GREMLIN Database
AZOR1 - FMN-dependent NADH-azoreductase 1
UniProt: O35022 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (187)
Sequences: 4956 (3548)
Seq/√Len: 259.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_T38_E3.8361.00
40_V89_K3.3661.00
40_V86_Q2.9091.00
25_A198_L2.8861.00
42_L86_Q2.8271.00
51_Y106_A2.7511.00
3_T40_V2.6971.00
123_K130_V2.5981.00
88_V120_V2.5511.00
26_F141_L2.4111.00
24_E28_A2.3371.00
85_N89_K2.3081.00
138_V167_L2.2511.00
43_D46_K2.1541.00
51_Y110_T2.1111.00
140_L177_T2.0201.00
4_V37_D2.0091.00
3_T89_K1.9861.00
6_F27_L1.9591.00
187_P191_Q1.9261.00
9_S107_V1.8131.00
81_D85_N1.7841.00
8_K23_Y1.7521.00
92_K139_A1.7431.00
84_L120_V1.7311.00
116_S170_W1.7301.00
112_V166_V1.7121.00
138_V172_V1.6721.00
19_S143_A1.6601.00
29_A202_K1.6311.00
104_V162_F1.6241.00
23_Y96_A1.5801.00
8_K41_E1.5761.00
50_P53_G1.5601.00
25_A29_A1.5381.00
26_F30_Y1.5041.00
191_Q195_E1.4931.00
195_E198_L1.4921.00
8_K20_T1.4801.00
27_L31_K1.4751.00
85_N88_V1.4741.00
112_V116_S1.4681.00
25_A28_A1.4671.00
93_V138_V1.4571.00
11_D100_W1.4271.00
79_I82_K1.4221.00
30_Y37_D1.3701.00
92_K137_K1.3611.00
85_N120_V1.3571.00
87_F115_L1.3241.00
125_T128_G1.3201.00
45_H107_V1.3121.00
28_A31_K1.3031.00
28_A32_E1.2941.00
93_V172_V1.2881.00
84_L121_T1.2811.00
190_A194_V1.2731.00
137_K176_H1.2531.00
116_S166_V1.2521.00
29_A32_E1.2441.00
157_E161_N1.2421.00
4_V30_Y1.2391.00
6_F24_E1.2371.00
12_R16_E1.2351.00
4_V92_K1.2151.00
123_K132_L1.1951.00
29_A33_N1.1661.00
133_M172_V1.1551.00
109_H113_D1.1521.00
6_F23_Y1.1491.00
19_S96_A1.1481.00
102_F169_F1.1451.00
47_E83_Y1.1441.00
9_S108_L1.1381.00
23_Y41_E1.1281.00
25_A202_K1.1261.00
151_G154_A1.1191.00
90_A93_V1.0991.00
47_E82_K1.0941.00
22_L201_A1.0931.00
87_F93_V1.0921.00
160_L164_K1.0881.00
88_V133_M1.0881.00
199_Q202_K1.0781.00
137_K174_D1.0671.00
115_L170_W1.0631.00
186_A189_Q1.0581.00
189_Q192_E1.0481.00
125_T130_V1.0471.00
37_D92_K1.0471.00
164_K168_G1.0461.00
53_G56_M1.0461.00
11_D107_V1.0451.00
30_Y92_K1.0381.00
195_E199_Q1.0341.00
196_K200_E1.0251.00
6_F41_E1.0211.00
78_A82_K1.0181.00
81_D120_V1.0171.00
5_L86_Q1.0111.00
22_L143_A1.0101.00
18_V183_H1.0081.00
21_K198_L0.9971.00
198_L202_K0.9961.00
86_Q111_Y0.9931.00
26_F139_A0.9931.00
112_V162_F0.9861.00
97_F108_L0.9751.00
57_I61_F0.9721.00
51_Y114_Y0.9601.00
147_V181_E0.9551.00
101_N113_D0.9491.00
80_A117_R0.9461.00
147_V182_G0.9441.00
18_V190_A0.9401.00
83_Y111_Y0.9381.00
7_V95_F0.9361.00
110_T114_Y0.9241.00
144_R179_V0.9211.00
144_R181_E0.9181.00
158_M161_N0.9071.00
4_V94_V0.9071.00
21_K190_A0.9071.00
52_L56_M0.8891.00
42_L83_Y0.8891.00
95_F108_L0.8871.00
142_N179_V0.8851.00
49_L114_Y0.8841.00
18_V194_V0.8841.00
106_A110_T0.8821.00
24_E41_E0.8801.00
49_L110_T0.8781.00
5_L90_A0.8721.00
97_F140_L0.8651.00
31_K38_E0.8551.00
29_A198_L0.8520.99
91_D136_K0.8360.99
27_L41_E0.8350.99
42_L111_Y0.8340.99
84_L117_R0.8320.99
22_L141_L0.8240.99
28_A198_L0.8180.99
7_V44_L0.8150.99
81_D117_R0.8090.99
87_F111_Y0.8050.99
192_E196_K0.8040.99
130_V134_G0.8040.99
135_G174_D0.8030.99
79_I114_Y0.8010.99
188_D192_E0.7970.99
139_A178_V0.7880.99
40_V90_A0.7870.99
144_R159_S0.7860.99
80_A84_L0.7840.99
187_P190_A0.7840.99
124_Y129_P0.7810.99
148_Y156_L0.7770.99
158_M165_T0.7750.99
104_V108_L0.7740.99
194_V197_G0.7670.99
75_K78_A0.7640.99
18_V180_I0.7630.99
56_M114_Y0.7600.99
61_F64_G0.7590.99
26_F94_V0.7550.99
157_E160_L0.7540.99
33_N37_D0.7540.99
154_A157_E0.7520.99
195_E202_K0.7510.99
188_D191_Q0.7460.99
7_V42_L0.7370.99
51_Y107_V0.7330.98
8_K24_E0.7260.98
38_E89_K0.7240.98
18_V21_K0.7230.98
99_L144_R0.7230.98
123_K126_Q0.7200.98
12_R58_N0.7190.98
100_W105_P0.7180.98
141_L197_G0.7150.98
99_L159_S0.7120.98
82_K85_N0.7120.98
56_M60_T0.7050.98
155_A161_N0.6950.98
198_L201_A0.6940.98
80_A114_Y0.6840.98
87_F133_M0.6820.98
21_K194_V0.6800.98
101_N122_F0.6800.98
141_L178_V0.6750.97
102_F165_T0.6740.97
140_L167_L0.6740.97
98_P105_P0.6710.97
112_V163_M0.6700.97
95_F167_L0.6630.97
79_I83_Y0.6620.97
20_T23_Y0.6570.97
12_R15_E0.6490.97
148_Y181_E0.6490.97
82_K86_Q0.6470.97
193_I196_K0.6440.97
3_T91_D0.6430.97
144_R148_Y0.6400.96
26_F92_K0.6360.96
44_L107_V0.6340.96
104_V166_V0.6320.96
47_E86_Q0.6310.96
100_W107_V0.6270.96
106_A114_Y0.6230.96
167_L175_L0.6200.96
53_G76_Q0.6150.96
3_T90_A0.6150.96
15_E46_K0.6150.96
137_K172_V0.6140.96
6_F96_A0.6130.95
147_V150_E0.6120.95
9_S45_H0.6110.95
57_I60_T0.6080.95
99_L142_N0.6070.95
22_L180_I0.6040.95
103_T162_F0.6040.95
59_G62_K0.6040.95
97_F159_S0.6030.95
164_K177_T0.6010.95
95_F163_M0.6010.95
59_G77_A0.6010.95
83_Y86_Q0.6000.95
47_E79_I0.5940.95
168_G175_L0.5940.95
161_N165_T0.5920.95
190_A193_I0.5900.94
25_A194_V0.5890.94
5_L42_L0.5860.94
23_Y27_L0.5850.94
49_L79_I0.5850.94
158_M162_F0.5820.94
103_T109_H0.5760.94
56_M77_A0.5750.94
8_K43_D0.5740.94
162_F166_V0.5720.93
156_L165_T0.5660.93
12_R54_R0.5630.93
127_E130_V0.5630.93
87_F170_W0.5610.93
50_P79_I0.5600.93
144_R151_G0.5600.93
129_P169_F0.5570.93
8_K96_A0.5560.93
105_P110_T0.5520.92
44_L83_Y0.5510.92
18_V184_N0.5490.92
86_Q89_K0.5480.92
152_P156_L0.5430.92
96_A141_L0.5420.92
84_L88_V0.5400.91
102_F146_G0.5390.91
123_K127_E0.5360.91
78_A81_D0.5350.91
142_N159_S0.5340.91
186_A193_I0.5260.90
97_F105_P0.5240.90
15_E54_R0.5240.90
84_L115_L0.5230.90
21_K25_A0.5230.90
166_V170_W0.5210.90
99_L148_Y0.5190.90
58_N61_F0.5180.90
189_Q193_I0.5160.89
176_H200_E0.5140.89
196_K199_Q0.5140.89
81_D84_L0.5130.89
58_N62_K0.5120.89
143_A183_H0.5120.89
155_A160_L0.5070.89
20_T24_E0.5060.89
178_V196_K0.5040.88
7_V111_Y0.5020.88
192_E195_E0.5020.88
168_G172_V0.5010.88
191_Q194_V0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w77A 2 0.9952 100 0.336 Contact Map
3w7aA 2 0.9952 100 0.343 Contact Map
2hpvA 2 0.9712 100 0.356 Contact Map
1d4aA 2 0.9808 100 0.37 Contact Map
3u7iA 2 0.9904 100 0.373 Contact Map
4n65A 2 0.9663 100 0.381 Contact Map
4c0xA 2 0.9567 100 0.386 Contact Map
1t5bA 2 0.9567 100 0.387 Contact Map
4gi5A 2 0.9808 100 0.395 Contact Map
4fglA 2 0.9808 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.