YVRG - BACSU - GREMLIN Contacts

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YVRG - Sensor histidine kinase YvrG

UniProt:	O34989	Sequences: MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNSGLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDVPGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQKIDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPWNYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWMTVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFESMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPEEVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNPFSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHISLKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSRTNIGTVITILFKKQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	580 (519)
Sequences:	12878 (11948)
Seq/√Len:	524.5

ECOLI - TORS BARA RCSC RCSD CREC CUSS BAES GLRK ATOS PHOQ QSEC YEDV CPXA RSTB ENVZ ARCB ZRAS NARQ EVGS DCUS NARX BASS DPIB KDPD PHOR
BACSU - YVRG YESM RESE YYCG YCLK KIND PHOR CSSS YKOH YVCQ KINE KINA KINB YCBM DCTS MALK YRKQ YXDK BCES CITS KINC
HALSA - Q9HQ15 Q9HQG5 Q9HQ16 O51970 Q9HQE9 Q9HRG1 Q9HNM2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
379_S	401_V	4.255	1.00
512_K	572_V	4.133	1.00
433_T	470_L	3.994	1.00
566_R	569_I	3.908	1.00
551_K	555_H	3.832	1.00
513_D	517_G	3.651	1.00
523_I	563_V	3.584	1.00
562_H	574_T	3.502	1.00
332_I	336_M	3.369	1.00
510_K	572_V	3.146	1.00
519_D	522_T	3.137	1.00
506_H	576_L	3.013	1.00
499_I	510_K	2.998	1.00
490_N	514_N	2.986	1.00
460_V	499_I	2.983	1.00
336_M	339_L	2.972	1.00
333_F	336_M	2.894	1.00
432_L	469_A	2.867	1.00
336_M	340_T	2.853	1.00
470_L	557_H	2.847	1.00
564_N	572_V	2.823	1.00
508_S	576_L	2.803	1.00
497_Q	512_K	2.757	1.00
376_Y	405_S	2.755	1.00
518_M	522_T	2.722	1.00
563_V	573_I	2.697	1.00
347_K	351_E	2.689	1.00
501_E	508_S	2.676	1.00
550_A	561_I	2.625	1.00
383_E	402_R	2.589	1.00
565_S	571_T	2.576	1.00
434_S	437_P	2.570	1.00
458_S	495_E	2.556	1.00
383_E	399_Q	2.554	1.00
499_I	512_K	2.554	1.00
458_S	497_Q	2.544	1.00
554_V	575_I	2.533	1.00
478_I	554_V	2.527	1.00
554_V	559_G	2.517	1.00
325_P	328_F	2.509	1.00
431_K	472_E	2.469	1.00
508_S	574_T	2.440	1.00
501_E	510_K	2.381	1.00
490_N	496_I	2.283	1.00
347_K	350_R	2.276	1.00
478_I	553_L	2.275	1.00
509_L	575_I	2.263	1.00
460_V	497_Q	2.243	1.00
522_T	525_H	2.204	1.00
510_K	574_T	2.189	1.00
520_E	523_I	2.187	1.00
519_D	567_T	2.175	1.00
343_L	346_D	2.171	1.00
555_H	560_T	2.140	1.00
495_E	514_N	2.138	1.00
478_I	550_A	2.115	1.00
456_D	495_E	2.088	1.00
87_D	91_N	2.074	1.00
565_S	569_I	2.054	1.00
523_I	565_S	2.009	1.00
390_S	394_V	2.002	1.00
391_P	394_V	1.991	1.00
383_E	395_K	1.957	1.00
333_F	337_D	1.952	1.00
332_I	337_D	1.949	1.00
332_I	340_T	1.928	1.00
340_T	343_L	1.891	1.00
564_N	574_T	1.880	1.00
355_A	359_E	1.871	1.00
489_H	532_R	1.862	1.00
446_F	480_E	1.840	1.00
503_T	508_S	1.835	1.00
325_P	329_F	1.829	1.00
450_P	487_V	1.799	1.00
447_K	451_F	1.797	1.00
333_F	340_T	1.788	1.00
560_T	576_L	1.775	1.00
432_L	467_E	1.737	1.00
479_L	509_L	1.737	1.00
382_L	394_V	1.728	1.00
339_L	343_L	1.718	1.00
525_H	531_Y	1.698	1.00
327_R	330_G	1.685	1.00
332_I	339_L	1.684	1.00
527_F	561_I	1.668	1.00
325_P	330_G	1.660	1.00
494_T	514_N	1.656	1.00
374_S	404_K	1.656	1.00
186_D	190_K	1.655	1.00
344_R	347_K	1.649	1.00
291_T	295_L	1.641	1.00
565_S	568_N	1.640	1.00
528_N	531_Y	1.637	1.00
340_T	344_R	1.630	1.00
357_R	361_I	1.620	1.00
471_D	474_W	1.615	1.00
441_N	476_R	1.610	1.00
326_Y	330_G	1.589	1.00
65_T	69_D	1.580	1.00
436_I	500_L	1.575	1.00
409_S	413_E	1.573	1.00
329_F	332_I	1.570	1.00
470_L	475_F	1.564	1.00
518_M	526_L	1.563	1.00
375_I	405_S	1.555	1.00
346_D	350_R	1.546	1.00
474_W	477_R	1.520	1.00
337_D	340_T	1.509	1.00
28_A	32_Y	1.500	1.00
378_Y	397_M	1.497	1.00
449_N	452_S	1.497	1.00
360_W	364_L	1.470	1.00
376_Y	406_E	1.468	1.00
351_E	355_A	1.467	1.00
380_M	402_R	1.467	1.00
326_Y	329_F	1.467	1.00
345_R	349_N	1.466	1.00
525_H	528_N	1.465	1.00
553_L	557_H	1.459	1.00
333_F	339_L	1.454	1.00
474_W	553_L	1.453	1.00
518_M	571_T	1.439	1.00
51_T	54_L	1.435	1.00
382_L	398_G	1.429	1.00
434_S	467_E	1.428	1.00
490_N	494_T	1.423	1.00
461_S	500_L	1.415	1.00
374_S	378_Y	1.409	1.00
343_L	347_K	1.408	1.00
562_H	576_L	1.404	1.00
55_E	59_D	1.379	1.00
349_N	352_K	1.377	1.00
149_Q	153_S	1.377	1.00
385_K	394_V	1.372	1.00
443_I	457_I	1.371	1.00
430_R	469_A	1.361	1.00
335_S	338_Q	1.361	1.00
43_N	47_T	1.346	1.00
325_P	333_F	1.344	1.00
348_R	351_E	1.332	1.00
379_S	402_R	1.329	1.00
416_N	419_Y	1.329	1.00
284_F	287_P	1.319	1.00
520_E	566_R	1.308	1.00
367_D	371_P	1.306	1.00
434_S	465_H	1.302	1.00
346_D	349_N	1.296	1.00
550_A	554_V	1.277	1.00
482_L	511_V	1.276	1.00
402_R	406_E	1.275	1.00
554_V	561_I	1.267	1.00
332_I	335_S	1.260	1.00
368_L	408_M	1.257	1.00
148_E	154_V	1.254	1.00
532_R	540_T	1.253	1.00
367_D	370_T	1.249	1.00
379_S	405_S	1.243	1.00
522_T	531_Y	1.237	1.00
513_D	570_G	1.235	1.00
381_M	397_M	1.222	1.00
292_I	296_V	1.207	1.00
351_E	354_Q	1.200	1.00
342_T	345_R	1.195	1.00
414_D	474_W	1.189	1.00
379_S	383_E	1.180	1.00
442_V	483_L	1.179	1.00
328_F	336_M	1.170	1.00
446_F	483_L	1.168	1.00
377_G	381_M	1.166	1.00
334_E	337_D	1.162	1.00
390_S	393_E	1.162	1.00
84_Q	87_D	1.159	1.00
446_F	487_V	1.158	1.00
344_R	348_R	1.156	1.00
139_L	142_G	1.149	1.00
29_S	33_L	1.148	1.00
483_L	498_V	1.146	1.00
506_H	560_T	1.140	1.00
478_I	575_I	1.135	1.00
325_P	336_M	1.134	1.00
436_I	440_K	1.132	1.00
139_L	143_W	1.126	1.00
73_K	77_D	1.125	1.00
520_E	524_T	1.119	1.00
537_K	540_T	1.117	1.00
375_I	401_V	1.115	1.00
282_F	286_L	1.114	1.00
362_A	367_D	1.107	1.00
350_R	353_I	1.104	1.00
341_E	345_R	1.104	1.00
482_L	573_I	1.099	1.00
462_K	501_E	1.095	1.00
386_Q	394_V	1.095	1.00
339_L	342_T	1.095	1.00
289_F	292_I	1.093	1.00
361_I	364_L	1.092	1.00
335_S	339_L	1.092	1.00
396_E	400_V	1.092	1.00
436_I	461_S	1.091	1.00
325_P	339_L	1.085	1.00
545_L	549_I	1.084	1.00
537_K	541_A	1.082	1.00
472_E	476_R	1.081	1.00
47_T	51_T	1.078	1.00
482_L	561_I	1.077	1.00
325_P	332_I	1.074	1.00
259_L	263_F	1.073	1.00
283_R	287_P	1.070	1.00
497_Q	514_N	1.069	1.00
378_Y	401_V	1.062	1.00
477_R	553_L	1.060	1.00
256_K	259_L	1.055	1.00
369_K	413_E	1.054	1.00
552_E	555_H	1.052	1.00
329_F	333_F	1.051	1.00
526_L	563_V	1.051	1.00
326_Y	332_I	1.050	1.00
435_L	507_I	1.046	1.00
413_E	417_L	1.045	1.00
87_D	90_G	1.042	1.00
376_Y	409_S	1.037	1.00
365_S	370_T	1.036	1.00
281_M	285_G	1.036	1.00
27_V	31_F	1.034	1.00
359_E	363_G	1.032	1.00
354_Q	358_E	1.031	1.00
445_D	480_E	1.031	1.00
518_M	565_S	1.030	1.00
41_E	44_S	1.030	1.00
438_F	442_V	1.029	1.00
369_K	409_S	1.028	1.00
47_T	50_T	1.027	1.00
484_G	488_K	1.023	1.00
230_N	234_W	1.023	1.00
139_L	144_K	1.023	1.00
366_H	370_T	1.022	1.00
443_I	459_F	1.020	1.00
476_R	480_E	1.015	1.00
518_M	523_I	1.014	1.00
92_T	95_S	1.013	1.00
338_Q	342_T	1.011	1.00
277_T	281_M	1.011	1.00
435_L	509_L	1.010	1.00
358_E	362_A	1.009	1.00
518_M	563_V	1.008	1.00
144_K	157_R	1.007	1.00
367_D	477_R	1.006	1.00
367_D	481_N	1.004	1.00
50_T	53_T	1.004	1.00
483_L	496_I	1.003	1.00
352_K	355_A	1.001	1.00
428_I	557_H	0.999	1.00
527_F	563_V	0.999	1.00
513_D	571_T	0.998	1.00
479_L	511_V	0.995	1.00
518_M	524_T	0.994	1.00
491_G	494_T	0.993	1.00
439_F	500_L	0.992	1.00
337_D	341_E	0.990	1.00
361_I	365_S	0.989	1.00
360_W	363_G	0.989	1.00
440_K	459_F	0.984	1.00
529_R	552_E	0.982	1.00
508_S	562_H	0.980	1.00
563_V	571_T	0.977	1.00
140_L	143_W	0.973	1.00
374_S	377_G	0.973	1.00
328_F	332_I	0.971	1.00
482_L	575_I	0.964	1.00
490_N	493_G	0.964	1.00
84_Q	159_Q	0.955	1.00
105_T	108_K	0.952	1.00
434_S	466_I	0.952	1.00
386_Q	390_S	0.949	1.00
72_L	76_V	0.949	1.00
399_Q	403_E	0.940	1.00
133_E	137_Y	0.939	1.00
400_V	404_K	0.939	1.00
500_L	509_L	0.937	1.00
450_P	496_I	0.935	1.00
233_R	237_A	0.934	1.00
256_K	260_K	0.931	1.00
439_F	479_L	0.931	1.00
503_T	576_L	0.930	1.00
373_S	377_G	0.929	1.00
430_R	557_H	0.926	1.00
426_L	474_W	0.926	1.00
474_W	556_L	0.924	1.00
477_R	549_I	0.922	1.00
516_K	540_T	0.921	1.00
32_Y	36_R	0.920	1.00
122_N	125_L	0.920	1.00
439_F	498_V	0.919	1.00
378_Y	400_V	0.917	1.00
30_F	34_D	0.915	1.00
53_T	57_Y	0.914	1.00
365_S	369_K	0.912	1.00
293_R	296_V	0.912	1.00
246_T	249_E	0.911	1.00
562_H	575_I	0.908	1.00
54_L	57_Y	0.906	1.00
45_G	49_A	0.906	1.00
75_S	80_H	0.905	1.00
342_T	346_D	0.891	1.00
142_G	161_I	0.890	1.00
373_S	376_Y	0.884	1.00
341_E	344_R	0.882	1.00
368_L	411_L	0.879	1.00
382_L	397_M	0.876	1.00
229_L	234_W	0.876	1.00
489_H	516_K	0.875	1.00
110_E	114_I	0.875	1.00
441_N	472_E	0.873	1.00
133_E	136_S	0.872	1.00
554_V	577_F	0.871	1.00
374_S	379_S	0.864	1.00
87_D	92_T	0.863	1.00
481_N	484_G	0.863	1.00
367_D	411_L	0.862	1.00
392_E	395_K	0.860	1.00
488_K	532_R	0.859	1.00
379_S	398_G	0.859	1.00
482_L	550_A	0.856	1.00
503_T	506_H	0.855	1.00
44_S	47_T	0.854	1.00
445_D	449_N	0.853	1.00
41_E	45_G	0.852	1.00
194_S	200_S	0.852	1.00
517_G	571_T	0.848	1.00
196_N	199_K	0.847	1.00
86_I	92_T	0.846	1.00
287_P	292_I	0.846	1.00
287_P	291_T	0.845	1.00
84_Q	90_G	0.844	1.00
475_F	557_H	0.843	1.00
260_K	264_L	0.840	1.00
181_A	195_I	0.840	1.00
370_T	374_S	0.838	1.00
397_M	401_V	0.838	1.00
433_T	438_F	0.838	1.00
407_Y	476_R	0.835	1.00
131_N	142_G	0.834	1.00
288_I	292_I	0.833	1.00
354_Q	357_R	0.832	1.00
358_E	422_K	0.832	1.00
437_P	441_N	0.831	1.00
46_L	50_T	0.826	1.00
368_L	372_L	0.826	1.00
50_T	54_L	0.824	1.00
289_F	293_R	0.821	1.00
92_T	96_Y	0.821	1.00
527_F	573_I	0.819	1.00
385_K	397_M	0.817	1.00
455_Y	487_V	0.817	1.00
385_K	390_S	0.817	1.00
442_V	446_F	0.816	1.00
165_A	168_K	0.816	1.00
171_T	174_Y	0.815	1.00
442_V	480_E	0.814	1.00
376_Y	380_M	0.810	1.00
194_S	199_K	0.809	1.00
364_L	415_L	0.809	1.00
65_T	68_V	0.806	1.00
156_K	159_Q	0.806	1.00
49_A	53_T	0.805	1.00
378_Y	382_L	0.804	1.00
349_N	353_I	0.804	1.00
328_F	339_L	0.803	1.00
548_A	552_E	0.802	1.00
416_N	543_T	0.801	1.00
48_K	52_D	0.801	1.00
378_Y	404_K	0.800	1.00
32_Y	35_A	0.799	1.00
234_W	239_V	0.798	1.00
177_R	180_G	0.798	1.00
479_L	483_L	0.797	1.00
523_I	527_F	0.797	1.00
495_E	512_K	0.795	1.00
142_G	159_Q	0.795	1.00
176_K	180_G	0.794	1.00
243_V	250_F	0.792	1.00
405_S	409_S	0.789	1.00
446_F	484_G	0.788	1.00
465_H	468_F	0.788	1.00
71_F	75_S	0.780	1.00
410_K	473_A	0.780	1.00
369_K	416_N	0.780	1.00
72_L	75_S	0.779	1.00
363_G	529_R	0.779	1.00
385_K	391_P	0.778	1.00
526_L	573_I	0.776	1.00
87_D	93_D	0.775	1.00
486_A	511_V	0.774	1.00
56_A	59_D	0.771	1.00
93_D	96_Y	0.771	1.00
357_R	362_A	0.769	1.00
357_R	363_G	0.767	1.00
279_W	283_R	0.767	1.00
163_S	167_Y	0.766	1.00
372_L	412_I	0.764	1.00
486_A	496_I	0.763	1.00
84_Q	92_T	0.762	1.00
243_V	246_T	0.762	1.00
360_W	408_M	0.761	1.00
18_V	22_L	0.761	1.00
410_K	414_D	0.759	1.00
378_Y	381_M	0.757	1.00
356_T	359_E	0.757	1.00
393_E	397_M	0.756	1.00
42_S	45_G	0.755	1.00
324_Q	328_F	0.754	1.00
133_E	138_L	0.753	1.00
31_F	35_A	0.752	1.00
261_A	264_L	0.750	1.00
370_T	377_G	0.749	1.00
292_I	295_L	0.748	1.00
105_T	109_K	0.748	1.00
440_K	444_E	0.748	1.00
229_L	233_R	0.748	1.00
140_L	144_K	0.748	1.00
105_T	110_E	0.747	1.00
420_R	532_R	0.747	1.00
362_A	365_S	0.744	1.00
367_D	404_K	0.744	1.00
518_M	547_L	0.743	1.00
133_E	139_L	0.742	1.00
255_L	258_V	0.742	1.00
223_E	227_K	0.741	1.00
263_F	267_A	0.741	1.00
231_K	234_W	0.740	1.00
442_V	476_R	0.740	1.00
462_K	465_H	0.740	1.00
395_K	399_Q	0.739	1.00
455_Y	490_N	0.734	1.00
366_H	372_L	0.733	1.00
325_P	337_D	0.732	1.00
436_I	466_I	0.731	1.00
328_F	331_E	0.730	1.00
49_A	52_D	0.729	1.00
373_S	378_Y	0.729	1.00
22_L	26_L	0.728	1.00
348_R	352_K	0.727	1.00
171_T	175_I	0.727	1.00
234_W	237_A	0.723	1.00
111_L	115_Y	0.721	1.00
326_Y	333_F	0.721	1.00
442_V	445_D	0.720	1.00
428_I	556_L	0.718	1.00
352_K	356_T	0.718	1.00
103_P	106_Y	0.716	1.00
288_I	291_T	0.714	1.00
404_K	409_S	0.714	1.00
132_I	139_L	0.712	1.00
90_G	93_D	0.712	1.00
350_R	354_Q	0.711	1.00
42_S	46_L	0.709	1.00
516_K	571_T	0.709	1.00
86_I	159_Q	0.708	1.00
195_I	200_S	0.708	1.00
346_D	351_E	0.708	1.00
400_V	403_E	0.707	1.00
252_K	256_K	0.705	1.00
194_S	197_S	0.703	1.00
334_E	338_Q	0.703	1.00
164_L	168_K	0.701	1.00
438_F	470_L	0.701	1.00
181_A	194_S	0.700	1.00
362_A	368_L	0.699	1.00
428_I	474_W	0.699	1.00
356_T	363_G	0.699	1.00
44_S	48_K	0.698	1.00
229_L	236_V	0.698	1.00
179_K	249_E	0.696	1.00
358_E	364_L	0.693	1.00
165_A	169_S	0.693	1.00
28_A	31_F	0.692	1.00
146_K	149_Q	0.691	1.00
401_V	405_S	0.690	1.00
70_N	73_K	0.688	1.00
374_S	400_V	0.687	1.00
175_I	179_K	0.686	1.00
31_F	34_D	0.686	1.00
161_I	164_L	0.686	1.00
191_I	194_S	0.686	1.00
234_W	238_T	0.685	1.00
281_M	284_F	0.684	1.00
183_Y	244_Y	0.683	1.00
116_K	154_V	0.682	1.00
327_R	331_E	0.682	1.00
404_K	407_Y	0.681	1.00
255_L	259_L	0.680	1.00
209_E	213_Y	0.679	1.00
212_K	215_S	0.679	1.00
448_K	452_S	0.678	1.00
443_I	447_K	0.677	1.00
265_V	269_L	0.677	1.00
407_Y	480_E	0.677	1.00
372_L	408_M	0.677	1.00
440_K	461_S	0.674	1.00
283_R	286_L	0.673	1.00
353_I	357_R	0.672	1.00
498_V	511_V	0.671	1.00
167_Y	171_T	0.671	1.00
328_F	333_F	0.670	1.00
112_L	116_K	0.670	1.00
290_H	294_W	0.670	1.00
46_L	49_A	0.670	1.00
164_L	167_Y	0.669	1.00
466_I	507_I	0.669	1.00
244_Y	247_D	0.668	1.00
536_T	540_T	0.668	1.00
552_E	556_L	0.668	1.00
257_V	261_A	0.666	1.00
154_V	157_R	0.664	1.00
455_Y	494_T	0.664	1.00
135_K	139_L	0.664	1.00
70_N	74_K	0.662	1.00
345_R	348_R	0.661	1.00
358_E	361_I	0.660	1.00
138_L	143_W	0.658	1.00
428_I	471_D	0.657	1.00
453_E	492_K	0.655	1.00
522_T	526_L	0.654	1.00
235_M	239_V	0.653	1.00
86_I	91_N	0.653	1.00
367_D	480_E	0.652	1.00
93_D	97_G	0.651	1.00
405_S	408_M	0.651	1.00
19_I	22_L	0.650	1.00
360_W	365_S	0.650	1.00
478_I	557_H	0.649	1.00
109_K	112_L	0.648	1.00
335_S	340_T	0.646	1.00
97_G	100_K	0.646	1.00
253_S	257_V	0.645	1.00
473_A	476_R	0.644	1.00
45_G	48_K	0.642	1.00
16_L	19_I	0.642	1.00
128_W	142_G	0.641	1.00
79_Q	82_W	0.641	1.00
391_P	395_K	0.641	1.00
371_P	408_M	0.640	1.00
436_I	465_H	0.640	1.00
146_K	154_V	0.640	1.00
278_V	282_F	0.639	1.00
453_E	487_V	0.639	1.00
361_I	553_L	0.639	1.00
214_S	217_P	0.637	1.00
84_Q	95_S	0.637	1.00
532_R	542_G	0.636	1.00
536_T	541_A	0.636	1.00
223_E	234_W	0.636	1.00
403_E	406_E	0.635	1.00
211_L	214_S	0.634	1.00
287_P	295_L	0.631	1.00
420_R	543_T	0.631	1.00
549_I	553_L	0.631	1.00
372_L	378_Y	0.630	1.00
291_T	294_W	0.630	1.00
132_I	136_S	0.629	1.00
396_E	399_Q	0.628	1.00
370_T	416_N	0.626	1.00
357_R	364_L	0.626	1.00
430_R	470_L	0.626	1.00
274_I	278_V	0.625	1.00
133_E	140_L	0.625	1.00
15_M	18_V	0.625	1.00
417_L	477_R	0.625	1.00
359_E	364_L	0.625	1.00
538_D	541_A	0.624	1.00
383_E	398_G	0.623	1.00
286_L	290_H	0.622	1.00
481_N	550_A	0.622	1.00
147_S	155_E	0.621	1.00
369_K	408_M	0.620	1.00
489_H	540_T	0.620	1.00
140_L	147_S	0.618	1.00
180_G	186_D	0.617	1.00
366_H	481_N	0.617	1.00
402_R	405_S	0.617	1.00
330_G	333_F	0.617	1.00
40_A	44_S	0.616	1.00
500_L	507_I	0.616	1.00
52_D	56_A	0.616	1.00
243_V	247_D	0.616	1.00
360_W	367_D	0.615	1.00
368_L	371_P	0.614	1.00
281_M	287_P	0.614	1.00
330_G	334_E	0.612	1.00
367_D	378_Y	0.611	1.00
406_E	410_K	0.611	1.00
90_G	94_Y	0.610	1.00
364_L	370_T	0.609	1.00
375_I	379_S	0.607	1.00
51_T	57_Y	0.607	1.00
362_A	419_Y	0.607	1.00
456_D	459_F	0.606	1.00
385_K	393_E	0.606	1.00
559_G	575_I	0.604	1.00
370_T	381_M	0.604	1.00
474_W	557_H	0.603	1.00
228_I	234_W	0.602	1.00
178_K	181_A	0.602	1.00
453_E	490_N	0.601	1.00
439_F	459_F	0.600	1.00
326_Y	336_M	0.599	1.00
229_L	232_D	0.598	1.00
168_K	172_I	0.597	1.00
246_T	250_F	0.597	1.00
430_R	558_N	0.597	1.00
286_L	289_F	0.596	0.99
53_T	56_A	0.596	0.99
493_G	514_N	0.595	0.99
440_K	443_I	0.595	0.99
434_S	438_F	0.594	0.99
498_V	509_L	0.594	0.99
367_D	373_S	0.594	0.99
194_S	198_T	0.593	0.99
27_V	30_F	0.593	0.99
60_V	64_G	0.593	0.99
356_T	365_S	0.592	0.99
324_Q	327_R	0.591	0.99
523_I	573_I	0.591	0.99
64_G	69_D	0.590	0.99
349_N	354_Q	0.589	0.99
36_R	40_A	0.588	0.99
357_R	488_K	0.588	0.99
247_D	252_K	0.588	0.99
365_S	371_P	0.587	0.99
368_L	412_I	0.586	0.99
356_T	529_R	0.586	0.99
252_K	255_L	0.585	0.99
109_K	113_S	0.584	0.99
213_Y	217_P	0.584	0.99
222_R	225_S	0.583	0.99
509_L	577_F	0.583	0.99
287_P	290_H	0.582	0.99
481_N	549_I	0.582	0.99
527_F	530_Y	0.582	0.99
369_K	373_S	0.582	0.99
553_L	556_L	0.581	0.99
460_V	501_E	0.581	0.99
363_G	370_T	0.580	0.99
111_L	114_I	0.579	0.99
523_I	564_N	0.579	0.99
87_D	96_Y	0.579	0.99
403_E	441_N	0.578	0.99
474_W	478_I	0.578	0.99
376_Y	379_S	0.578	0.99
84_Q	96_Y	0.577	0.99
138_L	141_S	0.573	0.99
52_D	55_E	0.573	0.99
414_D	477_R	0.572	0.99
444_E	447_K	0.571	0.99
50_T	58_L	0.571	0.99
75_S	79_Q	0.570	0.99
86_I	93_D	0.569	0.99
204_T	207_Q	0.569	0.99
203_K	207_Q	0.569	0.99
47_T	55_E	0.567	0.99
369_K	377_G	0.564	0.99
88_S	154_V	0.564	0.99
169_S	172_I	0.564	0.99
115_Y	144_K	0.563	0.99
76_V	80_H	0.563	0.99
438_F	476_R	0.562	0.99
368_L	374_S	0.562	0.99
520_E	565_S	0.562	0.99
233_R	238_T	0.562	0.99
91_N	105_T	0.560	0.99
43_N	46_L	0.560	0.99
71_F	74_K	0.559	0.99
408_M	417_L	0.558	0.99
364_L	368_L	0.557	0.99
365_S	368_L	0.556	0.99
177_R	181_A	0.556	0.99
373_S	414_D	0.556	0.99
408_M	412_I	0.555	0.99
412_I	418_T	0.555	0.99
480_E	484_G	0.554	0.99
51_T	55_E	0.553	0.99
25_M	29_S	0.552	0.99
156_K	160_K	0.551	0.99
47_T	57_Y	0.551	0.99
213_Y	216_K	0.551	0.99
71_F	80_H	0.550	0.99
108_K	111_L	0.550	0.99
408_M	416_N	0.549	0.99
96_Y	99_P	0.549	0.99
444_E	448_K	0.549	0.99
466_I	469_A	0.548	0.99
135_K	138_L	0.548	0.99
260_K	263_F	0.548	0.99
161_I	165_A	0.547	0.99
195_I	198_T	0.546	0.99
510_K	564_N	0.546	0.99
512_K	566_R	0.546	0.99
518_M	567_T	0.545	0.99
64_G	67_E	0.544	0.99
530_Y	548_A	0.542	0.99
231_K	238_T	0.542	0.99
438_F	472_E	0.542	0.99
328_F	335_S	0.541	0.99
485_N	546_G	0.541	0.99
258_V	261_A	0.541	0.99
416_N	420_R	0.540	0.99
367_D	530_Y	0.540	0.99
73_K	79_Q	0.539	0.99
225_S	228_I	0.539	0.99
243_V	248_Q	0.538	0.99
33_L	37_F	0.537	0.99
22_L	25_M	0.536	0.99
489_H	514_N	0.536	0.99
362_A	370_T	0.536	0.99
436_I	459_F	0.535	0.99
438_F	441_N	0.535	0.99
136_S	140_L	0.534	0.99
73_K	76_V	0.533	0.99
211_L	215_S	0.533	0.99
455_Y	514_N	0.533	0.99
366_H	374_S	0.532	0.99
110_E	116_K	0.532	0.99
418_T	548_A	0.532	0.99
266_M	270_F	0.531	0.99
210_L	214_S	0.531	0.99
450_P	453_E	0.530	0.99
486_A	490_N	0.530	0.99
75_S	78_K	0.529	0.99
108_K	113_S	0.529	0.99
380_M	384_S	0.529	0.99
373_S	404_K	0.527	0.99
450_P	457_I	0.527	0.99
567_T	571_T	0.527	0.99
418_T	422_K	0.526	0.99
111_L	116_K	0.526	0.99
105_T	111_L	0.526	0.99
191_I	199_K	0.525	0.99
350_R	358_E	0.525	0.99
106_Y	111_L	0.525	0.99
475_F	479_L	0.524	0.99
450_P	454_G	0.524	0.99
209_E	212_K	0.524	0.99
78_K	81_G	0.523	0.99
212_K	216_K	0.522	0.99
382_L	401_V	0.522	0.99
110_E	113_S	0.521	0.99
50_T	57_Y	0.521	0.99
390_S	398_G	0.521	0.99
502_Q	507_I	0.521	0.99
356_T	360_W	0.521	0.99
445_D	476_R	0.519	0.99
257_V	260_K	0.517	0.99
166_H	169_S	0.517	0.99
148_E	152_T	0.515	0.99
228_I	232_D	0.514	0.99
421_L	425_A	0.512	0.98
513_D	516_K	0.512	0.98
353_I	361_I	0.512	0.98
418_T	552_E	0.512	0.98
285_G	289_F	0.510	0.98
129_A	132_I	0.510	0.98
373_S	381_M	0.510	0.98
138_L	142_G	0.509	0.98
417_L	474_W	0.508	0.98
134_D	138_L	0.508	0.98
325_P	335_S	0.507	0.98
550_A	553_L	0.507	0.98
355_A	358_E	0.505	0.98
221_K	225_S	0.504	0.98
357_R	360_W	0.504	0.98
131_N	134_D	0.503	0.98
366_H	377_G	0.503	0.98
209_E	215_S	0.502	0.98
267_A	274_I	0.501	0.98
328_F	337_D	0.501	0.98
131_N	161_I	0.501	0.98
271_M	275_W	0.501	0.98
81_G	162_D	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.5086	100	0.436	Contact Map
4bixA	2	0.3914	100	0.507	Contact Map
4ctiA	2	0.3948	100	0.532	Contact Map
4q20A	2	0.3966	100	0.547	Contact Map
4mpcA	2	0.5241	100	0.556	Contact Map
3jz3A	2	0.2793	100	0.558	Contact Map
4gczA	2	0.619	100	0.559	Contact Map
3a0rA	2	0.5672	100	0.563	Contact Map
2c2aA	2	0.4052	100	0.564	Contact Map
4e01A	3	0.4776	100	0.568	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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