HIS4 - BACSU - GREMLIN Contacts

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HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

UniProt:	O35006	Sequences: MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEKEGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVERVILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELANEGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADGVSGAIIGKALYTNQFTLSEALERVKRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	245 (233)
Sequences:	5906 (3074)
Seq/√Len:	201.4

ECOLI - HIS6 HIS4
BACSU - HIS4 HIS6
HALSA - HIS4 HIS6
SULSO - HIS6 HIS4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
92_V	119_M	3.276	1.00
117_K	161_E	2.559	1.00
141_E	145_E	2.553	1.00
21_V	176_M	2.448	1.00
112_N	118_K	2.442	1.00
159_A	194_K	2.382	1.00
88_S	91_D	2.340	1.00
131_L	155_G	2.339	1.00
40_E	75_K	2.325	1.00
157_E	161_E	2.306	1.00
129_I	158_L	2.293	1.00
137_F	146_T	2.231	1.00
234_T	237_E	2.166	1.00
40_E	44_K	2.162	1.00
93_Y	97_S	2.154	1.00
111_S	141_E	2.083	1.00
137_F	150_K	2.047	1.00
41_L	45_E	2.033	1.00
206_A	209_E	2.014	1.00
43_E	77_N	1.953	1.00
177_L	232_Q	1.939	1.00
206_A	210_A	1.907	1.00
137_F	148_T	1.886	1.00
16_K	31_Y	1.878	1.00
119_M	127_I	1.851	1.00
86_I	95_Y	1.850	1.00
66_D	94_E	1.840	1.00
59_K	144_L	1.836	1.00
92_V	127_I	1.812	1.00
186_V	190_K	1.790	1.00
168_F	184_S	1.749	1.00
150_K	153_E	1.733	1.00
93_Y	122_Q	1.718	1.00
34_S	37_D	1.701	1.00
110_V	140_T	1.686	1.00
159_A	193_G	1.661	1.00
22_Q	176_M	1.649	1.00
182_V	210_A	1.617	1.00
89_E	119_M	1.614	1.00
209_E	241_R	1.612	1.00
224_I	228_L	1.553	1.00
50_I	78_L	1.541	1.00
45_E	236_S	1.527	1.00
202_V	211_L	1.527	1.00
34_S	71_E	1.526	1.00
205_V	233_F	1.513	1.00
24_D	27_K	1.513	1.00
204_S	207_D	1.506	1.00
149_L	157_E	1.498	1.00
156_K	191_E	1.491	1.00
14_N	56_D	1.486	1.00
102_R	128_A	1.471	1.00
105_L	108_S	1.448	1.00
130_G	167_I	1.448	1.00
157_E	160_N	1.448	1.00
224_I	227_A	1.444	1.00
209_E	213_R	1.443	1.00
65_N	68_H	1.442	1.00
227_A	233_F	1.437	1.00
67_R	70_I	1.436	1.00
25_Y	59_K	1.419	1.00
190_K	218_G	1.416	1.00
96_L	126_K	1.405	1.00
114_P	118_K	1.397	1.00
73_A	80_V	1.391	1.00
135_N	150_K	1.367	1.00
71_E	74_Q	1.366	1.00
108_S	115_F	1.353	1.00
139_S	146_T	1.352	1.00
7_Y	49_W	1.347	1.00
89_E	122_Q	1.338	1.00
8_P	47_A	1.334	1.00
207_D	210_A	1.323	1.00
189_A	196_V	1.320	1.00
21_V	27_K	1.313	1.00
233_F	238_A	1.295	1.00
205_V	241_R	1.294	1.00
89_E	118_K	1.294	1.00
90_N	93_Y	1.290	1.00
52_L	72_I	1.285	1.00
32_G	38_M	1.284	1.00
117_K	121_K	1.264	1.00
49_W	102_R	1.262	1.00
5_T	49_W	1.255	1.00
136_G	187_E	1.251	1.00
208_L	227_A	1.242	1.00
170_D	181_N	1.240	1.00
92_V	103_V	1.229	1.00
69_V	82_I	1.226	1.00
70_I	74_Q	1.213	1.00
114_P	117_K	1.206	1.00
109_A	129_I	1.198	1.00
41_L	44_K	1.191	1.00
236_S	240_E	1.178	1.00
155_G	188_L	1.170	1.00
45_E	234_T	1.170	1.00
208_L	224_I	1.163	1.00
168_F	188_L	1.161	1.00
130_G	169_T	1.160	1.00
133_A	168_F	1.154	1.00
110_V	149_L	1.148	1.00
211_L	219_V	1.147	1.00
212_A	222_A	1.134	1.00
70_I	98_A	1.133	1.00
107_S	111_S	1.128	1.00
152_T	191_E	1.120	1.00
128_A	167_I	1.115	1.00
187_E	190_K	1.111	1.00
140_T	145_E	1.091	1.00
5_T	48_E	1.074	1.00
180_P	202_V	1.071	1.00
41_L	231_N	1.070	1.00
167_I	223_I	1.069	1.00
164_E	195_S	1.069	1.00
166_F	194_K	1.066	1.00
16_K	33_D	1.052	1.00
159_A	192_T	1.050	1.00
111_S	145_E	1.048	1.00
17_C	38_M	1.042	1.00
237_E	240_E	1.037	1.00
205_V	238_A	1.037	1.00
133_A	184_S	1.032	1.00
156_K	160_N	1.030	1.00
187_E	191_E	1.024	1.00
13_R	25_Y	1.022	1.00
182_V	186_V	1.016	1.00
82_I	95_Y	1.016	1.00
49_W	79_K	1.015	1.00
4_F	212_A	1.014	1.00
129_I	163_A	1.013	1.00
211_L	222_A	1.011	1.00
36_Y	68_H	1.010	1.00
112_N	115_F	1.007	1.00
183_K	186_V	0.995	1.00
133_A	151_A	0.993	1.00
73_A	100_V	0.988	1.00
45_E	235_L	0.988	1.00
188_L	196_V	0.982	1.00
189_A	217_D	0.976	1.00
165_V	195_S	0.975	1.00
111_S	140_T	0.971	0.99
210_A	213_R	0.969	0.99
93_Y	123_Y	0.966	0.99
115_F	119_M	0.965	0.99
151_A	188_L	0.963	0.99
82_I	100_V	0.963	0.99
185_T	189_A	0.960	0.99
189_A	219_V	0.955	0.99
49_W	128_A	0.944	0.99
120_L	163_A	0.943	0.99
36_Y	71_E	0.939	0.99
38_M	41_L	0.934	0.99
155_G	192_T	0.930	0.99
151_A	155_G	0.929	0.99
43_E	76_L	0.917	0.99
113_P	157_E	0.915	0.99
67_R	71_E	0.913	0.99
186_V	217_D	0.910	0.99
73_A	101_E	0.910	0.99
153_E	157_E	0.904	0.99
90_N	94_E	0.904	0.99
128_A	165_V	0.904	0.99
19_R	226_K	0.899	0.99
205_V	237_E	0.894	0.99
226_K	230_T	0.894	0.99
69_V	100_V	0.891	0.99
58_A	107_S	0.889	0.99
70_I	94_E	0.887	0.99
63_R	94_E	0.885	0.99
205_V	209_E	0.885	0.99
42_F	229_Y	0.883	0.99
105_L	119_M	0.880	0.99
134_R	172_A	0.872	0.99
116_V	129_I	0.865	0.99
40_E	43_E	0.863	0.99
81_E	104_I	0.860	0.99
152_T	187_E	0.852	0.99
94_E	98_A	0.847	0.99
53_V	167_I	0.844	0.99
96_L	123_Y	0.843	0.99
6_L	224_I	0.841	0.99
140_T	147_S	0.838	0.99
189_A	220_S	0.837	0.99
48_E	79_K	0.833	0.98
234_T	238_A	0.831	0.98
63_R	91_D	0.831	0.98
92_V	123_Y	0.829	0.98
116_V	158_L	0.825	0.98
152_T	156_K	0.812	0.98
76_L	79_K	0.799	0.98
202_V	222_A	0.797	0.98
13_R	26_N	0.792	0.98
117_K	157_E	0.792	0.98
91_D	94_E	0.787	0.98
208_L	233_F	0.786	0.98
204_S	208_L	0.786	0.98
71_E	75_K	0.782	0.98
79_K	101_E	0.776	0.98
182_V	217_D	0.776	0.98
203_S	207_D	0.775	0.98
183_K	187_E	0.767	0.97
134_R	139_S	0.764	0.97
165_V	220_S	0.764	0.97
212_A	242_V	0.761	0.97
173_T	178_S	0.760	0.97
13_R	56_D	0.760	0.97
89_E	93_Y	0.759	0.97
89_E	123_Y	0.759	0.97
43_E	78_L	0.757	0.97
5_T	221_G	0.753	0.97
152_T	155_G	0.752	0.97
151_A	184_S	0.741	0.97
139_S	171_I	0.740	0.97
57_G	64_V	0.736	0.97
204_S	232_Q	0.736	0.97
110_V	154_L	0.732	0.97
133_A	136_G	0.729	0.96
63_R	87_R	0.729	0.96
185_T	196_V	0.726	0.96
36_Y	75_K	0.726	0.96
66_D	70_I	0.724	0.96
125_E	164_E	0.723	0.96
173_T	176_M	0.720	0.96
47_A	235_L	0.719	0.96
153_E	156_K	0.711	0.96
131_L	154_L	0.709	0.96
211_L	217_D	0.708	0.96
217_D	220_S	0.707	0.96
7_Y	197_I	0.703	0.96
4_F	222_A	0.700	0.96
53_V	169_T	0.699	0.95
66_D	95_Y	0.695	0.95
21_V	226_K	0.695	0.95
190_K	217_D	0.694	0.95
37_D	41_L	0.693	0.95
197_I	221_G	0.691	0.95
56_D	61_G	0.690	0.95
102_R	164_E	0.690	0.95
167_I	197_I	0.688	0.95
24_D	59_K	0.685	0.95
138_V	154_L	0.683	0.95
68_H	72_I	0.681	0.95
195_S	220_S	0.675	0.95
104_I	167_I	0.672	0.94
6_L	222_A	0.671	0.94
60_E	64_V	0.667	0.94
208_L	238_A	0.666	0.94
64_V	69_V	0.666	0.94
159_A	166_F	0.666	0.94
129_I	166_F	0.666	0.94
7_Y	128_A	0.665	0.94
180_P	203_S	0.660	0.94
124_G	165_V	0.659	0.94
20_L	106_G	0.658	0.94
72_I	80_V	0.657	0.94
86_I	92_V	0.656	0.94
37_D	40_E	0.655	0.94
135_N	172_A	0.654	0.94
156_K	159_A	0.653	0.94
92_V	105_L	0.652	0.93
140_T	144_L	0.645	0.93
101_E	125_E	0.639	0.93
73_A	98_A	0.639	0.93
120_L	124_G	0.637	0.93
185_T	219_V	0.634	0.93
94_E	97_S	0.632	0.92
108_S	112_N	0.630	0.92
39_A	72_I	0.630	0.92
31_Y	230_T	0.629	0.92
188_L	192_T	0.626	0.92
181_N	184_S	0.625	0.92
185_T	211_L	0.625	0.92
92_V	126_K	0.623	0.92
118_K	121_K	0.619	0.92
208_L	228_L	0.618	0.92
92_V	96_L	0.617	0.92
208_L	222_A	0.615	0.91
70_I	97_S	0.615	0.91
121_K	160_N	0.613	0.91
86_I	105_L	0.612	0.91
228_L	238_A	0.612	0.91
225_G	229_Y	0.609	0.91
131_L	138_V	0.604	0.91
155_G	166_F	0.603	0.91
235_L	239_L	0.603	0.91
213_R	217_D	0.601	0.90
7_Y	81_E	0.599	0.90
47_A	238_A	0.599	0.90
101_E	126_K	0.599	0.90
20_L	23_G	0.597	0.90
61_G	65_N	0.594	0.90
56_D	65_N	0.593	0.90
20_L	26_N	0.593	0.90
63_R	95_Y	0.581	0.89
136_G	150_K	0.579	0.89
189_A	218_G	0.578	0.89
90_N	97_S	0.578	0.89
5_T	220_S	0.578	0.89
48_E	239_L	0.570	0.88
19_R	174_D	0.569	0.88
120_L	129_I	0.568	0.88
202_V	224_I	0.568	0.88
108_S	119_M	0.566	0.88
102_R	165_V	0.565	0.88
18_V	23_G	0.565	0.88
63_R	66_D	0.564	0.87
175_G	201_G	0.564	0.87
131_L	158_L	0.560	0.87
12_M	52_L	0.560	0.87
52_L	80_V	0.560	0.87
185_T	198_A	0.557	0.87
12_M	68_H	0.556	0.87
149_L	153_E	0.554	0.87
25_Y	144_L	0.553	0.86
156_K	192_T	0.550	0.86
62_K	91_D	0.547	0.86
13_R	59_K	0.545	0.86
165_V	197_I	0.543	0.85
193_G	196_V	0.542	0.85
87_R	111_S	0.542	0.85
162_G	194_K	0.541	0.85
105_L	116_V	0.540	0.85
180_P	207_D	0.538	0.85
22_Q	27_K	0.537	0.85
234_T	240_E	0.535	0.85
7_Y	102_R	0.535	0.85
112_N	121_K	0.532	0.84
24_D	169_T	0.531	0.84
82_I	86_I	0.527	0.84
137_F	140_T	0.524	0.83
203_S	232_Q	0.523	0.83
53_V	130_G	0.523	0.83
198_A	211_L	0.523	0.83
208_L	212_A	0.521	0.83
175_G	179_G	0.521	0.83
117_K	160_N	0.519	0.83
41_L	236_S	0.518	0.83
119_M	123_Y	0.518	0.83
169_T	199_S	0.517	0.83
95_Y	100_V	0.516	0.82
35_P	68_H	0.515	0.82
179_G	201_G	0.515	0.82
61_G	87_R	0.508	0.81
136_G	184_S	0.507	0.81
130_G	197_I	0.506	0.81
27_K	230_T	0.505	0.81
38_M	42_F	0.503	0.81
9_A	223_I	0.503	0.81
209_E	242_V	0.501	0.81
33_D	37_D	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2agkA	1	0.8694	100	0.256	Contact Map
1jvnA	1	0.9469	100	0.285	Contact Map
1qo2A	1	0.9592	100	0.416	Contact Map
4gj1A	1	0.9143	100	0.434	Contact Map
2y88A	1	0.9796	100	0.469	Contact Map
1thfD	2	0.9755	100	0.475	Contact Map
4u28A	1	0.9429	100	0.479	Contact Map
4evzA	1	0.9755	100	0.485	Contact Map
4x2rA	1	0.951	100	0.493	Contact Map
4axkA	1	0.9633	100	0.505	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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