GREMLIN Database
YVRP - Putative efflux system protein YvrP
UniProt: O35007 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (346)
Sequences: 21753 (17297)
Seq/√Len: 929.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_K102_E3.1041.00
99_K187_V2.9661.00
355_E369_S2.7801.00
339_Y351_K2.7101.00
50_V376_Y2.7091.00
344_D350_V2.6721.00
95_K193_D2.6001.00
352_Q375_D2.4641.00
342_K352_Q2.3751.00
337_E353_P2.3231.00
67_E228_K2.3181.00
328_S365_V2.2651.00
53_G373_P2.2271.00
325_K364_M2.1741.00
262_T297_L2.1701.00
116_N180_T2.1651.00
244_K258_K2.1641.00
102_E187_V2.1641.00
130_Q134_T2.1411.00
259_G296_I2.1231.00
137_E141_K2.1121.00
54_G364_M2.0891.00
95_K98_D2.0531.00
87_Y102_E2.0401.00
159_N163_K2.0081.00
53_G322_D2.0031.00
99_K189_T1.9881.00
77_D185_S1.9541.00
54_G325_K1.9371.00
357_G366_E1.9251.00
372_T375_D1.9191.00
87_Y99_K1.9071.00
197_Q220_V1.8721.00
246_R256_E1.8681.00
93_Q195_I1.8671.00
229_S312_I1.8621.00
123_N173_Q1.8531.00
246_R258_K1.8291.00
348_K389_Q1.8141.00
163_K166_Q1.8091.00
105_G109_S1.7791.00
28_F31_F1.7741.00
350_V386_E1.7681.00
170_K173_Q1.7681.00
66_V227_V1.7611.00
228_K293_P1.7491.00
121_M168_E1.7361.00
162_L166_Q1.7331.00
59_G313_E1.7011.00
356_I365_V1.7011.00
355_E368_K1.6841.00
120_E123_N1.6801.00
245_V296_I1.6771.00
152_Q156_D1.6711.00
96_K193_D1.6691.00
135_E139_K1.6541.00
357_G368_K1.6511.00
113_E116_N1.6501.00
130_Q166_Q1.6411.00
112_V176_L1.6281.00
229_S296_I1.6261.00
226_L295_T1.6151.00
136_T150_Q1.6041.00
136_T158_T1.5871.00
83_I201_Q1.5781.00
70_K221_S1.5661.00
349_A378_I1.5591.00
133_I137_E1.5481.00
73_K215_P1.5391.00
343_A390_V1.5371.00
319_A366_E1.5331.00
137_E159_N1.5181.00
119_I176_L1.5161.00
51_Y374_E1.4981.00
358_E366_E1.4981.00
177_A180_T1.4801.00
55_D321_A1.4781.00
249_L310_V1.4721.00
51_Y324_I1.4671.00
342_K375_D1.4621.00
119_I123_N1.4511.00
83_I101_F1.4481.00
227_V310_V1.4471.00
45_A391_T1.4421.00
333_Q338_P1.4391.00
340_V354_V1.4291.00
127_N130_Q1.4261.00
66_V225_Y1.4231.00
123_N127_N1.4191.00
81_G103_Y1.4181.00
244_K260_K1.4161.00
328_S363_D1.4131.00
27_G31_F1.4091.00
89_K92_D1.4041.00
230_Q293_P1.3921.00
155_L159_N1.3871.00
169_L173_Q1.3861.00
142_V149_N1.3831.00
134_T137_E1.3821.00
61_T313_E1.3731.00
61_T311_N1.3711.00
128_R132_S1.3651.00
47_S379_Y1.3641.00
140_L152_Q1.3631.00
109_S113_E1.3491.00
126_I130_Q1.3411.00
232_N235_L1.3401.00
84_K104_E1.3371.00
48_V343_A1.3311.00
246_R313_E1.3261.00
100_L217_I1.3231.00
173_Q177_A1.3231.00
268_P292_Y1.3201.00
48_V376_Y1.3141.00
119_I169_L1.3131.00
133_I155_L1.3111.00
71_Q218_Q1.3031.00
166_Q170_K1.2961.00
326_L377_V1.2931.00
126_I162_L1.2871.00
221_S224_K1.2851.00
109_S183_K1.2771.00
25_A29_Y1.2741.00
344_D348_K1.2741.00
55_D322_D1.2701.00
196_V217_I1.2571.00
269_A288_Q1.2501.00
121_M125_Q1.2381.00
116_N120_E1.2341.00
190_S219_I1.2341.00
114_Q175_E1.2331.00
246_R315_M1.2331.00
334_D351_K1.2301.00
324_I373_P1.2101.00
323_T366_E1.2041.00
108_H186_N1.1971.00
154_E157_Q1.1901.00
248_T313_E1.1901.00
318_N321_A1.1891.00
260_K297_L1.1871.00
134_T138_K1.1831.00
140_L155_L1.1811.00
224_K297_L1.1811.00
73_K218_Q1.1791.00
354_V367_I1.1721.00
248_T256_E1.1721.00
126_I169_L1.1691.00
130_Q162_L1.1601.00
127_N131_K1.1471.00
247_V298_L1.1431.00
198_S218_Q1.1421.00
112_V116_N1.1421.00
132_S136_T1.1391.00
101_F217_I1.1361.00
126_I166_Q1.1351.00
99_K102_E1.1331.00
338_P356_I1.1291.00
85_K203_I1.1171.00
127_N163_K1.1161.00
118_Q121_M1.1131.00
263_S295_T1.1131.00
88_V98_D1.1101.00
228_K295_T1.1091.00
199_V202_D1.1091.00
180_T184_G1.1061.00
227_V312_I1.1021.00
178_G182_N1.0901.00
199_V217_I1.0851.00
252_G257_W1.0831.00
112_V180_T1.0811.00
328_S359_T1.0781.00
101_F188_I1.0761.00
161_D165_S1.0751.00
343_A376_Y1.0651.00
153_D157_Q1.0631.00
24_G28_F1.0621.00
157_Q161_D1.0591.00
111_E114_Q1.0591.00
90_E198_S1.0581.00
133_I159_N1.0561.00
265_G293_P1.0501.00
360_D363_D1.0481.00
342_K350_V1.0441.00
125_Q128_R1.0421.00
138_K141_K1.0381.00
69_E224_K1.0371.00
236_M292_Y1.0371.00
114_Q118_Q1.0371.00
89_K199_V1.0351.00
119_I173_Q1.0351.00
227_V247_V1.0211.00
176_L180_T1.0211.00
133_I162_L1.0211.00
77_D82_S1.0171.00
123_N169_L1.0131.00
261_V296_I1.0121.00
249_L252_G1.0101.00
125_Q168_E1.0081.00
72_Q192_H1.0051.00
50_V374_E1.0041.00
156_D159_N1.0011.00
331_V365_V0.9911.00
105_G186_N0.9881.00
269_A287_P0.9811.00
235_L238_T0.9801.00
83_I207_A0.9801.00
345_E350_V0.9791.00
331_V338_P0.9781.00
66_V310_V0.9771.00
122_T172_H0.9751.00
86_T203_I0.9721.00
359_T365_V0.9701.00
138_K142_V0.9681.00
260_K299_D0.9651.00
269_A289_S0.9621.00
342_K345_E0.9551.00
65_K290_S0.9541.00
84_K102_E0.9511.00
57_E315_M0.9501.00
347_H389_Q0.9371.00
360_D364_M0.9361.00
226_L297_L0.9361.00
129_L165_S0.9331.00
66_V304_L0.9311.00
26_G30_F0.9301.00
120_E170_K0.9281.00
161_D164_T0.9281.00
76_I188_I0.9271.00
137_E155_L0.9261.00
248_T311_N0.9151.00
88_V217_I0.9131.00
116_N176_L0.9131.00
190_S193_D0.9111.00
132_S157_Q0.9061.00
111_E182_N0.9041.00
224_K299_D0.9031.00
57_E318_N0.9011.00
26_G29_Y0.9001.00
69_E226_L0.8951.00
27_G30_F0.8891.00
207_A216_Y0.8841.00
252_G255_G0.8841.00
341_W386_E0.8831.00
79_E208_T0.8821.00
122_T165_S0.8801.00
148_K152_Q0.8721.00
58_S238_T0.8641.00
125_Q164_T0.8631.00
26_G31_F0.8611.00
78_S108_H0.8601.00
44_Y388_K0.8601.00
200_N215_P0.8591.00
93_Q193_D0.8551.00
59_G315_M0.8531.00
115_A172_H0.8491.00
93_Q303_G0.8471.00
101_F199_V0.8471.00
261_V294_F0.8451.00
113_E177_A0.8451.00
92_D98_D0.8441.00
194_G219_I0.8441.00
315_M318_N0.8421.00
351_K386_E0.8421.00
101_F216_Y0.8381.00
55_D318_N0.8351.00
168_E172_H0.8331.00
378_I384_V0.8301.00
192_H219_I0.8271.00
326_L340_V0.8261.00
168_E171_Q0.8251.00
319_A323_T0.8251.00
343_A349_A0.8211.00
334_D337_E0.8211.00
343_A347_H0.8211.00
357_G365_V0.8151.00
208_T214_G0.8131.00
88_V199_V0.8121.00
118_Q175_E0.8121.00
117_L174_K0.8021.00
106_E181_K0.8011.00
200_N218_Q0.7981.00
84_K105_G0.7921.00
68_P306_V0.7921.00
247_V259_G0.7921.00
53_G324_I0.7891.00
181_K185_S0.7881.00
136_T139_K0.7821.00
367_I371_L0.7811.00
28_F32_T0.7791.00
79_E212_A0.7791.00
111_E178_G0.7761.00
181_K184_G0.7751.00
341_W351_K0.7701.00
122_T125_Q0.7701.00
102_E105_G0.7691.00
225_Y306_V0.7691.00
88_V196_V0.7691.00
248_T254_E0.7641.00
208_T212_A0.7641.00
339_Y353_P0.7621.00
332_I339_Y0.7571.00
52_M373_P0.7551.00
56_S360_D0.7531.00
70_K203_I0.7531.00
31_F34_M0.7511.00
105_G187_V0.7511.00
118_Q122_T0.7461.00
76_I207_A0.7431.00
352_Q372_T0.7431.00
240_K243_S0.7421.00
165_S169_L0.7411.00
49_A327_P0.7411.00
231_I294_F0.7401.00
343_A378_I0.7371.00
76_I101_F0.7361.00
349_A390_V0.7351.00
49_A52_M0.7351.00
349_A384_V0.7341.00
58_S317_D0.7341.00
159_N162_L0.7331.00
136_T154_E0.7331.00
67_E226_L0.7311.00
23_I26_G0.7281.00
86_T101_F0.7271.00
82_S206_G0.7271.00
229_S314_V0.7261.00
300_S303_G0.7241.00
231_I239_I0.7221.00
128_R131_K0.7181.00
90_E199_V0.7171.00
132_S153_D0.7161.00
46_E378_I0.7131.00
344_D347_H0.7121.00
385_K388_K0.7121.00
319_A322_D0.7091.00
77_D107_D0.7081.00
357_G370_G0.7071.00
131_K134_T0.7061.00
123_N126_I0.7041.00
341_W349_A0.7031.00
29_Y32_T0.7021.00
74_V191_K0.7021.00
111_E115_A0.7011.00
175_E179_L0.6991.00
69_E297_L0.6981.00
329_D379_Y0.6981.00
69_E221_S0.6951.00
160_F164_T0.6941.00
125_Q129_L0.6941.00
43_P391_T0.6931.00
112_V183_K0.6901.00
250_K311_N0.6901.00
165_S168_E0.6881.00
345_E375_D0.6871.00
31_F35_N0.6821.00
43_P389_Q0.6801.00
345_E352_Q0.6801.00
24_G27_G0.6791.00
64_G310_V0.6781.00
264_I294_F0.6781.00
340_V377_V0.6731.00
60_Q235_L0.6701.00
345_E348_K0.6681.00
139_K142_V0.6671.00
164_T168_E0.6671.00
70_K202_D0.6661.00
93_Q222_T0.6661.00
356_I367_I0.6651.00
158_T161_D0.6641.00
352_Q370_G0.6641.00
262_T295_T0.6631.00
111_E179_L0.6621.00
334_D339_Y0.6611.00
249_L304_L0.6581.00
83_I216_Y0.6571.00
150_Q154_E0.6561.00
115_A118_Q0.6561.00
269_A293_P0.6541.00
364_M368_K0.6521.00
51_Y371_L0.6491.00
251_T255_G0.6491.00
247_V312_I0.6481.00
51_Y375_D0.6481.00
62_F229_S0.6471.00
326_L330_M0.6461.00
179_L182_N0.6461.00
341_W384_V0.6431.00
60_Q316_S0.6421.00
152_Q159_N0.6381.00
79_E206_G0.6371.00
241_K264_I0.6361.00
195_I222_T0.6321.00
244_K315_M0.6311.00
70_K192_H0.6301.00
128_R160_F0.6291.00
251_T254_E0.6271.00
110_D181_K0.6271.00
52_M364_M0.6251.00
62_F235_L0.6241.00
25_A31_F0.6241.00
62_F231_I0.6221.00
49_A364_M0.6181.00
154_E158_T0.6161.00
148_K151_L0.6161.00
110_D174_K0.6121.00
72_Q191_K0.6121.00
115_A179_L0.6121.00
71_Q220_V0.6081.00
118_Q171_Q0.6051.00
24_G31_F0.6041.00
340_V370_G0.5991.00
347_H376_Y0.5981.00
171_Q175_E0.5971.00
326_L331_V0.5951.00
226_L262_T0.5951.00
132_S161_D0.5951.00
330_M377_V0.5941.00
115_A119_I0.5941.00
25_A28_F0.5911.00
140_L148_K0.5901.00
225_Y300_S0.5891.00
182_N185_S0.5861.00
151_L154_E0.5861.00
107_D182_N0.5831.00
223_G303_G0.5831.00
94_V100_L0.5811.00
324_I370_G0.5801.00
305_E308_Y0.5801.00
342_K377_V0.5791.00
23_I27_G0.5781.00
67_E71_Q0.5781.00
74_V217_I0.5771.00
62_F314_V0.5771.00
75_Y215_P0.5761.00
150_Q155_L0.5751.00
128_R157_Q0.5741.00
120_E124_L0.5731.00
292_Y308_Y0.5731.00
33_H36_Q0.5721.00
19_V22_G0.5721.00
105_G183_K0.5721.00
247_V296_I0.5701.00
41_S389_Q0.5701.00
184_G189_T0.5681.00
201_Q205_D0.5681.00
179_L183_K0.5671.00
327_P330_M0.5671.00
230_Q291_N0.5671.00
68_P71_Q0.5671.00
124_L167_L0.5661.00
56_S358_E0.5661.00
139_K151_L0.5661.00
162_L165_S0.5651.00
88_V92_D0.5641.00
149_N153_D0.5641.00
84_K87_Y0.5641.00
62_F312_I0.5631.00
230_Q269_A0.5631.00
117_L167_L0.5611.00
68_P220_V0.5591.00
175_E178_G0.5551.00
172_H175_E0.5541.00
58_S316_S0.5541.00
223_G301_H0.5521.00
132_S135_E0.5521.00
49_A326_L0.5501.00
233_E309_H0.5501.00
73_K205_D0.5501.00
22_G26_G0.5501.00
135_E156_D0.5481.00
64_G227_V0.5481.00
245_V314_V0.5471.00
133_I140_L0.5451.00
343_A346_N0.5441.00
139_K149_N0.5421.00
81_G207_A0.5421.00
332_I341_W0.5411.00
17_V31_F0.5411.00
345_E376_Y0.5401.00
53_G372_T0.5401.00
169_L172_H0.5391.00
268_P290_S0.5391.00
174_K177_A0.5381.00
131_K156_D0.5381.00
257_W304_L0.5381.00
118_Q172_H0.5371.00
227_V298_L0.5361.00
76_I216_Y0.5331.00
58_S358_E0.5331.00
371_L375_D0.5321.00
34_M37_V0.5321.00
220_V306_V0.5321.00
140_L150_Q0.5291.00
50_V53_G0.5281.00
242_G260_K0.5251.00
122_T126_I0.5251.00
74_V192_H0.5251.00
72_Q219_I0.5241.00
87_Y98_D0.5231.00
125_Q161_D0.5231.00
56_S366_E0.5231.00
49_A53_G0.5191.00
135_E142_V0.5191.00
208_T213_A0.5171.00
86_T199_V0.5161.00
109_S112_V0.5151.00
97_G189_T0.5141.00
233_E290_S0.5121.00
325_K366_E0.5121.00
56_S325_K0.5121.00
66_V249_L0.5111.00
201_Q216_Y0.5101.00
239_I261_V0.5081.00
215_P218_Q0.5071.00
32_T35_N0.5041.00
384_V390_V0.5011.00
220_V266_K0.5011.00
112_V179_L0.5011.00
229_S245_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lnnA 6 0.8262 100 0.283 Contact Map
1vf7A 5 0.5668 100 0.288 Contact Map
4dk0A 5 0.7708 100 0.29 Contact Map
3fppA 3 0.6272 100 0.304 Contact Map
3ne5B 3 0.7783 100 0.308 Contact Map
4l8jA 2 0.7884 100 0.315 Contact Map
4kkuA 1 0.6423 100 0.36 Contact Map
2f1mA 2 0.5844 100 0.426 Contact Map
4tkoB 1 0.5844 100 0.5 Contact Map
2k32A 1 0.2897 99.8 0.72 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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