NAGB - BACSU - GREMLIN Contacts

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NAGB - Glucosamine-6-phosphate deaminase 1

UniProt:	O35000	Sequences: MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTYRQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIPNGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQTRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDFPASALHLHSDVTVLIDREAASLRP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	242 (223)
Sequences:	5238 (3817)
Seq/√Len:	255.6

ECOLI - NAGB AGAI YIEK
BACSU - NAGB GAMA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
82_F	86_D	3.521	1.00
200_K	236_E	2.805	1.00
7_Q	235_R	2.695	1.00
135_R	201_S	2.589	1.00
192_R	228_D	2.582	1.00
112_E	115_R	2.526	1.00
46_Q	49_R	2.491	1.00
8_T	11_E	2.443	1.00
206_V	233_I	2.413	1.00
85_N	90_Q	2.303	1.00
102_P	180_L	2.189	1.00
118_Q	122_S	2.176	1.00
13_S	42_G	2.103	1.00
57_S	93_D	2.094	1.00
23_T	30_A	2.092	1.00
204_E	208_K	2.076	1.00
233_I	238_A	2.053	1.00
6_C	15_I	1.979	1.00
62_T	100_F	1.975	1.00
74_S	81_H	1.954	1.00
23_T	192_R	1.930	1.00
171_S	174_S	1.927	1.00
22_D	26_E	1.914	1.00
127_D	191_K	1.907	1.00
86_D	90_Q	1.904	1.00
20_T	43_T	1.893	1.00
129_Q	190_S	1.888	1.00
12_L	198_S	1.872	1.00
14_Q	46_Q	1.817	1.00
100_F	119_L	1.803	1.00
63_T	89_F	1.793	1.00
207_R	211_E	1.776	1.00
81_H	85_N	1.750	1.00
41_E	87_R	1.709	1.00
208_K	218_F	1.699	1.00
188_L	222_A	1.672	1.00
9_Y	13_S	1.669	1.00
29_D	62_T	1.668	1.00
64_V	123_L	1.666	1.00
108_D	111_A	1.628	1.00
159_E	163_Q	1.595	1.00
81_H	101_I	1.566	1.00
39_T	196_L	1.560	1.00
106_A	112_E	1.550	1.00
21_A	56_L	1.541	1.00
70_A	109_L	1.538	1.00
114_R	118_Q	1.533	1.00
133_I	197_I	1.530	1.00
62_T	98_R	1.528	1.00
85_N	96_P	1.523	1.00
48_I	91_H	1.515	1.00
5_E	238_A	1.514	1.00
200_K	239_S	1.506	1.00
43_T	130_L	1.490	1.00
111_A	115_R	1.479	1.00
45_R	87_R	1.449	1.00
197_I	206_V	1.427	1.00
20_T	32_L	1.409	1.00
19_I	232_L	1.361	1.00
24_I	61_I	1.359	1.00
7_Q	11_E	1.357	1.00
133_I	209_L	1.353	1.00
59_Q	93_D	1.343	1.00
205_A	218_F	1.342	1.00
115_R	119_L	1.339	1.00
35_A	66_L	1.323	1.00
135_R	164_A	1.316	1.00
137_G	218_F	1.315	1.00
21_A	25_K	1.312	1.00
33_G	129_Q	1.310	1.00
49_R	53_T	1.298	1.00
128_I	194_L	1.295	1.00
182_M	186_T	1.284	1.00
209_L	220_A	1.279	1.00
75_D	82_F	1.266	1.00
95_K	98_R	1.258	1.00
6_C	232_L	1.230	1.00
115_R	118_Q	1.221	1.00
118_Q	121_D	1.220	1.00
31_V	64_V	1.203	1.00
117_E	186_T	1.199	1.00
133_I	220_A	1.199	1.00
140_G	187_I	1.180	1.00
65_N	84_M	1.177	1.00
33_G	66_L	1.169	1.00
192_R	230_T	1.166	1.00
209_L	231_V	1.165	1.00
24_I	30_A	1.165	1.00
15_I	18_R	1.164	1.00
19_I	192_R	1.163	1.00
43_T	196_L	1.154	1.00
31_V	62_T	1.153	1.00
77_P	82_F	1.149	1.00
16_A	43_T	1.144	1.00
121_D	189_S	1.141	1.00
9_Y	42_G	1.139	1.00
10_E	42_G	1.133	1.00
16_A	194_L	1.133	1.00
16_A	232_L	1.131	1.00
225_L	229_V	1.128	1.00
119_L	122_S	1.127	1.00
203_A	239_S	1.118	1.00
42_G	45_R	1.105	1.00
41_E	45_R	1.104	1.00
79_S	82_F	1.100	1.00
27_K	127_D	1.096	1.00
6_C	12_L	1.091	1.00
6_C	11_E	1.090	1.00
27_K	191_K	1.088	1.00
170_P	174_S	1.079	1.00
20_T	128_I	1.076	1.00
28_P	60_N	1.073	1.00
58_F	61_I	1.066	1.00
160_Q	164_A	1.043	1.00
18_R	22_D	1.040	1.00
203_A	207_R	1.025	1.00
5_E	235_R	1.021	1.00
4_M	15_I	1.020	1.00
33_G	126_T	1.013	1.00
62_T	123_L	1.012	1.00
73_S	105_N	1.012	1.00
94_S	98_R	1.010	1.00
41_E	83_Y	1.008	1.00
83_Y	87_R	1.003	1.00
4_M	230_T	0.998	1.00
9_Y	198_S	0.989	1.00
205_A	208_K	0.983	1.00
89_F	99_H	0.972	1.00
12_L	232_L	0.972	1.00
19_I	194_L	0.961	1.00
185_Q	189_S	0.957	1.00
103_N	112_E	0.957	1.00
30_A	61_I	0.955	1.00
110_E	114_R	0.950	1.00
111_A	114_R	0.949	1.00
45_R	91_H	0.948	1.00
19_I	23_T	0.947	1.00
38_G	168_Y	0.947	1.00
85_N	99_H	0.946	1.00
113_C	117_E	0.928	1.00
184_I	222_A	0.924	1.00
120_V	126_T	0.918	1.00
172_I	175_V	0.915	1.00
119_L	123_L	0.915	1.00
57_S	60_N	0.914	1.00
11_E	14_Q	0.908	1.00
4_M	232_L	0.899	1.00
62_T	95_K	0.899	1.00
25_K	55_N	0.894	1.00
148_F	222_A	0.890	1.00
190_S	193_I	0.885	1.00
34_L	63_T	0.885	1.00
30_A	128_I	0.881	1.00
56_L	61_I	0.881	1.00
13_S	43_T	0.878	1.00
10_E	46_Q	0.874	1.00
103_N	106_A	0.873	1.00
106_A	109_L	0.862	1.00
34_L	44_Y	0.862	1.00
20_T	130_L	0.859	0.99
188_L	226_H	0.858	0.99
58_F	92_I	0.855	0.99
35_A	129_Q	0.852	0.99
85_N	101_I	0.852	0.99
206_V	231_V	0.850	0.99
195_L	220_A	0.849	0.99
16_A	196_L	0.849	0.99
109_L	180_L	0.848	0.99
206_V	209_L	0.845	0.99
218_F	221_S	0.844	0.99
209_L	218_F	0.838	0.99
159_E	162_R	0.834	0.99
95_K	99_H	0.828	0.99
133_I	206_V	0.826	0.99
27_K	30_A	0.823	0.99
126_T	129_Q	0.812	0.99
208_K	212_G	0.805	0.99
69_Y	179_A	0.805	0.99
193_I	229_V	0.805	0.99
172_I	177_K	0.804	0.99
42_G	46_Q	0.799	0.99
148_F	216_E	0.795	0.99
39_T	198_S	0.795	0.99
208_K	217_D	0.794	0.99
69_Y	80_Y	0.793	0.99
67_D	138_H	0.790	0.99
64_V	119_L	0.788	0.99
40_P	44_Y	0.787	0.99
187_I	193_I	0.785	0.99
73_S	76_D	0.783	0.99
18_R	55_N	0.780	0.99
74_S	85_N	0.778	0.99
214_I	225_L	0.773	0.99
16_A	20_T	0.773	0.99
84_M	89_F	0.771	0.99
213_N	221_S	0.762	0.99
23_T	26_E	0.758	0.99
64_V	100_F	0.756	0.99
109_L	178_K	0.754	0.99
117_E	121_D	0.753	0.99
233_I	237_A	0.749	0.99
66_L	187_I	0.749	0.99
173_D	177_K	0.749	0.99
9_Y	12_L	0.746	0.99
66_L	182_M	0.743	0.99
10_E	14_Q	0.741	0.99
188_L	223_L	0.740	0.98
5_E	233_I	0.739	0.98
59_Q	95_K	0.738	0.98
188_L	225_L	0.736	0.98
35_A	139_I	0.730	0.98
74_S	101_I	0.721	0.98
14_Q	18_R	0.719	0.98
139_I	195_L	0.715	0.98
10_E	45_R	0.715	0.98
45_R	49_R	0.710	0.98
80_Y	179_A	0.709	0.98
131_L	187_I	0.706	0.98
130_L	196_L	0.705	0.98
135_R	205_A	0.698	0.98
103_N	115_R	0.697	0.98
137_G	205_A	0.693	0.98
81_H	99_H	0.689	0.98
69_Y	141_F	0.685	0.98
36_T	80_Y	0.681	0.97
17_A	47_L	0.681	0.97
96_P	99_H	0.678	0.97
78_N	177_K	0.677	0.97
29_D	60_N	0.677	0.97
112_E	180_L	0.673	0.97
72_L	82_F	0.668	0.97
234_D	237_A	0.668	0.97
204_E	207_R	0.667	0.97
38_G	83_Y	0.666	0.97
203_A	238_A	0.664	0.97
120_V	124_G	0.663	0.97
48_I	87_R	0.660	0.97
32_L	63_T	0.659	0.97
15_I	19_I	0.657	0.97
133_I	205_A	0.656	0.97
24_I	32_L	0.650	0.97
104_G	112_E	0.646	0.96
13_S	46_Q	0.644	0.96
15_I	232_L	0.638	0.96
65_N	101_I	0.636	0.96
11_E	15_I	0.631	0.96
21_A	47_L	0.626	0.96
210_L	231_V	0.624	0.96
145_G	216_E	0.622	0.96
35_A	44_Y	0.621	0.96
94_S	97_S	0.620	0.96
209_L	224_H	0.618	0.95
72_L	76_D	0.616	0.95
195_L	231_V	0.616	0.95
72_L	79_S	0.615	0.95
102_P	116_Y	0.615	0.95
108_D	178_K	0.612	0.95
146_T	217_D	0.611	0.95
141_F	179_A	0.610	0.95
25_K	56_L	0.610	0.95
17_A	46_Q	0.608	0.95
94_S	99_H	0.606	0.95
65_N	81_H	0.598	0.95
117_E	162_R	0.596	0.95
63_T	84_M	0.595	0.94
64_V	126_T	0.593	0.94
193_I	223_L	0.591	0.94
129_Q	187_I	0.590	0.94
69_Y	143_E	0.590	0.94
74_S	105_N	0.586	0.94
17_A	21_A	0.584	0.94
34_L	84_M	0.583	0.94
19_I	22_D	0.581	0.94
78_N	174_S	0.578	0.94
140_G	181_T	0.578	0.94
158_N	162_R	0.577	0.94
186_T	189_S	0.576	0.93
47_L	58_F	0.575	0.93
64_V	120_V	0.575	0.93
194_L	232_L	0.575	0.93
184_I	219_P	0.573	0.93
222_A	225_L	0.572	0.93
3_V	210_L	0.571	0.93
21_A	55_N	0.569	0.93
206_V	210_L	0.569	0.93
143_E	179_A	0.567	0.93
66_L	140_G	0.567	0.93
101_I	105_N	0.566	0.93
181_T	185_Q	0.563	0.93
38_G	41_E	0.562	0.93
84_M	99_H	0.561	0.93
19_I	230_T	0.558	0.92
174_S	177_K	0.557	0.92
20_T	24_I	0.555	0.92
132_G	202_K	0.554	0.92
79_S	104_G	0.554	0.92
171_S	177_K	0.550	0.92
54_E	58_F	0.550	0.92
70_A	104_G	0.548	0.92
205_A	209_L	0.545	0.91
88_F	92_I	0.545	0.91
38_G	135_R	0.542	0.91
193_I	225_L	0.541	0.91
66_L	129_Q	0.541	0.91
22_D	25_K	0.541	0.91
161_T	164_A	0.539	0.91
27_K	60_N	0.538	0.91
72_L	75_D	0.537	0.91
212_G	215_S	0.536	0.91
67_D	202_K	0.533	0.91
80_Y	141_F	0.533	0.91
129_Q	140_G	0.531	0.90
167_R	181_T	0.529	0.90
80_Y	143_E	0.529	0.90
102_P	112_E	0.527	0.90
49_R	91_H	0.524	0.90
215_S	221_S	0.523	0.90
142_N	157_L	0.523	0.90
21_A	54_E	0.522	0.90
113_C	116_Y	0.522	0.90
132_G	138_H	0.515	0.89
163_Q	172_I	0.515	0.89
100_F	123_L	0.515	0.89
85_N	89_F	0.513	0.89
44_Y	130_L	0.512	0.89
236_E	239_S	0.511	0.89
191_K	227_S	0.510	0.89
36_T	143_E	0.509	0.88
12_L	16_A	0.507	0.88
113_C	181_T	0.504	0.88
39_T	83_Y	0.504	0.88
120_V	186_T	0.501	0.88
23_T	128_I	0.501	0.88
70_A	112_E	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3icoA	1	0.9463	100	0.077	Contact Map
3tx2A	1	0.9463	100	0.08	Contact Map
4tm7A	1	0.9421	100	0.087	Contact Map
3eb9A	1	0.938	100	0.101	Contact Map
3cssA	1	0.9421	100	0.151	Contact Map
3e15A	2	0.9752	100	0.157	Contact Map
3lwdA	2	0.8967	100	0.165	Contact Map
1vl1A	1	0.876	100	0.167	Contact Map
1ne7A	4	1	100	0.181	Contact Map
1y89A	2	0.9421	100	0.181	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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