GREMLIN Database
YKOY - Uncharacterized membrane protein YkoY
UniProt: O34997 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (276)
Sequences: 2036 (1029)
Seq/√Len: 61.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_V74_L4.9811.00
55_F74_L4.3941.00
36_S42_A4.1611.00
68_E72_V4.0071.00
117_L182_I3.5881.00
47_D81_G3.5511.00
249_A296_A3.4451.00
146_S255_G3.3581.00
45_R49_E3.1881.00
76_L192_A3.1271.00
119_F123_F2.9171.00
60_F64_A2.7011.00
128_L134_V2.6661.00
106_A177_V2.5471.00
55_F59_S2.4561.00
41_P45_R2.3591.00
40_G238_K2.3301.00
113_G117_L2.3171.00
79_L195_L2.3091.00
252_V292_L2.3011.00
37_F101_E2.2091.00
277_H280_H2.2011.00
252_V295_I2.1961.00
59_S63_A2.1051.00
284_W288_F2.1001.00
26_S30_A2.0691.00
44_I48_E2.0511.00
58_V73_L2.0241.00
303_S307_K2.0121.00
11_W15_I1.9421.00
115_F223_I1.9171.00
253_I294_A1.9131.00
75_V195_L1.8841.00
113_G178_E1.8771.00
98_L173_T1.8761.00
167_Q171_W1.8751.00
69_Y214_Q1.8611.00
54_F73_L1.8601.00
134_V137_I1.8391.00
148_S151_L1.8211.00
56_G60_F1.8051.00
245_S303_S1.8021.00
253_I292_L1.8011.00
14_S18_V1.7700.99
52_N56_G1.7660.99
161_T166_K1.7540.99
22_E26_S1.7480.99
37_F100_E1.6340.99
11_W14_S1.6280.99
253_I293_A1.6190.99
132_W136_A1.5930.99
277_H281_S1.5850.99
147_A151_L1.5810.99
58_V70_G1.5720.99
263_L266_L1.5600.99
65_L214_Q1.5560.99
71_W75_V1.5460.99
61_M217_V1.5310.99
17_F219_L1.5150.98
15_I19_G1.5030.98
288_F292_L1.4950.98
259_V263_L1.4720.98
244_P303_S1.4380.98
126_S193_V1.4280.98
104_K108_F1.4260.98
62_D70_G1.4080.97
242_E304_G1.4070.97
98_L174_V1.4030.97
245_S299_G1.4020.97
152_K155_V1.3820.97
109_Y113_G1.3810.97
119_F219_L1.3630.97
143_L147_A1.3610.97
17_F21_P1.3560.97
298_C302_M1.3400.97
193_V196_A1.3340.96
51_E81_G1.3270.96
25_S29_F1.3270.96
59_S62_D1.2920.96
278_F281_S1.2800.95
48_E52_N1.2770.95
139_A262_A1.2740.95
196_A217_V1.2630.95
120_G124_A1.2530.95
79_L194_A1.2480.95
66_L70_G1.2430.95
100_E103_R1.2400.95
28_T112_A1.2380.95
85_A88_A1.2340.94
294_A298_C1.2320.94
28_T108_F1.2300.94
10_S14_S1.2300.94
76_L196_A1.2250.94
161_T164_E1.2210.94
143_L258_G1.2120.94
121_S249_A1.2050.94
88_A91_M1.2020.94
244_P304_G1.2010.94
124_A128_L1.1950.93
103_R237_V1.1940.93
255_G259_V1.1810.93
103_R233_A1.1770.93
55_F58_V1.1740.93
62_D67_L1.1720.93
70_G74_L1.1710.93
84_A232_A1.1680.93
161_T165_T1.1670.93
281_S287_I1.1660.93
256_W288_F1.1660.93
16_G220_A1.1410.92
92_A240_L1.1370.92
38_L100_E1.1130.91
38_L43_G1.1080.91
56_G59_S1.1080.91
155_V158_K1.1060.90
109_Y174_V1.1020.90
76_L218_I1.0910.90
214_Q217_V1.0870.90
9_I15_I1.0840.90
129_V134_V1.0830.90
72_V217_V1.0750.89
81_G227_V1.0750.89
293_A296_A1.0620.89
52_N59_S1.0420.88
163_K168_S1.0300.87
26_S50_K1.0250.87
35_R42_A1.0180.86
106_A112_A1.0150.86
288_F291_V1.0100.86
171_W175_L1.0030.86
81_G231_F1.0020.86
40_G44_I1.0000.85
28_T104_K0.9990.85
67_L71_W0.9940.85
264_Y268_H0.9910.85
183_A186_V0.9860.85
267_A277_H0.9850.85
46_S50_K0.9840.84
148_S152_K0.9790.84
144_Y148_S0.9730.84
217_V220_A0.9730.84
21_P158_K0.9680.83
101_E105_K0.9620.83
268_H277_H0.9590.83
26_S31_L0.9560.83
108_F178_E0.9550.83
144_Y147_A0.9540.83
141_Y145_I0.9470.82
59_S74_L0.9430.82
78_G290_G0.9420.82
132_W268_H0.9400.82
135_Q257_V0.9380.81
295_I299_G0.9300.81
129_V135_Q0.9300.81
253_I288_F0.9190.80
44_I235_M0.9180.80
82_I245_S0.9170.80
14_S17_F0.9140.80
77_I81_G0.9120.80
298_C301_F0.9060.79
66_L232_A0.9000.79
14_S25_S0.8960.78
15_I18_V0.8930.78
53_N91_M0.8900.78
162_H166_K0.8790.77
173_T180_A0.8760.77
284_W287_I0.8750.77
299_G302_M0.8740.77
60_F65_L0.8730.77
248_T251_F0.8720.77
61_M70_G0.8630.76
141_Y144_Y0.8620.76
51_E55_F0.8610.76
40_G47_D0.8540.75
281_S284_W0.8510.75
93_V186_V0.8490.75
32_C104_K0.8450.74
43_G46_S0.8450.74
28_T31_L0.8420.74
55_F73_L0.8410.74
12_I60_F0.8390.74
17_F22_E0.8290.73
81_G232_A0.8270.73
140_I144_Y0.8250.72
46_S49_E0.8250.72
149_H251_F0.8200.72
61_M69_Y0.8180.72
19_G60_F0.8140.71
178_E226_L0.8110.71
291_V294_A0.8100.71
189_I192_A0.8060.71
104_K178_E0.8040.70
20_M253_I0.7990.70
43_G47_D0.7950.70
192_A195_L0.7900.69
61_M66_L0.7840.69
19_G53_N0.7810.68
216_L220_A0.7810.68
222_G225_G0.7810.68
179_L183_A0.7800.68
157_K160_D0.7770.68
292_L295_I0.7760.68
85_A224_I0.7740.68
145_I149_H0.7740.68
34_Q77_I0.7710.67
248_T252_V0.7680.67
38_L104_K0.7650.67
106_A174_V0.7650.67
91_M177_V0.7650.67
38_L92_A0.7610.66
88_A261_L0.7590.66
297_V301_F0.7570.66
134_V141_Y0.7560.66
31_L38_L0.7500.65
84_A265_T0.7490.65
263_L278_F0.7400.64
195_L248_T0.7390.64
109_Y178_E0.7390.64
47_D51_E0.7380.64
23_F50_K0.7380.64
303_S306_K0.7350.64
291_V295_I0.7320.63
162_H165_T0.7320.63
193_V215_F0.7320.63
136_A265_T0.7270.63
139_A267_A0.7270.63
143_L255_G0.7260.63
36_S39_H0.7260.63
66_L69_Y0.7250.62
99_P106_A0.7210.62
9_I12_I0.7210.62
279_I284_W0.7200.62
128_L131_V0.7190.62
73_L224_I0.7170.62
175_L179_L0.7160.62
56_G73_L0.7140.61
13_V33_R0.7120.61
121_S296_A0.7120.61
137_I140_I0.7100.61
54_F77_I0.7070.61
151_L164_E0.7060.60
32_C38_L0.6980.60
12_I16_G0.6980.60
34_Q37_F0.6970.59
299_G303_S0.6950.59
178_E230_R0.6920.59
23_F49_E0.6910.59
233_A236_F0.6890.59
19_G22_E0.6870.58
16_G216_L0.6870.58
114_A181_D0.6850.58
235_M242_E0.6840.58
197_V215_F0.6830.58
79_L129_V0.6810.58
75_V79_L0.6780.57
225_G237_V0.6780.57
133_Q140_I0.6750.57
21_P25_S0.6710.57
92_A174_V0.6680.56
150_L255_G0.6680.56
20_M65_L0.6660.56
180_A186_V0.6660.56
23_F34_Q0.6660.56
31_L105_K0.6650.56
302_M306_K0.6650.56
43_G173_T0.6640.56
296_A299_G0.6630.56
47_D227_V0.6610.55
139_A249_A0.6600.55
143_L262_A0.6570.55
59_S70_G0.6560.55
197_V217_V0.6540.55
10_S56_G0.6540.55
174_V178_E0.6540.55
71_W288_F0.6500.54
88_A250_A0.6480.54
135_Q264_Y0.6470.54
92_A236_F0.6470.54
135_Q261_L0.6440.54
50_K70_G0.6440.54
138_G289_W0.6430.53
41_P137_I0.6360.53
124_A127_F0.6320.52
47_D50_K0.6290.52
141_Y186_V0.6280.52
38_L42_A0.6250.51
79_L265_T0.6250.51
99_P168_S0.6220.51
133_Q136_A0.6190.51
148_S175_L0.6180.51
292_L296_A0.6170.50
252_V288_F0.6160.50
176_K240_L0.6150.50
69_Y217_V0.6140.50
9_I22_E0.6130.50
301_F305_G0.6110.50
245_S300_W0.6110.50
19_G23_F0.6100.50
68_E147_A0.6090.50
285_K289_W0.6090.50
90_V246_L0.6070.49
153_R160_D0.6070.49
53_N60_F0.6060.49
10_S15_I0.6050.49
93_V149_H0.6010.49
12_I19_G0.6000.49
98_L171_W0.5990.48
136_A231_F0.5990.48
301_F304_G0.5980.48
192_A218_I0.5970.48
147_A263_L0.5960.48
98_L224_I0.5940.48
121_S289_W0.5940.48
43_G261_L0.5930.48
54_F104_K0.5910.47
153_R248_T0.5900.47
117_L178_E0.5900.47
114_A117_L0.5900.47
84_A176_K0.5880.47
136_A192_A0.5870.47
150_L153_R0.5870.47
197_V214_Q0.5860.47
93_V247_E0.5850.47
26_S29_F0.5830.47
38_L231_F0.5830.47
23_F31_L0.5820.46
290_G294_A0.5820.46
129_V218_I0.5770.46
69_Y72_V0.5760.46
29_F32_C0.5760.46
20_M73_L0.5740.46
75_V128_L0.5730.45
18_V22_E0.5680.45
88_A233_A0.5670.45
216_L253_I0.5660.45
30_A214_Q0.5650.45
29_F111_L0.5640.44
174_V177_V0.5630.44
287_I291_V0.5630.44
16_G19_G0.5620.44
219_L223_I0.5620.44
133_Q137_I0.5590.44
125_I228_I0.5580.44
119_F225_G0.5580.44
54_F227_V0.5560.44
151_L155_V0.5550.43
93_V250_A0.5550.43
49_E52_N0.5550.43
68_E175_L0.5540.43
89_L189_I0.5540.43
76_L239_L0.5530.43
197_V291_V0.5530.43
231_F289_W0.5520.43
243_R296_A0.5520.43
122_L222_G0.5510.43
24_M108_F0.5480.43
164_E167_Q0.5480.43
247_E251_F0.5440.42
158_K294_A0.5440.42
12_I22_E0.5430.42
253_I295_I0.5430.42
50_K289_W0.5400.42
24_M88_A0.5400.42
63_A284_W0.5380.42
147_A255_G0.5340.41
108_F250_A0.5340.41
249_A292_L0.5340.41
91_M249_A0.5330.41
95_V178_E0.5330.41
29_F34_Q0.5320.41
152_K159_E0.5310.41
12_I65_L0.5300.41
302_M305_G0.5300.41
74_L78_G0.5290.41
121_S223_I0.5280.40
85_A293_A0.5280.40
99_P102_K0.5280.40
122_L142_L0.5270.40
20_M227_V0.5260.40
50_K111_L0.5240.40
144_Y159_E0.5230.40
306_K310_E0.5210.40
93_V143_L0.5210.40
132_W265_T0.5210.40
111_L173_T0.5190.39
111_L245_S0.5190.39
170_F174_V0.5190.39
197_V264_Y0.5170.39
41_P63_A0.5170.39
192_A196_A0.5170.39
129_V189_I0.5170.39
9_I48_E0.5160.39
194_A257_V0.5160.39
67_L70_G0.5150.39
92_A96_K0.5150.39
9_I139_A0.5150.39
93_V240_L0.5150.39
192_A231_F0.5140.39
116_V120_G0.5130.39
22_E25_S0.5120.39
77_I230_R0.5110.39
100_E171_W0.5110.39
107_L230_R0.5080.38
106_A178_E0.5070.38
194_A256_W0.5060.38
45_R48_E0.5050.38
84_A182_I0.5040.38
17_F223_I0.5040.38
156_F160_D0.5030.38
98_L170_F0.5020.38
29_F109_Y0.5020.38
106_A170_F0.5010.37
48_E295_I0.5000.37
268_H278_F0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uisB 1 0.1389 37.5 0.967 Contact Map
4he8J 1 0.4537 35.2 0.967 Contact Map
2cfqA 1 0.4815 29.7 0.969 Contact Map
2gfpA 2 0.8827 27.7 0.969 Contact Map
2kncA 1 0.1512 26.6 0.969 Contact Map
4xnjA 1 0.466 25.1 0.97 Contact Map
4uvmA 1 0.4815 18.2 0.971 Contact Map
4tphA 2 0.4012 15.6 0.972 Contact Map
4w6vA 1 0.4321 13.7 0.973 Contact Map
3giaA 1 0.8395 13.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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