OPUCA - BACSU - GREMLIN Contacts

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OPUCA - Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA

UniProt:	O34992	Sequences: MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTTMKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPKLLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMDEPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVGTPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMREKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRKILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	380 (303)
Sequences:	7464 (6263)
Seq/√Len:	359.8

ECOLI - PROV POTA POTG MALK CYSA METN YCJV FBPC UGPC YDCT RBSA YHES YADG DPPF YEHX GSIA MODC DPPD SAPD UUP OPPF OPPD ARAG DDPD MACB DDPF MDLB CYDC MDLA MSBA CYDD FEPC YOJI SAPF MLAF ETTA LSRA YTFR TAUB HISP NIKE YECC FECE PHNC FHUC GLNQ LPTB SSUB YHDZ GLTL SUFC LIVG PHNK PSTB YPHE FTSE ARTP THIQ ZNUC MODF LOLD LIVF XYLG BTUD ALSA FETA YBBA NIKD MGLA YDDA PHNL YEJF CCMA YBHF YNJD YBIT
BACSU - OPUCA OPUBA OPUAA YVRA YURJ METN MSMX OPPD TAGH YKFD YDIF DPPD YFIL APPF YDBJ APPD YXLF YHCH YHEH YCBN YVFR YHAQ SUNT RBSA YFIC YFMR OPPF YKNV YFIB BMRA YGAD YKNU ECFA1 YWJA YHEI YUSV YTRB YFMF CYDC YKPA FHUC CYDD YFMM YCLP YLMA TCYN BCEA ECSA SUFC YXDL ECFA2 YVCR SKFE FTSE YTLC YKOD PSTB1 GLNQ TCYC ARTM YXEO YJKB NATA ALBC PSTB2 SSUB YTHP YVRO MNTB EXPZ YKNY YCLH ZNUC YYBJ YHCG YUFO YTRE YYDI
HALSA - Q9HMW0 BTUDA Q9HMX3 Q9HHQ5 Q9HNZ9 Q9HR06 Q9HMX2 Q9HMT3 Q9HRJ6 PSTB2 Q9HMU8 Q9HSQ7 Q9HMG1 Q9HRH8 PHNC Q9HHM2 Q9HMG6 Q9HRV7 Q9HNY3 PSTB1 Y2317 Q9HRZ9 Y1631 Q9HR96 Q9HHR7 Q9HT03 Q9HS04 Q9HQA8 Q9HR21 Q9HMC1 Q9HMW1
SULSO - Q97UJ9 Q97UF2 Q97YY4 Q97UY8 Q7LX64 Q97VF5 Q97UH3 Q97VC1 Q97ZC0 Q97YP3 Q97VK8 Q97VH6 Q97VK9 Q97VF4 Q97YP7 Q97YP8 Q97X18 Q97YK2 Q97UD4 Q97YQ7 Q980W0 Q97Z03 Q97U54 PSTB Q97UH4 Q97V01 Q97W42 Q97V00 Q7LY07 Q7LXM4 Y2030 Y1893 Q97VM2 Q97VY4 Q7LX80 Q97Z56 Q97UG5 Q97YP4 Q97Z96 Q97UC2 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
6_Q	20_S	5.225	1.00
4_L	7_V	4.003	1.00
5_E	58_R	3.875	1.00
200_I	221_D	3.851	1.00
16_K	19_N	3.486	1.00
29_E	205_R	3.282	1.00
90_H	134_H	3.217	1.00
9_K	47_M	3.150	1.00
45_M	192_V	3.126	1.00
9_K	55_S	2.952	1.00
91_M	99_L	2.937	1.00
7_V	54_P	2.692	1.00
19_N	213_E	2.406	1.00
3_K	24_D	2.369	1.00
25_I	31_I	2.320	1.00
8_S	56_S	2.294	1.00
10_V	55_S	2.220	1.00
32_C	203_A	2.187	1.00
88_F	91_M	2.172	1.00
310_I	314_V	2.151	1.00
6_Q	22_D	2.034	1.00
4_L	23_L	1.966	1.00
45_M	158_L	1.958	1.00
47_M	59_I	1.941	1.00
32_C	199_A	1.918	1.00
307_K	310_I	1.910	1.00
47_M	54_P	1.891	1.00
219_T	222_E	1.858	1.00
272_I	276_R	1.833	1.00
31_I	207_V	1.821	1.00
8_S	20_S	1.812	1.00
288_R	314_V	1.789	1.00
277_E	281_D	1.784	1.00
314_V	318_D	1.782	1.00
288_R	291_V	1.761	1.00
4_L	48_I	1.760	1.00
313_D	317_S	1.758	1.00
49_N	158_L	1.752	1.00
10_V	16_K	1.751	1.00
91_M	95_Q	1.725	1.00
312_G	316_R	1.691	1.00
26_A	29_E	1.675	1.00
318_D	321_T	1.673	1.00
281_D	284_L	1.649	1.00
46_K	51_L	1.646	1.00
79_G	154_P	1.600	1.00
273_Q	276_R	1.599	1.00
282_S	286_V	1.591	1.00
131_R	135_E	1.586	1.00
291_V	295_Y	1.586	1.00
179_K	201_K	1.572	1.00
268_L	271_A	1.572	1.00
9_K	52_I	1.566	1.00
92_T	95_Q	1.544	1.00
317_S	321_T	1.533	1.00
23_L	207_V	1.518	1.00
205_R	216_Q	1.509	1.00
309_S	313_D	1.485	1.00
94_Q	98_S	1.483	1.00
96_N	148_R	1.475	1.00
271_A	275_M	1.474	1.00
218_G	222_E	1.461	1.00
96_N	133_P	1.455	1.00
128_Y	131_R	1.453	1.00
314_V	317_S	1.450	1.00
316_R	320_Y	1.447	1.00
133_P	144_I	1.444	1.00
267_T	271_A	1.403	1.00
46_K	52_I	1.399	1.00
7_V	47_M	1.383	1.00
255_M	258_T	1.382	1.00
281_D	285_V	1.376	1.00
11_Y	17_A	1.375	1.00
295_Y	298_V	1.373	1.00
91_M	96_N	1.372	1.00
191_F	203_A	1.371	1.00
289_Q	318_D	1.363	1.00
3_K	60_F	1.359	1.00
283_L	287_D	1.353	1.00
18_V	47_M	1.347	1.00
269_S	272_I	1.342	1.00
261_T	264_A	1.336	1.00
309_S	312_G	1.333	1.00
262_V	265_D	1.328	1.00
270_Q	274_L	1.321	1.00
178_F	189_I	1.313	1.00
284_L	288_R	1.305	1.00
263_S	267_T	1.305	1.00
181_L	187_K	1.298	1.00
210_K	213_E	1.291	1.00
89_P	134_H	1.283	1.00
313_D	316_R	1.279	1.00
300_M	303_Q	1.270	1.00
107_P	110_K	1.265	1.00
269_S	273_Q	1.260	1.00
47_M	55_S	1.260	1.00
315_Y	319_I	1.249	1.00
199_A	203_A	1.243	1.00
31_I	190_V	1.242	1.00
36_P	39_C	1.235	1.00
116_R	126_P	1.233	1.00
306_K	309_S	1.224	1.00
268_L	272_I	1.220	1.00
18_V	21_I	1.218	1.00
299_E	302_D	1.210	1.00
283_L	286_V	1.206	1.00
316_R	319_I	1.202	1.00
264_A	267_T	1.201	1.00
280_V	283_L	1.198	1.00
114_R	117_E	1.197	1.00
79_G	149_A	1.190	1.00
311_V	314_V	1.185	1.00
310_I	313_D	1.184	1.00
214_I	217_V	1.183	1.00
221_D	225_R	1.179	1.00
87_L	96_N	1.178	1.00
29_E	204_D	1.170	1.00
25_I	188_T	1.169	1.00
5_E	22_D	1.167	1.00
257_R	260_V	1.166	1.00
5_E	60_F	1.164	1.00
270_Q	273_Q	1.155	1.00
93_I	144_I	1.151	1.00
281_D	321_T	1.146	1.00
95_Q	98_S	1.137	1.00
274_L	278_K	1.136	1.00
28_G	188_T	1.136	1.00
6_Q	56_S	1.134	1.00
232_V	236_I	1.132	1.00
100_V	148_R	1.128	1.00
293_K	319_I	1.090	1.00
8_S	16_K	1.090	1.00
13_G	16_K	1.088	1.00
158_L	190_V	1.082	1.00
90_H	132_Y	1.081	1.00
222_E	226_N	1.081	1.00
304_N	307_K	1.079	1.00
312_G	315_Y	1.073	1.00
306_K	310_I	1.070	1.00
307_K	311_V	1.061	1.00
191_F	199_A	1.058	1.00
9_K	43_T	1.052	1.00
92_T	96_N	1.048	1.00
317_S	320_Y	1.032	1.00
39_C	209_L	1.031	1.00
178_F	202_L	1.028	1.00
63_G	76_R	1.028	1.00
315_Y	318_D	1.022	1.00
286_V	289_Q	1.015	1.00
81_V	142_Q	1.011	1.00
298_V	304_N	1.011	1.00
113_E	117_E	1.011	1.00
171_R	195_D	1.009	1.00
208_I	223_I	1.009	1.00
274_L	277_E	1.008	1.00
230_E	233_E	1.005	1.00
10_V	14_G	1.003	1.00
191_F	202_L	1.002	1.00
273_Q	277_E	0.999	1.00
301_I	304_N	0.995	1.00
292_L	311_V	0.994	1.00
287_D	291_V	0.994	1.00
7_V	59_I	0.990	1.00
254_M	257_R	0.987	1.00
98_S	115_A	0.986	1.00
4_L	59_I	0.982	1.00
54_P	59_I	0.974	1.00
302_D	308_A	0.969	1.00
260_V	264_A	0.967	1.00
111_R	114_R	0.966	1.00
231_F	235_F	0.966	1.00
220_P	224_L	0.966	1.00
300_M	304_N	0.966	1.00
279_R	283_L	0.965	1.00
290_N	294_G	0.964	1.00
49_N	80_Y	0.962	1.00
261_T	265_D	0.958	1.00
132_Y	135_E	0.956	1.00
210_K	215_V	0.950	1.00
77_K	152_A	0.947	1.00
112_K	115_A	0.947	1.00
231_F	234_E	0.941	1.00
234_E	237_G	0.940	1.00
289_Q	293_K	0.940	1.00
117_E	121_L	0.927	1.00
252_E	255_M	0.922	1.00
101_P	104_L	0.921	1.00
292_L	296_V	0.921	1.00
110_K	113_E	0.920	1.00
263_S	266_K	0.917	1.00
81_V	149_A	0.916	1.00
266_K	269_S	0.911	1.00
118_L	147_L	0.905	1.00
275_M	278_K	0.903	1.00
108_E	111_R	0.903	1.00
280_V	284_L	0.901	1.00
225_R	228_A	0.901	1.00
208_I	227_P	0.899	1.00
298_V	301_I	0.899	1.00
308_A	312_G	0.898	1.00
312_G	319_I	0.896	1.00
259_P	263_S	0.889	1.00
253_Q	256_N	0.889	1.00
305_R	309_S	0.886	1.00
193_T	199_A	0.882	1.00
232_V	235_F	0.880	1.00
237_G	240_R	0.879	1.00
285_V	289_Q	0.879	1.00
233_E	237_G	0.878	1.00
256_N	260_V	0.872	1.00
234_E	238_K	0.870	1.00
64_E	76_R	0.870	1.00
154_P	181_L	0.869	1.00
118_L	151_A	0.865	1.00
251_V	254_M	0.861	1.00
293_K	297_D	0.856	1.00
278_K	282_S	0.855	1.00
224_L	228_A	0.855	1.00
88_F	96_N	0.846	1.00
305_R	308_A	0.845	1.00
297_D	300_M	0.843	1.00
34_I	208_I	0.842	1.00
8_S	19_N	0.841	1.00
276_R	280_V	0.839	1.00
299_E	304_N	0.835	1.00
236_I	240_R	0.834	1.00
296_V	301_I	0.833	1.00
176_E	180_K	0.828	1.00
168_P	172_D	0.826	1.00
258_T	261_T	0.823	1.00
267_T	275_M	0.820	1.00
217_V	226_N	0.815	1.00
265_D	269_S	0.811	1.00
25_I	190_V	0.803	1.00
236_I	239_E	0.799	1.00
221_D	224_L	0.799	1.00
302_D	305_R	0.797	1.00
94_Q	129_L	0.796	1.00
197_D	201_K	0.786	1.00
293_K	315_Y	0.784	1.00
93_I	133_P	0.784	1.00
116_R	129_L	0.781	1.00
213_E	216_Q	0.778	1.00
294_G	298_V	0.771	1.00
213_E	217_V	0.764	1.00
264_A	268_L	0.759	1.00
211_A	217_V	0.759	1.00
156_L	190_V	0.754	1.00
48_I	190_V	0.753	1.00
220_P	223_I	0.748	1.00
257_R	262_V	0.747	1.00
106_W	109_E	0.747	1.00
304_N	308_A	0.747	1.00
120_K	125_G	0.747	1.00
266_K	276_R	0.744	1.00
51_L	86_G	0.743	1.00
247_D	252_E	0.743	1.00
82_I	85_I	0.742	1.00
258_T	262_V	0.742	1.00
222_E	225_R	0.741	1.00
237_G	241_L	0.739	1.00
9_K	18_V	0.737	1.00
298_V	302_D	0.737	1.00
10_V	56_S	0.736	1.00
265_D	268_L	0.731	1.00
78_I	156_L	0.730	1.00
248_I	252_E	0.729	1.00
44_T	209_L	0.727	1.00
110_K	114_R	0.726	1.00
106_W	111_R	0.724	1.00
297_D	302_D	0.723	1.00
279_R	282_S	0.721	0.99
122_V	147_L	0.721	0.99
266_K	270_Q	0.719	0.99
109_E	113_E	0.719	0.99
93_I	99_L	0.719	0.99
301_I	308_A	0.718	0.99
25_I	156_L	0.718	0.99
271_A	274_L	0.715	0.99
191_F	198_E	0.715	0.99
284_L	287_D	0.714	0.99
97_I	101_P	0.711	0.99
116_R	120_K	0.710	0.99
42_T	46_K	0.710	0.99
209_L	214_I	0.710	0.99
50_R	61_I	0.709	0.99
265_D	270_Q	0.703	0.99
267_T	279_R	0.694	0.99
87_L	133_P	0.693	0.99
266_K	273_Q	0.693	0.99
290_N	293_K	0.693	0.99
99_L	103_L	0.690	0.99
301_I	307_K	0.687	0.99
109_E	112_K	0.685	0.99
62_D	155_P	0.685	0.99
192_V	195_D	0.684	0.99
255_M	259_P	0.684	0.99
288_R	292_L	0.684	0.99
269_S	275_M	0.683	0.99
272_I	275_M	0.683	0.99
271_A	282_S	0.682	0.99
51_L	82_I	0.680	0.99
117_E	120_K	0.678	0.99
239_E	243_Q	0.672	0.99
120_K	126_P	0.671	0.99
302_D	306_K	0.669	0.99
94_Q	130_D	0.669	0.99
93_I	136_L	0.668	0.99
230_E	234_E	0.668	0.99
234_E	239_E	0.667	0.99
271_A	276_R	0.667	0.99
155_P	187_K	0.664	0.99
262_V	269_S	0.663	0.99
308_A	314_V	0.661	0.99
242_I	246_P	0.660	0.99
233_E	236_I	0.659	0.99
242_I	245_R	0.658	0.99
7_V	18_V	0.656	0.99
242_I	253_Q	0.656	0.99
255_M	260_V	0.654	0.99
27_K	155_P	0.654	0.99
250_R	254_M	0.653	0.99
97_I	104_L	0.650	0.99
2_L	61_I	0.649	0.99
50_R	53_E	0.648	0.99
299_E	303_Q	0.647	0.99
272_I	292_L	0.646	0.99
278_K	281_D	0.646	0.99
293_K	296_V	0.644	0.99
224_L	227_P	0.643	0.99
106_W	114_R	0.640	0.99
227_P	232_V	0.638	0.99
211_A	215_V	0.638	0.99
235_F	238_K	0.637	0.99
288_R	295_Y	0.636	0.99
262_V	266_K	0.636	0.99
11_Y	52_I	0.636	0.99
223_I	227_P	0.632	0.99
291_V	294_G	0.630	0.99
285_V	288_R	0.630	0.99
268_L	273_Q	0.629	0.99
277_E	280_V	0.628	0.99
253_Q	257_R	0.625	0.99
161_E	194_H	0.625	0.99
99_L	102_K	0.625	0.99
289_Q	295_Y	0.623	0.99
250_R	253_Q	0.623	0.99
251_V	255_M	0.620	0.98
31_I	205_R	0.620	0.98
96_N	99_L	0.620	0.98
314_V	321_T	0.617	0.98
218_G	223_I	0.617	0.98
294_G	297_D	0.614	0.98
272_I	278_K	0.613	0.98
303_Q	307_K	0.610	0.98
312_G	318_D	0.610	0.98
205_R	217_V	0.608	0.98
99_L	104_L	0.606	0.98
311_V	316_R	0.603	0.98
262_V	267_T	0.602	0.98
157_I	187_K	0.602	0.98
272_I	296_V	0.601	0.98
289_Q	292_L	0.601	0.98
285_V	318_D	0.600	0.98
311_V	315_Y	0.600	0.98
289_Q	296_V	0.599	0.98
247_D	250_R	0.598	0.98
271_A	279_R	0.597	0.98
2_L	156_L	0.597	0.98
289_Q	319_I	0.596	0.98
316_R	321_T	0.595	0.98
108_E	112_K	0.594	0.98
275_M	279_R	0.590	0.98
107_P	111_R	0.588	0.98
292_L	295_Y	0.587	0.98
159_M	189_I	0.585	0.98
107_P	112_K	0.583	0.98
33_F	44_T	0.582	0.98
77_K	155_P	0.582	0.98
94_Q	115_A	0.582	0.98
260_V	263_S	0.582	0.98
246_P	249_E	0.581	0.98
127_E	130_D	0.580	0.98
133_P	141_Q	0.578	0.98
193_T	196_M	0.578	0.98
240_R	243_Q	0.577	0.98
276_R	279_R	0.577	0.98
256_N	259_P	0.576	0.98
122_V	140_Q	0.575	0.98
279_R	285_V	0.575	0.98
274_L	281_D	0.572	0.97
212_G	217_V	0.572	0.97
235_F	239_E	0.570	0.97
297_D	301_I	0.570	0.97
207_V	214_I	0.569	0.97
175_Q	201_K	0.568	0.97
259_P	262_V	0.568	0.97
95_Q	99_L	0.565	0.97
274_L	279_R	0.565	0.97
92_T	132_Y	0.563	0.97
273_Q	278_K	0.561	0.97
105_K	112_K	0.561	0.97
238_K	241_L	0.560	0.97
153_E	187_K	0.560	0.97
193_T	198_E	0.559	0.97
287_D	290_N	0.558	0.97
256_N	262_V	0.556	0.97
181_L	189_I	0.556	0.97
206_I	219_T	0.554	0.97
304_N	319_I	0.552	0.97
92_T	130_D	0.552	0.97
101_P	151_A	0.551	0.97
11_Y	14_G	0.550	0.97
206_I	220_P	0.550	0.97
304_N	311_V	0.550	0.97
97_I	100_V	0.549	0.97
219_T	223_I	0.543	0.97
175_Q	198_E	0.542	0.96
232_V	237_G	0.541	0.96
279_R	286_V	0.539	0.96
111_R	115_A	0.539	0.96
269_S	274_L	0.537	0.96
250_R	255_M	0.536	0.96
62_D	76_R	0.535	0.96
248_I	251_V	0.534	0.96
308_A	311_V	0.534	0.96
138_G	143_R	0.532	0.96
100_V	152_A	0.531	0.96
240_R	244_S	0.530	0.96
47_M	53_E	0.529	0.96
272_I	282_S	0.526	0.96
301_I	305_R	0.525	0.96
269_S	296_V	0.525	0.96
21_I	214_I	0.522	0.96
307_K	314_V	0.519	0.96
262_V	268_L	0.519	0.96
119_L	122_V	0.518	0.95
252_E	257_R	0.516	0.95
267_T	270_Q	0.512	0.95
41_K	161_E	0.510	0.95
164_G	196_M	0.509	0.95
94_Q	97_I	0.508	0.95
296_V	299_E	0.508	0.95
98_S	102_K	0.508	0.95
33_F	207_V	0.507	0.95
247_D	251_V	0.506	0.95
227_P	235_F	0.503	0.95
255_M	261_T	0.502	0.95
238_K	242_I	0.502	0.95
97_I	147_L	0.501	0.95
6_Q	9_K	0.500	0.95
81_V	145_G	0.500	0.95
259_P	265_D	0.500	0.95
260_V	267_T	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f4cA	1	0.5842	100	0.267	Contact Map
4ry2A	2	0.6184	100	0.268	Contact Map
3tuiC	2	0.8421	100	0.277	Contact Map
4yerA	2	0.7447	100	0.291	Contact Map
4q9hA	1	0.6184	100	0.291	Contact Map
4mrsA	2	0.6395	100	0.295	Contact Map
3zdqA	2	0.5842	100	0.295	Contact Map
4a82A	2	0.6	100	0.296	Contact Map
4u00A	1	0.6263	100	0.297	Contact Map
2oljA	2	0.6237	100	0.297	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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