GREMLIN Database
YFKJ - Low molecular weight protein-tyrosine-phosphatase YfkJ
UniProt: O35016 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (144)
Sequences: 4702 (3527)
Seq/√Len: 293.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_L144_E3.3541.00
24_D28_K3.2641.00
19_E23_R2.9041.00
74_V96_L2.7981.00
87_A96_L2.4561.00
124_P138_L2.4351.00
3_S36_K2.3531.00
59_L66_F2.1201.00
9_L92_N2.1091.00
17_M55_T2.0751.00
90_A122_D2.0701.00
61_R133_E1.8531.00
6_F22_F1.8391.00
27_A32_E1.8021.00
5_L40_A1.7851.00
38_D72_R1.7621.00
58_I133_E1.7091.00
111_L143_C1.6841.00
17_M59_L1.6651.00
93_I97_R1.5841.00
109_K114_Y1.5701.00
77_Q81_D1.5661.00
62_E140_K1.5101.00
4_V22_F1.4811.00
87_A93_I1.4801.00
26_A35_I1.4481.00
62_E136_C1.4411.00
111_L139_I1.4351.00
25_L140_K1.4351.00
38_D82_F1.4331.00
58_I61_R1.4281.00
26_A37_A1.4231.00
36_K81_D1.4171.00
58_I136_C1.4111.00
47_I71_A1.3861.00
21_I136_C1.3851.00
9_L43_G1.3841.00
72_R78_D1.3811.00
21_I139_I1.3731.00
62_E137_Q1.3581.00
90_A110_R1.3531.00
42_I95_S1.3411.00
25_L143_C1.3301.00
22_F37_A1.3181.00
47_I73_Q1.3101.00
134_E138_L1.3091.00
51_P56_Q1.3011.00
21_I143_C1.2951.00
50_P56_Q1.2501.00
112_L115_V1.2441.00
56_Q66_F1.2151.00
109_K113_D1.2141.00
20_A66_F1.2011.00
64_I140_K1.1971.00
51_P66_F1.1901.00
112_L138_L1.1781.00
46_H49_N1.1751.00
110_R122_D1.1651.00
20_A64_I1.1491.00
93_I108_I1.1411.00
23_R37_A1.1371.00
51_P69_M1.1301.00
101_G104_N1.1191.00
29_K148_A1.1181.00
97_R108_I1.1131.00
79_L85_I1.0901.00
58_I62_E1.0891.00
44_G73_Q1.0861.00
40_A72_R1.0851.00
79_L104_N1.0771.00
114_Y149_S1.0571.00
24_D27_A1.0451.00
18_A88_M1.0421.00
56_Q60_R1.0421.00
3_S81_D1.0341.00
22_F143_C1.0331.00
55_T58_I1.0291.00
114_Y146_L0.9991.00
140_K144_E0.9991.00
115_V141_T0.9941.00
57_E61_R0.9801.00
96_L108_I0.9781.00
145_Q148_A0.9771.00
89_D92_N0.9721.00
95_S98_S0.9711.00
91_E95_S0.9681.00
88_M111_L0.9671.00
76_E99_M0.9631.00
93_I110_R0.9611.00
87_A110_R0.9521.00
133_E137_Q0.9471.00
135_V139_I0.9341.00
84_Y146_L0.9271.00
84_Y109_K0.9221.00
86_I146_L0.9131.00
20_A69_M0.9011.00
74_V79_L0.8981.00
42_I96_L0.8981.00
17_M136_C0.8971.00
104_N107_H0.8971.00
25_L28_K0.8961.00
111_L142_G0.8951.00
20_A23_R0.8871.00
25_L29_K0.8871.00
25_L147_L0.8871.00
52_H132_F0.8861.00
100_A108_I0.8821.00
86_I109_K0.8821.00
95_S99_M0.8811.00
6_F18_A0.8801.00
9_L91_E0.8801.00
53_E57_E0.8791.00
20_A51_P0.8751.00
5_L82_F0.8701.00
7_V85_I0.8471.00
112_L142_G0.8431.00
43_G47_I0.8421.00
146_L150_I0.8401.00
29_K144_E0.8331.00
88_M123_V0.8241.00
51_P59_L0.8211.00
64_I136_C0.8201.00
54_G129_T0.8191.00
44_G47_I0.8101.00
120_L134_E0.8071.00
97_R100_A0.8041.00
113_D120_L0.8011.00
116_E141_T0.7960.99
86_I114_Y0.7930.99
7_V96_L0.7750.99
66_F69_M0.7730.99
40_A74_V0.7650.99
26_A147_L0.7540.99
45_W49_N0.7440.99
21_I64_I0.7430.99
109_K149_S0.7400.99
77_Q80_D0.7380.99
3_S82_F0.7340.99
136_C140_K0.7310.99
131_N134_E0.7290.99
60_R66_F0.7250.99
17_M58_I0.7240.99
9_L89_D0.7030.99
79_L100_A0.6980.99
5_L72_R0.6970.99
85_I96_L0.6950.99
100_A104_N0.6910.99
114_Y145_Q0.6850.98
50_P70_L0.6820.98
80_D104_N0.6820.98
117_D141_T0.6780.98
52_H129_T0.6750.98
79_L96_L0.6740.98
86_I111_L0.6640.98
18_A111_L0.6580.98
78_D82_F0.6580.98
22_F25_L0.6540.98
65_S68_G0.6540.98
76_E80_D0.6540.98
110_R113_D0.6530.98
115_V145_Q0.6490.98
75_S78_D0.6460.98
23_R27_A0.6430.98
79_L101_G0.6390.98
5_L85_I0.6280.97
44_G49_N0.6270.97
43_G46_H0.6250.97
88_M92_N0.6240.97
18_A139_I0.6220.97
26_A31_L0.6160.97
62_E133_E0.6160.97
100_A106_S0.6120.97
115_V146_L0.6110.97
17_M135_V0.6080.97
123_V142_G0.6070.97
3_S38_D0.6060.97
43_G95_S0.6010.96
22_F146_L0.5970.96
55_T59_L0.5960.96
72_R82_F0.5960.96
29_K147_L0.5950.96
54_G130_G0.5920.96
135_V138_L0.5860.96
100_A107_H0.5850.96
139_I143_C0.5830.96
60_R65_S0.5820.96
84_Y114_Y0.5810.96
9_L95_S0.5790.96
84_Y150_I0.5770.96
116_E121_A0.5730.95
20_A68_G0.5670.95
11_N15_S0.5670.95
40_A78_D0.5580.95
123_V138_L0.5520.94
20_A67_D0.5520.94
43_G73_Q0.5510.94
111_L146_L0.5470.94
112_L122_D0.5450.94
38_D81_D0.5440.94
124_P135_V0.5430.94
59_L64_I0.5430.94
20_A65_S0.5410.94
50_P69_M0.5410.94
12_I132_F0.5400.94
102_F105_T0.5390.94
21_I140_K0.5380.94
52_H127_Y0.5340.93
128_Y131_N0.5320.93
6_F143_C0.5250.93
26_A32_E0.5190.92
131_N135_V0.5180.92
146_L149_S0.5130.92
21_I25_L0.5080.92
12_I52_H0.5050.91
49_N71_A0.5000.91
41_G87_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4etmA 2 1 100 0.127 Contact Map
2gi4A 1 0.9936 100 0.13 Contact Map
3jviA 1 0.9808 100 0.15 Contact Map
3rofA 1 0.9679 100 0.151 Contact Map
4lrqA 2 0.9487 100 0.154 Contact Map
1d1qA 1 0.9615 100 0.163 Contact Map
2cwdA 1 0.9359 100 0.168 Contact Map
3n8iA 1 0.9551 100 0.177 Contact Map
1u2pA 1 0.9744 100 0.179 Contact Map
4picA 2 0.9423 100 0.197 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.