GREMLIN Database
OPUCA - Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA
UniProt: O34992 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (303)
Sequences: 7464 (6263)
Seq/√Len: 359.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_Q20_S5.2251.00
4_L7_V4.0031.00
5_E58_R3.8751.00
200_I221_D3.8511.00
16_K19_N3.4861.00
29_E205_R3.2821.00
90_H134_H3.2171.00
9_K47_M3.1501.00
45_M192_V3.1261.00
9_K55_S2.9521.00
91_M99_L2.9371.00
7_V54_P2.6921.00
19_N213_E2.4061.00
3_K24_D2.3691.00
25_I31_I2.3201.00
8_S56_S2.2941.00
10_V55_S2.2201.00
32_C203_A2.1871.00
88_F91_M2.1721.00
310_I314_V2.1511.00
6_Q22_D2.0341.00
4_L23_L1.9661.00
45_M158_L1.9581.00
47_M59_I1.9411.00
32_C199_A1.9181.00
307_K310_I1.9101.00
47_M54_P1.8911.00
219_T222_E1.8581.00
272_I276_R1.8331.00
31_I207_V1.8211.00
8_S20_S1.8121.00
288_R314_V1.7891.00
277_E281_D1.7841.00
314_V318_D1.7821.00
288_R291_V1.7611.00
4_L48_I1.7601.00
313_D317_S1.7581.00
49_N158_L1.7521.00
10_V16_K1.7511.00
91_M95_Q1.7251.00
312_G316_R1.6911.00
26_A29_E1.6751.00
318_D321_T1.6731.00
281_D284_L1.6491.00
46_K51_L1.6461.00
79_G154_P1.6001.00
273_Q276_R1.5991.00
282_S286_V1.5911.00
131_R135_E1.5861.00
291_V295_Y1.5861.00
179_K201_K1.5721.00
268_L271_A1.5721.00
9_K52_I1.5661.00
92_T95_Q1.5441.00
317_S321_T1.5331.00
23_L207_V1.5181.00
205_R216_Q1.5091.00
309_S313_D1.4851.00
94_Q98_S1.4831.00
96_N148_R1.4751.00
271_A275_M1.4741.00
218_G222_E1.4611.00
96_N133_P1.4551.00
128_Y131_R1.4531.00
314_V317_S1.4501.00
316_R320_Y1.4471.00
133_P144_I1.4441.00
267_T271_A1.4031.00
46_K52_I1.3991.00
7_V47_M1.3831.00
255_M258_T1.3821.00
281_D285_V1.3761.00
11_Y17_A1.3751.00
295_Y298_V1.3731.00
91_M96_N1.3721.00
191_F203_A1.3711.00
289_Q318_D1.3631.00
3_K60_F1.3591.00
283_L287_D1.3531.00
18_V47_M1.3471.00
269_S272_I1.3421.00
261_T264_A1.3361.00
309_S312_G1.3331.00
262_V265_D1.3281.00
270_Q274_L1.3211.00
178_F189_I1.3131.00
284_L288_R1.3051.00
263_S267_T1.3051.00
181_L187_K1.2981.00
210_K213_E1.2911.00
89_P134_H1.2831.00
313_D316_R1.2791.00
300_M303_Q1.2701.00
107_P110_K1.2651.00
269_S273_Q1.2601.00
47_M55_S1.2601.00
315_Y319_I1.2491.00
199_A203_A1.2431.00
31_I190_V1.2421.00
36_P39_C1.2351.00
116_R126_P1.2331.00
306_K309_S1.2241.00
268_L272_I1.2201.00
18_V21_I1.2181.00
299_E302_D1.2101.00
283_L286_V1.2061.00
316_R319_I1.2021.00
264_A267_T1.2011.00
280_V283_L1.1981.00
114_R117_E1.1971.00
79_G149_A1.1901.00
311_V314_V1.1851.00
310_I313_D1.1841.00
214_I217_V1.1831.00
221_D225_R1.1791.00
87_L96_N1.1781.00
29_E204_D1.1701.00
25_I188_T1.1691.00
5_E22_D1.1671.00
257_R260_V1.1661.00
5_E60_F1.1641.00
270_Q273_Q1.1551.00
93_I144_I1.1511.00
281_D321_T1.1461.00
95_Q98_S1.1371.00
274_L278_K1.1361.00
28_G188_T1.1361.00
6_Q56_S1.1341.00
232_V236_I1.1321.00
100_V148_R1.1281.00
293_K319_I1.0901.00
8_S16_K1.0901.00
13_G16_K1.0881.00
158_L190_V1.0821.00
90_H132_Y1.0811.00
222_E226_N1.0811.00
304_N307_K1.0791.00
312_G315_Y1.0731.00
306_K310_I1.0701.00
307_K311_V1.0611.00
191_F199_A1.0581.00
9_K43_T1.0521.00
92_T96_N1.0481.00
317_S320_Y1.0321.00
39_C209_L1.0311.00
178_F202_L1.0281.00
63_G76_R1.0281.00
315_Y318_D1.0221.00
286_V289_Q1.0151.00
81_V142_Q1.0111.00
298_V304_N1.0111.00
113_E117_E1.0111.00
171_R195_D1.0091.00
208_I223_I1.0091.00
274_L277_E1.0081.00
230_E233_E1.0051.00
10_V14_G1.0031.00
191_F202_L1.0021.00
273_Q277_E0.9991.00
301_I304_N0.9951.00
292_L311_V0.9941.00
287_D291_V0.9941.00
7_V59_I0.9901.00
254_M257_R0.9871.00
98_S115_A0.9861.00
4_L59_I0.9821.00
54_P59_I0.9741.00
302_D308_A0.9691.00
260_V264_A0.9671.00
111_R114_R0.9661.00
231_F235_F0.9661.00
220_P224_L0.9661.00
300_M304_N0.9661.00
279_R283_L0.9651.00
290_N294_G0.9641.00
49_N80_Y0.9621.00
261_T265_D0.9581.00
132_Y135_E0.9561.00
210_K215_V0.9501.00
77_K152_A0.9471.00
112_K115_A0.9471.00
231_F234_E0.9411.00
234_E237_G0.9401.00
289_Q293_K0.9401.00
117_E121_L0.9271.00
252_E255_M0.9221.00
101_P104_L0.9211.00
292_L296_V0.9211.00
110_K113_E0.9201.00
263_S266_K0.9171.00
81_V149_A0.9161.00
266_K269_S0.9111.00
118_L147_L0.9051.00
275_M278_K0.9031.00
108_E111_R0.9031.00
280_V284_L0.9011.00
225_R228_A0.9011.00
208_I227_P0.8991.00
298_V301_I0.8991.00
308_A312_G0.8981.00
312_G319_I0.8961.00
259_P263_S0.8891.00
253_Q256_N0.8891.00
305_R309_S0.8861.00
193_T199_A0.8821.00
232_V235_F0.8801.00
237_G240_R0.8791.00
285_V289_Q0.8791.00
233_E237_G0.8781.00
256_N260_V0.8721.00
234_E238_K0.8701.00
64_E76_R0.8701.00
154_P181_L0.8691.00
118_L151_A0.8651.00
251_V254_M0.8611.00
293_K297_D0.8561.00
278_K282_S0.8551.00
224_L228_A0.8551.00
88_F96_N0.8461.00
305_R308_A0.8451.00
297_D300_M0.8431.00
34_I208_I0.8421.00
8_S19_N0.8411.00
276_R280_V0.8391.00
299_E304_N0.8351.00
236_I240_R0.8341.00
296_V301_I0.8331.00
176_E180_K0.8281.00
168_P172_D0.8261.00
258_T261_T0.8231.00
267_T275_M0.8201.00
217_V226_N0.8151.00
265_D269_S0.8111.00
25_I190_V0.8031.00
236_I239_E0.7991.00
221_D224_L0.7991.00
302_D305_R0.7971.00
94_Q129_L0.7961.00
197_D201_K0.7861.00
293_K315_Y0.7841.00
93_I133_P0.7841.00
116_R129_L0.7811.00
213_E216_Q0.7781.00
294_G298_V0.7711.00
213_E217_V0.7641.00
264_A268_L0.7591.00
211_A217_V0.7591.00
156_L190_V0.7541.00
48_I190_V0.7531.00
220_P223_I0.7481.00
257_R262_V0.7471.00
106_W109_E0.7471.00
304_N308_A0.7471.00
120_K125_G0.7471.00
266_K276_R0.7441.00
51_L86_G0.7431.00
247_D252_E0.7431.00
82_I85_I0.7421.00
258_T262_V0.7421.00
222_E225_R0.7411.00
237_G241_L0.7391.00
9_K18_V0.7371.00
298_V302_D0.7371.00
10_V56_S0.7361.00
265_D268_L0.7311.00
78_I156_L0.7301.00
248_I252_E0.7291.00
44_T209_L0.7271.00
110_K114_R0.7261.00
106_W111_R0.7241.00
297_D302_D0.7231.00
279_R282_S0.7210.99
122_V147_L0.7210.99
266_K270_Q0.7190.99
109_E113_E0.7190.99
93_I99_L0.7190.99
301_I308_A0.7180.99
25_I156_L0.7180.99
271_A274_L0.7150.99
191_F198_E0.7150.99
284_L287_D0.7140.99
97_I101_P0.7110.99
116_R120_K0.7100.99
42_T46_K0.7100.99
209_L214_I0.7100.99
50_R61_I0.7090.99
265_D270_Q0.7030.99
267_T279_R0.6940.99
87_L133_P0.6930.99
266_K273_Q0.6930.99
290_N293_K0.6930.99
99_L103_L0.6900.99
301_I307_K0.6870.99
109_E112_K0.6850.99
62_D155_P0.6850.99
192_V195_D0.6840.99
255_M259_P0.6840.99
288_R292_L0.6840.99
269_S275_M0.6830.99
272_I275_M0.6830.99
271_A282_S0.6820.99
51_L82_I0.6800.99
117_E120_K0.6780.99
239_E243_Q0.6720.99
120_K126_P0.6710.99
302_D306_K0.6690.99
94_Q130_D0.6690.99
93_I136_L0.6680.99
230_E234_E0.6680.99
234_E239_E0.6670.99
271_A276_R0.6670.99
155_P187_K0.6640.99
262_V269_S0.6630.99
308_A314_V0.6610.99
242_I246_P0.6600.99
233_E236_I0.6590.99
242_I245_R0.6580.99
7_V18_V0.6560.99
242_I253_Q0.6560.99
255_M260_V0.6540.99
27_K155_P0.6540.99
250_R254_M0.6530.99
97_I104_L0.6500.99
2_L61_I0.6490.99
50_R53_E0.6480.99
299_E303_Q0.6470.99
272_I292_L0.6460.99
278_K281_D0.6460.99
293_K296_V0.6440.99
224_L227_P0.6430.99
106_W114_R0.6400.99
227_P232_V0.6380.99
211_A215_V0.6380.99
235_F238_K0.6370.99
288_R295_Y0.6360.99
262_V266_K0.6360.99
11_Y52_I0.6360.99
223_I227_P0.6320.99
291_V294_G0.6300.99
285_V288_R0.6300.99
268_L273_Q0.6290.99
277_E280_V0.6280.99
253_Q257_R0.6250.99
161_E194_H0.6250.99
99_L102_K0.6250.99
289_Q295_Y0.6230.99
250_R253_Q0.6230.99
251_V255_M0.6200.98
31_I205_R0.6200.98
96_N99_L0.6200.98
314_V321_T0.6170.98
218_G223_I0.6170.98
294_G297_D0.6140.98
272_I278_K0.6130.98
303_Q307_K0.6100.98
312_G318_D0.6100.98
205_R217_V0.6080.98
99_L104_L0.6060.98
311_V316_R0.6030.98
262_V267_T0.6020.98
157_I187_K0.6020.98
272_I296_V0.6010.98
289_Q292_L0.6010.98
285_V318_D0.6000.98
311_V315_Y0.6000.98
289_Q296_V0.5990.98
247_D250_R0.5980.98
271_A279_R0.5970.98
2_L156_L0.5970.98
289_Q319_I0.5960.98
316_R321_T0.5950.98
108_E112_K0.5940.98
275_M279_R0.5900.98
107_P111_R0.5880.98
292_L295_Y0.5870.98
159_M189_I0.5850.98
107_P112_K0.5830.98
33_F44_T0.5820.98
77_K155_P0.5820.98
94_Q115_A0.5820.98
260_V263_S0.5820.98
246_P249_E0.5810.98
127_E130_D0.5800.98
133_P141_Q0.5780.98
193_T196_M0.5780.98
240_R243_Q0.5770.98
276_R279_R0.5770.98
256_N259_P0.5760.98
122_V140_Q0.5750.98
279_R285_V0.5750.98
274_L281_D0.5720.97
212_G217_V0.5720.97
235_F239_E0.5700.97
297_D301_I0.5700.97
207_V214_I0.5690.97
175_Q201_K0.5680.97
259_P262_V0.5680.97
95_Q99_L0.5650.97
274_L279_R0.5650.97
92_T132_Y0.5630.97
273_Q278_K0.5610.97
105_K112_K0.5610.97
238_K241_L0.5600.97
153_E187_K0.5600.97
193_T198_E0.5590.97
287_D290_N0.5580.97
256_N262_V0.5560.97
181_L189_I0.5560.97
206_I219_T0.5540.97
304_N319_I0.5520.97
92_T130_D0.5520.97
101_P151_A0.5510.97
11_Y14_G0.5500.97
206_I220_P0.5500.97
304_N311_V0.5500.97
97_I100_V0.5490.97
219_T223_I0.5430.97
175_Q198_E0.5420.96
232_V237_G0.5410.96
279_R286_V0.5390.96
111_R115_A0.5390.96
269_S274_L0.5370.96
250_R255_M0.5360.96
62_D76_R0.5350.96
248_I251_V0.5340.96
308_A311_V0.5340.96
138_G143_R0.5320.96
100_V152_A0.5310.96
240_R244_S0.5300.96
47_M53_E0.5290.96
272_I282_S0.5260.96
301_I305_R0.5250.96
269_S296_V0.5250.96
21_I214_I0.5220.96
307_K314_V0.5190.96
262_V268_L0.5190.96
119_L122_V0.5180.95
252_E257_R0.5160.95
267_T270_Q0.5120.95
41_K161_E0.5100.95
164_G196_M0.5090.95
94_Q97_I0.5080.95
296_V299_E0.5080.95
98_S102_K0.5080.95
33_F207_V0.5070.95
247_D251_V0.5060.95
227_P235_F0.5030.95
255_M261_T0.5020.95
238_K242_I0.5020.95
97_I147_L0.5010.95
6_Q9_K0.5000.95
81_V145_G0.5000.95
259_P265_D0.5000.95
260_V267_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f4cA 1 0.5842 100 0.267 Contact Map
4ry2A 2 0.6184 100 0.268 Contact Map
3tuiC 2 0.8421 100 0.277 Contact Map
4yerA 2 0.7447 100 0.291 Contact Map
4q9hA 1 0.6184 100 0.291 Contact Map
4mrsA 2 0.6395 100 0.295 Contact Map
3zdqA 2 0.5842 100 0.295 Contact Map
4a82A 2 0.6 100 0.296 Contact Map
4u00A 1 0.6263 100 0.297 Contact Map
2oljA 2 0.6237 100 0.297 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.