GREMLIN Database
YOEC - Probable integrase/recombinase YoeC
UniProt: O35009 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (170)
Sequences: 27924 (21673)
Seq/√Len: 1662.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_G152_L4.5961.00
49_V85_T3.1831.00
69_R153_N2.9441.00
134_F151_I2.6791.00
126_G129_T2.6741.00
57_H78_K2.2811.00
34_G44_I2.2441.00
48_Q103_P2.2121.00
34_G127_T2.2101.00
48_Q93_Y2.1831.00
38_A134_F2.1071.00
41_I128_H2.0511.00
146_A149_Q2.0111.00
60_A70_K1.9611.00
132_K165_G1.8971.00
36_N74_L1.8771.00
13_I35_I1.8081.00
29_F84_Y1.7641.00
78_K82_Y1.7491.00
144_D147_E1.7421.00
138_F143_K1.7071.00
73_I78_K1.6871.00
154_H160_T1.6761.00
67_K155_S1.6731.00
139_Y148_L1.6701.00
32_I80_E1.6411.00
146_A150_R1.6391.00
27_D112_I1.6251.00
140_Q170_T1.5711.00
58_L70_K1.5691.00
72_L151_I1.5661.00
152_L160_T1.5621.00
20_L116_A1.5021.00
9_S12_K1.4781.00
43_D69_R1.4651.00
42_S46_P1.4371.00
41_I45_L1.4081.00
13_I137_H1.4021.00
53_Q56_D1.4011.00
10_L137_H1.3721.00
48_Q51_D1.3701.00
35_I137_H1.3591.00
28_Y32_I1.3401.00
138_F148_L1.3191.00
30_L109_A1.3151.00
48_Q92_E1.3001.00
139_Y164_I1.2961.00
149_Q157_P1.2911.00
108_Q111_R1.2851.00
136_Y165_G1.2741.00
39_L44_I1.2741.00
93_Y103_P1.2551.00
54_N82_Y1.2511.00
117_A125_I1.2381.00
112_I115_E1.2381.00
49_V94_L1.2301.00
140_Q167_D1.2261.00
41_I106_R1.2211.00
19_Y119_A1.2071.00
134_F138_F1.1991.00
159_I162_R1.1941.00
36_N77_L1.1891.00
35_I130_L1.1851.00
8_R133_T1.1781.00
10_L141_R1.1771.00
158_S161_M1.1671.00
29_F80_E1.1581.00
51_D62_E1.1541.00
106_R110_Y1.1471.00
8_R125_I1.1441.00
145_I161_M1.1351.00
53_Q58_L1.1271.00
62_E68_K1.1201.00
30_L44_I1.1191.00
107_I110_Y1.1181.00
35_I133_T1.1121.00
157_P161_M1.1031.00
8_R16_V1.0971.00
113_L117_A1.0951.00
12_K15_E1.0921.00
156_S162_R1.0881.00
28_Y80_E1.0811.00
50_K92_E1.0771.00
57_H75_E1.0751.00
147_E174_A1.0721.00
17_K32_I1.0681.00
64_K67_K1.0661.00
36_N76_S1.0631.00
19_Y120_C1.0611.00
137_H140_Q1.0521.00
41_I110_Y1.0451.00
25_K87_D1.0381.00
150_R171_T1.0331.00
133_T137_H1.0301.00
29_F83_E1.0161.00
54_N78_K1.0161.00
15_E19_Y1.0091.00
39_L61_T1.0001.00
20_L31_F0.9951.00
158_S162_R0.9861.00
30_L95_F0.9821.00
105_S108_Q0.9801.00
41_I109_A0.9791.00
110_Y114_R0.9761.00
74_L77_L0.9511.00
63_S67_K0.9491.00
114_R124_E0.9461.00
45_L109_A0.9461.00
47_L59_W0.9401.00
156_S159_I0.9261.00
14_Q18_Q0.9261.00
93_Y96_K0.9251.00
37_S71_I0.9211.00
60_A68_K0.9181.00
50_K91_N0.9171.00
170_T173_A0.9171.00
110_Y127_T0.9071.00
75_E79_Q0.9071.00
62_E66_K0.8981.00
7_I133_T0.8881.00
115_E119_A0.8881.00
16_V31_F0.8851.00
97_S102_K0.8781.00
46_P103_P0.8771.00
146_A161_M0.8721.00
63_S69_R0.8691.00
10_L14_Q0.8651.00
32_I76_S0.8611.00
151_I171_T0.8581.00
116_A119_A0.8571.00
33_F95_F0.8431.00
134_F152_L0.8421.00
108_Q112_I0.8381.00
77_L80_E0.8341.00
113_L130_L0.8331.00
149_Q160_T0.8311.00
6_P129_T0.8261.00
19_Y116_A0.8151.00
10_L140_Q0.8101.00
83_E87_D0.8061.00
8_R12_K0.8021.00
43_D63_S0.8011.00
29_F95_F0.7991.00
7_I165_G0.7941.00
33_F77_L0.7921.00
40_R128_H0.7881.00
34_G130_L0.7821.00
143_K147_E0.7811.00
172_R176_K0.7811.00
97_S100_T0.7771.00
140_Q169_D0.7711.00
112_I116_A0.7691.00
33_F39_L0.7611.00
29_F77_L0.7601.00
25_K83_E0.7531.00
73_I77_L0.7511.00
20_L28_Y0.7501.00
113_L127_T0.7481.00
53_Q60_A0.7471.00
72_L172_R0.7421.00
13_I17_K0.7421.00
32_I36_N0.7391.00
32_I77_L0.7301.00
76_S79_Q0.7301.00
80_E83_E0.7271.00
149_Q161_M0.7271.00
114_R118_A0.7261.00
169_D173_A0.7221.00
143_K174_A0.7131.00
168_E171_T0.7081.00
99_R102_K0.7071.00
125_I129_T0.7061.00
145_I157_P0.7051.00
41_I127_T0.7001.00
11_E15_E0.6951.00
33_F59_W0.6851.00
138_F142_T0.6831.00
84_Y87_D0.6801.00
31_F130_L0.6801.00
45_L106_R0.6701.00
54_N57_H0.6701.00
33_F44_I0.6701.00
111_R115_E0.6691.00
19_Y22_N0.6671.00
26_R84_Y0.6671.00
31_F113_L0.6671.00
167_D170_T0.6651.00
27_D116_A0.6631.00
139_Y167_D0.6591.00
25_K29_F0.6531.00
109_A127_T0.6471.00
34_G41_I0.6471.00
107_I114_R0.6451.00
26_R29_F0.6401.00
129_T132_K0.6291.00
135_G148_L0.6271.00
37_S74_L0.6251.00
29_F81_I0.6201.00
135_G164_I0.6191.00
52_V94_L0.6161.00
26_R112_I0.6141.00
25_K28_Y0.6121.00
7_I136_Y0.6111.00
143_K148_L0.6101.00
17_K28_Y0.6061.00
136_Y164_I0.6041.00
29_F33_F0.6031.00
15_E120_C0.6021.00
114_R117_A0.5991.00
54_N73_I0.5921.00
39_L59_W0.5851.00
139_Y144_D0.5851.00
8_R129_T0.5821.00
8_R13_I0.5801.00
89_K92_E0.5801.00
155_S159_I0.5711.00
57_H73_I0.5701.00
147_E151_I0.5671.00
53_Q57_H0.5651.00
52_V59_W0.5651.00
82_Y86_K0.5631.00
110_Y126_G0.5621.00
39_L43_D0.5621.00
117_A122_L0.5551.00
173_A176_K0.5541.00
135_G160_T0.5531.00
146_A164_I0.5491.00
38_A152_L0.5491.00
79_Q83_E0.5481.00
113_L125_I0.5461.00
11_E14_Q0.5451.00
83_E86_K0.5421.00
26_R104_I0.5401.00
12_K123_E0.5391.00
85_T94_L0.5341.00
108_Q115_E0.5341.00
148_L164_I0.5331.00
33_F81_I0.5331.00
15_E18_Q0.5271.00
116_A120_C0.5251.00
142_T148_L0.5241.00
97_S108_Q0.5211.00
96_K103_P0.5211.00
136_Y166_I0.5141.00
146_A157_P0.5131.00
16_V113_L0.5111.00
17_K20_L0.5101.00
139_Y166_I0.5071.00
79_Q82_Y0.5061.00
54_N94_L0.5041.00
139_Y143_K0.5031.00
48_Q91_N0.5031.00
5_Q132_K0.5021.00
81_I94_L0.5011.00
16_V117_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nkhA 2 0.989 100 0.191 Contact Map
2a3vA 3 0.9834 100 0.211 Contact Map
1a0pA 1 0.9282 100 0.231 Contact Map
4a8eA 2 0.9503 100 0.248 Contact Map
1z1bA 3 0.9503 100 0.27 Contact Map
1xo0A 3 0.9945 100 0.278 Contact Map
1z19A 3 0.9558 100 0.28 Contact Map
1ae9A 4 0.884 100 0.284 Contact Map
1aihA 2 0.895 100 0.333 Contact Map
3vcfA 1 0.8508 99.9 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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