GREMLIN Database
YTVI - UPF0118 membrane protein YtvI
UniProt: O34991 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (327)
Sequences: 10949 (8484)
Seq/√Len: 469.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_F257_A5.1331.00
52_Y56_V5.0231.00
244_G296_I4.3331.00
327_A347_L3.2581.00
54_D61_R3.0091.00
44_S220_K2.9241.00
238_M261_G2.7731.00
60_P63_I2.6391.00
291_A295_G2.6331.00
242_F246_S2.6311.00
52_Y55_K2.5341.00
42_L186_T2.5101.00
288_L292_I2.4581.00
59_F67_G2.4001.00
238_M257_A2.3991.00
97_T100_P2.3371.00
351_Q355_T2.2251.00
245_L250_V2.1191.00
279_I294_I2.0621.00
214_A356_T2.0411.00
20_A24_A1.9421.00
204_L212_S1.9231.00
62_T66_L1.9181.00
23_I27_Y1.9021.00
231_A265_L1.8871.00
47_H51_D1.8831.00
103_S106_I1.8701.00
218_E356_T1.8671.00
39_A186_T1.8601.00
142_H145_T1.8591.00
295_G299_L1.8451.00
229_A312_I1.8291.00
201_V213_K1.8151.00
259_L263_V1.8031.00
187_F191_K1.8021.00
50_V68_V1.7951.00
182_S186_T1.7741.00
219_L349_I1.7641.00
241_V260_I1.7581.00
140_V144_Q1.7501.00
288_L291_A1.7161.00
65_V187_F1.7151.00
253_A257_A1.7131.00
50_V65_V1.7001.00
47_H61_R1.6911.00
243_I246_S1.6871.00
292_I295_G1.6721.00
19_T23_I1.6661.00
49_V68_V1.6491.00
108_Y111_K1.6421.00
62_T191_K1.6391.00
65_V69_L1.6231.00
246_S253_A1.6221.00
138_S142_H1.6211.00
106_I110_E1.6211.00
192_D320_D1.6171.00
311_K315_K1.6131.00
185_A322_L1.6061.00
53_L71_F1.6041.00
77_F81_T1.6001.00
242_F253_A1.5871.00
36_F326_I1.5851.00
50_V61_R1.5791.00
185_A189_M1.5701.00
92_A96_K1.5691.00
104_T107_S1.5491.00
332_F340_L1.5291.00
308_T312_I1.5231.00
289_P292_I1.5161.00
251_E285_T1.5161.00
287_Q290_Q1.5141.00
263_V274_V1.5101.00
237_T264_D1.5011.00
27_Y30_F1.4931.00
241_V300_V1.4161.00
125_T128_F1.4161.00
104_T108_Y1.4151.00
282_L293_G1.4061.00
244_G248_L1.4021.00
303_I308_T1.4011.00
298_Y302_L1.3791.00
198_A202_L1.3791.00
151_A155_G1.3571.00
275_F279_I1.3531.00
138_S141_T1.3401.00
107_S111_K1.3381.00
205_P209_T1.3361.00
46_I190_T1.3311.00
145_T148_D1.3181.00
59_F63_I1.3141.00
222_A348_V1.3111.00
61_R194_H1.2971.00
73_L77_F1.2811.00
100_P103_S1.2791.00
240_I300_V1.2691.00
100_P104_T1.2681.00
62_T187_F1.2621.00
99_P103_S1.2561.00
243_I247_L1.2551.00
50_V64_N1.2541.00
294_I298_Y1.2371.00
50_V190_T1.2291.00
43_S189_M1.2261.00
250_V282_L1.2261.00
16_I20_A1.2221.00
328_L340_L1.2211.00
39_A182_S1.2191.00
165_I169_F1.2151.00
301_V305_R1.2081.00
46_I72_F1.1931.00
256_I278_W1.1901.00
35_P39_A1.1871.00
292_I296_I1.1871.00
228_K232_V1.1841.00
49_V52_Y1.1841.00
298_Y301_V1.1831.00
66_L70_A1.1781.00
149_S152_K1.1721.00
42_L182_S1.1641.00
20_A23_I1.1631.00
13_L17_S1.1621.00
215_I353_F1.1601.00
192_D195_K1.1581.00
279_I290_Q1.1571.00
50_V54_D1.1511.00
63_I66_L1.1431.00
323_A347_L1.1421.00
59_F64_N1.1391.00
47_H193_W1.1351.00
278_W293_G1.1341.00
233_L304_Q1.1321.00
156_L159_S1.1271.00
331_G335_F1.1191.00
327_A331_G1.1181.00
89_T93_Y1.1161.00
108_Y112_L1.1131.00
24_A28_Y1.1131.00
64_N68_V1.1111.00
39_A43_S1.1081.00
154_A157_L1.1071.00
36_F185_A1.1061.00
12_T16_I1.1041.00
257_A261_G1.1031.00
24_A27_Y1.1021.00
125_T129_Q1.1021.00
218_E355_T1.0961.00
299_L303_I1.0961.00
282_L290_Q1.0961.00
195_K198_A1.0891.00
103_S107_S1.0811.00
231_A235_F1.0811.00
40_L189_M1.0791.00
237_T300_V1.0771.00
54_D64_N1.0771.00
38_I182_S1.0631.00
214_A218_E1.0611.00
235_F261_G1.0601.00
107_S110_E1.0561.00
84_V88_V1.0561.00
152_K156_L1.0551.00
157_L161_I1.0541.00
331_G347_L1.0521.00
95_A99_P1.0501.00
145_T149_S1.0401.00
232_V236_I1.0361.00
175_T179_L1.0361.00
303_I307_L1.0341.00
338_L342_A1.0291.00
148_D151_A1.0281.00
153_N156_L1.0261.00
296_I300_V1.0241.00
185_A326_I1.0241.00
142_H146_L1.0241.00
248_L293_G1.0221.00
141_T144_Q1.0201.00
93_Y96_K1.0181.00
234_V264_D1.0171.00
307_L311_K1.0141.00
201_V209_T1.0111.00
110_E113_F1.0081.00
327_A343_G1.0071.00
242_F254_A1.0051.00
181_F185_A1.0041.00
305_R309_E1.0031.00
53_L68_V1.0001.00
199_M202_L0.9991.00
259_L274_V0.9911.00
238_M242_F0.9901.00
233_L237_T0.9841.00
148_D152_K0.9811.00
230_Q309_E0.9811.00
69_L186_T0.9791.00
101_H105_F0.9791.00
15_V19_T0.9761.00
193_W197_K0.9721.00
281_Y285_T0.9691.00
353_F357_G0.9671.00
323_A351_Q0.9671.00
257_A260_I0.9641.00
51_D54_D0.9631.00
245_L256_I0.9591.00
261_G265_L0.9591.00
126_L129_Q0.9591.00
32_L330_A0.9561.00
350_I354_I0.9541.00
225_G316_S0.9531.00
273_S277_P0.9441.00
215_I356_T0.9441.00
252_H255_T0.9431.00
195_K199_M0.9421.00
14_F18_M0.9411.00
244_G300_V0.9361.00
92_A95_A0.9361.00
225_G229_A0.9351.00
141_T145_T0.9341.00
168_F172_L0.9341.00
52_Y58_G0.9331.00
237_T241_V0.9321.00
237_T271_A0.9231.00
143_I146_L0.9221.00
283_S290_Q0.9161.00
221_K225_G0.9141.00
245_L260_I0.9141.00
239_V242_F0.9101.00
16_I19_T0.8941.00
293_G297_L0.8921.00
233_L308_T0.8901.00
155_G159_S0.8881.00
302_L306_Q0.8861.00
22_S25_A0.8861.00
39_A185_A0.8861.00
51_D55_K0.8811.00
239_V243_I0.8771.00
81_T85_A0.8771.00
236_I240_I0.8761.00
56_V59_F0.8751.00
246_S257_A0.8751.00
13_L16_I0.8751.00
149_S153_N0.8741.00
197_K201_V0.8691.00
86_E89_T0.8651.00
139_I142_H0.8641.00
326_I330_A0.8591.00
313_L324_T0.8561.00
246_S249_K0.8521.00
139_I143_I0.8521.00
235_F239_V0.8511.00
343_G347_L0.8481.00
245_L293_G0.8341.00
152_K155_G0.8341.00
18_M22_S0.8331.00
97_T101_H0.8321.00
233_L309_E0.8291.00
169_F173_P0.8271.00
46_I68_V0.8271.00
199_M203_I0.8261.00
91_T95_A0.8261.00
264_D271_A0.8261.00
287_Q291_A0.8191.00
144_Q147_G0.8181.00
96_K100_P0.8181.00
93_Y97_T0.8111.00
102_I106_I0.8111.00
210_A214_A0.8031.00
234_V238_M0.8011.00
233_L264_D0.7951.00
75_A79_V0.7931.00
212_S216_S0.7911.00
88_V91_T0.7911.00
218_E352_A0.7851.00
161_I165_I0.7811.00
256_I281_Y0.7791.00
232_V312_I0.7761.00
213_K217_S0.7711.00
241_V245_L0.7691.00
151_A154_A0.7661.00
38_I42_L0.7651.00
234_V265_L0.7631.00
279_I283_S0.7631.00
236_I308_T0.7591.00
218_E222_A0.7581.00
17_S21_G0.7561.00
53_L67_G0.7531.00
260_I274_V0.7491.00
284_I287_Q0.7491.00
280_L284_I0.7491.00
174_N178_V0.7421.00
211_N214_A0.7391.00
293_G296_I0.7371.00
237_T309_E0.7351.00
315_K318_G0.7341.00
289_P293_G0.7341.00
204_L208_V0.7331.00
319_I347_L0.7331.00
175_T178_V0.7301.00
36_F189_M0.7281.00
224_T228_K0.7271.00
53_L64_N0.7251.00
260_I297_L0.7241.00
109_C113_F0.7231.00
232_V235_F0.7231.00
304_Q309_E0.7231.00
160_H164_M0.7161.00
160_H163_E0.7161.00
241_V257_A0.7151.00
233_L313_L0.7131.00
166_P170_A0.7131.00
83_L87_I0.7111.00
43_S186_T0.7111.00
76_A80_L0.7111.00
248_L296_I0.7101.00
285_T289_P0.7071.00
161_I164_M0.7061.00
22_S26_A0.7061.00
78_G82_I0.7031.00
80_L84_V0.7021.00
260_I264_D0.7011.00
186_T190_T0.6971.00
162_L166_P0.6961.00
23_I26_A0.6951.00
158_L162_L0.6941.00
143_I149_S0.6941.00
314_S324_T0.6931.00
244_G297_L0.6871.00
309_E313_L0.6871.00
147_G150_A0.6861.00
47_H190_T0.6821.00
25_A29_S0.6801.00
69_L187_F0.6781.00
171_L174_N0.6781.00
51_D194_H0.6761.00
222_A225_G0.6731.00
238_M258_F0.6711.00
71_F74_L0.6701.00
199_M323_A0.6701.00
211_N356_T0.6681.00
46_I186_T0.6681.00
164_M168_F0.6681.00
15_V18_M0.6671.00
53_L59_F0.6671.00
197_K217_S0.6661.00
177_A181_F0.6661.00
96_K99_P0.6651.00
82_I86_E0.6651.00
201_V204_L0.6641.00
90_G93_Y0.6641.00
158_L161_I0.6631.00
198_A201_V0.6631.00
268_Y321_P0.6621.00
159_S163_E0.6621.00
28_Y31_P0.6611.00
98_L101_H0.6611.00
337_F340_L0.6601.00
98_L102_I0.6591.00
259_L277_P0.6551.00
321_P325_L0.6551.00
324_T344_P0.6531.00
179_L183_L0.6531.00
302_L305_R0.6521.00
236_I304_Q0.6461.00
171_L175_T0.6451.00
317_I344_P0.6441.00
91_T99_P0.6421.00
286_G289_P0.6421.00
162_L165_I0.6421.00
331_G346_V0.6421.00
153_N157_L0.6421.00
198_A213_K0.6411.00
264_D309_E0.6361.00
219_L352_A0.6361.00
215_I219_L0.6351.00
46_I49_V0.6331.00
238_M254_A0.6331.00
248_L289_P0.6321.00
275_F298_Y0.6311.00
75_A78_G0.6300.99
60_P64_N0.6300.99
196_L199_M0.6280.99
230_Q234_V0.6240.99
35_P178_V0.6230.99
74_L77_F0.6230.99
335_F339_G0.6210.99
251_E254_A0.6190.99
142_H147_G0.6170.99
347_L351_Q0.6130.99
219_L222_A0.6120.99
309_E312_I0.6090.99
54_D60_P0.6090.99
169_F172_L0.6090.99
181_F329_F0.6090.99
218_E221_K0.6080.99
21_G25_A0.6080.99
144_Q148_D0.6060.99
43_S47_H0.6060.99
225_G228_K0.6050.99
240_I244_G0.6020.99
88_V92_A0.6000.99
143_I147_G0.5980.99
205_P208_V0.5970.99
54_D58_G0.5970.99
308_T311_K0.5960.99
156_L160_H0.5940.99
246_S254_A0.5930.99
250_V253_A0.5860.99
13_L18_M0.5850.99
260_I271_A0.5850.99
61_R65_V0.5850.99
174_N306_Q0.5830.99
291_A297_L0.5770.99
230_Q264_D0.5750.99
319_I324_T0.5730.99
150_A153_N0.5720.99
20_A27_Y0.5670.99
86_E90_G0.5650.99
35_P314_S0.5620.99
274_V278_W0.5620.99
230_Q233_L0.5620.99
304_Q308_T0.5590.99
290_Q293_G0.5590.99
250_V285_T0.5580.99
68_V72_F0.5580.99
299_L302_L0.5570.99
45_V227_I0.5570.99
12_T15_V0.5560.99
274_V301_V0.5550.99
217_S221_K0.5540.99
237_T301_V0.5540.99
223_M226_F0.5510.99
64_N67_G0.5510.99
105_F109_C0.5480.99
43_S190_T0.5480.99
65_V191_K0.5470.99
105_F108_Y0.5450.99
241_V261_G0.5440.99
287_Q292_I0.5420.98
229_A316_S0.5420.98
141_T146_L0.5410.98
185_A329_F0.5400.98
241_V244_G0.5390.98
271_A274_V0.5370.98
352_A356_T0.5340.98
34_Y37_L0.5320.98
90_G94_L0.5320.98
222_A352_A0.5320.98
87_I91_T0.5320.98
290_Q294_I0.5310.98
196_L320_D0.5300.98
219_L223_M0.5300.98
233_L271_A0.5300.98
15_V22_S0.5300.98
328_L344_P0.5290.98
228_K316_S0.5290.98
89_T92_A0.5270.98
233_L312_I0.5270.98
301_V304_Q0.5270.98
77_F80_L0.5260.98
229_A348_V0.5250.98
209_T213_K0.5250.98
234_V237_T0.5250.98
274_V344_P0.5250.98
297_L301_V0.5240.98
237_T304_Q0.5230.98
314_S318_G0.5210.98
102_I105_F0.5200.98
172_L176_A0.5200.98
237_T240_I0.5190.98
204_L209_T0.5180.98
323_A327_A0.5180.98
189_M322_L0.5160.98
200_L203_I0.5140.98
97_T251_E0.5140.98
238_M275_F0.5120.98
234_V261_G0.5120.98
94_L98_L0.5120.98
208_V212_S0.5100.98
353_F358_A0.5100.98
276_V280_L0.5100.98
354_I358_A0.5090.98
288_L295_G0.5090.98
264_D272_G0.5080.98
167_R170_A0.5080.98
188_F321_P0.5070.98
40_L193_W0.5060.98
338_L343_G0.5050.98
39_A189_M0.5050.98
185_A325_L0.5040.98
278_W282_L0.5040.98
264_D304_Q0.5030.98
261_G264_D0.5020.98
203_I354_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkrA 2 0.2965 40.8 0.949 Contact Map
3mktA 1 0.9515 30.1 0.953 Contact Map
2kv5A 1 0.0889 29.7 0.953 Contact Map
2kncB 1 0.1375 22.5 0.955 Contact Map
4humA 1 0.8652 19.1 0.957 Contact Map
3w4tA 1 0.841 17.1 0.958 Contact Map
4lz6A 1 0.8571 13.5 0.96 Contact Map
4b19A 1 0.0809 10 0.962 Contact Map
4ltoA 3 0.2857 9.6 0.962 Contact Map
4p6vB 1 0.1482 8.4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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