GREMLIN Database
YOGA - Uncharacterized zinc-type alcohol dehydrogenase-like protein YogA
UniProt: O35017 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (298)
Sequences: 52877 (36390)
Seq/√Len: 2108.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_K132_W2.9761.00
33_K68_E2.9371.00
307_K310_E2.8961.00
35_K66_I2.8401.00
7_N18_Q2.6771.00
31_K68_E2.6391.00
160_H184_T2.6171.00
30_V123_A2.4921.00
82_E126_K2.4781.00
78_T81_T2.4491.00
131_S134_E2.4471.00
81_T125_K2.4071.00
179_K204_D2.3921.00
303_Y314_R2.3661.00
166_I187_V2.3601.00
33_K66_I2.2691.00
22_S115_Y2.2671.00
33_K115_Y2.2001.00
133_E302_I2.1651.00
161_L178_A2.1591.00
7_N16_S2.1531.00
195_R199_L2.1161.00
184_T205_Y2.1081.00
156_K159_E2.0921.00
5_I18_Q2.0801.00
63_G111_T2.0561.00
63_G85_I2.0501.00
26_G29_E2.0481.00
301_R314_R2.0351.00
27_Y72_E2.0291.00
76_N120_S2.0161.00
288_A292_K2.0141.00
175_L203_A2.0011.00
304_P307_K1.9961.00
129_Y291_D1.9841.00
27_Y73_G1.9561.00
196_K200_K1.9181.00
28_G73_G1.9131.00
64_A132_W1.8881.00
82_E132_W1.8861.00
31_K117_I1.8851.00
313_K317_E1.8761.00
142_A173_Y1.8701.00
48_K316_Q1.8611.00
68_E115_Y1.8611.00
162_L188_T1.7941.00
180_A294_K1.7751.00
162_L222_I1.7531.00
186_S222_I1.7511.00
246_R271_N1.7281.00
314_R319_R1.7101.00
196_K199_L1.7081.00
310_E313_K1.7021.00
223_D242_K1.7001.00
189_S195_R1.6931.00
24_K69_E1.6791.00
126_K132_W1.6731.00
303_Y311_A1.6491.00
195_R206_A1.6441.00
197_K200_K1.6381.00
310_E314_R1.6231.00
246_R273_L1.6231.00
192_E196_K1.6201.00
159_E246_R1.6031.00
164_P237_Y1.5711.00
4_V308_A1.5571.00
241_V247_I1.5321.00
241_V270_V1.5271.00
126_K135_A1.5241.00
31_K115_Y1.5231.00
71_G74_V1.5191.00
153_G224_V1.5161.00
184_T204_D1.5121.00
77_V125_K1.5101.00
211_S216_Q1.4991.00
70_I79_V1.4961.00
69_E79_V1.4891.00
300_D314_R1.4881.00
66_I82_E1.4861.00
29_E119_P1.4761.00
112_L312_Y1.4751.00
77_V81_T1.4721.00
34_L63_G1.4621.00
241_V245_G1.4571.00
25_P117_I1.4241.00
225_V241_V1.4231.00
28_G119_P1.4231.00
309_C313_K1.4211.00
82_E128_A1.3961.00
29_E117_I1.3851.00
31_K69_E1.3821.00
25_P31_K1.3811.00
212_N215_E1.3781.00
225_V237_Y1.3661.00
36_S133_E1.3621.00
192_E208_D1.3581.00
47_M312_Y1.3211.00
160_H186_S1.3201.00
67_I77_V1.3171.00
30_V77_V1.3141.00
175_L187_V1.3101.00
66_I132_W1.2971.00
180_A289_F1.2841.00
288_A291_D1.2801.00
174_A226_L1.2791.00
164_P188_T1.2761.00
4_V17_V1.2621.00
190_R209_S1.2461.00
35_K82_E1.2151.00
151_T282_E1.2011.00
192_E195_R1.1871.00
77_V123_A1.1831.00
22_S31_K1.1811.00
34_L116_V1.1651.00
199_L206_A1.1641.00
160_H223_D1.1621.00
155_L183_A1.1591.00
212_N216_Q1.1421.00
28_G120_S1.1341.00
11_G14_G1.1181.00
195_R208_D1.1151.00
151_T285_A1.1051.00
280_G284_Q1.1031.00
118_I123_A1.1011.00
176_F296_R1.0931.00
285_A288_A1.0881.00
159_E223_D1.0831.00
239_R264_S1.0811.00
147_R282_E1.0771.00
289_F294_K1.0601.00
4_V305_L1.0541.00
39_L311_A1.0531.00
153_G248_V1.0531.00
186_S205_Y1.0481.00
5_I20_V1.0431.00
152_K271_N1.0421.00
199_L205_Y1.0411.00
32_V65_G1.0401.00
197_K321_F1.0381.00
68_E79_V1.0361.00
145_A174_A1.0361.00
47_M316_Q1.0341.00
229_I233_L1.0311.00
17_V306_E1.0301.00
187_V203_A1.0261.00
37_A112_L1.0221.00
32_V83_V1.0191.00
134_E296_R1.0161.00
155_L159_E1.0141.00
308_A326_I1.0101.00
145_A177_M1.0101.00
130_L135_A1.0101.00
36_S132_W1.0061.00
284_Q288_A0.9961.00
178_A183_A0.9861.00
186_S207_F0.9851.00
25_P29_E0.9851.00
214_D239_R0.9761.00
148_A250_F0.9691.00
166_I189_S0.9671.00
40_N62_D0.9601.00
35_K64_A0.9531.00
314_R324_I0.9511.00
236_E239_R0.9461.00
313_K316_Q0.9441.00
74_V120_S0.9441.00
227_D230_G0.9431.00
146_Y285_A0.9431.00
190_R210_Y0.9371.00
142_A286_M0.9351.00
112_L308_A0.9341.00
40_N61_S0.9321.00
37_A111_T0.9311.00
235_S239_R0.9241.00
44_L315_M0.9231.00
190_R195_R0.9221.00
57_M109_D0.9171.00
175_L185_V0.9121.00
148_A226_L0.9081.00
191_S194_K0.9041.00
4_V15_L0.8961.00
264_S268_P0.8961.00
22_S69_E0.8961.00
75_K120_S0.8951.00
33_K114_E0.8911.00
164_P225_V0.8911.00
5_I58_I0.8891.00
36_S325_G0.8851.00
172_T197_K0.8851.00
70_I74_V0.8841.00
163_I178_A0.8821.00
303_Y307_K0.8811.00
187_V198_A0.8811.00
285_A289_F0.8791.00
162_L240_H0.8781.00
7_N14_G0.8771.00
188_T209_S0.8771.00
84_V287_L0.8741.00
163_I174_A0.8721.00
214_D236_E0.8691.00
166_I175_L0.8691.00
166_I198_A0.8631.00
244_N269_Q0.8581.00
193_E196_K0.8541.00
194_K321_F0.8531.00
159_E224_V0.8521.00
177_M286_M0.8501.00
63_G116_V0.8471.00
138_L290_I0.8471.00
189_S206_A0.8391.00
78_T125_K0.8381.00
22_S68_E0.8301.00
20_V109_D0.8291.00
112_L326_I0.8281.00
149_L178_A0.8261.00
38_G62_D0.8241.00
152_K273_L0.8231.00
24_K31_K0.8201.00
217_L222_I0.8171.00
143_L282_E0.8151.00
28_G71_G0.8131.00
191_S208_D0.8121.00
160_H222_I0.8121.00
281_E285_A0.8111.00
301_R310_E0.8091.00
320_Q324_I0.8031.00
40_N43_D0.8021.00
200_K298_V0.8011.00
178_A185_V0.7961.00
198_A203_A0.7921.00
237_Y247_I0.7921.00
70_I78_T0.7901.00
161_L183_A0.7861.00
39_L315_M0.7861.00
128_A291_D0.7831.00
265_L272_V0.7811.00
148_A174_A0.7791.00
281_E284_Q0.7781.00
225_V247_I0.7741.00
177_M289_F0.7741.00
145_A173_Y0.7681.00
200_K296_R0.7671.00
85_I118_I0.7621.00
124_I284_Q0.7591.00
30_V120_S0.7541.00
154_Q246_R0.7541.00
289_F292_K0.7541.00
315_M324_I0.7531.00
42_R61_S0.7511.00
17_V305_L0.7511.00
26_G117_I0.7491.00
181_I285_A0.7471.00
228_S250_F0.7461.00
212_N236_E0.7461.00
20_V58_I0.7431.00
299_I302_I0.7361.00
261_P264_S0.7351.00
25_P69_E0.7351.00
84_V126_K0.7331.00
145_A170_V0.7331.00
111_T116_V0.7331.00
28_G72_E0.7321.00
163_I187_V0.7311.00
164_P233_L0.7291.00
186_S217_L0.7281.00
83_V123_A0.7281.00
185_V204_D0.7261.00
4_V309_C0.7251.00
213_W236_E0.7251.00
160_H220_K0.7241.00
289_F293_H0.7221.00
147_R269_Q0.7201.00
314_R317_E0.7201.00
62_D140_L0.7181.00
130_L290_I0.7171.00
167_G198_A0.7121.00
303_Y324_I0.7121.00
183_A224_V0.7061.00
155_L224_V0.7041.00
127_P291_D0.7011.00
40_N140_L0.6981.00
146_Y286_M0.6981.00
249_S272_V0.6961.00
36_S302_I0.6911.00
189_S198_A0.6901.00
303_Y326_I0.6901.00
154_Q271_N0.6891.00
124_I283_F0.6851.00
235_S257_N0.6841.00
234_F247_I0.6821.00
146_Y289_F0.6791.00
222_I225_V0.6791.00
224_V248_V0.6781.00
287_L291_D0.6771.00
154_Q273_L0.6771.00
145_A149_L0.6711.00
84_V139_P0.6701.00
13_L313_K0.6691.00
6_H14_G0.6691.00
214_D240_H0.6681.00
61_S140_L0.6671.00
64_A136_G0.6671.00
28_G121_Q0.6661.00
301_R324_I0.6641.00
235_S264_S0.6621.00
167_G189_S0.6621.00
25_P71_G0.6601.00
23_T117_I0.6591.00
265_L274_G0.6591.00
265_L270_V0.6581.00
144_T170_V0.6581.00
172_T298_V0.6581.00
34_L37_A0.6541.00
81_T128_A0.6531.00
64_A126_K0.6531.00
232_A235_S0.6511.00
220_K242_K0.6501.00
137_V325_G0.6501.00
36_S64_A0.6491.00
30_V67_I0.6491.00
195_R198_A0.6471.00
39_L112_L0.6451.00
222_I240_H0.6431.00
197_K201_L0.6431.00
177_M181_I0.6421.00
227_D247_I0.6421.00
40_N141_S0.6391.00
82_E129_Y0.6381.00
53_Q57_M0.6351.00
124_I287_L0.6331.00
146_Y282_E0.6321.00
141_S169_G0.6281.00
243_P268_P0.6281.00
197_K298_V0.6271.00
54_D57_M0.6261.00
175_L201_L0.6251.00
44_L316_Q0.6241.00
42_R46_L0.6241.00
269_Q279_S0.6231.00
64_A82_E0.6211.00
41_H45_F0.6201.00
32_V85_I0.6201.00
76_N280_G0.6201.00
205_Y216_Q0.6191.00
174_A250_F0.6181.00
176_F201_L0.6181.00
179_K185_V0.6171.00
312_Y316_Q0.6151.00
213_W217_L0.6141.00
86_F124_I0.6141.00
45_F50_K0.6131.00
151_T181_I0.6111.00
224_V246_R0.6091.00
157_K182_G0.6081.00
85_I123_A0.6051.00
203_A206_A0.6031.00
141_S173_Y0.6031.00
235_S259_S0.5981.00
140_L144_T0.5961.00
153_G246_R0.5951.00
144_T250_F0.5911.00
256_D259_S0.5881.00
233_L237_Y0.5881.00
12_L313_K0.5881.00
314_R320_Q0.5851.00
148_A275_T0.5851.00
290_I297_P0.5841.00
189_S209_S0.5831.00
283_F287_L0.5821.00
131_S135_A0.5821.00
161_L224_V0.5791.00
227_D251_G0.5781.00
257_N261_P0.5761.00
137_V297_P0.5751.00
189_S208_D0.5751.00
124_I280_G0.5721.00
76_N79_V0.5721.00
213_W216_Q0.5711.00
37_A326_I0.5711.00
217_L240_H0.5691.00
42_R45_F0.5681.00
188_T207_F0.5671.00
77_V120_S0.5651.00
70_I81_T0.5631.00
149_L177_M0.5631.00
23_T115_Y0.5621.00
75_K78_T0.5611.00
225_V240_H0.5601.00
32_V123_A0.5591.00
301_R307_K0.5591.00
44_L48_K0.5591.00
167_G194_K0.5571.00
60_G112_L0.5561.00
175_L198_A0.5561.00
195_R209_S0.5561.00
151_T154_Q0.5561.00
162_L225_V0.5531.00
21_P24_K0.5521.00
264_S267_F0.5521.00
15_L312_Y0.5451.00
258_L261_P0.5441.00
148_A248_V0.5431.00
56_H60_G0.5431.00
22_S117_I0.5431.00
248_V275_T0.5421.00
282_E285_A0.5421.00
157_K181_I0.5401.00
189_S194_K0.5401.00
190_R208_D0.5391.00
160_H221_K0.5381.00
23_T31_K0.5371.00
46_L51_S0.5371.00
58_I110_G0.5361.00
40_N323_N0.5361.00
207_F216_Q0.5351.00
172_T201_L0.5331.00
64_A135_A0.5311.00
34_L85_I0.5281.00
179_K203_A0.5271.00
173_Y177_M0.5271.00
14_G47_M0.5261.00
39_L326_I0.5261.00
14_G309_C0.5251.00
119_P122_N0.5241.00
85_I111_T0.5211.00
163_I175_L0.5211.00
256_D261_P0.5201.00
146_Y181_I0.5201.00
6_H47_M0.5191.00
151_T281_E0.5171.00
23_T29_E0.5141.00
120_S123_A0.5141.00
221_K242_K0.5131.00
62_D323_N0.5131.00
173_Y295_L0.5121.00
293_H296_R0.5121.00
218_Q221_K0.5111.00
198_A206_A0.5091.00
173_Y176_F0.5081.00
262_V265_L0.5071.00
160_H205_Y0.5071.00
149_L174_A0.5071.00
46_L53_Q0.5061.00
25_P73_G0.5051.00
34_L111_T0.5031.00
235_S261_P0.5021.00
193_E319_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gi2A 2 1 100 0.133 Contact Map
2eihA 4 1 100 0.15 Contact Map
1f8fA 4 0.9818 100 0.159 Contact Map
3jv7A 4 0.9787 100 0.16 Contact Map
4c4oA 4 0.9696 100 0.161 Contact Map
4oh1A 4 0.9848 100 0.162 Contact Map
4oaqA 2 0.9909 100 0.163 Contact Map
1h2bA 4 0.9787 100 0.163 Contact Map
4ej6A 1 0.9757 100 0.165 Contact Map
3ukoA 4 0.9848 100 0.165 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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