DPO1 - BACSU - GREMLIN Contacts

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DPO1 - DNA polymerase I

UniProt:	O34996	Sequences: MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMILMKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQISRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVEFYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLESIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFKDLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEEPILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELKGAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEHLGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMGEELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLEKLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTDPNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTNDMDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFIDRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNTPIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVMEHALALDVPLKVDFASGPSWYDAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	880 (867)
Sequences:	3500 (2359)
Seq/√Len:	80.1

ECOLI - DPO1
BACSU - DPO1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
219_S	222_E	6.351	1.00
528_E	545_K	6.106	1.00
760_E	764_K	4.334	1.00
163_T	166_H	4.046	1.00
476_E	480_E	3.987	1.00
491_E	816_A	3.986	1.00
770_L	803_S	3.794	1.00
588_Q	593_E	3.766	1.00
230_E	234_E	3.751	1.00
677_E	681_N	3.667	1.00
818_K	822_K	3.606	1.00
521_K	577_Y	3.534	1.00
29_D	279_G	3.533	1.00
124_E	144_T	3.450	1.00
235_F	238_Q	3.434	1.00
501_V	599_T	3.312	1.00
117_G	248_I	3.221	1.00
737_G	741_D	3.134	1.00
196_P	235_F	3.126	1.00
510_E	639_K	3.089	1.00
236_K	240_L	3.041	1.00
752_A	756_D	2.991	1.00
540_V	544_E	2.961	1.00
671_K	863_D	2.842	1.00
226_K	230_E	2.831	1.00
528_E	541_I	2.821	1.00
174_T	177_Q	2.809	1.00
267_N	270_Q	2.781	1.00
198_V	228_L	2.770	1.00
652_L	874_P	2.769	1.00
214_E	243_K	2.717	1.00
478_F	483_M	2.702	1.00
217_L	240_L	2.679	1.00
195_V	232_L	2.649	1.00
362_K	366_E	2.616	1.00
209_Q	222_E	2.594	1.00
95_E	277_D	2.582	1.00
853_P	857_E	2.531	1.00
217_L	236_K	2.530	1.00
470_E	475_L	2.526	1.00
523_H	529_P	2.517	1.00
229_K	233_E	2.488	1.00
682_D	867_K	2.461	1.00
508_G	593_E	2.456	1.00
828_L	838_F	2.453	1.00
71_T	244_E	2.453	1.00
515_L	585_G	2.447	1.00
214_E	240_L	2.442	1.00
696_V	705_M	2.423	1.00
94_R	106_E	2.417	1.00
526_A	574_I	2.417	1.00
522_I	532_I	2.414	1.00
98_D	104_R	2.387	1.00
257_S	260_G	2.387	1.00
374_V	377_S	2.382	1.00
528_E	540_V	2.379	1.00
28_N	279_G	2.376	1.00
372_K	393_G	2.367	1.00
215_K	218_E	2.357	1.00
375_F	398_T	2.352	1.00
481_L	771_M	2.352	1.00
514_K	517_E	2.325	1.00
217_L	220_I	2.319	1.00
192_I	246_A	2.319	1.00
825_K	844_E	2.307	1.00
850_K	854_E	2.290	1.00
541_I	545_K	2.281	1.00
165_E	169_E	2.266	1.00
165_E	168_K	2.261	1.00
826_A	844_E	2.247	1.00
498_K	647_S	2.222	1.00
210_F	223_V	2.213	1.00
818_K	855_V	2.210	1.00
20_F	85_E	2.210	1.00
751_K	755_E	2.205	1.00
822_K	847_I	2.197	1.00
810_K	859_A	2.173	1.00
650_D	842_K	2.163	1.00
6_K	129_E	2.161	1.00
652_L	842_K	2.153	1.00
759_Q	763_Q	2.127	1.00
491_E	820_K	2.125	1.00
525_I	577_Y	2.120	1.00
507_M	511_L	2.106	1.00
164_P	176_E	2.066	1.00
468_E	471_N	2.046	1.00
514_K	580_Q	2.038	1.00
212_S	215_K	2.021	1.00
396_F	401_A	2.009	1.00
304_N	307_T	2.004	1.00
366_E	389_I	2.003	1.00
826_A	848_L	1.998	1.00
272_I	284_L	1.993	1.00
181_M	207_L	1.989	1.00
121_K	125_K	1.980	1.00
145_D	164_P	1.975	1.00
816_A	820_K	1.969	1.00
120_A	147_T	1.965	1.00
396_F	478_F	1.959	1.00
756_D	760_E	1.956	1.00
215_K	219_S	1.955	1.00
179_I	247_T	1.953	1.00
413_D	416_S	1.946	1.00
654_F	840_A	1.936	1.00
697_A	700_E	1.932	1.00
220_I	229_K	1.924	1.00
721_S	724_G	1.917	1.00
84_P	87_S	1.902	1.00
546_I	572_H	1.897	1.00
475_L	479_E	1.895	1.00
838_F	852_V	1.892	1.00
838_F	848_L	1.887	1.00
687_T	698_K	1.886	1.00
520_E	529_P	1.880	1.00
516_K	519_E	1.877	1.00
359_E	362_K	1.876	1.00
651_W	841_P	1.861	1.00
65_T	70_G	1.858	1.00
95_E	98_D	1.848	1.00
223_V	232_L	1.846	1.00
523_H	532_I	1.845	1.00
210_F	219_S	1.838	1.00
771_M	860_L	1.835	1.00
368_D	392_K	1.817	1.00
168_K	174_T	1.806	1.00
845_I	849_E	1.802	1.00
220_I	233_E	1.791	1.00
533_N	581_Y	1.758	1.00
854_E	858_H	1.752	1.00
818_K	821_E	1.748	1.00
780_L	791_A	1.744	1.00
819_L	848_L	1.744	1.00
818_K	854_E	1.734	1.00
327_I	335_P	1.733	1.00
814_D	855_V	1.725	1.00
274_I	278_L	1.720	1.00
814_D	817_A	1.717	1.00
874_P	878_D	1.708	1.00
195_V	239_A	1.706	1.00
30_K	277_D	1.706	1.00
497_V	829_L	1.700	1.00
611_N	623_T	1.698	1.00
845_I	872_S	1.695	1.00
464_K	468_E	1.694	1.00
691_M	697_A	1.693	1.00
82_T	87_S	1.685	1.00
569_A	576_D	1.678	1.00
400_L	613_A	1.675	1.00
124_E	147_T	1.672	1.00
810_K	814_D	1.672	1.00
540_V	545_K	1.664	1.00
17_Y	21_F	1.654	1.00
671_K	676_I	1.654	1.00
785_F	788_R	1.654	1.00
205_K	209_Q	1.646	1.00
576_D	580_Q	1.645	1.00
514_K	636_E	1.644	1.00
817_A	821_E	1.641	1.00
243_K	247_T	1.626	1.00
385_R	494_S	1.620	1.00
64_K	108_E	1.619	1.00
826_A	841_P	1.606	1.00
521_K	524_E	1.597	1.00
504_L	643_A	1.588	1.00
517_E	521_K	1.587	1.00
46_K	50_D	1.584	1.00
382_V	490_G	1.583	1.00
309_T	360_V	1.581	1.00
755_E	758_V	1.579	1.00
197_G	231_K	1.577	1.00
231_K	234_E	1.569	1.00
71_T	241_M	1.560	1.00
121_K	250_T	1.556	1.00
749_G	752_A	1.553	0.99
173_L	204_I	1.550	0.99
841_P	844_E	1.543	0.99
376_D	379_R	1.535	0.99
134_S	139_L	1.525	0.99
164_P	168_K	1.522	0.99
116_I	132_V	1.520	0.99
503_R	642_Q	1.519	0.99
779_E	791_A	1.513	0.99
181_M	185_M	1.512	0.99
311_V	348_Y	1.508	0.99
225_G	229_K	1.507	0.99
768_T	774_R	1.503	0.99
481_L	810_K	1.501	0.99
429_D	433_Y	1.499	0.99
367_N	370_Q	1.492	0.99
488_I	813_I	1.492	0.99
181_M	200_E	1.488	0.99
341_I	350_I	1.487	0.99
231_K	235_F	1.487	0.99
305_V	356_V	1.485	0.99
654_F	845_I	1.483	0.99
825_K	843_E	1.482	0.99
665_V	800_I	1.480	0.99
477_L	481_L	1.479	0.99
419_K	425_I	1.478	0.99
610_F	830_L	1.476	0.99
512_G	588_Q	1.469	0.99
848_L	852_V	1.458	0.99
37_V	278_L	1.458	0.99
96_L	275_F	1.450	0.99
520_E	524_E	1.448	0.99
124_E	146_K	1.431	0.99
414_V	458_I	1.428	0.99
244_E	249_M	1.420	0.99
185_M	200_E	1.418	0.99
117_G	250_T	1.417	0.99
57_L	261_L	1.415	0.99
8_V	133_F	1.415	0.99
495_T	827_R	1.409	0.99
689_T	713_N	1.400	0.99
129_E	146_K	1.395	0.99
59_A	115_I	1.394	0.99
184_L	202_T	1.382	0.99
32_V	92_F	1.381	0.99
205_K	225_G	1.379	0.99
352_K	357_E	1.378	0.99
815_M	838_F	1.377	0.99
711_A	728_N	1.376	0.99
762_K	788_R	1.376	0.99
418_A	457_A	1.372	0.99
676_I	680_T	1.372	0.99
118_T	252_A	1.368	0.99
824_L	844_E	1.362	0.99
41_A	96_L	1.362	0.99
499_V	599_T	1.360	0.99
840_A	848_L	1.358	0.99
272_I	276_K	1.354	0.99
492_M	495_T	1.353	0.99
70_G	109_Q	1.352	0.99
403_Y	614_L	1.347	0.99
785_F	789_S	1.347	0.99
166_H	169_E	1.340	0.98
605_K	647_S	1.339	0.98
23_L	35_N	1.338	0.98
436_G	440_A	1.335	0.98
519_E	529_P	1.333	0.98
323_V	454_K	1.331	0.98
673_E	749_G	1.325	0.98
676_I	863_D	1.320	0.98
673_E	677_E	1.320	0.98
33_H	88_E	1.318	0.98
502_D	506_R	1.312	0.98
209_Q	224_S	1.310	0.98
818_K	851_L	1.309	0.98
204_I	208_K	1.306	0.98
99_A	274_I	1.304	0.98
508_G	592_I	1.303	0.98
704_A	708_Q	1.302	0.98
316_L	367_N	1.302	0.98
270_Q	273_A	1.301	0.98
849_E	853_P	1.300	0.98
143_A	149_V	1.292	0.98
521_K	525_I	1.288	0.98
553_K	557_G	1.286	0.98
766_Y	774_R	1.286	0.98
110_Y	253_P	1.286	0.98
16_A	93_I	1.284	0.98
693_V	711_A	1.277	0.98
65_T	69_H	1.277	0.98
824_L	847_I	1.276	0.98
570_D	576_D	1.274	0.98
55_H	128_F	1.274	0.98
121_K	144_T	1.266	0.98
28_N	32_V	1.264	0.98
846_E	850_K	1.256	0.98
214_E	218_E	1.255	0.98
462_R	466_V	1.254	0.98
62_A	108_E	1.254	0.98
207_L	212_S	1.254	0.98
554_T	557_G	1.253	0.98
12_G	58_V	1.252	0.98
196_P	238_Q	1.237	0.97
249_M	252_A	1.234	0.97
456_L	460_S	1.231	0.97
651_W	827_R	1.230	0.97
217_L	232_L	1.229	0.97
722_D	737_G	1.223	0.97
345_T	463_E	1.222	0.97
330_N	333_E	1.220	0.97
152_T	155_G	1.219	0.97
642_Q	877_Y	1.219	0.97
759_Q	762_K	1.218	0.97
815_M	855_V	1.217	0.97
400_L	486_A	1.211	0.97
683_M	688_K	1.211	0.97
647_S	651_W	1.209	0.97
376_D	399_L	1.208	0.97
5_K	128_F	1.207	0.97
503_R	506_R	1.207	0.97
639_K	642_Q	1.205	0.97
37_V	92_F	1.197	0.97
130_V	147_T	1.195	0.97
467_Q	471_N	1.192	0.97
401_A	478_F	1.191	0.97
122_S	126_D	1.191	0.97
512_G	516_K	1.190	0.97
236_K	239_A	1.187	0.97
819_L	826_A	1.186	0.97
210_F	222_E	1.182	0.97
466_V	470_E	1.181	0.97
143_A	167_V	1.181	0.97
183_G	246_A	1.179	0.97
21_F	80_Q	1.178	0.97
555_K	558_Y	1.178	0.97
807_I	860_L	1.177	0.97
654_F	852_V	1.176	0.97
875_S	878_D	1.176	0.97
140_T	149_V	1.174	0.97
825_K	841_P	1.174	0.97
335_P	387_Q	1.173	0.96
418_A	426_V	1.172	0.96
324_V	336_I	1.172	0.96
322_F	384_L	1.171	0.96
790_F	794_T	1.168	0.96
47_M	133_F	1.165	0.96
652_L	872_S	1.163	0.96
762_K	792_E	1.162	0.96
573_D	576_D	1.162	0.96
10_V	15_L	1.161	0.96
738_A	742_R	1.159	0.96
385_R	491_E	1.156	0.96
282_T	285_E	1.154	0.96
220_I	232_L	1.152	0.96
322_F	365_V	1.150	0.96
726_S	733_R	1.148	0.96
275_F	283_L	1.148	0.96
303_I	307_T	1.147	0.96
692_D	746_S	1.146	0.96
123_A	130_V	1.144	0.96
269_E	273_A	1.141	0.96
5_K	54_T	1.141	0.96
36_A	93_I	1.141	0.96
849_E	872_S	1.137	0.96
192_I	242_S	1.133	0.96
233_E	236_K	1.131	0.96
570_D	575_V	1.129	0.96
491_E	495_T	1.128	0.96
498_K	645_V	1.127	0.96
120_A	250_T	1.125	0.96
362_K	389_I	1.125	0.96
822_K	855_V	1.124	0.96
668_H	862_L	1.120	0.95
846_E	849_E	1.119	0.95
508_G	588_Q	1.116	0.95
857_E	867_K	1.114	0.95
723_Y	733_R	1.113	0.95
319_P	373_W	1.112	0.95
45_M	275_F	1.112	0.95
561_S	564_V	1.107	0.95
325_E	454_K	1.106	0.95
66_T	69_H	1.104	0.95
217_L	239_A	1.104	0.95
518_Y	523_H	1.102	0.95
777_I	791_A	1.102	0.95
541_I	574_I	1.102	0.95
842_K	874_P	1.102	0.95
37_V	93_I	1.100	0.95
768_T	772_H	1.098	0.95
572_H	575_V	1.097	0.95
200_E	204_I	1.093	0.95
177_Q	211_D	1.093	0.95
708_Q	735_E	1.092	0.95
374_V	380_A	1.092	0.95
367_N	372_K	1.089	0.95
742_R	745_E	1.086	0.95
371_K	395_E	1.085	0.95
99_A	270_Q	1.084	0.95
687_T	703_S	1.084	0.95
95_E	270_Q	1.083	0.95
653_I	837_I	1.078	0.94
42_M	286_R	1.078	0.94
33_H	85_E	1.077	0.94
807_I	866_L	1.074	0.94
180_D	243_K	1.071	0.94
656_A	870_F	1.070	0.94
320_S	364_W	1.069	0.94
216_L	223_V	1.068	0.94
520_E	523_H	1.067	0.94
651_W	839_E	1.066	0.94
305_V	309_T	1.065	0.94
858_H	861_A	1.064	0.94
110_Y	252_A	1.064	0.94
688_K	692_D	1.063	0.94
668_H	863_D	1.062	0.94
91_P	95_E	1.061	0.94
327_I	379_R	1.061	0.94
437_A	440_A	1.060	0.94
328_G	334_E	1.059	0.94
808_I	828_L	1.059	0.94
501_V	505_K	1.058	0.94
139_L	248_I	1.058	0.94
409_N	420_D	1.058	0.94
230_E	233_E	1.056	0.94
754_M	796_M	1.054	0.94
38_Y	282_T	1.054	0.94
14_S	152_T	1.050	0.94
110_Y	249_M	1.049	0.94
206_L	228_L	1.047	0.93
101_Q	267_N	1.046	0.93
497_V	830_L	1.046	0.93
19_A	43_I	1.043	0.93
826_A	852_V	1.042	0.93
724_G	728_N	1.042	0.93
220_I	225_G	1.039	0.93
430_E	435_K	1.039	0.93
533_N	585_G	1.038	0.93
569_A	575_V	1.036	0.93
373_W	462_R	1.034	0.93
468_E	472_N	1.032	0.93
64_K	69_H	1.032	0.93
107_L	115_I	1.030	0.93
652_L	845_I	1.030	0.93
654_F	849_E	1.029	0.93
532_I	578_I	1.026	0.93
62_A	65_T	1.025	0.93
536_K	540_V	1.024	0.93
377_S	486_A	1.021	0.93
757_S	767_V	1.020	0.93
148_T	161_F	1.017	0.92
732_T	735_E	1.014	0.92
851_L	855_V	1.011	0.92
62_A	106_E	1.008	0.92
172_G	208_K	1.008	0.92
764_K	768_T	1.005	0.92
259_S	262_E	1.002	0.92
853_P	870_F	1.000	0.92
530_F	541_I	0.999	0.92
406_N	420_D	0.999	0.92
78_G	81_K	0.998	0.92
665_V	669_I	0.998	0.92
656_A	868_V	0.997	0.92
757_S	760_E	0.996	0.92
220_I	236_K	0.995	0.92
309_T	313_S	0.995	0.92
364_W	370_Q	0.993	0.92
49_E	286_R	0.993	0.92
124_E	130_V	0.993	0.92
137_K	182_K	0.992	0.91
692_D	739_F	0.992	0.91
123_A	127_G	0.989	0.91
328_G	379_R	0.989	0.91
442_P	447_L	0.989	0.91
381_V	490_G	0.988	0.91
677_E	680_T	0.988	0.91
789_S	792_E	0.987	0.91
513_A	517_E	0.983	0.91
24_P	39_G	0.983	0.91
741_D	745_E	0.982	0.91
32_V	277_D	0.982	0.91
302_D	348_Y	0.978	0.91
213_V	240_L	0.978	0.91
483_M	486_A	0.975	0.91
498_K	646_P	0.973	0.91
771_M	810_K	0.971	0.91
512_G	593_E	0.969	0.90
105_Y	261_L	0.968	0.90
96_L	274_I	0.966	0.90
223_V	226_K	0.965	0.90
315_I	341_I	0.964	0.90
38_Y	42_M	0.960	0.90
414_V	426_V	0.960	0.90
96_L	278_L	0.958	0.90
134_S	246_A	0.958	0.90
712_V	720_I	0.957	0.90
788_R	792_E	0.954	0.90
691_M	698_K	0.952	0.90
495_T	816_A	0.951	0.90
32_V	88_E	0.950	0.90
514_K	584_I	0.949	0.90
65_T	109_Q	0.947	0.89
814_D	859_A	0.946	0.89
567_K	727_Q	0.945	0.89
738_A	741_D	0.944	0.89
844_E	848_L	0.942	0.89
375_F	414_V	0.941	0.89
649_K	842_K	0.940	0.89
386_W	602_D	0.937	0.89
223_V	228_L	0.937	0.89
511_L	592_I	0.937	0.89
17_Y	82_T	0.935	0.89
503_R	643_A	0.933	0.89
24_P	35_N	0.933	0.89
733_R	737_G	0.933	0.89
334_E	379_R	0.933	0.89
276_K	284_L	0.932	0.89
216_L	220_I	0.931	0.89
212_S	218_E	0.931	0.89
405_I	472_N	0.930	0.89
871_A	879_A	0.929	0.89
502_D	505_K	0.928	0.89
519_E	523_H	0.928	0.89
544_E	558_Y	0.928	0.89
5_K	55_H	0.928	0.89
188_S	200_E	0.927	0.88
376_D	380_A	0.927	0.88
173_L	177_Q	0.924	0.88
366_E	392_K	0.923	0.88
436_G	439_R	0.922	0.88
446_V	449_E	0.922	0.88
428_S	431_S	0.919	0.88
466_V	479_E	0.917	0.88
840_A	845_I	0.916	0.88
181_M	204_I	0.916	0.88
683_M	698_K	0.914	0.88
342_V	347_A	0.914	0.88
382_V	494_S	0.913	0.88
702_T	705_M	0.912	0.88
173_L	178_I	0.911	0.88
210_F	220_I	0.911	0.88
441_V	444_E	0.910	0.88
206_L	216_L	0.910	0.88
147_T	250_T	0.909	0.87
107_L	253_P	0.905	0.87
355_A	359_E	0.902	0.87
44_L	102_I	0.902	0.87
62_A	115_I	0.900	0.87
539_G	558_Y	0.899	0.87
424_H	460_S	0.899	0.87
525_I	573_D	0.898	0.87
219_S	223_V	0.898	0.87
595_L	606_V	0.897	0.87
323_V	329_D	0.896	0.87
105_Y	115_I	0.896	0.87
481_L	813_I	0.894	0.87
516_K	520_E	0.893	0.87
523_H	530_F	0.890	0.86
185_M	207_L	0.885	0.86
454_K	458_I	0.883	0.86
224_S	228_L	0.882	0.86
429_D	432_V	0.880	0.86
764_K	767_V	0.880	0.86
310_D	313_S	0.879	0.86
323_V	380_A	0.878	0.86
716_I	720_I	0.877	0.86
21_F	25_L	0.877	0.86
518_Y	577_Y	0.875	0.85
273_A	277_D	0.875	0.85
473_D	768_T	0.872	0.85
505_K	509_E	0.871	0.85
166_H	170_K	0.870	0.85
177_Q	212_S	0.869	0.85
271_V	275_F	0.868	0.85
195_V	231_K	0.868	0.85
205_K	228_L	0.867	0.85
669_I	753_Y	0.866	0.85
500_D	645_V	0.864	0.85
685_I	713_N	0.863	0.85
436_G	442_P	0.862	0.85
647_S	839_E	0.860	0.84
247_T	250_T	0.859	0.84
704_A	707_R	0.859	0.84
414_V	457_A	0.855	0.84
794_T	798_T	0.855	0.84
23_L	39_G	0.854	0.84
505_K	596_L	0.853	0.84
84_P	88_E	0.853	0.84
827_R	839_E	0.851	0.84
701_V	705_M	0.851	0.84
763_Q	781_T	0.850	0.84
122_S	125_K	0.849	0.84
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503_R	507_M	0.845	0.83
826_A	838_F	0.845	0.83
696_V	701_V	0.844	0.83
319_P	462_R	0.843	0.83
391_L	394_A	0.841	0.83
151_I	182_K	0.840	0.83
509_E	513_A	0.838	0.83
178_I	207_L	0.838	0.83
8_V	131_K	0.837	0.83
41_A	275_F	0.835	0.83
691_M	696_V	0.832	0.82
819_L	851_L	0.830	0.82
435_K	438_K	0.829	0.82
308_V	312_T	0.829	0.82
266_F	271_V	0.828	0.82
254_I	257_S	0.828	0.82
760_E	768_T	0.827	0.82
711_A	715_G	0.827	0.82
819_L	838_F	0.827	0.82
666_L	717_V	0.824	0.82
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211_D	215_K	0.818	0.81
386_W	494_S	0.817	0.81
195_V	220_I	0.817	0.81
56_M	263_Y	0.814	0.81
140_T	162_Y	0.814	0.81
41_A	45_M	0.813	0.81
367_N	393_G	0.813	0.81
256_V	261_L	0.812	0.81
756_D	759_Q	0.811	0.81
559_S	564_V	0.811	0.81
433_Y	439_R	0.810	0.81
526_A	530_F	0.809	0.81
450_H	454_K	0.808	0.80
808_I	836_L	0.807	0.80
675_L	750_V	0.805	0.80
651_W	825_K	0.805	0.80
726_S	732_T	0.803	0.80
129_E	148_T	0.803	0.80
522_I	577_Y	0.803	0.80
575_V	578_I	0.803	0.80
646_P	653_I	0.803	0.80
754_M	758_V	0.802	0.80
162_Y	166_H	0.802	0.80
324_V	380_A	0.801	0.80
379_R	383_A	0.801	0.80
20_F	24_P	0.800	0.80
206_L	236_K	0.800	0.80
210_F	229_K	0.798	0.80
210_F	225_G	0.798	0.80
407_P	616_Q	0.797	0.80
688_K	691_M	0.797	0.80
25_L	35_N	0.797	0.80
563_D	727_Q	0.797	0.80
198_V	202_T	0.795	0.79
401_A	462_R	0.794	0.79
406_N	409_N	0.794	0.79
238_Q	241_M	0.793	0.79
720_I	728_N	0.793	0.79
198_V	231_K	0.792	0.79
8_V	47_M	0.791	0.79
463_E	467_Q	0.791	0.79
172_G	204_I	0.790	0.79
722_D	733_R	0.790	0.79
645_V	875_S	0.790	0.79
56_M	102_I	0.788	0.79
669_I	770_L	0.787	0.79
819_L	841_P	0.786	0.79
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744_L	751_K	0.785	0.79
55_H	262_E	0.785	0.79
223_V	229_K	0.785	0.79
522_I	574_I	0.784	0.78
608_T	622_S	0.784	0.78
160_E	166_H	0.784	0.78
92_F	95_E	0.784	0.78
181_M	198_V	0.784	0.78
824_L	848_L	0.783	0.78
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178_I	181_M	0.779	0.78
340_S	451_L	0.779	0.78
598_V	624_D	0.778	0.78
306_K	309_T	0.776	0.78
752_A	755_E	0.775	0.78
400_L	478_F	0.775	0.78
873_G	878_D	0.774	0.78
366_E	390_E	0.774	0.78
705_M	708_Q	0.774	0.78
45_M	283_L	0.773	0.77
198_V	206_L	0.773	0.77
167_V	204_I	0.772	0.77
400_L	404_I	0.772	0.77
7_L	261_L	0.772	0.77
26_L	69_H	0.772	0.77
63_G	87_S	0.770	0.77
692_D	742_R	0.770	0.77
551_V	567_K	0.769	0.77
48_L	263_Y	0.769	0.77
20_F	35_N	0.768	0.77
209_Q	219_S	0.767	0.77
239_A	242_S	0.767	0.77
144_T	147_T	0.766	0.77
498_K	649_K	0.766	0.77
608_T	829_L	0.765	0.77
206_L	225_G	0.764	0.77
220_I	223_V	0.764	0.77
323_V	458_I	0.764	0.77
319_P	371_K	0.764	0.77
9_L	119_L	0.763	0.77
815_M	828_L	0.763	0.77
339_F	350_I	0.762	0.76
356_V	359_E	0.761	0.76
167_V	170_K	0.760	0.76
100_Y	271_V	0.758	0.76
216_L	219_S	0.758	0.76
829_L	839_E	0.757	0.76
398_T	458_I	0.757	0.76
140_T	143_A	0.755	0.76
281_N	285_E	0.754	0.76
404_I	474_Q	0.754	0.76
492_M	828_L	0.753	0.76
335_P	354_I	0.753	0.76
137_K	151_I	0.753	0.76
703_S	707_R	0.753	0.76
488_I	816_A	0.752	0.76
103_S	260_G	0.751	0.75
599_T	604_H	0.750	0.75
851_L	854_E	0.749	0.75
608_T	620_L	0.749	0.75
275_F	280_F	0.748	0.75
72_F	193_P	0.747	0.75
273_A	276_K	0.747	0.75
187_D	246_A	0.745	0.75
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328_G	383_A	0.744	0.75
592_I	640_I	0.743	0.75
510_E	514_K	0.741	0.74
325_E	340_S	0.741	0.74
173_L	181_M	0.740	0.74
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196_P	234_E	0.739	0.74
550_V	558_Y	0.739	0.74
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220_I	240_L	0.738	0.74
41_A	93_I	0.738	0.74
82_T	90_M	0.738	0.74
162_Y	170_K	0.736	0.74
324_V	454_K	0.735	0.74
433_Y	442_P	0.735	0.74
198_V	235_F	0.734	0.74
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101_Q	266_F	0.733	0.74
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381_V	391_L	0.731	0.73
708_Q	711_A	0.731	0.73
375_F	399_L	0.730	0.73
426_V	457_A	0.726	0.73
508_G	512_G	0.725	0.73
547_G	550_V	0.724	0.73
126_D	259_S	0.724	0.73
90_M	94_R	0.724	0.73
356_V	360_V	0.724	0.73
583_Q	634_L	0.723	0.73
205_K	229_K	0.722	0.73
92_F	277_D	0.722	0.73
45_M	100_Y	0.722	0.73
723_Y	727_Q	0.721	0.72
151_I	154_K	0.720	0.72
8_V	56_M	0.720	0.72
771_M	803_S	0.719	0.72
331_Y	382_V	0.718	0.72
231_K	238_Q	0.718	0.72
385_R	390_E	0.718	0.72
302_D	350_I	0.717	0.72
164_P	174_T	0.717	0.72
728_N	739_F	0.717	0.72
543_F	551_V	0.716	0.72
118_T	253_P	0.716	0.72
72_F	241_M	0.715	0.72
185_M	246_A	0.714	0.72
121_K	124_E	0.713	0.72
32_V	37_V	0.712	0.71
38_Y	280_F	0.712	0.71
206_L	220_I	0.711	0.71
335_P	386_W	0.711	0.71
171_Y	178_I	0.710	0.71
21_F	24_P	0.709	0.71
307_T	310_D	0.709	0.71
174_T	211_D	0.709	0.71
107_L	252_A	0.707	0.71
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312_T	360_V	0.706	0.71
183_G	213_V	0.706	0.71
150_A	161_F	0.705	0.71
30_K	279_G	0.705	0.71
665_V	859_A	0.705	0.71
669_I	800_I	0.704	0.71
207_L	211_D	0.704	0.71
282_T	286_R	0.704	0.71
206_L	239_A	0.704	0.71
685_I	689_T	0.703	0.71
548_L	572_H	0.703	0.71
183_G	239_A	0.703	0.71
27_S	35_N	0.703	0.71
832_V	876_W	0.702	0.70
179_I	248_I	0.702	0.70
323_V	450_H	0.702	0.70
81_K	84_P	0.701	0.70
72_F	245_L	0.700	0.70
848_L	851_L	0.700	0.70
439_R	442_P	0.700	0.70
275_F	287_L	0.699	0.70
52_K	263_Y	0.698	0.70
373_W	398_T	0.698	0.70
646_P	651_W	0.697	0.70
569_A	572_H	0.696	0.70
379_R	454_K	0.696	0.70
322_F	341_I	0.696	0.70
225_G	233_E	0.695	0.70
183_G	240_L	0.694	0.70
206_L	233_E	0.694	0.70
507_M	592_I	0.693	0.69
239_A	246_A	0.693	0.69
168_K	208_K	0.693	0.69
735_E	738_A	0.692	0.69
467_Q	470_E	0.692	0.69
48_L	56_M	0.691	0.69
326_Q	383_A	0.691	0.69
78_G	188_S	0.691	0.69
160_E	170_K	0.691	0.69
581_Y	585_G	0.691	0.69
777_I	794_T	0.690	0.69
342_V	459_Q	0.690	0.69
202_T	205_K	0.690	0.69
82_T	86_L	0.690	0.69
98_D	270_Q	0.689	0.69
762_K	781_T	0.689	0.69
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148_T	164_P	0.688	0.69
433_Y	440_A	0.688	0.69
675_L	685_I	0.688	0.69
225_G	230_E	0.688	0.69
326_Q	454_K	0.688	0.69
338_G	349_F	0.687	0.69
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44_L	93_I	0.687	0.69
609_R	623_T	0.686	0.69
206_L	217_L	0.685	0.69
130_V	146_K	0.684	0.68
400_L	483_M	0.684	0.68
322_F	339_F	0.683	0.68
440_A	443_S	0.683	0.68
760_E	763_Q	0.683	0.68
549_P	571_K	0.682	0.68
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430_E	439_R	0.682	0.68
305_V	360_V	0.681	0.68
642_Q	878_D	0.681	0.68
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15_L	151_I	0.680	0.68
715_G	720_I	0.679	0.68
593_E	597_K	0.678	0.68
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562_A	566_E	0.677	0.68
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310_D	314_D	0.675	0.67
668_H	675_L	0.675	0.67
173_L	207_L	0.675	0.67
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844_E	847_I	0.670	0.67
569_A	573_D	0.670	0.67
353_D	356_V	0.669	0.67
193_P	242_S	0.669	0.67
464_K	467_Q	0.668	0.67
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177_Q	207_L	0.666	0.66
585_G	588_Q	0.665	0.66
311_V	315_I	0.665	0.66
167_V	178_I	0.665	0.66
318_S	370_Q	0.665	0.66
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320_S	341_I	0.661	0.66
417_V	421_Y	0.661	0.66
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647_S	827_R	0.661	0.66
338_G	451_L	0.660	0.66
348_Y	351_P	0.659	0.66
174_T	212_S	0.658	0.65
6_K	51_E	0.657	0.65
754_M	757_S	0.655	0.65
202_T	228_L	0.655	0.65
235_F	239_A	0.655	0.65
398_T	454_K	0.654	0.65
761_A	780_L	0.654	0.65
818_K	847_I	0.654	0.65
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24_P	43_I	0.653	0.65
530_F	574_I	0.653	0.65
779_E	782_S	0.652	0.65
380_A	454_K	0.652	0.65
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611_N	621_S	0.650	0.65
492_M	829_L	0.649	0.64
543_F	558_Y	0.649	0.64
548_L	568_L	0.645	0.64
218_E	236_K	0.645	0.64
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822_K	851_L	0.644	0.64
376_D	454_K	0.643	0.64
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43_I	152_T	0.642	0.64
755_E	759_Q	0.641	0.63
65_T	71_T	0.641	0.63
519_E	532_I	0.639	0.63
183_G	242_S	0.639	0.63
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424_H	427_S	0.638	0.63
396_F	465_L	0.638	0.63
308_V	311_V	0.637	0.63
680_T	863_D	0.636	0.63
503_R	645_V	0.635	0.63
99_A	271_V	0.635	0.63
585_G	589_S	0.635	0.63
323_V	451_L	0.635	0.63
846_E	872_S	0.635	0.63
564_V	568_L	0.635	0.63
120_A	124_E	0.634	0.63
182_K	248_I	0.633	0.62
7_L	130_V	0.632	0.62
9_L	748_Q	0.632	0.62
439_R	443_S	0.632	0.62
326_Q	337_L	0.631	0.62
396_F	462_R	0.631	0.62
429_D	450_H	0.631	0.62
638_R	877_Y	0.631	0.62
51_E	161_F	0.631	0.62
340_S	347_A	0.631	0.62
717_V	720_I	0.630	0.62
815_M	852_V	0.630	0.62
321_A	340_S	0.629	0.62
636_E	639_K	0.628	0.62
197_G	206_L	0.628	0.62
122_S	257_S	0.627	0.62
148_T	163_T	0.626	0.62
781_T	791_A	0.626	0.62
321_A	459_Q	0.626	0.62
312_T	316_L	0.625	0.61
372_K	391_L	0.624	0.61
314_D	343_N	0.624	0.61
381_V	385_R	0.624	0.61
845_I	848_L	0.624	0.61
342_V	452_G	0.620	0.61
720_I	790_F	0.620	0.61
381_V	487_L	0.620	0.61
653_I	832_V	0.618	0.61
508_G	596_L	0.617	0.60
323_V	379_R	0.616	0.60
807_I	859_A	0.616	0.60
237_D	240_L	0.616	0.60
515_L	584_I	0.615	0.60
144_T	250_T	0.615	0.60
185_M	202_T	0.615	0.60
131_K	161_F	0.615	0.60
849_E	870_F	0.615	0.60
440_A	444_E	0.614	0.60
140_T	182_K	0.614	0.60
179_I	243_K	0.614	0.60
134_S	137_K	0.614	0.60
630_I	644_F	0.613	0.60
213_V	216_L	0.612	0.60
822_K	826_A	0.612	0.60
143_A	166_H	0.612	0.60
179_I	182_K	0.612	0.60
6_K	131_K	0.611	0.60
341_I	348_Y	0.611	0.60
333_E	601_P	0.611	0.60
325_E	329_D	0.610	0.60
21_F	83_P	0.609	0.60
847_I	850_K	0.609	0.60
398_T	465_L	0.609	0.60
210_F	215_K	0.609	0.60
196_P	231_K	0.609	0.60
421_Y	468_E	0.609	0.60
615_T	623_T	0.609	0.60
226_K	231_K	0.608	0.59
268_R	272_I	0.608	0.59
436_G	441_V	0.608	0.59
671_K	749_G	0.606	0.59
840_A	852_V	0.606	0.59
24_P	27_S	0.606	0.59
850_K	853_P	0.604	0.59
37_V	96_L	0.603	0.59
375_F	380_A	0.601	0.58
826_A	845_I	0.601	0.58
72_F	246_A	0.601	0.58
134_S	151_I	0.601	0.58
782_S	788_R	0.601	0.58
577_Y	580_Q	0.600	0.58
521_K	573_D	0.600	0.58
312_T	364_W	0.600	0.58
720_I	724_G	0.599	0.58
7_L	128_F	0.599	0.58
506_R	510_E	0.599	0.58
808_I	838_F	0.599	0.58
527_G	545_K	0.598	0.58
721_S	789_S	0.598	0.58
17_Y	22_A	0.598	0.58
410_S	420_D	0.598	0.58
14_S	624_D	0.598	0.58
373_W	395_E	0.598	0.58
515_L	533_N	0.597	0.58
143_A	164_P	0.597	0.58
88_E	91_P	0.597	0.58
716_I	790_F	0.596	0.58
524_E	527_G	0.596	0.58
437_A	441_V	0.596	0.58
688_K	713_N	0.596	0.58
810_K	860_L	0.596	0.58
149_V	162_Y	0.595	0.58
14_S	135_G	0.595	0.58
417_V	461_L	0.594	0.58
221_D	229_K	0.593	0.57
168_K	172_G	0.593	0.57
744_L	754_M	0.593	0.57
610_F	832_V	0.593	0.57
180_D	212_S	0.592	0.57
346_G	460_S	0.592	0.57
723_Y	739_F	0.592	0.57
304_N	311_V	0.590	0.57
121_K	147_T	0.590	0.57
325_E	458_I	0.589	0.57
13_N	90_M	0.589	0.57
422_G	457_A	0.588	0.57
857_E	868_V	0.588	0.57
46_K	49_E	0.588	0.57
98_D	103_S	0.588	0.57
185_M	228_L	0.587	0.57
70_G	73_K	0.587	0.57
25_L	39_G	0.586	0.57
25_L	33_H	0.586	0.57
532_I	535_P	0.586	0.57
469_L	478_F	0.585	0.56
430_E	438_K	0.585	0.56
58_V	97_L	0.585	0.56
56_M	99_A	0.585	0.56
766_Y	776_Y	0.584	0.56
221_D	233_E	0.583	0.56
552_K	561_S	0.583	0.56
342_V	455_A	0.583	0.56
403_Y	615_T	0.583	0.56
140_T	167_V	0.582	0.56
477_L	803_S	0.580	0.56
225_G	228_L	0.580	0.56
415_A	426_V	0.580	0.56
330_N	600_R	0.580	0.56
614_L	621_S	0.580	0.56
853_P	867_K	0.579	0.56
118_T	255_E	0.579	0.56
347_A	452_G	0.579	0.56
81_K	87_S	0.578	0.56
302_D	311_V	0.578	0.56
15_L	153_R	0.578	0.56
600_R	604_H	0.577	0.55
5_K	262_E	0.577	0.55
107_L	110_Y	0.577	0.55
217_L	231_K	0.577	0.55
551_V	564_V	0.577	0.55
653_I	879_A	0.577	0.55
212_S	243_K	0.576	0.55
649_K	874_P	0.576	0.55
323_V	376_D	0.576	0.55
508_G	511_L	0.576	0.55
150_A	154_K	0.575	0.55
234_E	238_Q	0.574	0.55
832_V	879_A	0.574	0.55
117_G	182_K	0.574	0.55
734_K	737_G	0.574	0.55
654_F	870_F	0.571	0.55
41_A	100_Y	0.570	0.55
367_N	392_K	0.570	0.55
650_D	841_P	0.570	0.55
786_N	790_F	0.570	0.55
551_V	561_S	0.569	0.54
508_G	594_G	0.569	0.54
567_K	570_D	0.569	0.54
469_L	475_L	0.569	0.54
487_L	491_E	0.569	0.54
117_G	139_L	0.568	0.54
347_A	455_A	0.568	0.54
477_L	487_L	0.568	0.54
401_A	465_L	0.568	0.54
8_V	14_S	0.568	0.54
410_S	416_S	0.567	0.54
16_A	90_M	0.567	0.54
728_N	754_M	0.565	0.54
779_E	786_N	0.564	0.54
340_S	454_K	0.564	0.54
115_I	119_L	0.563	0.54
757_S	764_K	0.563	0.54
380_A	450_H	0.563	0.54
711_A	720_I	0.562	0.54
519_E	533_N	0.562	0.54
217_L	235_F	0.561	0.53
669_I	767_V	0.561	0.53
572_H	576_D	0.561	0.53
742_R	746_S	0.561	0.53
151_I	160_E	0.561	0.53
357_E	360_V	0.560	0.53
117_G	246_A	0.560	0.53
182_K	189_S	0.560	0.53
610_F	623_T	0.560	0.53
224_S	231_K	0.560	0.53
210_F	224_S	0.560	0.53
168_K	176_E	0.559	0.53
744_L	755_E	0.559	0.53
28_N	33_H	0.559	0.53
404_I	776_Y	0.559	0.53
425_I	431_S	0.559	0.53
315_I	320_S	0.559	0.53
15_L	139_L	0.558	0.53
86_L	89_Q	0.558	0.53
143_A	174_T	0.558	0.53
562_A	579_L	0.557	0.53
27_S	33_H	0.557	0.53
218_E	240_L	0.557	0.53
683_M	689_T	0.557	0.53
552_K	555_K	0.556	0.53
407_P	798_T	0.556	0.53
680_T	865_P	0.555	0.53
599_T	606_V	0.555	0.53
38_Y	283_L	0.555	0.53
642_Q	875_S	0.554	0.52
183_G	238_Q	0.553	0.52
375_F	379_R	0.553	0.52
349_F	447_L	0.553	0.52
69_H	78_G	0.553	0.52
304_N	308_V	0.553	0.52
347_A	351_P	0.553	0.52
707_R	715_G	0.552	0.52
472_N	774_R	0.552	0.52
434_G	437_A	0.552	0.52
197_G	226_K	0.552	0.52
712_V	739_F	0.552	0.52
632_I	640_I	0.551	0.52
40_F	97_L	0.551	0.52
396_F	479_E	0.551	0.52
315_I	370_Q	0.551	0.52
329_D	454_K	0.551	0.52
326_Q	379_R	0.551	0.52
178_I	182_K	0.550	0.52
28_N	748_Q	0.549	0.52
693_V	708_Q	0.549	0.52
326_Q	334_E	0.549	0.52
708_Q	739_F	0.549	0.52
375_F	458_I	0.549	0.52
213_V	239_A	0.549	0.52
650_D	843_E	0.549	0.52
213_V	217_L	0.548	0.52
740_I	794_T	0.548	0.52
24_P	28_N	0.547	0.52
669_I	757_S	0.547	0.52
117_G	247_T	0.547	0.52
13_N	86_L	0.547	0.52
171_Y	200_E	0.547	0.52
364_W	393_G	0.546	0.51
616_Q	670_S	0.546	0.51
195_V	217_L	0.546	0.51
101_Q	264_Q	0.546	0.51
65_T	82_T	0.546	0.51
22_A	154_K	0.545	0.51
272_I	288_G	0.545	0.51
669_I	754_M	0.544	0.51
240_L	244_E	0.543	0.51
323_V	375_F	0.543	0.51
318_S	367_N	0.542	0.51
674_N	677_E	0.542	0.51
414_V	461_L	0.542	0.51
711_A	739_F	0.542	0.51
615_T	747_F	0.541	0.51
654_F	872_S	0.540	0.51
739_F	746_S	0.540	0.51
173_L	200_E	0.540	0.51
5_K	126_D	0.540	0.51
373_W	458_I	0.540	0.51
616_Q	798_T	0.539	0.51
777_I	789_S	0.539	0.51
344_E	348_Y	0.539	0.51
217_L	225_G	0.538	0.50
325_E	379_R	0.538	0.50
377_S	606_V	0.538	0.50
229_K	236_K	0.538	0.50
634_L	668_H	0.538	0.50
55_H	259_S	0.537	0.50
666_L	750_V	0.537	0.50
182_K	246_A	0.537	0.50
826_A	840_A	0.537	0.50
518_Y	522_I	0.536	0.50
429_D	442_P	0.536	0.50
185_M	248_I	0.536	0.50
112_A	245_L	0.535	0.50
429_D	441_V	0.535	0.50
525_I	574_I	0.535	0.50
424_H	457_A	0.535	0.50
332_H	600_R	0.535	0.50
723_Y	788_R	0.535	0.50
293_E	296_Q	0.534	0.50
103_S	400_L	0.534	0.50
364_W	372_K	0.534	0.50
429_D	454_K	0.533	0.50
125_K	147_T	0.533	0.50
435_K	439_R	0.532	0.50
316_L	370_Q	0.531	0.49
323_V	413_D	0.531	0.49
690_A	713_N	0.531	0.49
346_G	456_L	0.531	0.49
775_R	800_I	0.530	0.49
651_W	842_K	0.530	0.49
680_T	861_A	0.530	0.49
434_G	442_P	0.530	0.49
564_V	747_F	0.529	0.49
173_L	208_K	0.529	0.49
57_L	105_Y	0.529	0.49
434_G	438_K	0.528	0.49
775_R	798_T	0.528	0.49
59_A	105_Y	0.527	0.49
611_N	614_L	0.527	0.49
669_I	803_S	0.527	0.49
510_E	635_E	0.527	0.49
665_V	807_I	0.526	0.49
242_S	246_A	0.526	0.49
150_A	155_G	0.525	0.49
402_A	417_V	0.524	0.49
110_Y	250_T	0.524	0.49
285_E	289_E	0.523	0.48
117_G	179_I	0.523	0.48
415_A	453_R	0.522	0.48
365_V	375_F	0.522	0.48
503_R	875_S	0.522	0.48
842_K	845_I	0.522	0.48
690_A	709_A	0.521	0.48
137_K	185_M	0.521	0.48
132_V	139_L	0.521	0.48
707_R	721_S	0.520	0.48
17_Y	80_Q	0.520	0.48
228_L	231_K	0.519	0.48
580_Q	584_I	0.519	0.48
408_G	615_T	0.518	0.48
583_Q	747_F	0.518	0.48
489_L	612_Q	0.518	0.48
751_K	758_V	0.518	0.48
445_D	449_E	0.518	0.48
431_S	815_M	0.517	0.48
333_E	600_R	0.517	0.48
140_T	178_I	0.517	0.48
179_I	250_T	0.516	0.48
544_E	547_G	0.515	0.47
461_L	465_L	0.515	0.47
50_D	161_F	0.515	0.47
137_K	171_Y	0.515	0.47
134_S	815_M	0.515	0.47
17_Y	81_K	0.514	0.47
366_E	393_G	0.514	0.47
24_P	152_T	0.513	0.47
123_A	126_D	0.513	0.47
501_V	604_H	0.513	0.47
231_K	754_M	0.513	0.47
824_L	851_L	0.512	0.47
683_M	713_N	0.511	0.47
13_N	17_Y	0.511	0.47
549_P	572_H	0.511	0.47
675_L	683_M	0.511	0.47
105_Y	119_L	0.511	0.47
381_V	486_A	0.510	0.47
112_A	497_V	0.510	0.47
323_V	327_I	0.510	0.47
195_V	235_F	0.510	0.47
13_N	16_A	0.509	0.47
372_K	394_A	0.509	0.47
696_V	700_E	0.509	0.47
509_E	680_T	0.509	0.47
10_V	56_M	0.509	0.47
20_F	25_L	0.509	0.47
276_K	288_G	0.508	0.47
826_A	849_E	0.508	0.47
91_P	106_E	0.508	0.47
240_L	243_K	0.508	0.47
27_S	38_Y	0.508	0.47
372_K	392_K	0.507	0.46
358_S	362_K	0.507	0.46
187_D	589_S	0.507	0.46
780_L	796_M	0.507	0.46
401_A	466_V	0.507	0.46
54_T	128_F	0.506	0.46
134_S	248_I	0.506	0.46
716_I	744_L	0.506	0.46
451_L	455_A	0.505	0.46
673_E	680_T	0.505	0.46
646_P	837_I	0.505	0.46
769_T	802_G	0.505	0.46
374_V	394_A	0.505	0.46
209_Q	215_K	0.504	0.46
398_T	414_V	0.504	0.46
396_F	483_M	0.504	0.46
717_V	790_F	0.504	0.46
517_E	577_Y	0.504	0.46
19_A	26_L	0.504	0.46
547_G	782_S	0.503	0.46
181_M	216_L	0.503	0.46
28_N	278_L	0.503	0.46
616_Q	775_R	0.502	0.46
764_K	774_R	0.502	0.46
324_V	458_I	0.502	0.46
325_E	337_L	0.502	0.46
41_A	278_L	0.502	0.46
353_D	357_E	0.502	0.46
615_T	871_A	0.502	0.46
433_Y	436_G	0.501	0.46
13_N	151_I	0.501	0.46
605_K	839_E	0.501	0.46
432_V	446_V	0.501	0.46
205_K	217_L	0.500	0.45
490_G	494_S	0.500	0.45
43_I	153_R	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1bgxT	1	0.9284	100	0.253	Contact Map
2kfnA	1	0.6636	100	0.474	Contact Map
4x0qA	1	0.6477	100	0.486	Contact Map
4yfuA	1	0.658	100	0.491	Contact Map
4bwjA	1	0.608	100	0.502	Contact Map
4xvkA	1	0.6568	100	0.504	Contact Map
1x9mA	1	0.6125	100	0.547	Contact Map
3ikmA	1	0.7307	100	0.753	Contact Map
3h7iA	1	0.3057	100	0.781	Contact Map
1exnA	1	0.2909	100	0.781	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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