86_P155_F0.5520.16
108_H152_H0.5510.16
241_A244_L0.5500.16
211_G252_S0.5500.16
177_L187_E0.5480.16
210_S267_E0.5470.16
109_H248_N0.5470.16
65_S70_E0.5470.16
164_K192_A0.5470.16
80_H224_F0.5430.16
193_S228_D0.5410.16
82_L161_P0.5400.16
126_A130_K0.5400.16
257_W261_V0.5390.16
157_F268_K0.5370.16
82_L94_P0.5370.16
129_T173_Q0.5370.16
59_Y65_S0.5330.16
209_R261_V0.5330.16
73_A215_I0.5330.16
65_S68_T0.5330.16
175_I242_Y0.5330.16
194_K199_V0.5300.16
107_K112_Y0.5280.15
73_A268_K0.5280.15
126_A132_Y0.5280.15
184_A251_A0.5270.15
163_G192_A0.5270.15
95_Y133_D0.5260.15
144_F225_S0.5250.15
186_K255_D0.5210.15
150_Y228_D0.5210.15
74_Y211_G0.5200.15
74_Y172_F0.5190.15
60_R162_N0.5190.15
251_A272_Q0.5180.15
264_R271_E0.5140.15
174_M233_L0.5140.15
64_E68_T0.5130.15
81_V255_D0.5120.15
199_V245_Q0.5110.15
60_R172_F0.5110.15
159_M197_E0.5090.15
89_Y96_I0.5070.15
185_F269_R0.5050.15
152_H242_Y0.5020.15
264_R267_E0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ak2A 4 0.7367 100 0.24 Contact Map
1b06A 4 0.7224 100 0.241 Contact Map
1pl4A 4 0.6975 100 0.244 Contact Map
1gv3A 2 0.7331 100 0.247 Contact Map
3tjtA 2 0.694 100 0.248 Contact Map
1bsmA 4 0.7082 100 0.248 Contact Map
1mngA 3 0.6797 100 0.249 Contact Map
2rcvA 2 0.6868 100 0.25 Contact Map
2cw2A 2 0.7046 100 0.251 Contact Map
1idsA 4 0.7046 100 0.252 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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