GREMLIN Database
YKFC - Gamma-D-glutamyl-L-lysine endopeptidase
UniProt: O35010 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (260)
Sequences: 3673 (3179)
Seq/√Len: 197.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_V275_I3.9091.00
234_M290_V3.5571.00
181_A264_L3.3581.00
183_F186_L3.3481.00
192_G197_G3.1191.00
181_A275_I2.9191.00
230_P233_D2.8891.00
287_L290_V2.8251.00
177_I258_V2.8171.00
267_P272_S2.7751.00
271_K274_E2.7631.00
228_G291_R2.6741.00
216_P225_A2.6491.00
204_M256_L2.6111.00
184_L264_L2.4631.00
205_Y217_R2.3831.00
198_F206_S2.3791.00
204_M222_Q2.2901.00
218_D221_D2.2311.00
204_M239_L2.1151.00
180_G264_L2.0721.00
194_S197_G2.0621.00
193_I217_R1.9761.00
223_A251_I1.9661.00
242_F255_G1.9641.00
186_L198_F1.9171.00
204_M215_I1.9131.00
255_G263_M1.9021.00
242_F263_M1.8941.00
226_G291_R1.8741.00
174_E178_Q1.8661.00
239_L254_V1.8291.00
243_A252_H1.8051.00
231_L287_L1.8031.00
219_A223_A1.7771.00
203_F207_I1.7701.00
186_L197_G1.7621.00
268_K271_K1.7501.00
179_T206_S1.7501.00
187_P197_G1.7271.00
242_F287_L1.7061.00
186_L194_S1.6961.00
265_H276_L1.6761.00
173_A177_I1.6731.00
223_A289_A1.6391.00
179_T210_A1.6341.00
179_T198_F1.6171.00
231_L234_M1.5911.00
267_P274_E1.5841.00
267_P270_G1.5801.00
262_K275_I1.5791.00
179_T182_F1.5541.00
241_F254_V1.5291.00
178_Q181_A1.5221.00
179_T183_F1.5211.00
206_S210_A1.5161.00
179_T211_N1.4891.00
244_Y252_H1.4831.00
262_K277_T1.4601.00
219_A251_I1.4411.00
174_E236_A1.4311.00
263_M278_L1.4181.00
21_P24_Q1.3941.00
186_L192_G1.3811.00
135_T139_L1.3761.00
118_A121_Y1.3651.00
205_Y209_K1.3601.00
117_A121_Y1.3551.00
184_L272_S1.3451.00
126_E130_E1.3391.00
179_T207_I1.3061.00
183_F194_S1.2861.00
131_L135_T1.2621.00
234_M240_L1.2621.00
177_I264_L1.2541.00
184_L275_I1.2451.00
267_P271_K1.2411.00
255_G265_H1.2391.00
193_I205_Y1.2391.00
208_F215_I1.2351.00
231_L279_T1.2251.00
243_A286_E1.2251.00
216_P219_A1.2171.00
114_S117_A1.2141.00
173_A236_A1.2111.00
220_G251_I1.1971.00
223_A226_G1.1961.00
120_L123_S1.1951.00
20_R24_Q1.1941.00
89_G93_W1.1911.00
113_I117_A1.1711.00
87_P91_P1.1681.00
217_R221_D1.1661.00
243_A250_A1.1651.00
130_E134_L1.1631.00
91_P94_M1.1621.00
27_L31_V1.1531.00
205_Y222_Q1.1521.00
109_H112_M1.1501.00
257_Y261_G1.1371.00
81_Q85_K1.1341.00
128_E132_S1.1321.00
186_L273_I1.1241.00
116_P119_F1.1201.00
223_A288_C1.1091.00
89_G92_G1.1061.00
127_K131_L1.0971.00
195_G198_F1.0911.00
241_F251_I1.0871.00
119_F123_S1.0851.00
269_T272_S1.0851.00
138_P141_A1.0831.00
181_A258_V1.0821.00
146_Y149_V1.0801.00
118_A122_R1.0721.00
189_L197_G1.0691.00
265_H279_T1.0681.00
135_T138_P1.0661.00
186_L196_F1.0611.00
127_K130_E1.0591.00
85_K89_G1.0571.00
176_I208_F1.0541.00
234_M278_L1.0511.00
114_S118_A1.0451.00
216_P221_D1.0411.00
149_V153_F1.0401.00
176_I211_N1.0341.00
195_G206_S1.0331.00
268_K272_S1.0331.00
130_E133_F1.0311.00
132_S136_V1.0281.00
265_H274_E1.0261.00
112_M116_P1.0231.00
73_W78_V1.0151.00
207_I211_N1.0151.00
180_G256_L1.0141.00
109_H113_I1.0101.00
66_V69_E1.0001.00
119_F122_R0.9981.00
75_S78_V0.9961.00
106_H110_D0.9951.00
124_N128_E0.9931.00
189_L192_G0.9871.00
177_I181_A0.9831.00
180_G203_F0.9831.00
221_D224_K0.9831.00
81_Q86_D0.9821.00
236_A258_V0.9740.99
251_I288_C0.9690.99
219_A254_V0.9610.99
132_S135_T0.9570.99
175_D211_N0.9500.99
129_I133_F0.9380.99
25_F29_P0.9350.99
258_V264_L0.9310.99
220_G223_A0.9240.99
128_E131_L0.9220.99
59_L62_E0.9150.99
102_T105_I0.9150.99
23_D27_L0.9140.99
194_S198_F0.9090.99
137_L140_I0.9040.99
136_V140_I0.8940.99
217_R220_G0.8930.99
107_T111_V0.8910.99
223_A241_F0.8880.99
133_F136_V0.8850.99
41_T45_R0.8840.99
206_S209_K0.8810.99
30_T34_R0.8780.99
242_F252_H0.8740.99
209_K214_S0.8710.99
264_L275_I0.8620.99
151_T154_G0.8600.99
281_T286_E0.8600.99
42_Y45_R0.8590.99
230_P234_M0.8580.99
172_T175_D0.8560.99
110_D114_S0.8550.99
39_R43_D0.8550.99
157_F161_S0.8540.99
231_L290_V0.8510.99
47_G51_D0.8490.99
175_D178_Q0.8480.99
157_F163_A0.8480.99
176_I256_L0.8460.99
204_M208_F0.8460.99
240_L255_G0.8410.98
228_G289_A0.8400.98
95_K99_L0.8390.98
73_W76_V0.8350.98
134_L141_A0.8270.98
205_Y218_D0.8260.98
234_M287_L0.8200.98
26_M29_P0.8190.98
33_I36_W0.8180.98
74_V78_V0.8130.98
160_Q163_A0.8100.98
61_G67_T0.8080.98
32_M36_W0.8070.98
258_V262_K0.7990.98
190_W197_G0.7980.98
208_F213_Y0.7980.98
271_K276_L0.7970.98
190_W202_G0.7910.98
33_I37_L0.7850.98
47_G52_N0.7830.98
21_P25_F0.7820.98
189_L269_T0.7810.97
61_G66_V0.7800.97
152_V155_E0.7780.97
252_H286_E0.7730.97
133_F137_L0.7710.97
87_P90_Y0.7700.97
62_E66_V0.7680.97
149_V152_V0.7620.97
151_T158_V0.7590.97
229_V233_D0.7560.97
156_R159_R0.7520.97
136_V139_L0.7510.97
112_M120_L0.7470.97
151_T155_E0.7460.97
34_R38_E0.7460.97
90_Y93_W0.7450.97
243_A288_C0.7410.97
48_L52_N0.7400.97
49_C52_N0.7340.96
173_A176_I0.7330.96
146_Y150_S0.7310.96
244_Y250_A0.7300.96
73_W77_I0.7290.96
240_L278_L0.7260.96
217_R225_A0.7240.96
141_A144_N0.7210.96
62_E69_E0.7180.96
219_A241_F0.7170.96
121_Y125_G0.7160.96
242_F278_L0.7110.96
183_F206_S0.7100.96
124_N127_K0.7040.95
110_D113_I0.7040.95
193_I198_F0.7030.95
137_L141_A0.7030.95
236_A257_Y0.7010.95
231_L240_L0.7000.95
88_R91_P0.7000.95
193_I218_D0.6980.95
183_F207_I0.6970.95
88_R92_G0.6960.95
242_F279_T0.6960.95
139_L142_K0.6960.95
92_G96_K0.6910.95
158_V162_D0.6900.95
187_P272_S0.6860.95
198_F273_I0.6850.95
180_G207_I0.6840.95
157_F160_Q0.6840.95
116_P120_L0.6830.95
28_Q31_V0.6790.94
223_A291_R0.6770.94
109_H117_A0.6700.94
148_K152_V0.6680.94
223_A228_G0.6660.94
159_R162_D0.6640.94
257_Y260_G0.6620.94
98_Q102_T0.6620.94
171_G174_E0.6580.93
131_L134_L0.6580.93
223_A290_V0.6570.93
86_D89_G0.6540.93
20_R23_D0.6530.93
176_I213_Y0.6500.93
120_L124_N0.6500.93
91_P95_K0.6480.93
132_S139_L0.6470.93
156_R163_A0.6460.93
81_Q84_R0.6400.92
27_L30_T0.6400.92
176_I207_I0.6390.92
24_Q28_Q0.6390.92
242_F265_H0.6390.92
100_E103_K0.6390.92
148_K151_T0.6370.92
111_V115_K0.6360.92
183_F211_N0.6350.92
26_M30_T0.6340.92
48_L51_D0.6280.92
97_Y101_K0.6270.92
173_A266_S0.6260.92
29_P32_M0.6250.92
181_A184_L0.6250.92
239_L256_L0.6240.92
240_L287_L0.6210.91
124_N138_P0.6190.91
99_L103_K0.6160.91
72_E76_V0.6150.91
55_Q59_L0.6120.91
222_Q254_V0.6080.90
173_A258_V0.6080.90
223_A250_A0.6070.90
45_R48_L0.6050.90
69_E72_E0.6050.90
240_L257_Y0.6050.90
28_Q32_M0.6040.90
86_D90_Y0.6020.90
122_R126_E0.6020.90
177_I236_A0.6010.90
230_P287_L0.5970.90
115_K118_A0.5960.90
44_E48_L0.5950.89
55_Q66_V0.5950.89
261_G278_L0.5940.89
150_S153_F0.5930.89
147_F152_V0.5930.89
72_E75_S0.5920.89
104_P108_Q0.5890.89
149_V154_G0.5880.89
134_L137_L0.5880.89
183_F203_F0.5870.89
125_G129_I0.5850.89
89_G94_M0.5850.89
193_I202_G0.5850.89
234_M258_V0.5840.89
192_G202_G0.5840.89
134_L138_P0.5830.89
205_Y220_G0.5830.89
177_I256_L0.5830.89
215_I226_G0.5790.88
138_P142_K0.5770.88
101_K104_P0.5750.88
37_L41_T0.5710.88
205_Y219_A0.5700.87
244_Y251_I0.5680.87
108_Q111_V0.5660.87
31_V34_R0.5660.87
64_V68_A0.5660.87
156_R162_D0.5650.87
215_I222_Q0.5640.87
154_G161_S0.5630.87
158_V161_S0.5620.87
130_E138_P0.5610.87
186_L195_G0.5580.86
156_R164_V0.5530.86
242_F251_I0.5530.86
150_S154_G0.5510.86
182_F186_L0.5500.86
36_W39_R0.5490.85
90_Y95_K0.5460.85
59_L69_E0.5450.85
157_F162_D0.5450.85
85_K90_Y0.5440.85
124_N130_E0.5440.85
23_D30_T0.5430.85
31_V35_D0.5430.85
263_M279_T0.5420.85
37_L40_M0.5400.84
270_G274_E0.5380.84
55_Q58_V0.5380.84
127_K138_P0.5380.84
85_K88_R0.5370.84
243_A251_I0.5360.84
74_V77_I0.5360.84
153_F159_R0.5350.84
32_M35_D0.5350.84
130_E137_L0.5340.84
140_I144_N0.5310.84
156_R160_Q0.5290.83
106_H109_H0.5280.83
92_G95_K0.5280.83
208_F256_L0.5270.83
44_E54_I0.5260.83
21_P28_Q0.5260.83
234_M257_Y0.5250.83
158_V163_A0.5250.83
155_E160_Q0.5230.83
193_I206_S0.5220.82
58_V66_V0.5200.82
244_Y286_E0.5190.82
107_T110_D0.5190.82
181_A262_K0.5190.82
20_R28_Q0.5170.82
263_M281_T0.5160.82
57_Q61_G0.5130.81
204_M254_V0.5090.81
81_Q91_P0.5090.81
62_E70_Q0.5090.81
22_S26_M0.5080.81
38_E41_T0.5030.80
100_E104_P0.5020.80
227_K233_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h41A 1 0.9932 100 0.334 Contact Map
4q4gX 1 0.4561 100 0.35 Contact Map
3npfA 2 0.8818 100 0.363 Contact Map
3m1uA 2 0.9392 100 0.405 Contact Map
2hbwA 1 0.6824 100 0.431 Contact Map
2k1gA 1 0.4223 100 0.444 Contact Map
4xcmA 2 0.75 100 0.456 Contact Map
4hpeA 1 0.8851 100 0.465 Contact Map
4fdyA 1 0.8851 100 0.476 Contact Map
3pbiA 1 0.6115 100 0.478 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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