GREMLIN Database
CTPB - Carboxy-terminal processing protease CtpB
UniProt: O35002 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 480 (389)
Sequences: 3056 (2226)
Seq/√Len: 112.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
303_T331_S10.0641.00
318_L324_Y8.5471.00
251_G304_D7.6931.00
174_S191_R4.8571.00
174_S193_K4.2751.00
149_S178_K4.2221.00
242_I245_L3.8821.00
219_I226_T3.8151.00
319_K362_N3.3721.00
219_I263_I3.2341.00
236_E240_K3.1321.00
247_I314_L3.1271.00
263_I314_L2.9981.00
305_K329_D2.9911.00
153_E166_K2.9451.00
204_A233_A2.9421.00
171_K195_A2.7881.00
214_V244_G2.7501.00
213_S243_E2.7131.00
233_A236_E2.6981.00
307_S311_S2.6911.00
127_I141_L2.6441.00
227_A262_E2.5061.00
124_K146_E2.4681.00
300_N327_V2.4621.00
176_S189_S2.4261.00
112_E171_K2.4141.00
100_A348_N2.3901.00
215_G237_L2.3701.00
141_L179_I2.3521.00
234_L245_L2.3441.00
138_K195_A2.2981.00
176_S191_R2.2901.00
330_T370_E2.2701.00
303_T326_V2.2291.00
316_G369_I2.2281.00
179_I190_F2.2191.00
268_V321_A2.1881.00
315_A326_V2.1781.00
181_R188_L2.1271.00
230_F267_F2.1241.00
244_G298_P2.0971.00
327_V373_I2.0731.00
71_D74_K1.9611.00
126_I146_E1.9481.00
209_V242_I1.9281.00
125_I163_A1.9241.00
273_P276_Q1.9211.00
178_K189_S1.8891.00
121_E126_I1.8201.00
264_L314_L1.7921.00
232_K236_E1.7811.00
229_D232_K1.7631.00
225_H228_E1.7501.00
63_S72_R1.7501.00
370_E374_A1.7391.00
149_S152_G1.7361.00
264_L274_Y1.7211.00
265_K274_Y1.7101.00
385_P391_P1.6291.00
219_I247_I1.6161.00
93_V350_K1.6081.00
150_I155_M1.5631.00
385_P395_D1.5381.00
96_D99_T1.5161.00
247_I299_V1.5111.00
78_G86_T1.5081.00
234_L294_K1.5011.00
432_A435_D1.4861.00
238_E297_Y1.4791.00
110_S196_E1.4661.00
68_E355_K1.4631.00
329_D376_K1.4481.00
177_M192_I1.4371.00
107_L256_Y1.4371.00
112_E196_E1.4261.00
264_L268_V1.4071.00
120_M125_I1.4011.00
402_K405_Q1.4001.00
231_A235_R1.3811.00
178_K187_Q1.3781.00
430_V433_F1.3771.00
146_E180_Q1.3631.00
180_Q187_Q1.3581.00
387_Q391_P1.3551.00
260_V264_L1.3481.00
316_G358_T1.3411.00
228_E232_K1.3261.00
221_T253_P1.3191.00
415_P419_D1.3020.99
401_V404_A1.2940.99
141_L190_F1.2920.99
431_M434_Q1.2910.99
261_E274_Y1.2850.99
57_K344_G1.2840.99
269_T293_H1.2760.99
226_T263_I1.2760.99
314_L318_L1.2730.99
132_K137_E1.2690.99
139_A190_F1.2670.99
319_K372_T1.2650.99
217_I230_F1.2460.99
118_V160_L1.2350.99
95_M103_F1.2350.99
429_A432_A1.2280.99
265_K290_T1.2270.99
413_F416_G1.2260.99
278_A357_L1.2250.99
428_K431_M1.2150.99
385_P388_L1.2130.99
102_Q105_D1.2080.99
258_Q262_E1.2080.99
385_P392_L1.2010.99
158_K166_K1.1990.99
230_F263_I1.1910.99
92_S351_L1.1870.99
259_S262_E1.1860.99
169_G194_R1.1810.99
278_A284_K1.1600.99
279_E282_G1.1570.99
177_M190_F1.1550.99
231_A266_H1.1500.99
200_E229_D1.1450.99
269_T272_Q1.1420.99
201_T226_T1.1390.99
77_E94_Y1.1360.99
241_E244_G1.1340.99
430_V434_Q1.1330.99
385_P394_V1.1300.99
184_T188_L1.1240.98
101_K105_D1.1230.98
227_A259_S1.1210.98
91_Y365_H1.1200.98
237_L245_L1.1150.98
162_H165_L1.1050.98
424_K428_K1.1020.98
119_G128_V1.0900.98
114_I175_V1.0890.98
62_I351_L1.0890.98
420_G423_S1.0870.98
320_E362_N1.0730.98
385_P390_E1.0710.98
279_E283_D1.0710.98
94_Y347_S1.0700.98
215_G242_I1.0690.98
211_G214_V1.0660.98
179_I188_L1.0610.98
145_D181_R1.0590.98
78_G82_G1.0560.98
227_A263_I1.0530.98
256_Y259_S1.0520.98
404_A408_L1.0510.98
316_G362_N1.0470.98
416_G420_G1.0450.98
171_K196_E1.0430.98
428_K432_A1.0400.97
70_V75_L1.0390.97
84_L349_I1.0360.97
59_Y63_S1.0340.97
117_E128_V1.0310.97
261_E275_I1.0260.97
384_G387_Q1.0100.97
337_V354_Y1.0060.97
391_P394_V0.9950.97
219_I230_F0.9940.97
253_P307_S0.9940.97
358_T369_I0.9940.97
260_V314_L0.9920.97
120_M123_G0.9890.97
148_I187_Q0.9830.96
417_R420_G0.9830.96
411_L415_P0.9830.96
215_G245_L0.9790.96
59_Y72_R0.9770.96
192_I195_A0.9750.96
409_K412_S0.9690.96
91_Y336_T0.9670.96
129_S253_P0.9670.96
159_D162_H0.9580.96
418_E421_Y0.9580.96
130_P306_G0.9570.96
129_S143_P0.9560.96
339_Q353_L0.9560.96
249_V311_S0.9520.96
150_I175_V0.9500.96
326_V331_S0.9500.96
390_E393_K0.9490.96
420_G426_M0.9470.96
384_G391_P0.9460.96
265_K291_L0.9460.96
245_L299_V0.9440.96
264_L318_L0.9420.96
320_E360_N0.9400.95
237_L242_I0.9390.95
173_S194_R0.9350.95
400_D404_A0.9340.95
391_P402_K0.9300.95
429_A435_D0.9290.95
301_V318_L0.9270.95
133_K138_K0.9260.95
265_K272_Q0.9220.95
246_V300_N0.9210.95
247_I301_V0.9210.95
135_P139_A0.9160.95
408_L411_L0.9150.95
127_I190_F0.9130.95
103_F340_A0.9120.95
299_V324_Y0.9120.95
77_E81_Q0.9060.94
148_I180_Q0.9060.94
408_L412_S0.8980.94
105_D111_F0.8980.94
390_E394_V0.8980.94
387_Q395_D0.8970.94
339_Q354_Y0.8970.94
400_D403_H0.8940.94
151_N176_S0.8860.94
117_E129_S0.8850.94
111_F168_R0.8700.93
429_A434_Q0.8690.93
325_D373_I0.8660.93
414_D418_E0.8600.93
315_A319_K0.8590.93
118_V163_A0.8500.92
47_E50_K0.8490.92
338_Q352_T0.8430.92
415_P423_S0.8430.92
163_A167_I0.8420.92
301_V324_Y0.8420.92
427_K431_M0.8360.92
387_Q390_E0.8360.92
100_A104_S0.8360.92
426_M429_A0.8330.92
287_Y290_T0.8320.92
56_E60_E0.8310.91
213_S244_G0.8310.91
308_A334_K0.8310.91
194_R197_I0.8300.91
141_L188_L0.8300.91
113_G335_G0.8290.91
417_R421_Y0.8290.91
112_E134_S0.8290.91
81_Q99_T0.8290.91
175_V194_R0.8280.91
393_K396_M0.8270.91
230_F266_H0.8250.91
62_I70_V0.8240.91
414_D420_G0.8230.91
112_E167_I0.8230.91
273_P287_Y0.8220.91
316_G359_P0.8210.91
336_T365_H0.8200.91
273_P278_A0.8200.91
61_L65_E0.8190.91
416_G419_D0.8170.91
160_L164_V0.8130.91
136_A139_A0.8130.91
423_S426_M0.8120.91
172_G195_A0.8110.90
393_K398_N0.8080.90
54_K77_E0.8060.90
308_A332_F0.8060.90
277_I354_Y0.8040.90
265_K295_K0.8040.90
431_M435_D0.8020.90
320_E323_H0.7960.90
269_T289_S0.7940.90
268_V274_Y0.7930.89
111_F131_F0.7930.89
413_F417_R0.7910.89
367_K370_E0.7900.89
419_D423_S0.7860.89
90_P332_F0.7840.89
257_L275_I0.7830.89
394_V427_K0.7830.89
393_K397_N0.7780.89
412_S419_D0.7760.88
411_L420_G0.7740.88
150_I166_K0.7740.88
249_V314_L0.7730.88
158_K162_H0.7710.88
414_D421_Y0.7710.88
390_E398_N0.7710.88
357_L363_W0.7700.88
422_F426_M0.7690.88
152_G176_S0.7680.88
149_S189_S0.7660.88
79_A82_G0.7640.88
341_V351_L0.7630.88
110_S225_H0.7630.88
114_I167_I0.7620.88
130_P143_P0.7600.87
398_N401_V0.7600.87
410_G413_F0.7590.87
226_T230_F0.7580.87
76_L80_I0.7570.87
381_F390_E0.7570.87
210_Q213_S0.7560.87
105_D168_R0.7550.87
429_A433_F0.7530.87
148_I178_K0.7520.87
48_R51_A0.7520.87
401_V406_V0.7510.87
201_T223_S0.7500.87
139_A192_I0.7490.87
312_E334_K0.7460.86
116_A141_L0.7450.86
110_S170_K0.7450.86
230_F234_L0.7440.86
394_V398_N0.7440.86
334_K338_Q0.7440.86
167_I177_M0.7440.86
155_M158_K0.7420.86
212_H243_E0.7400.86
124_K156_A0.7400.86
54_K345_D0.7390.86
273_P289_S0.7370.86
276_Q361_G0.7370.86
103_F350_K0.7370.86
401_V405_Q0.7360.86
313_I337_V0.7350.86
427_K430_V0.7340.86
427_K433_F0.7330.85
308_A312_E0.7310.85
224_E256_Y0.7290.85
408_L413_F0.7290.85
281_N284_K0.7270.85
230_F247_I0.7260.85
98_Q165_L0.7220.85
149_S154_S0.7220.85
272_Q289_S0.7210.84
79_A83_M0.7190.84
393_K400_D0.7180.84
316_G320_E0.7170.84
114_I169_G0.7160.84
127_I147_I0.7160.84
183_G187_Q0.7160.84
356_W364_I0.7150.84
405_Q417_R0.7140.84
227_A231_A0.7140.84
405_Q420_G0.7140.84
412_S415_P0.7100.84
294_K297_Y0.7090.83
117_E131_F0.7070.83
245_L297_Y0.7070.83
219_I314_L0.7040.83
396_M402_K0.7040.83
113_G194_R0.7030.83
300_N325_D0.7020.83
404_A417_R0.6960.82
316_G360_N0.6950.82
258_Q263_I0.6940.82
425_D432_A0.6930.82
424_K427_K0.6920.82
405_Q408_L0.6910.82
54_K347_S0.6890.82
416_G423_S0.6880.82
169_G173_S0.6870.82
416_G435_D0.6870.82
342_P348_N0.6860.81
90_P365_H0.6840.81
152_G189_S0.6800.81
408_L415_P0.6790.81
289_S293_H0.6780.81
97_K347_S0.6770.81
217_I233_A0.6750.80
118_V164_V0.6740.80
331_S368_G0.6730.80
58_A62_I0.6720.80
320_E358_T0.6720.80
423_S429_A0.6700.80
413_F419_D0.6690.80
418_E425_D0.6690.80
420_G430_V0.6680.80
418_E423_S0.6680.80
100_A107_L0.6670.80
388_L391_P0.6670.80
112_E170_K0.6650.79
247_I318_L0.6600.79
116_A127_I0.6580.79
142_K181_R0.6580.79
400_D409_K0.6560.78
233_A237_L0.6560.78
286_R289_S0.6560.78
148_I165_L0.6550.78
194_R313_I0.6510.78
421_Y425_D0.6510.78
53_D57_K0.6480.78
422_F427_K0.6480.78
415_P422_F0.6460.77
282_G288_F0.6440.77
412_S416_G0.6420.77
396_M399_E0.6400.77
313_I364_I0.6390.77
237_L240_K0.6390.77
74_K78_G0.6390.77
385_P389_K0.6340.76
416_G421_Y0.6340.76
249_V301_V0.6330.76
91_Y363_W0.6320.76
295_K299_V0.6320.76
269_T294_K0.6320.76
50_K53_D0.6280.75
334_K352_T0.6280.75
209_V240_K0.6280.75
275_I337_V0.6270.75
126_I163_A0.6270.75
355_K363_W0.6230.75
52_M56_E0.6230.75
201_T221_T0.6220.75
424_K431_M0.6210.75
257_L337_V0.6210.75
180_Q183_G0.6170.74
95_M347_S0.6170.74
238_E296_A0.6170.74
155_M166_K0.6160.74
142_K189_S0.6160.74
95_M99_T0.6150.74
428_K433_F0.6140.74
111_F164_V0.6130.74
391_P397_N0.6110.73
46_S50_K0.6110.73
398_N403_H0.6110.73
90_P308_A0.6100.73
257_L313_I0.6100.73
244_G300_N0.6090.73
379_D383_A0.6080.73
153_E158_K0.6080.73
392_L396_M0.6070.73
408_L416_G0.6070.73
278_A285_K0.6060.73
412_S420_G0.6040.73
242_I297_Y0.6030.72
80_I83_M0.6030.72
281_N379_D0.6020.72
242_I299_V0.6010.72
55_I59_Y0.6010.72
118_V130_P0.6000.72
270_K292_T0.5980.72
400_D408_L0.5970.72
340_A343_M0.5970.72
391_P400_D0.5970.72
307_S337_V0.5950.71
413_F422_F0.5950.71
407_L410_G0.5950.71
172_G194_R0.5940.71
422_F430_V0.5940.71
127_I360_N0.5920.71
327_V375_I0.5900.71
299_V318_L0.5870.70
209_V213_S0.5860.70
227_A266_H0.5860.70
426_M430_V0.5860.70
308_A352_T0.5850.70
48_R52_M0.5840.70
386_L390_E0.5810.70
391_P395_D0.5810.70
80_I84_L0.5800.70
335_G352_T0.5800.70
303_T371_P0.5790.69
401_V408_L0.5780.69
272_Q321_A0.5780.69
308_A338_Q0.5780.69
320_E361_G0.5770.69
125_I147_I0.5760.69
253_P306_G0.5760.69
57_K61_L0.5740.69
332_F365_H0.5740.69
123_G134_S0.5740.69
232_K235_R0.5720.68
251_G306_G0.5660.68
411_L416_G0.5660.68
402_K406_V0.5650.68
273_P286_R0.5630.67
106_S221_T0.5630.67
313_I338_Q0.5620.67
120_M160_L0.5610.67
400_D405_Q0.5610.67
89_D334_K0.5600.67
216_Y237_L0.5600.67
272_Q290_T0.5600.67
103_F107_L0.5590.67
209_V241_E0.5590.67
46_S51_A0.5590.67
132_K220_S0.5590.67
426_M434_Q0.5580.67
238_E295_K0.5580.67
416_G424_K0.5580.67
89_D352_T0.5580.67
422_F433_F0.5570.66
252_N255_G0.5560.66
316_G356_W0.5560.66
407_L412_S0.5550.66
335_G338_Q0.5540.66
84_L93_V0.5540.66
114_I118_V0.5540.66
115_G334_K0.5530.66
114_I194_R0.5520.66
339_Q349_I0.5510.66
168_R313_I0.5510.66
183_G186_K0.5510.66
58_A61_L0.5500.65
320_E357_L0.5470.65
315_A369_I0.5470.65
182_P187_Q0.5470.65
402_K411_L0.5460.65
164_V168_R0.5460.65
204_A236_E0.5450.65
207_K210_Q0.5440.65
423_S431_M0.5440.65
43_Q46_S0.5430.65
387_Q398_N0.5420.64
276_Q284_K0.5420.64
413_F420_G0.5410.64
92_S226_T0.5410.64
113_G337_V0.5400.64
303_T307_S0.5400.64
337_V364_I0.5400.64
333_G368_G0.5390.64
421_Y426_M0.5380.64
132_K203_F0.5380.64
317_A358_T0.5380.64
396_M401_V0.5380.64
401_V413_F0.5370.64
409_K413_F0.5370.64
410_G419_D0.5340.63
84_L92_S0.5330.63
409_K415_P0.5330.63
76_L83_M0.5310.63
329_D374_A0.5310.63
357_L365_H0.5310.63
396_M400_D0.5310.63
319_K323_H0.5300.63
390_E414_D0.5290.63
409_K424_K0.5290.63
96_D347_S0.5280.62
412_S421_Y0.5270.62
198_P229_D0.5260.62
356_W365_H0.5250.62
422_F434_Q0.5240.62
425_D429_A0.5230.62
49_D56_E0.5230.62
77_E97_K0.5220.61
416_G422_F0.5210.61
421_Y429_A0.5210.61
220_S311_S0.5210.61
238_E245_L0.5200.61
277_I337_V0.5200.61
51_A55_I0.5180.61
234_L299_V0.5170.61
67_V341_V0.5170.61
340_A348_N0.5170.61
98_Q161_N0.5150.60
323_H365_H0.5150.60
263_I266_H0.5140.60
262_E327_V0.5130.60
124_K180_Q0.5130.60
386_L391_P0.5110.60
418_E426_M0.5110.60
105_D349_I0.5110.60
391_P396_M0.5110.60
181_R326_V0.5100.60
210_Q231_A0.5100.60
306_G383_A0.5090.60
403_H406_V0.5090.60
169_G197_I0.5080.59
381_F387_Q0.5080.59
43_Q47_E0.5080.59
54_K94_Y0.5080.59
341_V349_I0.5070.59
209_V237_L0.5060.59
285_K289_S0.5060.59
194_R337_V0.5050.59
170_K383_A0.5030.59
401_V426_M0.5030.59
412_S426_M0.5030.59
111_F199_L0.5020.59
323_H356_W0.5010.58
240_K399_E0.5010.58
329_D377_Q0.5010.58
203_F220_S0.5010.58
128_V143_P0.5010.58
409_K416_G0.5000.58
135_P197_I0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c2eA 2 0.9062 100 0.252 Contact Map
4ql6A 2 0.725 100 0.343 Contact Map
1fc6A 1 0.7688 100 0.351 Contact Map
3k50A 1 0.7021 100 0.388 Contact Map
4ghnA 1 0.7417 100 0.441 Contact Map
1k32A 5 0.8 100 0.448 Contact Map
3dorA 2 0.7625 100 0.47 Contact Map
4lurA 1 0.6062 100 0.486 Contact Map
1j7xA 1 0.5958 100 0.512 Contact Map
4l8kA 3 0.6312 100 0.553 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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