GREMLIN Database
YTQA - Putative protein YtqA
UniProt: O35008 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (263)
Sequences: 3710 (2670)
Seq/√Len: 164.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_D177_C4.3781.00
141_D188_H3.5761.00
213_K263_I3.4081.00
186_R221_Q3.2881.00
137_D184_K3.1981.00
111_R145_E2.9541.00
196_I211_T2.7701.00
55_T239_Q2.7381.00
163_E175_F2.7301.00
249_S252_D2.6801.00
205_R259_D2.6721.00
180_E184_K2.6401.00
154_V185_L2.6241.00
162_H207_M2.6011.00
163_E176_N2.4901.00
111_R115_E2.4151.00
162_H210_E2.4101.00
210_E213_K2.3911.00
140_V188_H2.3271.00
137_D187_K2.2521.00
237_V283_I2.2251.00
179_V214_A2.1651.00
176_N180_E2.0721.00
205_R255_Q2.0571.00
186_R219_D2.0521.00
183_N187_K2.0461.00
178_Y194_S2.0251.00
290_N293_E2.0121.00
209_M259_D2.0041.00
136_P139_V1.9951.00
163_E167_L1.9561.00
170_N235_P1.9411.00
214_A217_D1.9231.00
164_R207_M1.9091.00
74_I116_S1.9011.00
259_D262_E1.8921.00
239_Q244_K1.8731.00
158_L178_Y1.8481.00
164_R167_L1.8371.00
168_L239_Q1.8351.00
196_I215_V1.8071.00
142_Y146_L1.7881.00
238_K242_K1.7691.00
160_T165_T1.7531.00
156_L185_L1.7311.00
39_G43_P1.7211.00
74_I78_H1.7001.00
78_H116_S1.6921.00
55_T236_M1.6611.00
204_D207_M1.6331.00
212_A260_Q1.6131.00
182_V192_V1.5781.00
185_L192_V1.5671.00
144_A188_H1.5621.00
237_V241_E1.5541.00
216_A265_P1.5461.00
194_S220_V1.5411.00
175_F214_A1.5221.00
111_R142_Y1.5151.00
198_N260_Q1.5091.00
107_V142_Y1.5041.00
197_I228_L1.4851.00
109_V113_K1.4781.00
127_S153_W1.4731.00
177_C180_E1.4551.00
169_I200_L1.4491.00
175_F179_V1.4371.00
235_P238_K1.4301.00
72_D75_T1.4281.00
115_E149_R1.4171.00
179_V183_N1.4021.00
158_L194_S1.3971.00
71_D75_T1.3811.00
184_K187_K1.3731.00
138_D141_D1.3261.00
213_K217_D1.3261.00
205_R209_M1.3261.00
109_V112_E1.3231.00
116_S119_A1.3051.00
141_D145_E1.2961.00
209_M213_K1.2951.00
29_H92_K1.2931.00
75_T79_D1.2871.00
168_L202_L1.2871.00
185_L190_I1.2831.00
292_W296_G1.2731.00
41_D44_N1.2531.00
258_C262_E1.2401.00
94_I98_Q1.2281.00
191_R221_Q1.2271.00
107_V111_R1.2251.00
84_M88_W1.2251.00
198_N208_M1.2191.00
161_V214_A1.2061.00
278_P281_L1.2031.00
216_A264_I1.1991.00
248_L256_L1.1911.00
115_E146_L1.1781.00
216_A263_I1.1581.00
180_E183_N1.1531.00
154_V190_I1.1511.00
223_I264_I1.1471.00
73_L80_I1.1351.00
209_M263_I1.1341.00
93_Y98_Q1.1291.00
78_H82_N1.1141.00
210_E214_A1.1051.00
111_R146_L1.0991.00
82_N120_L1.0901.00
161_V211_T1.0871.00
243_G246_E1.0760.99
184_K188_H1.0750.99
259_D263_I1.0700.99
38_G43_P1.0690.99
238_K241_E1.0610.99
222_G271_H1.0590.99
93_Y124_V1.0560.99
182_V218_L1.0480.99
29_H91_G1.0460.99
37_D43_P1.0460.99
78_H120_L1.0430.99
182_V194_S1.0390.99
79_D83_R1.0340.99
208_M260_Q1.0320.99
132_P181_G1.0280.99
93_Y96_Y1.0210.99
230_L237_V1.0190.99
140_V185_L1.0140.99
193_C222_G0.9930.99
232_K241_E0.9890.99
105_A109_V0.9880.99
55_T169_I0.9820.99
141_D144_A0.9670.99
77_F120_L0.9580.99
114_F146_L0.9580.99
293_E297_A0.9460.99
225_I260_Q0.9430.99
160_T166_A0.9390.99
107_V139_V0.9390.99
112_E116_S0.9370.99
178_Y220_V0.9350.99
115_E119_A0.9340.99
212_A216_A0.9260.98
195_H226_H0.9250.98
71_D79_D0.9240.98
211_T215_V0.9160.98
73_L76_Q0.9150.98
181_G184_K0.9110.98
196_I212_A0.9110.98
169_I201_P0.9060.98
164_R202_L0.9050.98
230_L236_M0.9050.98
137_D141_D0.9030.98
140_V184_K0.8960.98
92_K124_V0.8900.98
183_N217_D0.8890.98
235_P239_Q0.8890.98
272_R275_G0.8830.98
39_G44_N0.8830.98
72_D76_Q0.8800.98
78_H112_E0.8780.98
273_I276_D0.8740.98
37_D69_R0.8740.98
81_K122_D0.8720.98
194_S215_V0.8700.98
36_L43_P0.8690.98
132_P171_R0.8670.98
81_K120_L0.8580.98
167_L174_D0.8520.97
97_F117_V0.8490.97
135_L181_G0.8470.97
80_I84_M0.8440.97
73_L77_F0.8370.97
254_V297_A0.8360.97
79_D82_N0.8350.97
94_I99_A0.8300.97
254_V258_C0.8270.97
161_V215_V0.8240.97
104_H134_C0.8210.97
205_R252_D0.8180.97
112_E115_E0.8170.97
75_T112_E0.8110.97
53_G170_N0.8100.96
99_A102_N0.8060.96
236_M245_L0.8060.96
206_D210_E0.8050.96
142_Y145_E0.7990.96
254_V257_V0.7980.96
44_N49_V0.7970.96
140_V144_A0.7960.96
38_G41_D0.7920.96
114_F118_L0.7870.96
110_L142_Y0.7870.96
71_D109_V0.7830.96
215_V220_V0.7810.96
158_L161_V0.7790.96
75_T78_H0.7730.95
216_A268_M0.7710.95
36_L41_D0.7700.95
82_N116_S0.7700.95
39_G42_C0.7690.95
49_V177_C0.7690.95
163_E174_D0.7680.95
91_G122_D0.7670.95
246_E252_D0.7660.95
135_L184_K0.7620.95
262_E266_P0.7610.95
137_D188_H0.7570.95
95_A98_Q0.7560.95
153_W193_C0.7540.95
55_T168_L0.7530.95
208_M256_L0.7490.95
227_L288_S0.7480.95
166_A173_H0.7480.95
288_S291_K0.7390.94
287_W291_K0.7380.94
40_F43_P0.7350.94
291_K295_L0.7340.94
272_R276_D0.7320.94
231_L234_T0.7290.94
255_Q258_C0.7270.94
261_L270_V0.7270.94
265_P268_M0.7240.94
164_R168_L0.7230.93
195_H224_K0.7220.93
94_I127_S0.7210.93
176_N179_V0.7210.93
178_Y182_V0.7160.93
128_I148_E0.7130.93
114_F126_I0.7110.93
173_H177_C0.7110.93
282_M285_P0.7100.93
198_N225_I0.7100.93
83_R87_K0.7080.93
110_L117_V0.7080.93
136_P184_K0.7040.93
84_M87_K0.7030.93
118_L146_L0.7030.93
81_K117_V0.7000.92
130_T154_V0.6990.92
207_M210_E0.6970.92
257_V261_L0.6970.92
228_L236_M0.6960.92
96_Y99_A0.6940.92
165_T200_L0.6940.92
159_Q171_R0.6940.92
82_N86_E0.6910.92
209_M256_L0.6900.92
153_W222_G0.6900.92
155_E195_H0.6880.92
285_P290_N0.6870.92
37_D41_D0.6860.92
186_R220_V0.6850.92
131_R134_C0.6790.91
247_F284_G0.6790.91
179_V218_L0.6770.91
32_F88_W0.6770.91
182_V220_V0.6760.91
219_D267_E0.6710.91
138_D142_Y0.6710.91
141_D187_K0.6700.91
162_H165_T0.6670.90
101_T134_C0.6640.90
42_C105_A0.6640.90
77_F81_K0.6630.90
286_M289_V0.6570.90
213_K216_A0.6530.89
269_I272_R0.6520.89
153_W191_R0.6510.89
49_V52_G0.6490.89
31_V92_K0.6470.89
255_Q259_D0.6460.89
240_Y283_I0.6460.89
106_P109_V0.6450.89
58_S231_L0.6450.89
279_I289_V0.6430.89
85_H91_G0.6400.89
98_Q226_H0.6380.88
203_E252_D0.6380.88
156_L178_Y0.6360.88
36_L40_F0.6340.88
173_H178_Y0.6330.88
36_L95_A0.6320.88
216_A267_E0.6320.88
285_P294_V0.6310.88
71_D112_E0.6300.88
103_T143_L0.6250.87
165_T169_I0.6240.87
208_M212_A0.6220.87
194_S223_I0.6210.87
77_F80_I0.6200.87
276_D279_I0.6200.87
92_K98_Q0.6200.87
236_M239_Q0.6170.87
82_N85_H0.6100.86
97_F110_L0.6060.86
107_V146_L0.6040.86
163_E166_A0.6040.86
55_T170_N0.6020.85
98_Q195_H0.6010.85
224_K231_L0.6010.85
41_D49_V0.5990.85
37_D40_F0.5990.85
285_P288_S0.5980.85
63_G66_A0.5970.85
54_C57_C0.5950.85
186_R192_V0.5940.85
132_P173_H0.5930.85
76_Q80_I0.5920.84
53_G61_G0.5880.84
125_G153_W0.5840.84
131_R224_K0.5830.84
212_A263_I0.5810.83
145_E183_N0.5790.83
144_A190_I0.5790.83
105_A110_L0.5780.83
289_V293_E0.5780.83
205_R256_L0.5780.83
110_L114_F0.5760.83
272_R277_G0.5760.83
74_I85_H0.5760.83
212_A215_V0.5730.82
182_V186_R0.5720.82
78_H81_K0.5710.82
74_I119_A0.5710.82
232_K237_V0.5710.82
198_N257_V0.5680.82
74_I113_K0.5670.82
50_A170_N0.5670.82
40_F105_A0.5660.82
236_M240_Y0.5660.82
49_V172_A0.5650.82
29_H33_K0.5640.81
135_L139_V0.5640.81
192_V221_Q0.5640.81
110_L143_L0.5620.81
50_A172_A0.5620.81
128_I234_T0.5620.81
81_K121_D0.5610.81
248_L253_Y0.5600.81
55_T235_P0.5580.81
40_F109_V0.5570.81
206_D209_M0.5560.81
101_T201_P0.5560.81
118_L126_I0.5550.80
246_E249_S0.5550.80
80_I83_R0.5540.80
192_V220_V0.5540.80
169_I236_M0.5520.80
220_V268_M0.5520.80
115_E142_Y0.5510.80
193_C271_H0.5510.80
125_G193_C0.5450.79
179_V217_D0.5440.79
239_Q242_K0.5410.79
116_S120_L0.5400.79
135_L140_V0.5390.78
156_L192_V0.5390.78
72_D80_I0.5380.78
108_E112_E0.5380.78
65_F68_N0.5370.78
56_F271_H0.5330.78
41_D104_H0.5300.77
95_A123_V0.5280.77
95_A99_A0.5270.77
224_K275_G0.5260.77
56_F194_S0.5260.77
231_L277_G0.5250.77
85_H89_K0.5240.77
283_I294_V0.5200.76
123_V126_I0.5200.76
59_A231_L0.5180.76
133_D173_H0.5170.76
31_V36_L0.5160.75
155_E224_K0.5160.75
230_L239_Q0.5140.75
37_D99_A0.5140.75
133_D172_A0.5130.75
225_I257_V0.5120.75
52_G235_P0.5120.75
105_A113_K0.5120.75
212_A264_I0.5110.75
281_L285_P0.5100.75
52_G170_N0.5090.74
165_T207_M0.5070.74
271_H275_G0.5070.74
94_I125_G0.5060.74
34_V80_I0.5060.74
115_E118_L0.5060.74
72_D116_S0.5030.74
275_G278_P0.5030.74
30_K33_K0.5020.73
79_D112_E0.5010.73
215_V223_I0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oltA 1 0.9441 100 0.481 Contact Map
4jc0A 1 0.9379 100 0.604 Contact Map
2qgqA 1 0.7578 100 0.61 Contact Map
1r30A 2 0.8758 100 0.662 Contact Map
4u0oB 1 0.7795 99.9 0.666 Contact Map
3iixA 1 0.9068 99.9 0.675 Contact Map
4wcxA 1 0.913 99.9 0.679 Contact Map
3t7vA 1 0.8882 99.9 0.682 Contact Map
4r33A 2 0.913 99.9 0.688 Contact Map
4rtbA 2 0.9068 99.9 0.693 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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