GREMLIN Database
CCPN - Transcriptional repressor CcpN
UniProt: O34994 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (168)
Sequences: 3370 (1947)
Seq/√Len: 150.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_K189_E4.6451.00
157_C180_V3.9451.00
27_H33_N3.5581.00
90_I113_V3.1441.00
25_G33_N2.9431.00
142_V146_I2.7571.00
94_V98_D2.6891.00
158_R183_D2.5091.00
91_H94_V2.4431.00
159_R191_I2.3941.00
97_Y101_C2.2981.00
157_C161_D2.2871.00
74_K77_K2.2821.00
101_C105_L2.1921.00
92_E121_V2.1871.00
132_A142_V2.1751.00
184_T189_E2.1611.00
155_T173_K2.1361.00
67_G70_L2.0311.00
166_I178_L2.0111.00
99_A124_L2.0001.00
143_P146_I1.9941.00
90_I94_V1.9871.00
97_Y141_S1.9861.00
49_S74_K1.9131.00
124_L147_I1.8531.00
56_P59_G1.8271.00
168_K172_E1.8181.00
119_V189_E1.8141.00
162_Y165_D1.7821.00
28_I39_L1.7391.00
165_D168_K1.7311.00
91_H116_R1.7091.00
25_G35_T1.6991.00
98_D101_C1.6711.00
99_A103_M1.6551.00
90_I99_A1.5571.00
163_V167_A1.5521.00
93_N145_H1.5521.00
95_S98_D1.5081.00
90_I144_V1.4791.00
100_I140_T1.4721.00
92_E145_H1.4391.00
108_V111_L1.4241.00
93_N143_P1.4191.00
96_V132_A1.4061.00
161_D165_D1.3851.00
181_I188_F1.3791.00
118_A189_E1.3761.00
92_E115_D1.3711.00
70_L74_K1.3671.00
73_D77_K1.3561.00
107_D126_R1.3291.00
73_D76_K1.3241.00
113_V144_V1.3011.00
170_L178_L1.2801.00
139_L142_V1.2741.00
115_D119_V1.2731.00
103_M111_L1.2701.00
100_I104_F1.2431.00
133_S168_K1.2391.00
128_D149_T1.2061.00
79_Q82_D1.1991.00
184_T188_F1.1721.00
188_F191_I1.1711.00
47_T60_Y1.1661.00
28_I59_G1.1321.00
163_V199_M1.1291.00
159_R182_K1.1270.99
92_E114_V1.1090.99
151_M188_F1.0960.99
91_H145_H1.0900.99
183_D188_F1.0870.99
26_E34_L1.0720.99
158_R161_D1.0680.99
114_V118_A1.0600.99
158_R184_T1.0460.99
142_V147_I1.0440.99
132_A147_I1.0410.99
110_T177_A1.0240.99
97_Y140_T1.0210.99
176_D197_T1.0060.99
70_L73_D0.9790.99
159_R183_D0.9650.98
171_I174_Q0.9510.98
26_E36_R0.9390.98
91_H115_D0.9310.98
37_A52_L0.9300.98
179_P190_V0.9280.98
158_R165_D0.9280.98
115_D121_V0.9260.98
119_V184_T0.9250.98
81_K84_Q0.9140.98
120_L177_A0.9130.98
83_F163_V0.9120.98
125_S198_N0.8940.97
45_I48_M0.8930.97
88_V108_V0.8890.97
72_A75_L0.8880.97
145_H150_R0.8850.97
176_D196_K0.8850.97
112_F177_A0.8710.97
88_V111_L0.8680.97
72_A76_K0.8660.97
161_D178_L0.8660.97
38_T50_G0.8610.97
96_V147_I0.8540.97
132_A139_L0.8420.96
39_L59_G0.8360.96
68_T72_A0.8270.96
96_V142_V0.8210.96
117_D189_E0.8210.96
177_A193_R0.8150.96
132_A140_T0.8060.95
27_H30_E0.7980.95
75_L78_L0.7980.95
37_A41_P0.7960.95
58_V62_Y0.7950.95
106_E111_L0.7870.95
166_I170_L0.7840.95
88_V113_V0.7730.94
115_D189_E0.7630.94
49_S77_K0.7580.93
102_T111_L0.7520.93
93_N116_R0.7490.93
108_V195_T0.7350.92
95_S143_P0.7350.92
80_V166_I0.7310.92
167_A199_M0.7300.92
72_A78_L0.7290.92
129_L200_T0.7290.92
102_T106_E0.7220.92
40_R46_L0.7130.91
103_M129_L0.7120.91
40_R55_R0.7080.91
165_D169_H0.7070.91
46_L60_Y0.7070.91
91_H121_V0.7050.91
65_K112_F0.7000.90
168_K171_I0.6990.90
94_V111_L0.6970.90
103_M199_M0.6970.90
91_H114_V0.6890.90
109_G126_R0.6880.90
84_Q89_V0.6850.90
100_I111_L0.6850.90
161_D169_H0.6840.89
54_A166_I0.6790.89
103_M108_V0.6740.89
28_I61_F0.6710.89
101_C104_F0.6650.88
129_L167_A0.6620.88
57_R62_Y0.6590.88
133_S140_T0.6580.88
166_I193_R0.6480.87
71_L75_L0.6450.87
73_D105_L0.6430.86
41_P48_M0.6410.86
110_T176_D0.6410.86
76_K80_V0.6400.86
63_T66_T0.6330.86
28_I31_K0.6310.85
27_H31_K0.6300.85
109_G195_T0.6290.85
156_V181_I0.6280.85
96_V144_V0.6270.85
123_V128_D0.6230.85
96_V146_I0.6220.85
71_L82_D0.6210.84
71_L79_Q0.6140.84
40_R44_A0.6140.84
40_R45_I0.6130.84
95_S152_P0.6040.83
109_G149_T0.6020.83
75_L82_D0.5980.82
157_C194_V0.5980.82
42_D112_F0.5970.82
155_T169_H0.5960.82
75_L79_Q0.5950.82
140_T143_P0.5910.81
46_L52_L0.5900.81
47_T52_L0.5890.81
196_K199_M0.5870.81
65_K78_L0.5860.81
76_K81_K0.5860.81
131_R171_I0.5850.81
169_H178_L0.5820.80
37_A46_L0.5780.80
104_F133_S0.5750.80
126_R130_L0.5750.80
76_K191_I0.5730.79
163_V194_V0.5730.79
40_R47_T0.5720.79
63_T75_L0.5700.79
65_K75_L0.5690.79
93_N115_D0.5660.79
98_D144_V0.5650.78
85_S90_I0.5640.78
109_G196_K0.5630.78
52_L60_Y0.5630.78
37_A45_I0.5620.78
51_F55_R0.5620.78
127_K177_A0.5570.77
36_R40_R0.5550.77
62_Y75_L0.5540.77
122_G148_M0.5540.77
139_L146_I0.5530.77
40_R60_Y0.5520.77
124_L196_K0.5510.77
78_L82_D0.5500.77
157_C179_P0.5480.76
71_L198_N0.5470.76
125_S128_D0.5460.76
93_N118_A0.5450.76
166_I174_Q0.5440.76
110_T193_R0.5420.76
30_E39_L0.5410.75
40_R52_L0.5410.75
29_A32_L0.5400.75
85_S191_I0.5390.75
167_A200_T0.5380.75
66_T71_L0.5370.75
154_I179_P0.5350.75
53_E190_V0.5340.74
111_L196_K0.5320.74
43_L46_L0.5300.74
125_S176_D0.5270.74
88_V103_M0.5260.73
80_V126_R0.5250.73
72_A79_Q0.5230.73
89_V118_A0.5220.73
68_T71_L0.5200.73
26_E30_E0.5180.72
37_A40_R0.5170.72
84_Q180_V0.5140.72
120_L179_P0.5140.72
109_G127_K0.5140.72
84_Q200_T0.5140.72
99_A129_L0.5140.72
81_K106_E0.5130.72
44_A48_M0.5120.71
41_P47_T0.5110.71
115_D118_A0.5100.71
66_T70_L0.5100.71
169_H172_E0.5070.71
90_I163_V0.5060.71
166_I194_V0.5030.70
28_I32_L0.5030.70
37_A47_T0.5020.70
116_R121_V0.5000.70
129_L140_T0.5000.70
95_S100_I0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l2bA 2 0.5566 99.9 0.491 Contact Map
3fv6A 2 0.6792 99.9 0.508 Contact Map
1pvmA 2 0.6509 99.9 0.513 Contact Map
2j9lA 3 0.6085 99.9 0.518 Contact Map
2zy9A 2 0.9198 99.9 0.52 Contact Map
3fhmA 2 0.6179 99.9 0.52 Contact Map
3ocoA 2 0.6179 99.9 0.523 Contact Map
4nocA 2 0.5896 99.9 0.524 Contact Map
2ouxA 2 0.9292 99.9 0.525 Contact Map
3lv9A 2 0.5943 99.9 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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