GREMLIN Database
HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
UniProt: O35006 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (233)
Sequences: 5906 (3074)
Seq/√Len: 201.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_V119_M3.2761.00
117_K161_E2.5591.00
141_E145_E2.5531.00
21_V176_M2.4481.00
112_N118_K2.4421.00
159_A194_K2.3821.00
88_S91_D2.3401.00
131_L155_G2.3391.00
40_E75_K2.3251.00
157_E161_E2.3061.00
129_I158_L2.2931.00
137_F146_T2.2311.00
234_T237_E2.1661.00
40_E44_K2.1621.00
93_Y97_S2.1541.00
111_S141_E2.0831.00
137_F150_K2.0471.00
41_L45_E2.0331.00
206_A209_E2.0141.00
43_E77_N1.9531.00
177_L232_Q1.9391.00
206_A210_A1.9071.00
137_F148_T1.8861.00
16_K31_Y1.8781.00
119_M127_I1.8511.00
86_I95_Y1.8501.00
66_D94_E1.8401.00
59_K144_L1.8361.00
92_V127_I1.8121.00
186_V190_K1.7901.00
168_F184_S1.7491.00
150_K153_E1.7331.00
93_Y122_Q1.7181.00
34_S37_D1.7011.00
110_V140_T1.6861.00
159_A193_G1.6611.00
22_Q176_M1.6491.00
182_V210_A1.6171.00
89_E119_M1.6141.00
209_E241_R1.6121.00
224_I228_L1.5531.00
50_I78_L1.5411.00
45_E236_S1.5271.00
202_V211_L1.5271.00
34_S71_E1.5261.00
205_V233_F1.5131.00
24_D27_K1.5131.00
204_S207_D1.5061.00
149_L157_E1.4981.00
156_K191_E1.4911.00
14_N56_D1.4861.00
102_R128_A1.4711.00
105_L108_S1.4481.00
130_G167_I1.4481.00
157_E160_N1.4481.00
224_I227_A1.4441.00
209_E213_R1.4431.00
65_N68_H1.4421.00
227_A233_F1.4371.00
67_R70_I1.4361.00
25_Y59_K1.4191.00
190_K218_G1.4161.00
96_L126_K1.4051.00
114_P118_K1.3971.00
73_A80_V1.3911.00
135_N150_K1.3671.00
71_E74_Q1.3661.00
108_S115_F1.3531.00
139_S146_T1.3521.00
7_Y49_W1.3471.00
89_E122_Q1.3381.00
8_P47_A1.3341.00
207_D210_A1.3231.00
189_A196_V1.3201.00
21_V27_K1.3131.00
233_F238_A1.2951.00
205_V241_R1.2941.00
89_E118_K1.2941.00
90_N93_Y1.2901.00
52_L72_I1.2851.00
32_G38_M1.2841.00
117_K121_K1.2641.00
49_W102_R1.2621.00
5_T49_W1.2551.00
136_G187_E1.2511.00
208_L227_A1.2421.00
170_D181_N1.2401.00
92_V103_V1.2291.00
69_V82_I1.2261.00
70_I74_Q1.2131.00
114_P117_K1.2061.00
109_A129_I1.1981.00
41_L44_K1.1911.00
236_S240_E1.1781.00
155_G188_L1.1701.00
45_E234_T1.1701.00
208_L224_I1.1631.00
168_F188_L1.1611.00
130_G169_T1.1601.00
133_A168_F1.1541.00
110_V149_L1.1481.00
211_L219_V1.1471.00
212_A222_A1.1341.00
70_I98_A1.1331.00
107_S111_S1.1281.00
152_T191_E1.1201.00
128_A167_I1.1151.00
187_E190_K1.1111.00
140_T145_E1.0911.00
5_T48_E1.0741.00
180_P202_V1.0711.00
41_L231_N1.0701.00
167_I223_I1.0691.00
164_E195_S1.0691.00
166_F194_K1.0661.00
16_K33_D1.0521.00
159_A192_T1.0501.00
111_S145_E1.0481.00
17_C38_M1.0421.00
237_E240_E1.0371.00
205_V238_A1.0371.00
133_A184_S1.0321.00
156_K160_N1.0301.00
187_E191_E1.0241.00
13_R25_Y1.0221.00
182_V186_V1.0161.00
82_I95_Y1.0161.00
49_W79_K1.0151.00
4_F212_A1.0141.00
129_I163_A1.0131.00
211_L222_A1.0111.00
36_Y68_H1.0101.00
112_N115_F1.0071.00
183_K186_V0.9951.00
133_A151_A0.9931.00
73_A100_V0.9881.00
45_E235_L0.9881.00
188_L196_V0.9821.00
189_A217_D0.9761.00
165_V195_S0.9751.00
111_S140_T0.9710.99
210_A213_R0.9690.99
93_Y123_Y0.9660.99
115_F119_M0.9650.99
151_A188_L0.9630.99
82_I100_V0.9630.99
185_T189_A0.9600.99
189_A219_V0.9550.99
49_W128_A0.9440.99
120_L163_A0.9430.99
36_Y71_E0.9390.99
38_M41_L0.9340.99
155_G192_T0.9300.99
151_A155_G0.9290.99
43_E76_L0.9170.99
113_P157_E0.9150.99
67_R71_E0.9130.99
186_V217_D0.9100.99
73_A101_E0.9100.99
153_E157_E0.9040.99
90_N94_E0.9040.99
128_A165_V0.9040.99
19_R226_K0.8990.99
205_V237_E0.8940.99
226_K230_T0.8940.99
69_V100_V0.8910.99
58_A107_S0.8890.99
70_I94_E0.8870.99
63_R94_E0.8850.99
205_V209_E0.8850.99
42_F229_Y0.8830.99
105_L119_M0.8800.99
134_R172_A0.8720.99
116_V129_I0.8650.99
40_E43_E0.8630.99
81_E104_I0.8600.99
152_T187_E0.8520.99
94_E98_A0.8470.99
53_V167_I0.8440.99
96_L123_Y0.8430.99
6_L224_I0.8410.99
140_T147_S0.8380.99
189_A220_S0.8370.99
48_E79_K0.8330.98
234_T238_A0.8310.98
63_R91_D0.8310.98
92_V123_Y0.8290.98
116_V158_L0.8250.98
152_T156_K0.8120.98
76_L79_K0.7990.98
202_V222_A0.7970.98
13_R26_N0.7920.98
117_K157_E0.7920.98
91_D94_E0.7870.98
208_L233_F0.7860.98
204_S208_L0.7860.98
71_E75_K0.7820.98
79_K101_E0.7760.98
182_V217_D0.7760.98
203_S207_D0.7750.98
183_K187_E0.7670.97
134_R139_S0.7640.97
165_V220_S0.7640.97
212_A242_V0.7610.97
173_T178_S0.7600.97
13_R56_D0.7600.97
89_E93_Y0.7590.97
89_E123_Y0.7590.97
43_E78_L0.7570.97
5_T221_G0.7530.97
152_T155_G0.7520.97
151_A184_S0.7410.97
139_S171_I0.7400.97
57_G64_V0.7360.97
204_S232_Q0.7360.97
110_V154_L0.7320.97
133_A136_G0.7290.96
63_R87_R0.7290.96
185_T196_V0.7260.96
36_Y75_K0.7260.96
66_D70_I0.7240.96
125_E164_E0.7230.96
173_T176_M0.7200.96
47_A235_L0.7190.96
153_E156_K0.7110.96
131_L154_L0.7090.96
211_L217_D0.7080.96
217_D220_S0.7070.96
7_Y197_I0.7030.96
4_F222_A0.7000.96
53_V169_T0.6990.95
66_D95_Y0.6950.95
21_V226_K0.6950.95
190_K217_D0.6940.95
37_D41_L0.6930.95
197_I221_G0.6910.95
56_D61_G0.6900.95
102_R164_E0.6900.95
167_I197_I0.6880.95
24_D59_K0.6850.95
138_V154_L0.6830.95
68_H72_I0.6810.95
195_S220_S0.6750.95
104_I167_I0.6720.94
6_L222_A0.6710.94
60_E64_V0.6670.94
208_L238_A0.6660.94
64_V69_V0.6660.94
159_A166_F0.6660.94
129_I166_F0.6660.94
7_Y128_A0.6650.94
180_P203_S0.6600.94
124_G165_V0.6590.94
20_L106_G0.6580.94
72_I80_V0.6570.94
86_I92_V0.6560.94
37_D40_E0.6550.94
135_N172_A0.6540.94
156_K159_A0.6530.94
92_V105_L0.6520.93
140_T144_L0.6450.93
101_E125_E0.6390.93
73_A98_A0.6390.93
120_L124_G0.6370.93
185_T219_V0.6340.93
94_E97_S0.6320.92
108_S112_N0.6300.92
39_A72_I0.6300.92
31_Y230_T0.6290.92
188_L192_T0.6260.92
181_N184_S0.6250.92
185_T211_L0.6250.92
92_V126_K0.6230.92
118_K121_K0.6190.92
208_L228_L0.6180.92
92_V96_L0.6170.92
208_L222_A0.6150.91
70_I97_S0.6150.91
121_K160_N0.6130.91
86_I105_L0.6120.91
228_L238_A0.6120.91
225_G229_Y0.6090.91
131_L138_V0.6040.91
155_G166_F0.6030.91
235_L239_L0.6030.91
213_R217_D0.6010.90
7_Y81_E0.5990.90
47_A238_A0.5990.90
101_E126_K0.5990.90
20_L23_G0.5970.90
61_G65_N0.5940.90
56_D65_N0.5930.90
20_L26_N0.5930.90
63_R95_Y0.5810.89
136_G150_K0.5790.89
189_A218_G0.5780.89
90_N97_S0.5780.89
5_T220_S0.5780.89
48_E239_L0.5700.88
19_R174_D0.5690.88
120_L129_I0.5680.88
202_V224_I0.5680.88
108_S119_M0.5660.88
102_R165_V0.5650.88
18_V23_G0.5650.88
63_R66_D0.5640.87
175_G201_G0.5640.87
131_L158_L0.5600.87
12_M52_L0.5600.87
52_L80_V0.5600.87
185_T198_A0.5570.87
12_M68_H0.5560.87
149_L153_E0.5540.87
25_Y144_L0.5530.86
156_K192_T0.5500.86
62_K91_D0.5470.86
13_R59_K0.5450.86
165_V197_I0.5430.85
193_G196_V0.5420.85
87_R111_S0.5420.85
162_G194_K0.5410.85
105_L116_V0.5400.85
180_P207_D0.5380.85
22_Q27_K0.5370.85
234_T240_E0.5350.85
7_Y102_R0.5350.85
112_N121_K0.5320.84
24_D169_T0.5310.84
82_I86_I0.5270.84
137_F140_T0.5240.83
203_S232_Q0.5230.83
53_V130_G0.5230.83
198_A211_L0.5230.83
208_L212_A0.5210.83
175_G179_G0.5210.83
117_K160_N0.5190.83
41_L236_S0.5180.83
119_M123_Y0.5180.83
169_T199_S0.5170.83
95_Y100_V0.5160.82
35_P68_H0.5150.82
179_G201_G0.5150.82
61_G87_R0.5080.81
136_G184_S0.5070.81
130_G197_I0.5060.81
27_K230_T0.5050.81
38_M42_F0.5030.81
9_A223_I0.5030.81
209_E242_V0.5010.81
33_D37_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2agkA 1 0.8694 100 0.256 Contact Map
1jvnA 1 0.9469 100 0.285 Contact Map
1qo2A 1 0.9592 100 0.416 Contact Map
4gj1A 1 0.9143 100 0.434 Contact Map
2y88A 1 0.9796 100 0.469 Contact Map
1thfD 2 0.9755 100 0.475 Contact Map
4u28A 1 0.9429 100 0.479 Contact Map
4evzA 1 0.9755 100 0.485 Contact Map
4x2rA 1 0.951 100 0.493 Contact Map
4axkA 1 0.9633 100 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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