GREMLIN Database
YVOF - Putative acetyltransferase YvoF
UniProt: O34993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (137)
Sequences: 7039 (4707)
Seq/√Len: 402.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_G146_G3.1421.00
110_G129_D3.0151.00
61_Q83_N2.9801.00
70_P78_I2.6781.00
143_V149_V2.6471.00
92_I107_V2.6151.00
112_E130_G2.5831.00
134_S150_G2.4431.00
129_D145_D2.4421.00
60_K82_T2.4351.00
111_D129_D2.4011.00
57_K79_S2.3861.00
150_G157_I2.2471.00
122_L135_A2.1051.00
38_R57_K2.0341.00
110_G126_K1.9971.00
149_V154_M1.9891.00
131_A147_A1.8611.00
147_A159_T1.8541.00
67_M89_N1.8451.00
59_G82_T1.8411.00
83_N112_E1.7351.00
126_K142_D1.7211.00
79_S108_L1.6851.00
137_T154_M1.6821.00
131_A145_D1.6761.00
149_V156_I1.6701.00
93_L117_A1.6541.00
81_G111_D1.5821.00
131_A143_V1.5711.00
58_V62_T1.5241.00
29_K33_V1.5191.00
156_I159_T1.4711.00
108_L126_K1.4511.00
144_P156_I1.4481.00
125_V142_D1.4231.00
40_T60_K1.4091.00
147_A156_I1.4051.00
89_N118_N1.3961.00
115_I121_I1.3621.00
62_T82_T1.3151.00
109_I115_I1.3011.00
57_K77_K1.2691.00
128_G145_D1.2531.00
144_P147_A1.2511.00
133_V143_V1.2231.00
42_F61_Q1.2211.00
100_H103_R1.2071.00
75_P104_I1.2031.00
120_T136_G1.1981.00
92_I109_I1.1861.00
115_I119_T1.1601.00
82_T111_D1.1451.00
64_F68_V1.1341.00
76_E104_I1.0951.00
39_Y43_I1.0931.00
99_I132_V1.0821.00
62_T84_T1.0561.00
91_T118_N1.0541.00
110_G145_D1.0541.00
58_V64_F1.0511.00
31_F35_Q1.0421.00
113_V131_A1.0401.00
133_V139_V1.0311.00
86_I92_I1.0171.00
144_P149_V1.0061.00
138_L152_N0.9881.00
81_G110_G0.9821.00
27_V30_N0.9791.00
86_I115_I0.9771.00
86_I90_T0.9691.00
62_T111_D0.9511.00
84_T129_D0.9481.00
80_V92_I0.9331.00
112_E129_D0.9281.00
133_V149_V0.9251.00
69_M89_N0.9241.00
90_T119_T0.9181.00
80_V86_I0.9171.00
113_V129_D0.9161.00
122_L140_H0.9121.00
113_V145_D0.9001.00
62_T80_V0.8901.00
58_V80_V0.8901.00
84_T111_D0.8781.00
99_I148_F0.8781.00
109_I113_V0.8771.00
27_V31_F0.8761.00
148_F160_K0.8731.00
64_F70_P0.8511.00
64_F86_I0.8421.00
132_V148_F0.8421.00
129_D146_G0.8381.00
51_R56_M0.8371.00
24_F27_V0.8291.00
69_M73_M0.8221.00
128_G142_D0.8211.00
96_E105_G0.8211.00
127_I133_V0.8141.00
91_T120_T0.8131.00
91_T117_A0.8051.00
55_R77_K0.8051.00
41_P60_K0.8041.00
33_V37_A0.7971.00
119_T137_T0.7961.00
33_V39_Y0.7931.00
80_V84_T0.7871.00
118_N136_G0.7871.00
36_I39_Y0.7871.00
68_V90_T0.7851.00
43_I62_T0.7781.00
136_G152_N0.7771.00
81_G108_L0.7701.00
48_W51_R0.7551.00
77_K106_K0.7521.00
120_T138_L0.7521.00
26_K30_N0.7501.00
42_F60_K0.7481.00
37_A40_T0.7421.00
97_Y114_M0.7401.00
110_G131_A0.7311.00
46_K63_S0.7141.00
110_G128_G0.7131.00
147_A150_G0.7091.00
158_Y161_E0.7051.00
125_V141_K0.7031.00
150_G154_M0.6971.00
88_Y117_A0.6961.00
30_N34_I0.6921.00
107_V123_P0.6891.00
146_G159_T0.6861.00
148_F158_Y0.6841.00
62_T86_I0.6780.99
142_D149_V0.6770.99
98_L103_R0.6750.99
79_S106_K0.6660.99
87_G114_M0.6660.99
130_G145_D0.6610.99
25_L29_K0.6480.99
137_T152_N0.6470.99
50_Y67_M0.6430.99
92_I121_I0.6420.99
45_M49_L0.6420.99
43_I46_K0.6370.99
46_K66_L0.6330.99
80_V109_I0.6300.99
26_K29_K0.6290.99
147_A160_K0.6240.99
139_V154_M0.6230.99
56_M70_P0.6230.99
52_T75_P0.6200.99
50_Y66_L0.6200.99
131_A149_V0.6190.99
109_I121_I0.6160.99
45_M48_W0.6160.99
127_I131_A0.6150.99
128_G131_A0.6120.99
105_G124_G0.6100.99
83_N111_D0.6070.99
45_M51_R0.6070.99
84_T109_I0.6050.99
128_G144_P0.6050.99
70_P92_I0.5990.99
96_E99_I0.5990.99
84_T113_V0.5970.99
50_Y53_F0.5960.99
43_I58_V0.5940.99
59_G84_T0.5930.99
37_A57_K0.5870.98
136_G140_H0.5830.98
109_I127_I0.5790.98
95_H104_I0.5710.98
121_I127_I0.5700.98
140_H154_M0.5680.98
99_I102_Y0.5670.98
148_F157_I0.5670.98
121_I125_V0.5610.98
128_G149_V0.5560.98
81_G84_T0.5560.98
32_I36_I0.5530.98
77_K108_L0.5520.98
49_L68_V0.5520.98
76_E94_A0.5500.98
96_E123_P0.5480.98
28_V31_F0.5470.98
98_L102_Y0.5440.98
46_K51_R0.5390.97
143_V147_A0.5390.97
69_M88_Y0.5380.97
48_W67_M0.5330.97
48_W52_T0.5320.97
59_G81_G0.5320.97
150_G155_R0.5280.97
34_I37_A0.5270.97
55_R75_P0.5260.97
137_T150_G0.5250.97
33_V41_P0.5240.97
75_P95_H0.5210.97
93_L120_T0.5190.97
126_K145_D0.5160.97
122_L138_L0.5070.96
23_P27_V0.5070.96
32_I58_V0.5050.96
63_S85_I0.5030.96
107_V125_V0.5000.96
65_A114_M0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fttA 3 0.9419 100 0.285 Contact Map
3srtA 3 0.9302 100 0.294 Contact Map
3nz2A 4 0.9244 100 0.298 Contact Map
1krrA 3 0.9884 100 0.3 Contact Map
3hjjA 3 0.9302 100 0.308 Contact Map
2p2oA 3 0.9244 100 0.313 Contact Map
1ocxA 3 0.9128 100 0.337 Contact Map
3vbiA 3 0.8488 99.9 0.406 Contact Map
3eevA 3 0.8023 99.9 0.412 Contact Map
1xatA 3 0.7965 99.9 0.418 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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