GREMLIN Database
NAGB - Glucosamine-6-phosphate deaminase 1
UniProt: O35000 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (223)
Sequences: 5238 (3817)
Seq/√Len: 255.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_F86_D3.5211.00
200_K236_E2.8051.00
7_Q235_R2.6951.00
135_R201_S2.5891.00
192_R228_D2.5821.00
112_E115_R2.5261.00
46_Q49_R2.4911.00
8_T11_E2.4431.00
206_V233_I2.4131.00
85_N90_Q2.3031.00
102_P180_L2.1891.00
118_Q122_S2.1761.00
13_S42_G2.1031.00
57_S93_D2.0941.00
23_T30_A2.0921.00
204_E208_K2.0761.00
233_I238_A2.0531.00
6_C15_I1.9791.00
62_T100_F1.9751.00
74_S81_H1.9541.00
23_T192_R1.9301.00
171_S174_S1.9271.00
22_D26_E1.9141.00
127_D191_K1.9071.00
86_D90_Q1.9041.00
20_T43_T1.8931.00
129_Q190_S1.8881.00
12_L198_S1.8721.00
14_Q46_Q1.8171.00
100_F119_L1.8031.00
63_T89_F1.7931.00
207_R211_E1.7761.00
81_H85_N1.7501.00
41_E87_R1.7091.00
208_K218_F1.6991.00
188_L222_A1.6721.00
9_Y13_S1.6691.00
29_D62_T1.6681.00
64_V123_L1.6661.00
108_D111_A1.6281.00
159_E163_Q1.5951.00
81_H101_I1.5661.00
39_T196_L1.5601.00
106_A112_E1.5501.00
21_A56_L1.5411.00
70_A109_L1.5381.00
114_R118_Q1.5331.00
133_I197_I1.5301.00
62_T98_R1.5281.00
85_N96_P1.5231.00
48_I91_H1.5151.00
5_E238_A1.5141.00
200_K239_S1.5061.00
43_T130_L1.4901.00
111_A115_R1.4791.00
45_R87_R1.4491.00
197_I206_V1.4271.00
20_T32_L1.4091.00
19_I232_L1.3611.00
24_I61_I1.3591.00
7_Q11_E1.3571.00
133_I209_L1.3531.00
59_Q93_D1.3431.00
205_A218_F1.3421.00
115_R119_L1.3391.00
35_A66_L1.3231.00
135_R164_A1.3161.00
137_G218_F1.3151.00
21_A25_K1.3121.00
33_G129_Q1.3101.00
49_R53_T1.2981.00
128_I194_L1.2951.00
182_M186_T1.2841.00
209_L220_A1.2791.00
75_D82_F1.2661.00
95_K98_R1.2581.00
6_C232_L1.2301.00
115_R118_Q1.2211.00
118_Q121_D1.2201.00
31_V64_V1.2031.00
117_E186_T1.1991.00
133_I220_A1.1991.00
140_G187_I1.1801.00
65_N84_M1.1771.00
33_G66_L1.1691.00
192_R230_T1.1661.00
209_L231_V1.1651.00
24_I30_A1.1651.00
15_I18_R1.1641.00
19_I192_R1.1631.00
43_T196_L1.1541.00
31_V62_T1.1531.00
77_P82_F1.1491.00
16_A43_T1.1441.00
121_D189_S1.1411.00
9_Y42_G1.1391.00
10_E42_G1.1331.00
16_A194_L1.1331.00
16_A232_L1.1311.00
225_L229_V1.1281.00
119_L122_S1.1271.00
203_A239_S1.1181.00
42_G45_R1.1051.00
41_E45_R1.1041.00
79_S82_F1.1001.00
27_K127_D1.0961.00
6_C12_L1.0911.00
6_C11_E1.0901.00
27_K191_K1.0881.00
170_P174_S1.0791.00
20_T128_I1.0761.00
28_P60_N1.0731.00
58_F61_I1.0661.00
160_Q164_A1.0431.00
18_R22_D1.0401.00
203_A207_R1.0251.00
5_E235_R1.0211.00
4_M15_I1.0201.00
33_G126_T1.0131.00
62_T123_L1.0121.00
73_S105_N1.0121.00
94_S98_R1.0101.00
41_E83_Y1.0081.00
83_Y87_R1.0031.00
4_M230_T0.9981.00
9_Y198_S0.9891.00
205_A208_K0.9831.00
89_F99_H0.9721.00
12_L232_L0.9721.00
19_I194_L0.9611.00
185_Q189_S0.9571.00
103_N112_E0.9571.00
30_A61_I0.9551.00
110_E114_R0.9501.00
111_A114_R0.9491.00
45_R91_H0.9481.00
19_I23_T0.9471.00
38_G168_Y0.9471.00
85_N99_H0.9461.00
113_C117_E0.9281.00
184_I222_A0.9241.00
120_V126_T0.9181.00
172_I175_V0.9151.00
119_L123_L0.9151.00
57_S60_N0.9141.00
11_E14_Q0.9081.00
4_M232_L0.8991.00
62_T95_K0.8991.00
25_K55_N0.8941.00
148_F222_A0.8901.00
190_S193_I0.8851.00
34_L63_T0.8851.00
30_A128_I0.8811.00
56_L61_I0.8811.00
13_S43_T0.8781.00
10_E46_Q0.8741.00
103_N106_A0.8731.00
106_A109_L0.8621.00
34_L44_Y0.8621.00
20_T130_L0.8590.99
188_L226_H0.8580.99
58_F92_I0.8550.99
35_A129_Q0.8520.99
85_N101_I0.8520.99
206_V231_V0.8500.99
195_L220_A0.8490.99
16_A196_L0.8490.99
109_L180_L0.8480.99
206_V209_L0.8450.99
218_F221_S0.8440.99
209_L218_F0.8380.99
159_E162_R0.8340.99
95_K99_H0.8280.99
133_I206_V0.8260.99
27_K30_A0.8230.99
126_T129_Q0.8120.99
208_K212_G0.8050.99
69_Y179_A0.8050.99
193_I229_V0.8050.99
172_I177_K0.8040.99
42_G46_Q0.7990.99
148_F216_E0.7950.99
39_T198_S0.7950.99
208_K217_D0.7940.99
69_Y80_Y0.7930.99
67_D138_H0.7900.99
64_V119_L0.7880.99
40_P44_Y0.7870.99
187_I193_I0.7850.99
73_S76_D0.7830.99
18_R55_N0.7800.99
74_S85_N0.7780.99
214_I225_L0.7730.99
16_A20_T0.7730.99
84_M89_F0.7710.99
213_N221_S0.7620.99
23_T26_E0.7580.99
64_V100_F0.7560.99
109_L178_K0.7540.99
117_E121_D0.7530.99
233_I237_A0.7490.99
66_L187_I0.7490.99
173_D177_K0.7490.99
9_Y12_L0.7460.99
66_L182_M0.7430.99
10_E14_Q0.7410.99
188_L223_L0.7400.98
5_E233_I0.7390.98
59_Q95_K0.7380.98
188_L225_L0.7360.98
35_A139_I0.7300.98
74_S101_I0.7210.98
14_Q18_R0.7190.98
139_I195_L0.7150.98
10_E45_R0.7150.98
45_R49_R0.7100.98
80_Y179_A0.7090.98
131_L187_I0.7060.98
130_L196_L0.7050.98
135_R205_A0.6980.98
103_N115_R0.6970.98
137_G205_A0.6930.98
81_H99_H0.6890.98
69_Y141_F0.6850.98
36_T80_Y0.6810.97
17_A47_L0.6810.97
96_P99_H0.6780.97
78_N177_K0.6770.97
29_D60_N0.6770.97
112_E180_L0.6730.97
72_L82_F0.6680.97
234_D237_A0.6680.97
204_E207_R0.6670.97
38_G83_Y0.6660.97
203_A238_A0.6640.97
120_V124_G0.6630.97
48_I87_R0.6600.97
32_L63_T0.6590.97
15_I19_I0.6570.97
133_I205_A0.6560.97
24_I32_L0.6500.97
104_G112_E0.6460.96
13_S46_Q0.6440.96
15_I232_L0.6380.96
65_N101_I0.6360.96
11_E15_I0.6310.96
21_A47_L0.6260.96
210_L231_V0.6240.96
145_G216_E0.6220.96
35_A44_Y0.6210.96
94_S97_S0.6200.96
209_L224_H0.6180.95
72_L76_D0.6160.95
195_L231_V0.6160.95
72_L79_S0.6150.95
102_P116_Y0.6150.95
108_D178_K0.6120.95
146_T217_D0.6110.95
141_F179_A0.6100.95
25_K56_L0.6100.95
17_A46_Q0.6080.95
94_S99_H0.6060.95
65_N81_H0.5980.95
117_E162_R0.5960.95
63_T84_M0.5950.94
64_V126_T0.5930.94
193_I223_L0.5910.94
129_Q187_I0.5900.94
69_Y143_E0.5900.94
74_S105_N0.5860.94
17_A21_A0.5840.94
34_L84_M0.5830.94
19_I22_D0.5810.94
78_N174_S0.5780.94
140_G181_T0.5780.94
158_N162_R0.5770.94
186_T189_S0.5760.93
47_L58_F0.5750.93
64_V120_V0.5750.93
194_L232_L0.5750.93
184_I219_P0.5730.93
222_A225_L0.5720.93
3_V210_L0.5710.93
21_A55_N0.5690.93
206_V210_L0.5690.93
143_E179_A0.5670.93
66_L140_G0.5670.93
101_I105_N0.5660.93
181_T185_Q0.5630.93
38_G41_E0.5620.93
84_M99_H0.5610.93
19_I230_T0.5580.92
174_S177_K0.5570.92
20_T24_I0.5550.92
132_G202_K0.5540.92
79_S104_G0.5540.92
171_S177_K0.5500.92
54_E58_F0.5500.92
70_A104_G0.5480.92
205_A209_L0.5450.91
88_F92_I0.5450.91
38_G135_R0.5420.91
193_I225_L0.5410.91
66_L129_Q0.5410.91
22_D25_K0.5410.91
161_T164_A0.5390.91
27_K60_N0.5380.91
72_L75_D0.5370.91
212_G215_S0.5360.91
67_D202_K0.5330.91
80_Y141_F0.5330.91
129_Q140_G0.5310.90
167_R181_T0.5290.90
80_Y143_E0.5290.90
102_P112_E0.5270.90
49_R91_H0.5240.90
215_S221_S0.5230.90
142_N157_L0.5230.90
21_A54_E0.5220.90
113_C116_Y0.5220.90
132_G138_H0.5150.89
163_Q172_I0.5150.89
100_F123_L0.5150.89
85_N89_F0.5130.89
44_Y130_L0.5120.89
236_E239_S0.5110.89
191_K227_S0.5100.89
36_T143_E0.5090.88
12_L16_A0.5070.88
113_C181_T0.5040.88
39_T83_Y0.5040.88
120_V186_T0.5010.88
23_T128_I0.5010.88
70_A112_E0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3icoA 1 0.9463 100 0.077 Contact Map
3tx2A 1 0.9463 100 0.08 Contact Map
4tm7A 1 0.9421 100 0.087 Contact Map
3eb9A 1 0.938 100 0.101 Contact Map
3cssA 1 0.9421 100 0.151 Contact Map
3e15A 2 0.9752 100 0.157 Contact Map
3lwdA 2 0.8967 100 0.165 Contact Map
1vl1A 1 0.876 100 0.167 Contact Map
1ne7A 4 1 100 0.181 Contact Map
1y89A 2 0.9421 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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