GREMLIN Database
YKUI - Uncharacterized EAL-domain containing protein YkuI
UniProt: O35014 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (341)
Sequences: 577 (474)
Seq/√Len: 25.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_L199_A4.1211.00
70_R111_A4.0541.00
125_E209_E3.3771.00
35_L209_E3.2171.00
125_E153_N3.1811.00
155_G159_S3.1791.00
35_L88_N3.1441.00
35_L212_E2.8901.00
125_E155_G2.8581.00
35_L152_D2.8271.00
231_Y236_P2.8041.00
209_E236_P2.7210.99
155_G209_E2.6970.99
153_N209_E2.5750.99
88_N122_E2.5670.99
19_Q37_R2.5410.99
153_N157_E2.4830.99
125_E159_S2.4800.99
24_A228_F2.4770.99
35_L236_P2.4080.99
35_L122_E2.3980.98
37_R231_Y2.3120.98
16_P36_G2.3120.98
175_D210_D2.3060.98
212_E231_Y2.2930.98
40_A44_I2.2730.98
70_R74_D2.2600.98
37_R152_D2.2230.97
19_Q35_L2.1850.97
88_N173_K2.1830.97
35_L231_Y2.1770.97
122_E212_E2.1290.97
37_R88_N2.1260.97
37_R122_E2.0690.96
153_N210_D2.0520.96
38_I51_F2.0000.95
209_E231_Y1.9730.95
102_F109_Y1.9350.94
88_N152_D1.9180.94
69_I105_L1.9060.94
59_E147_I1.8990.94
41_D44_I1.8800.93
205_A226_R1.8690.93
159_S175_D1.8650.93
67_R71_Q1.8620.93
152_D175_D1.8300.92
344_W347_R1.8240.92
71_Q74_D1.8230.92
35_L125_E1.7760.91
18_Y75_R1.7680.91
111_A211_I1.7410.90
73_L87_M1.7370.90
122_E173_K1.6910.89
203_G321_Q1.6870.89
35_L173_K1.6730.89
88_N212_E1.6690.88
14_V36_G1.6580.88
157_E209_E1.6540.88
200_R226_R1.6540.88
46_S240_F1.6460.88
152_D212_E1.6420.88
208_Y220_A1.6410.88
124_T159_S1.6260.87
209_E212_E1.6180.87
80_D118_R1.6170.87
36_G48_G1.6110.87
21_I120_V1.6000.86
121_L142_Y1.5770.85
69_I142_Y1.5580.85
104_E108_E1.5440.84
54_A57_P1.5430.84
33_E88_N1.5280.83
120_V171_L1.5230.83
313_Y319_G1.5230.83
37_R229_Q1.5030.82
108_E112_K1.4710.81
120_V150_A1.4580.80
88_N231_Y1.4330.79
344_W348_P1.4320.79
56_I59_E1.4310.79
296_D299_K1.4230.79
153_N173_K1.4000.78
57_P60_Y1.3960.77
122_E231_Y1.3950.77
89_Q121_L1.3840.77
359_N362_K1.3810.77
35_L153_N1.3660.76
24_A221_W1.3550.75
234_V237_S1.3510.75
125_E154_I1.3410.74
155_G160_N1.3340.74
51_F68_I1.3250.73
314_M323_T1.3200.73
152_D231_Y1.3200.73
18_Y195_I1.3120.73
198_L280_H1.3110.73
159_S209_E1.3060.72
33_E173_K1.2940.72
125_E152_D1.2940.72
77_L81_S1.2720.70
211_I361_R1.2700.70
55_G59_E1.2670.70
37_R212_E1.2660.70
19_Q229_Q1.2630.70
125_E163_R1.2630.70
173_K209_E1.2630.70
343_N347_R1.2610.70
155_G173_K1.2570.69
143_R170_D1.2550.69
105_L142_Y1.2510.69
19_Q88_N1.2490.69
88_N153_N1.2380.68
238_E300_K1.2360.68
32_Y52_L1.2320.68
37_R173_K1.2260.67
203_G313_Y1.2260.67
125_E160_N1.2210.67
37_R236_P1.2060.66
19_Q122_E1.1970.66
267_T284_T1.1920.65
217_L233_L1.1890.65
65_D93_L1.1880.65
37_R209_E1.1870.65
115_E207_L1.1820.65
258_I261_E1.1820.65
344_W350_F1.1810.64
258_I343_N1.1730.64
54_A59_E1.1720.64
18_Y250_L1.1720.64
176_L180_K1.1680.64
248_Q252_T1.1680.64
213_A233_L1.1580.63
36_G172_L1.1580.63
196_S223_N1.1490.62
51_F216_Q1.1440.62
311_R344_W1.1440.62
157_E210_D1.1440.62
122_E236_P1.1410.62
208_Y343_N1.1390.62
32_Y203_G1.1370.61
125_E236_P1.1350.61
22_F201_K1.1300.61
21_I86_F1.1270.61
119_F235_S1.1200.60
102_F105_L1.1050.59
72_A199_A1.1050.59
125_E173_K1.0950.59
66_N69_I1.0940.58
155_G198_L1.0940.58
33_E37_R1.0930.58
17_Y238_E1.0820.58
333_W346_W1.0770.57
105_L121_L1.0740.57
139_L149_I1.0710.57
122_E229_Q1.0680.57
88_N229_Q1.0660.56
23_S150_A1.0630.56
19_Q33_E1.0630.56
36_G68_I1.0560.56
295_D324_G1.0490.55
24_A219_Y1.0460.55
16_P68_I1.0450.55
122_E153_N1.0440.55
34_V233_L1.0440.55
210_D213_A1.0420.55
169_P204_A1.0390.54
153_N159_S1.0360.54
109_Y147_I1.0330.54
115_E118_R1.0320.54
187_S195_I1.0300.54
244_D293_S1.0220.53
264_K277_K1.0150.53
56_I61_K1.0100.52
125_E175_D1.0030.52
65_D88_N1.0020.52
26_E200_R1.0000.52
121_L149_I0.9950.51
195_I340_A0.9840.50
78_E110_E0.9820.50
36_G51_F0.9780.50
33_E229_Q0.9770.50
325_N348_P0.9680.49
275_F286_L0.9650.49
203_G319_G0.9620.49
154_I175_D0.9610.49
122_E209_E0.9570.48
19_Q173_K0.9550.48
139_L213_A0.9520.48
66_N233_L0.9500.48
124_T209_E0.9480.48
69_I164_I0.9460.48
172_L237_S0.9410.47
120_V169_P0.9350.47
122_E155_G0.9330.47
332_E335_Y0.9300.46
86_F220_A0.9220.46
124_T175_D0.9170.46
118_R227_Y0.9130.45
172_L309_S0.9100.45
173_K212_E0.9060.45
114_I299_K0.9050.45
123_I151_V0.9050.45
110_E288_K0.9020.44
15_L39_L0.9000.44
17_Y237_S0.8990.44
31_G120_V0.8970.44
169_P319_G0.8960.44
175_D209_E0.8940.44
268_V279_V0.8940.44
68_I71_Q0.8920.44
51_F76_F0.8890.44
231_Y235_S0.8870.43
122_E152_D0.8860.43
107_K277_K0.8850.43
33_E212_E0.8820.43
65_D163_R0.8810.43
152_D173_K0.8780.43
285_S295_D0.8750.43
65_D171_L0.8710.42
238_E248_Q0.8700.42
159_S210_D0.8680.42
64_V155_G0.8660.42
169_P203_G0.8650.42
121_L147_I0.8610.42
49_P191_V0.8610.42
108_E172_L0.8600.41
198_L231_Y0.8590.41
155_G210_D0.8580.41
153_N156_K0.8520.41
208_Y225_G0.8520.41
128_F131_D0.8500.41
52_L61_K0.8490.41
91_A124_T0.8460.40
34_V159_S0.8450.40
114_I135_L0.8440.40
85_I197_L0.8390.40
19_Q212_E0.8370.40
48_G152_D0.8360.40
198_L209_E0.8310.39
23_S148_K0.8310.39
319_G325_N0.8270.39
52_L135_L0.8270.39
52_L119_F0.8240.39
107_K110_E0.8220.39
175_D231_Y0.8220.39
91_A202_I0.8190.39
35_L155_G0.8190.39
69_I169_P0.8180.38
116_L147_I0.8150.38
55_G188_Y0.8120.38
160_N163_R0.8120.38
48_G68_I0.8120.38
315_C319_G0.8070.38
154_I165_A0.8060.38
125_E157_E0.8060.38
62_L93_L0.8020.37
158_S198_L0.8020.37
52_L169_P0.8010.37
338_E342_K0.8000.37
105_L109_Y0.7980.37
41_D231_Y0.7980.37
37_R65_D0.7980.37
62_L98_H0.7880.36
32_Y242_E0.7850.36
72_A201_K0.7780.36
273_E276_Y0.7710.35
272_S278_R0.7700.35
345_S360_L0.7700.35
169_P221_W0.7690.35
335_Y338_E0.7650.35
351_L362_K0.7640.35
313_Y321_Q0.7610.35
321_Q325_N0.7580.34
123_I164_I0.7580.34
33_E152_D0.7550.34
85_I135_L0.7550.34
76_F216_Q0.7520.34
25_E226_R0.7500.34
169_P313_Y0.7490.34
37_R125_E0.7480.34
16_P51_F0.7460.34
135_L148_K0.7420.33
21_I32_Y0.7400.33
84_L121_L0.7390.33
76_F118_R0.7390.33
52_L142_Y0.7370.33
34_V309_S0.7360.33
159_S198_L0.7360.33
18_Y69_I0.7350.33
341_E350_F0.7340.33
319_G349_Y0.7320.33
122_E125_E0.7320.33
90_D93_L0.7320.33
283_V293_S0.7300.33
36_G154_I0.7290.32
107_K293_S0.7280.32
155_G175_D0.7260.32
345_S350_F0.7250.32
72_A84_L0.7220.32
22_F245_V0.7210.32
22_F120_V0.7210.32
220_A344_W0.7210.32
83_L243_R0.7170.32
76_F174_I0.7160.32
143_R183_Q0.7160.32
82_D149_I0.7160.32
40_A123_I0.7160.32
153_N160_N0.7150.32
40_A79_A0.7140.32
119_F290_N0.7120.31
173_K229_Q0.7110.31
35_L229_Q0.7100.31
279_V298_I0.7100.31
101_S142_Y0.7090.31
24_A207_L0.7090.31
99_G102_F0.7070.31
52_L163_R0.7050.31
109_Y123_I0.7030.31
146_G230_G0.7000.31
29_V195_I0.6990.31
169_P205_A0.6970.30
103_L110_E0.6930.30
154_I234_V0.6910.30
186_P219_Y0.6900.30
88_N209_E0.6900.30
140_A143_R0.6900.30
131_D157_E0.6880.30
174_I195_I0.6870.30
211_I234_V0.6860.30
79_A243_R0.6840.30
206_L226_R0.6810.29
38_I225_G0.6810.29
16_P34_V0.6810.29
65_D147_I0.6800.29
35_L175_D0.6760.29
82_D113_G0.6750.29
18_Y185_S0.6740.29
40_A170_D0.6740.29
212_E236_P0.6720.29
299_K303_E0.6720.29
99_G103_L0.6710.29
21_I150_A0.6650.29
240_F264_K0.6650.29
152_D155_G0.6640.28
217_L222_R0.6640.28
311_R315_C0.6590.28
161_L165_A0.6580.28
150_A159_S0.6580.28
103_L149_I0.6560.28
38_I46_S0.6540.28
122_E175_D0.6540.28
28_K280_H0.6530.28
347_R350_F0.6490.28
290_N297_F0.6490.28
192_L329_Q0.6480.28
199_A353_N0.6450.27
72_A321_Q0.6440.27
16_P72_A0.6430.27
122_E157_E0.6420.27
65_D69_I0.6380.27
221_W234_V0.6380.27
142_Y169_P0.6370.27
179_L208_Y0.6360.27
128_F156_K0.6320.27
68_I121_L0.6320.27
248_Q259_T0.6310.27
192_L208_Y0.6310.27
138_M183_Q0.6300.26
76_F91_A0.6300.26
197_L217_L0.6300.26
283_V289_N0.6300.26
20_A341_E0.6290.26
311_R347_R0.6280.26
21_I204_A0.6280.26
90_D124_T0.6270.26
77_L215_F0.6250.26
42_S149_I0.6230.26
118_R163_R0.6230.26
151_V274_Q0.6220.26
18_Y85_I0.6210.26
44_I164_I0.6210.26
325_N347_R0.6190.26
155_G212_E0.6190.26
53_D56_I0.6190.26
281_Q297_F0.6170.26
139_L168_S0.6170.26
240_F308_C0.6160.26
143_R222_R0.6140.26
265_L268_V0.6130.26
69_I108_E0.6120.25
333_W347_R0.6120.25
169_P321_Q0.6120.25
206_L262_K0.6100.25
84_L353_N0.6100.25
128_F232_Y0.6090.25
180_K184_P0.6090.25
35_L65_D0.6080.25
56_I60_Y0.6060.25
151_V176_L0.6050.25
72_A161_L0.6040.25
164_I204_A0.6040.25
14_V240_F0.6030.25
321_Q345_S0.6030.25
135_L194_S0.6010.25
37_R175_D0.5990.25
21_I234_V0.5980.25
194_S295_D0.5960.25
179_L182_S0.5950.25
48_G220_A0.5950.25
29_V181_V0.5950.25
50_F203_G0.5900.24
255_H258_I0.5890.24
202_I224_G0.5890.24
19_Q209_E0.5870.24
124_T158_S0.5850.24
335_Y360_L0.5830.24
256_Q259_T0.5810.24
339_Y346_W0.5790.24
325_N350_F0.5790.24
14_V86_F0.5770.24
120_V311_R0.5770.24
94_L174_I0.5760.23
211_I342_K0.5760.23
19_Q231_Y0.5750.23
34_V210_D0.5750.23
30_V227_Y0.5750.23
154_I210_D0.5710.23
225_G228_F0.5710.23
283_V287_R0.5700.23
18_Y38_I0.5660.23
177_Q281_Q0.5650.23
353_N360_L0.5640.23
139_L228_F0.5630.23
21_I313_Y0.5630.23
67_R151_V0.5630.23
64_V196_S0.5630.23
254_F261_E0.5630.23
176_L182_S0.5620.23
69_I119_F0.5620.23
181_V303_E0.5590.23
87_M172_L0.5580.23
48_G153_N0.5580.23
86_F236_P0.5550.22
40_A243_R0.5550.22
215_F241_L0.5520.22
158_S175_D0.5510.22
35_L48_G0.5510.22
51_F353_N0.5510.22
227_Y333_W0.5500.22
332_E336_Q0.5490.22
51_F69_I0.5470.22
61_K90_D0.5470.22
56_I90_D0.5460.22
210_D231_Y0.5460.22
325_N349_Y0.5460.22
202_I231_Y0.5450.22
142_Y232_Y0.5450.22
256_Q290_N0.5440.22
33_E48_G0.5440.22
12_D70_R0.5430.22
270_E284_T0.5430.22
23_S226_R0.5420.22
268_V286_L0.5420.22
171_L233_L0.5410.22
119_F313_Y0.5400.22
153_N213_A0.5400.22
39_L290_N0.5400.22
110_E167_L0.5390.22
63_E70_R0.5380.22
87_M139_L0.5380.22
65_D122_E0.5370.21
150_A163_R0.5360.21
65_D233_L0.5340.21
105_L108_E0.5340.21
26_E199_A0.5340.21
100_E103_L0.5340.21
148_K170_D0.5330.21
165_A191_V0.5330.21
174_I192_L0.5330.21
32_Y123_I0.5330.21
94_L233_L0.5330.21
29_V243_R0.5310.21
188_Y193_Y0.5310.21
227_Y325_N0.5300.21
135_L163_R0.5290.21
121_L162_D0.5270.21
15_L45_Q0.5260.21
43_E66_N0.5250.21
18_Y307_D0.5250.21
140_A239_T0.5230.21
59_E64_V0.5210.21
321_Q349_Y0.5210.21
36_G206_L0.5200.21
70_R302_A0.5170.21
250_L257_F0.5170.21
135_L142_Y0.5170.21
33_E230_G0.5170.21
248_Q330_D0.5150.20
188_Y196_S0.5150.20
315_C343_N0.5140.20
63_E76_F0.5100.20
130_G133_E0.5090.20
128_F204_A0.5090.20
149_I181_V0.5080.20
86_F227_Y0.5060.20
86_F171_L0.5060.20
168_S202_I0.5050.20
140_A259_T0.5050.20
124_T153_N0.5050.20
29_V245_V0.5040.20
266_E282_A0.5000.20
174_I282_A0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2basA 2 0.9803 100 0.249 Contact Map
4hjfA 1 0.6167 100 0.417 Contact Map
4kieA 1 0.6044 100 0.423 Contact Map
4rnhA 2 0.602 100 0.425 Contact Map
3sy8A 6 0.6216 100 0.434 Contact Map
4j40A 2 0.5946 100 0.434 Contact Map
2r6oA 2 0.6143 100 0.441 Contact Map
4rniA 2 0.6044 100 0.446 Contact Map
3pjxA 1 0.5774 100 0.447 Contact Map
4hu4A 1 0.5897 100 0.448 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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