GREMLIN Database
LMRB - Lincomycin resistance protein LmrB
UniProt: O35018 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (442)
Sequences: 34884 (25423)
Seq/√Len: 1209.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_P107_F5.1811.00
93_I181_L4.4531.00
91_F118_G3.7621.00
100_A175_W3.5591.00
98_I111_A3.3091.00
106_S110_A3.1321.00
214_G248_L3.0671.00
353_F369_L2.9741.00
392_L400_G2.8881.00
210_L254_R2.8761.00
81_T132_V2.7541.00
15_V138_K2.7251.00
104_S107_F2.6491.00
60_G113_I2.6201.00
266_R396_F2.5321.00
319_L371_T2.4371.00
213_I247_G2.4091.00
323_M375_I2.3901.00
206_L254_R2.3781.00
221_G241_L2.3411.00
64_V113_I2.3241.00
456_V460_I2.3111.00
86_T189_I2.2861.00
49_I105_F2.2591.00
305_T308_A2.2561.00
168_L172_W2.2441.00
95_G118_G2.1831.00
68_L117_L2.1711.00
218_I244_G2.1451.00
393_P396_F2.0861.00
99_A111_A2.0841.00
281_F411_A2.0721.00
50_T53_T2.0581.00
249_I253_I2.0451.00
264_N396_F2.0131.00
186_V190_A2.0111.00
86_T185_L1.9901.00
164_V172_W1.9681.00
138_K141_A1.9661.00
285_M415_G1.9321.00
238_I242_I1.9151.00
107_F111_A1.8851.00
95_G114_V1.8751.00
350_V373_L1.8651.00
169_N172_W1.8611.00
23_L149_V1.8571.00
25_A85_F1.8511.00
204_D207_S1.8251.00
225_A232_W1.8211.00
188_G192_M1.8171.00
348_T463_I1.8141.00
299_Q309_S1.8071.00
39_A165_L1.8021.00
355_S456_V1.8011.00
88_S121_L1.7831.00
72_S121_L1.7371.00
134_F142_A1.7231.00
53_T105_F1.7221.00
258_M261_P1.7211.00
105_F109_L1.7151.00
95_G111_A1.7141.00
97_F101_L1.6861.00
214_G244_G1.6661.00
97_F178_L1.6571.00
297_Y302_L1.6531.00
77_Q398_P1.6511.00
289_S419_A1.6501.00
49_I53_T1.6371.00
82_R86_T1.6351.00
448_T452_Q1.6331.00
352_W459_M1.6271.00
329_R333_K1.6201.00
166_E307_F1.6061.00
217_G240_S1.5881.00
344_F465_G1.5771.00
99_A108_L1.5661.00
288_L412_G1.5591.00
140_G332_D1.5471.00
60_G109_L1.5441.00
217_G247_G1.5401.00
18_I133_I1.5391.00
102_A107_F1.5231.00
27_F153_A1.5201.00
345_V466_L1.5181.00
96_T177_S1.5181.00
135_P138_K1.5161.00
239_V243_V1.5031.00
254_R258_M1.5001.00
42_D45_K1.4931.00
426_G430_Y1.4891.00
304_L312_V1.4651.00
57_L108_L1.4621.00
76_L81_T1.4601.00
346_I376_G1.4431.00
235_P239_V1.4431.00
86_T188_G1.4361.00
202_K260_Q1.4351.00
449_A453_H1.4321.00
214_G247_G1.4191.00
136_P139_R1.4171.00
131_L139_R1.4161.00
102_A111_A1.4151.00
16_M20_I1.4101.00
350_V376_G1.4071.00
364_V368_I1.4051.00
308_A311_L1.4041.00
19_M134_F1.4021.00
256_L266_R1.4011.00
44_M54_V1.3991.00
90_I185_L1.3901.00
251_F255_Q1.3891.00
426_G453_H1.3831.00
74_L78_W1.3821.00
39_A173_I1.3821.00
83_Q194_N1.3791.00
75_L84_L1.3781.00
343_G379_M1.3771.00
338_W341_I1.3761.00
87_V91_F1.3701.00
268_F274_I1.3701.00
172_W179_P1.3681.00
319_L323_M1.3671.00
67_I212_T1.3611.00
98_I107_F1.3561.00
348_T352_W1.3551.00
350_V369_L1.3541.00
93_I185_L1.3541.00
304_L308_A1.3531.00
76_L125_L1.3471.00
274_I278_I1.3401.00
32_S35_A1.3371.00
252_S256_L1.3331.00
362_T365_L1.3271.00
217_G243_V1.3221.00
61_Y119_T1.3221.00
276_G388_G1.3111.00
286_V462_A1.3111.00
187_F191_Y1.3091.00
205_V209_I1.3061.00
68_L120_G1.3001.00
220_F224_N1.2991.00
210_L247_G1.2891.00
163_L167_H1.2831.00
35_A173_I1.2751.00
363_A367_I1.2671.00
224_N230_G1.2631.00
15_V134_F1.2631.00
21_S191_Y1.2571.00
328_G332_D1.2511.00
106_S109_L1.2501.00
64_V116_A1.2501.00
453_H457_F1.2471.00
221_G244_G1.2361.00
316_G374_M1.2361.00
355_S459_M1.2351.00
343_G380_I1.2251.00
21_S184_A1.2231.00
347_V376_G1.2131.00
426_G429_D1.2041.00
244_G248_L1.1981.00
21_S187_F1.1951.00
253_I257_T1.1941.00
23_L145_T1.1941.00
94_L98_I1.1921.00
166_E305_T1.1871.00
348_T466_L1.1851.00
207_S254_R1.1841.00
329_R332_D1.1641.00
243_V247_G1.1541.00
347_V462_A1.1531.00
210_L250_L1.1481.00
323_M378_S1.1381.00
253_I256_L1.1381.00
345_V349_V1.1271.00
252_S265_L1.1251.00
348_T459_M1.1221.00
221_G237_V1.1211.00
80_T83_Q1.1131.00
82_R189_I1.1111.00
30_M150_I1.1081.00
56_W60_G1.1021.00
337_K341_I1.1021.00
73_G77_Q1.0981.00
271_P275_L1.0961.00
308_A312_V1.0941.00
463_I467_I1.0921.00
298_L366_I1.0881.00
99_A174_F1.0871.00
75_L79_F1.0871.00
86_T90_I1.0861.00
364_V367_I1.0851.00
24_L184_A1.0841.00
327_T379_M1.0771.00
182_V186_V1.0751.00
103_P106_S1.0721.00
266_R269_K1.0711.00
85_F188_G1.0661.00
32_S177_S1.0621.00
162_G306_A1.0611.00
335_G338_W1.0601.00
230_G236_T1.0581.00
93_I178_L1.0581.00
365_L369_L1.0551.00
453_H456_V1.0521.00
365_L368_I1.0511.00
130_I146_I1.0391.00
298_L312_V1.0391.00
277_V407_L1.0361.00
81_T194_N1.0331.00
93_I97_F1.0331.00
264_N399_D1.0321.00
459_M463_I1.0321.00
230_G237_V1.0311.00
89_L184_A1.0281.00
352_W356_N1.0271.00
270_Y274_I1.0211.00
368_I371_T1.0181.00
213_I217_G1.0151.00
101_L175_W1.0111.00
33_E62_L1.0081.00
460_I464_I1.0061.00
456_V459_M1.0041.00
341_I469_A1.0031.00
60_G64_V1.0021.00
131_L397_Y0.9991.00
263_M403_I0.9991.00
330_L334_Y0.9991.00
449_A452_Q0.9981.00
312_V363_A0.9971.00
91_F95_G0.9961.00
250_L253_I0.9961.00
137_H141_A0.9951.00
83_Q87_V0.9941.00
343_G376_G0.9931.00
338_W342_P0.9921.00
350_V372_C0.9921.00
273_F277_V0.9881.00
248_L252_S0.9831.00
352_W355_S0.9831.00
164_V168_L0.9821.00
110_A113_I0.9821.00
160_F163_L0.9801.00
207_S258_M0.9791.00
283_C380_I0.9771.00
35_A161_S0.9761.00
230_G234_S0.9751.00
71_V208_I0.9751.00
178_L182_V0.9731.00
427_Q431_M0.9691.00
430_Y433_T0.9661.00
28_I181_L0.9611.00
17_P191_Y0.9601.00
388_G404_M0.9601.00
344_F466_L0.9591.00
164_V176_I0.9541.00
325_P329_R0.9531.00
221_G240_S0.9521.00
452_Q456_V0.9511.00
342_P379_M0.9511.00
236_T240_S0.9441.00
273_F400_G0.9431.00
281_F407_L0.9401.00
430_Y434_V0.9401.00
42_D46_E0.9391.00
59_T223_S0.9391.00
358_T361_S0.9391.00
323_M327_T0.9361.00
77_Q81_T0.9351.00
98_I101_L0.9351.00
299_Q306_A0.9351.00
353_F356_N0.9321.00
107_F110_A0.9321.00
87_V90_I0.9311.00
163_L307_F0.9311.00
326_V329_R0.9311.00
430_Y449_A0.9301.00
270_Y393_P0.9291.00
233_S238_I0.9271.00
250_L254_R0.9271.00
450_G454_A0.9261.00
245_V249_I0.9241.00
203_I208_I0.9231.00
64_V68_L0.9231.00
58_T292_L0.9191.00
197_E200_K0.9181.00
368_I372_C0.9181.00
316_G373_L0.9151.00
323_M326_V0.9141.00
22_L126_M0.9131.00
270_Y396_F0.9131.00
224_N229_S0.9101.00
49_I54_V0.9081.00
279_M469_A0.9041.00
84_L87_V0.8981.00
451_V455_F0.8971.00
323_M379_M0.8941.00
236_T239_V0.8911.00
219_V413_A0.8881.00
271_P274_I0.8801.00
171_H175_W0.8791.00
356_N369_L0.8771.00
57_L105_F0.8761.00
185_L189_I0.8741.00
361_S365_L0.8661.00
298_L302_L0.8611.00
277_V403_I0.8601.00
342_P346_I0.8601.00
190_A193_Q0.8591.00
422_I457_F0.8571.00
88_S118_G0.8561.00
280_V404_M0.8561.00
357_V361_S0.8551.00
132_V397_Y0.8551.00
101_L111_A0.8551.00
355_S452_Q0.8541.00
110_A114_V0.8511.00
140_G328_G0.8491.00
43_L108_L0.8481.00
167_H307_F0.8471.00
208_I212_T0.8451.00
89_L185_L0.8391.00
311_L315_P0.8391.00
241_L245_V0.8371.00
84_L121_L0.8361.00
179_P182_V0.8331.00
209_I213_I0.8291.00
457_F461_V0.8261.00
140_G144_G0.8261.00
457_F460_I0.8241.00
348_T462_A0.8221.00
93_I182_V0.8201.00
103_P111_A0.8161.00
282_I465_G0.8141.00
275_L468_G0.8121.00
187_F190_A0.8091.00
36_L57_L0.8091.00
246_V250_L0.8081.00
341_I345_V0.8071.00
179_P183_L0.8061.00
422_I426_G0.8051.00
327_T378_S0.8041.00
103_P171_H0.8031.00
212_T216_G0.8021.00
256_L265_L0.7991.00
77_Q399_D0.7981.00
450_G453_H0.7971.00
339_L342_P0.7951.00
85_F129_T0.7951.00
349_V353_F0.7921.00
201_P260_Q0.7911.00
254_R257_T0.7901.00
83_Q86_T0.7881.00
79_F84_L0.7851.00
367_I371_T0.7831.00
318_I322_F0.7821.00
172_W175_W0.7821.00
351_L373_L0.7811.00
66_G413_A0.7771.00
40_L54_V0.7771.00
53_T106_S0.7751.00
359_T448_T0.7741.00
82_R194_N0.7711.00
128_N398_P0.7701.00
278_I468_G0.7701.00
202_K259_K0.7681.00
16_M134_F0.7671.00
81_T128_N0.7671.00
330_L339_L0.7671.00
131_L143_M0.7661.00
29_G122_L0.7661.00
270_Y391_Q0.7651.00
162_G310_G0.7631.00
217_G244_G0.7611.00
293_L420_V0.7601.00
460_I467_I0.7601.00
95_G98_I0.7591.00
186_V189_I0.7581.00
334_Y339_L0.7561.00
341_I466_L0.7541.00
298_L304_L0.7521.00
405_N408_Q0.7511.00
220_F240_S0.7501.00
126_M146_I0.7491.00
96_T115_Q0.7451.00
25_A89_L0.7441.00
331_F383_P0.7441.00
37_N58_T0.7441.00
418_V421_S0.7431.00
356_N365_L0.7421.00
21_S188_G0.7401.00
344_F380_I0.7401.00
465_G469_A0.7391.00
427_Q430_Y0.7391.00
222_F225_A0.7381.00
31_F35_A0.7361.00
130_I142_A0.7351.00
153_A157_G0.7341.00
213_I243_V0.7311.00
67_I216_G0.7301.00
272_M391_Q0.7301.00
261_P264_N0.7301.00
76_L128_N0.7271.00
90_I94_L0.7261.00
39_A43_L0.7251.00
245_V248_L0.7251.00
351_L355_S0.7241.00
464_I468_G0.7231.00
386_T390_N0.7211.00
26_G150_I0.7201.00
43_L54_V0.7201.00
344_F348_T0.7191.00
65_L409_Q0.7191.00
148_L152_F0.7191.00
232_W237_V0.7181.00
144_G148_L0.7171.00
127_F146_I0.7161.00
249_I252_S0.7161.00
357_V369_L0.7121.00
346_I372_C0.7091.00
166_E306_A0.7091.00
235_P238_I0.7091.00
345_V348_T0.7091.00
233_S236_T0.7071.00
46_E170_W0.7061.00
335_G339_L0.7061.00
25_A122_L0.7061.00
151_M320_N0.7061.00
379_M383_P0.7041.00
385_Q404_M0.7031.00
423_M454_A0.7031.00
312_V315_P0.7001.00
353_F365_L0.6991.00
207_S255_Q0.6991.00
18_I21_S0.6991.00
319_L375_I0.6991.00
293_L454_A0.6991.00
40_L58_T0.6991.00
295_P309_S0.6991.00
73_G402_A0.6961.00
234_S238_I0.6961.00
129_T133_I0.6951.00
334_Y338_W0.6951.00
43_L47_L0.6941.00
294_L370_H0.6941.00
273_F388_G0.6931.00
203_I207_S0.6931.00
296_M300_G0.6921.00
161_S165_L0.6921.00
46_E171_H0.6921.00
30_M153_A0.6921.00
157_G161_S0.6911.00
14_K17_P0.6901.00
389_L401_T0.6891.00
355_S358_T0.6891.00
234_S237_V0.6881.00
241_L244_G0.6881.00
214_G252_S0.6881.00
239_V242_I0.6871.00
461_V465_G0.6861.00
292_L416_T0.6861.00
411_A415_G0.6851.00
269_K274_I0.6831.00
342_P345_V0.6821.00
315_P319_L0.6821.00
92_S118_G0.6821.00
208_I262_M0.6811.00
243_V250_L0.6751.00
141_A329_R0.6731.00
322_F325_P0.6731.00
206_L209_I0.6711.00
100_A171_H0.6711.00
242_I246_V0.6701.00
65_L119_T0.6701.00
64_V117_L0.6681.00
215_F406_T0.6661.00
165_L168_L0.6651.00
326_V330_L0.6641.00
47_L105_F0.6641.00
226_G231_G0.6621.00
98_I114_V0.6611.00
70_P211_S0.6611.00
304_L363_A0.6611.00
99_A102_A0.6611.00
68_L71_V0.6601.00
331_F386_T0.6601.00
413_A417_A0.6591.00
81_T195_V0.6591.00
72_S88_S0.6591.00
43_L46_E0.6561.00
175_W179_P0.6551.00
206_L210_L0.6551.00
279_M468_G0.6541.00
237_V240_S0.6541.00
97_F175_W0.6531.00
165_L173_I0.6531.00
344_F462_A0.6521.00
285_M461_V0.6521.00
62_L412_G0.6511.00
354_F357_V0.6511.00
312_V367_I0.6481.00
374_M378_S0.6481.00
141_A145_T0.6471.00
32_S92_S0.6471.00
347_V350_V0.6461.00
112_R115_Q0.6451.00
155_A317_G0.6451.00
215_F410_M0.6431.00
247_G250_L0.6421.00
458_A462_A0.6421.00
139_R390_N0.6411.00
231_G234_S0.6381.00
177_S181_L0.6371.00
163_L168_L0.6361.00
417_A421_S0.6311.00
214_G217_G0.6301.00
421_S425_A0.6291.00
72_S124_P0.6281.00
331_F335_G0.6271.00
143_M147_G0.6271.00
419_A458_A0.6261.00
62_L413_A0.6251.00
351_L458_A0.6241.00
213_I216_G0.6241.00
27_F149_V0.6231.00
206_L258_M0.6191.00
158_P310_G0.6181.00
272_M276_G0.6181.00
211_S262_M0.6181.00
77_Q80_T0.6181.00
189_I193_Q0.6171.00
221_G225_A0.6161.00
150_I154_P0.6161.00
111_A114_V0.6151.00
234_S239_V0.6151.00
224_N237_V0.6121.00
45_K48_N0.6111.00
288_L291_M0.6111.00
141_A332_D0.6081.00
19_M142_A0.6071.00
132_V195_V0.6061.00
202_K206_L0.6061.00
274_I277_V0.6051.00
272_M387_N0.6051.00
307_F311_L0.6041.00
272_M275_L0.6021.00
82_R193_Q0.6021.00
297_Y301_G0.6011.00
133_I193_Q0.6001.00
287_I377_I0.5991.00
175_W178_L0.5971.00
196_S199_T0.5971.00
281_F414_I0.5971.00
28_I32_S0.5971.00
311_L314_L0.5971.00
22_L133_I0.5941.00
351_L462_A0.5921.00
341_I348_T0.5901.00
14_K193_Q0.5901.00
268_F273_F0.5891.00
349_V352_W0.5891.00
66_G410_M0.5891.00
54_V57_L0.5891.00
429_D433_T0.5871.00
279_M344_F0.5861.00
448_T451_V0.5861.00
143_M386_T0.5851.00
131_L389_L0.5841.00
346_I375_I0.5831.00
76_L398_P0.5831.00
294_L298_L0.5831.00
277_V404_M0.5821.00
149_V153_A0.5811.00
341_I344_F0.5791.00
367_I370_H0.5791.00
89_L181_L0.5791.00
17_P20_I0.5771.00
156_I159_T0.5771.00
67_I208_I0.5761.00
66_G409_Q0.5741.00
279_M384_A0.5701.00
137_H140_G0.5691.00
95_G115_Q0.5681.00
194_N197_E0.5651.00
128_N401_T0.5651.00
427_Q450_G0.5641.00
339_L379_M0.5631.00
419_A454_A0.5631.00
242_I245_V0.5611.00
33_E408_Q0.5601.00
389_L397_Y0.5601.00
211_S251_F0.5591.00
137_H332_D0.5591.00
214_G218_I0.5571.00
416_T420_V0.5561.00
28_I177_S0.5551.00
32_S112_R0.5551.00
153_A158_P0.5541.00
267_A273_F0.5541.00
431_M434_V0.5541.00
44_M50_T0.5521.00
251_F263_M0.5521.00
224_N236_T0.5511.00
44_M49_I0.5501.00
183_L187_F0.5501.00
290_S373_L0.5491.00
423_M426_G0.5491.00
159_T314_L0.5481.00
79_F83_Q0.5481.00
316_G370_H0.5481.00
415_G418_V0.5481.00
16_M142_A0.5471.00
61_Y112_R0.5451.00
343_G350_V0.5451.00
225_A237_V0.5451.00
34_T154_P0.5431.00
244_G247_G0.5431.00
99_A115_Q0.5401.00
454_A458_A0.5391.00
424_A427_Q0.5381.00
69_V405_N0.5351.00
421_S424_A0.5341.00
356_N359_T0.5331.00
388_G391_Q0.5311.00
147_G151_M0.5301.00
73_G125_L0.5301.00
256_L259_K0.5291.00
78_W202_K0.5271.00
294_L455_F0.5261.00
353_F368_I0.5261.00
85_F126_M0.5251.00
16_M141_A0.5251.00
319_L322_F0.5251.00
54_V105_F0.5241.00
34_T157_G0.5231.00
78_W200_K0.5211.00
56_W63_L0.5211.00
214_G249_I0.5211.00
27_F31_F0.5191.00
165_L306_A0.5181.00
211_S215_F0.5171.00
96_T178_L0.5171.00
220_F230_G0.5161.00
375_I379_M0.5151.00
458_A461_V0.5141.00
205_V208_I0.5101.00
43_L165_L0.5101.00
426_G450_G0.5091.00
32_S36_L0.5061.00
152_F156_I0.5061.00
455_F462_A0.5061.00
151_M324_S0.5051.00
255_Q262_M0.5041.00
81_T129_T0.5041.00
16_M138_K0.5031.00
159_T311_L0.5031.00
225_A230_G0.5021.00
369_L372_C0.5021.00
164_V173_I0.5021.00
226_G229_S0.5021.00
280_V384_A0.5011.00
193_Q196_S0.5011.00
314_L317_G0.5001.00
371_T375_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8497 100 0.365 Contact Map
4j05A 3 0.7724 100 0.386 Contact Map
4pypA 1 0.8706 100 0.406 Contact Map
2gfpA 2 0.7829 100 0.407 Contact Map
3wdoA 1 0.8163 100 0.409 Contact Map
3o7qA 1 0.8017 100 0.418 Contact Map
4gc0A 1 0.8914 100 0.431 Contact Map
4zw9A 1 0.881 100 0.435 Contact Map
4ldsA 2 0.8559 100 0.436 Contact Map
4xnjA 1 0.904 100 0.448 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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