GREMLIN Database
PBUG - Guanine/hypoxanthine permease PbuG
UniProt: O34987 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (385)
Sequences: 10795 (6219)
Seq/√Len: 317.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_F303_A3.6181.00
159_S183_T3.4901.00
18_I332_V3.4401.00
390_M403_I3.3661.00
386_L407_F3.3441.00
74_G331_I3.1191.00
123_S293_L3.0931.00
14_Y328_F2.8601.00
203_F206_M2.8461.00
71_I334_G2.7751.00
72_L301_I2.6261.00
324_A329_A2.6111.00
129_E289_G2.5631.00
76_I297_S2.5561.00
114_I255_I2.4111.00
71_I331_I2.3701.00
21_G332_V2.3521.00
65_A310_T2.3381.00
165_N171_T2.3381.00
121_A125_T2.2701.00
117_L121_A2.2681.00
41_L95_F2.2491.00
204_I207_L2.1821.00
67_A338_L2.1681.00
387_T404_G2.1571.00
204_I208_L2.1481.00
319_G329_A2.1421.00
417_K420_E2.1331.00
175_I180_V2.1311.00
335_I339_L2.0841.00
117_L300_V2.0751.00
69_G298_S2.0381.00
113_F300_V2.0301.00
205_G209_T2.0061.00
181_L185_F1.9911.00
187_V361_I1.9831.00
209_T214_M1.9741.00
302_G307_T1.9711.00
120_V300_V1.9641.00
396_S399_T1.9591.00
210_A213_G1.9521.00
186_G209_T1.9511.00
203_F209_T1.9021.00
185_F189_V1.8881.00
14_Y18_I1.8671.00
206_M214_M1.8601.00
204_I210_A1.8481.00
124_L293_L1.8351.00
169_L172_I1.8211.00
231_S234_P1.8101.00
214_M217_G1.7861.00
72_L76_I1.7771.00
210_A214_M1.7681.00
332_V336_L1.7611.00
20_G324_A1.7421.00
82_A333_T1.7321.00
81_I312_S1.6861.00
70_C334_G1.6851.00
67_A334_G1.6851.00
211_V215_I1.6831.00
13_S325_R1.6741.00
168_T171_T1.6731.00
371_G375_W1.6611.00
118_I259_L1.6531.00
209_T213_G1.6491.00
183_T357_P1.6401.00
20_G329_A1.6291.00
91_A308_S1.6231.00
206_M210_A1.6041.00
301_I305_L1.5951.00
72_L294_A1.5901.00
16_N325_R1.5821.00
22_L336_L1.5801.00
220_P223_T1.5661.00
188_I192_I1.5601.00
186_G357_P1.5531.00
390_M394_T1.5471.00
187_V357_P1.5391.00
120_V293_L1.5261.00
206_M209_T1.5241.00
389_I393_L1.5181.00
273_V320_V1.5041.00
378_F382_V1.4971.00
116_G300_V1.4961.00
204_I209_T1.4691.00
14_Y332_V1.4671.00
114_I251_M1.4501.00
194_M365_L1.4431.00
87_M90_N1.4381.00
412_M420_E1.4281.00
148_G363_G1.4091.00
242_H246_I1.3971.00
201_G204_I1.3901.00
203_F207_L1.3871.00
190_T194_M1.3731.00
159_S356_A1.3631.00
201_G205_G1.3621.00
69_G310_T1.3611.00
25_F336_L1.3611.00
104_S107_A1.3471.00
203_F208_L1.3411.00
97_V258_F1.3391.00
149_L392_P1.3261.00
17_E325_R1.3201.00
18_I22_L1.3141.00
192_I196_L1.3121.00
287_R290_R1.3071.00
297_S301_I1.3031.00
122_L127_F1.3031.00
75_L331_I1.2901.00
182_L209_T1.2861.00
118_I252_L1.2851.00
191_V361_I1.2841.00
178_G181_L1.2801.00
121_A124_L1.2781.00
67_A71_I1.2751.00
386_L390_M1.2621.00
385_F389_I1.2611.00
152_T360_I1.2611.00
242_H245_D1.2591.00
206_M213_G1.2561.00
179_P353_N1.2521.00
203_F210_A1.2511.00
157_Q169_L1.2481.00
97_V254_V1.2431.00
159_S360_I1.2421.00
328_F332_V1.2411.00
74_G330_A1.2391.00
203_F214_M1.2311.00
203_F216_F1.2311.00
168_T172_I1.2291.00
145_A388_M1.2251.00
202_V207_L1.2221.00
76_I294_A1.2201.00
276_Q316_S1.2181.00
40_A55_Q1.2131.00
410_I414_C1.2091.00
243_L246_I1.2081.00
90_N258_F1.2041.00
194_M361_I1.1931.00
177_S180_V1.1921.00
176_H179_P1.1891.00
72_L297_S1.1881.00
174_N177_S1.1881.00
190_T205_G1.1811.00
202_V358_A1.1781.00
232_L235_T1.1771.00
38_T87_M1.1751.00
177_S181_L1.1731.00
339_L342_F1.1721.00
250_Q253_I1.1681.00
120_V296_S1.1671.00
190_T361_I1.1661.00
334_G338_L1.1641.00
224_Q227_G1.1551.00
187_V191_V1.1471.00
126_G130_K1.1471.00
215_I218_L1.1451.00
225_I228_S1.1431.00
115_S259_L1.1401.00
319_G324_A1.1371.00
111_G251_M1.1341.00
227_G230_P1.1271.00
180_V183_T1.1261.00
184_I188_I1.1251.00
215_I219_V1.1231.00
413_V418_A1.1231.00
15_R19_I1.1221.00
33_F37_I1.1181.00
141_L372_K1.1171.00
244_P247_F1.1161.00
331_I335_I1.1151.00
255_I259_L1.1151.00
293_L297_S1.1141.00
138_E380_V1.1141.00
241_I304_V1.1111.00
225_I229_V1.1071.00
290_R293_L1.1051.00
379_E415_K1.1051.00
214_M218_L1.1011.00
204_I214_M1.0981.00
120_V124_L1.0941.00
180_V184_I1.0891.00
271_V275_T1.0891.00
155_G360_I1.0881.00
226_I229_V1.0871.00
122_L259_L1.0831.00
129_E133_N1.0821.00
262_G309_T1.0801.00
115_S258_F1.0721.00
391_M400_G1.0721.00
57_A308_S1.0701.00
340_A343_F1.0691.00
209_T212_A1.0671.00
210_A217_G1.0551.00
179_P183_T1.0531.00
332_V335_I1.0521.00
20_G24_T1.0481.00
329_A333_T1.0471.00
118_I256_L1.0361.00
85_P315_E1.0351.00
126_G289_G1.0321.00
229_V233_A1.0311.00
213_G216_F1.0301.00
13_S16_N1.0291.00
244_P248_S1.0271.00
201_G206_M1.0261.00
118_I255_I1.0181.00
411_T415_K1.0161.00
230_P237_G1.0141.00
191_V382_V1.0091.00
33_F318_S1.0091.00
203_F213_G1.0041.00
300_V303_A1.0001.00
369_P372_K0.9891.00
202_V205_G0.9861.00
213_G217_G0.9821.00
60_T341_T0.9811.00
186_G354_V0.9791.00
204_I213_G0.9771.00
112_V303_A0.9731.00
149_L388_M0.9691.00
377_K380_V0.9671.00
95_F99_L0.9641.00
193_L204_I0.9641.00
68_A301_I0.9611.00
142_A387_T0.9601.00
73_M84_A0.9591.00
153_F393_L0.9591.00
234_P237_G0.9551.00
372_K376_D0.9541.00
297_S300_V0.9541.00
81_I320_V0.9511.00
110_S114_I0.9501.00
298_S310_T0.9491.00
298_S301_I0.9461.00
110_S243_L0.9451.00
183_T360_I0.9441.00
205_G214_M0.9381.00
370_L388_M0.9381.00
230_P233_A0.9271.00
145_A148_G0.9241.00
351_T354_V0.9201.00
113_F241_I0.9201.00
328_F331_I0.9081.00
384_A388_M0.9021.00
243_L247_F0.8961.00
108_A112_V0.8951.00
235_T238_Q0.8851.00
111_G258_F0.8831.00
233_A236_F0.8821.00
269_T273_V0.8811.00
181_L184_I0.8801.00
236_F239_A0.8801.00
35_N337_F0.8721.00
205_G210_A0.8711.00
213_G354_V0.8711.00
224_Q228_S0.8701.00
86_G311_T0.8681.00
137_P141_L0.8681.00
16_N20_G0.8661.00
407_F411_T0.8641.00
84_A295_D0.8591.00
37_I55_Q0.8561.00
17_E326_S0.8551.00
300_V304_V0.8551.00
242_H248_S0.8551.00
111_G254_V0.8531.00
41_L94_A0.8521.00
262_G299_I0.8521.00
234_P238_Q0.8511.00
79_Y291_A0.8511.00
191_V194_M0.8491.00
206_M212_A0.8481.00
158_G356_A0.8471.00
208_L213_G0.8461.00
53_I58_V0.8441.00
68_A305_L0.8441.00
317_S321_A0.8421.00
63_A67_A0.8391.00
402_A406_I0.8381.00
225_I230_P0.8371.00
202_V213_G0.8331.00
175_I178_G0.8301.00
35_N90_N0.8231.00
113_F304_V0.8221.00
346_L349_V0.8201.00
191_V195_V0.8191.00
371_G376_D0.8171.00
275_T280_M0.8171.00
249_V253_I0.8161.00
212_A216_F0.8151.00
57_A61_A0.8121.00
153_F157_Q0.8121.00
374_A381_A0.8111.00
76_I293_L0.8081.00
146_G392_P0.8061.00
61_A105_W0.8051.00
157_Q164_A0.8041.00
239_A305_L0.8021.00
152_T363_G0.8011.00
204_I216_F0.8011.00
340_A347_L0.7971.00
216_F219_V0.7951.00
270_L291_A0.7931.00
371_G374_A0.7881.00
66_S70_C0.7871.00
242_H247_F0.7851.00
186_G190_T0.7841.00
146_G391_M0.7831.00
189_V208_L0.7831.00
206_M217_G0.7801.00
21_G25_F0.7781.00
367_V370_L0.7781.00
207_L214_M0.7751.00
399_T402_A0.7751.00
54_D58_V0.7721.00
148_G367_V0.7711.00
381_A385_F0.7700.99
94_A309_T0.7700.99
71_I75_L0.7690.99
115_S309_T0.7690.99
185_F212_A0.7680.99
249_V252_L0.7680.99
379_E412_M0.7670.99
115_S262_G0.7650.99
412_M417_K0.7650.99
191_V364_A0.7640.99
57_A98_V0.7630.99
386_L403_I0.7620.99
390_M399_T0.7590.99
379_E411_T0.7570.99
109_L112_V0.7560.99
211_V214_M0.7530.99
203_F217_G0.7500.99
247_F250_Q0.7500.99
394_T399_T0.7490.99
183_T353_N0.7480.99
21_G336_L0.7470.99
182_L186_G0.7470.99
37_I41_L0.7420.99
183_T186_G0.7390.99
38_T66_S0.7380.99
123_S129_E0.7360.99
93_F258_F0.7360.99
65_A69_G0.7360.99
192_I414_C0.7350.99
189_V193_L0.7340.99
18_I328_F0.7330.99
76_I290_R0.7330.99
203_F212_A0.7280.99
163_T166_P0.7260.99
228_S233_A0.7250.99
259_L263_F0.7250.99
318_S322_A0.7250.99
209_T216_F0.7230.99
79_Y285_L0.7230.99
90_N94_A0.7220.99
153_F170_V0.7220.99
251_M254_V0.7180.99
71_I74_G0.7170.99
277_A280_M0.7170.99
195_V199_N0.7160.99
146_G388_M0.7140.99
35_N62_T0.7130.99
270_L273_V0.7100.99
83_I330_A0.7100.99
164_A169_L0.7060.99
274_A277_A0.7060.99
197_R200_A0.7060.99
183_T187_V0.7050.99
201_G209_T0.7040.99
164_A167_S0.7040.99
204_I217_G0.7020.99
412_M416_G0.7010.99
167_S171_T0.6980.99
111_G115_S0.6970.99
96_S99_L0.6970.99
205_G208_L0.6950.99
133_N284_K0.6940.99
86_G90_N0.6930.99
240_W243_L0.6910.99
138_E142_A0.6910.99
199_N322_A0.6870.99
123_S296_S0.6860.99
114_I118_I0.6810.99
122_L292_L0.6790.99
73_M83_I0.6770.99
205_G217_G0.6770.99
414_C418_A0.6750.99
15_R18_I0.6730.99
106_Q109_L0.6730.99
109_L303_A0.6720.99
160_G180_V0.6720.99
126_G129_E0.6710.99
196_L199_N0.6700.99
112_V309_T0.6690.99
205_G213_G0.6680.99
130_K133_N0.6670.99
380_V383_P0.6660.99
90_N115_S0.6660.99
229_V235_T0.6650.99
201_G210_A0.6640.99
153_F156_L0.6630.98
263_F292_L0.6630.98
98_V104_S0.6620.98
361_I365_L0.6620.98
52_R58_V0.6600.98
66_S337_F0.6600.98
185_F188_I0.6560.98
195_V198_V0.6540.98
293_L300_V0.6530.98
333_T340_A0.6530.98
381_A384_A0.6500.98
141_L369_P0.6490.98
241_I245_D0.6490.98
190_T357_P0.6460.98
233_A238_Q0.6440.98
296_S300_V0.6410.98
230_P236_F0.6410.98
110_S248_S0.6400.98
19_I23_T0.6380.98
166_P169_L0.6370.98
87_M312_S0.6360.98
230_P234_P0.6360.98
20_G322_A0.6360.98
119_F262_G0.6360.98
89_L94_A0.6350.98
301_I304_V0.6340.98
240_W304_V0.6330.98
403_I407_F0.6330.98
69_G302_G0.6320.98
142_A384_A0.6290.98
73_M294_A0.6280.98
253_I257_T0.6270.98
237_G304_V0.6270.98
370_L375_W0.6260.98
210_A218_L0.6250.98
99_L102_G0.6240.98
226_I230_P0.6210.98
116_G299_I0.6200.98
339_L343_F0.6200.98
409_P413_V0.6190.98
374_A378_F0.6160.98
271_V277_A0.6140.98
144_G272_A0.6140.98
98_V108_A0.6130.98
34_V333_T0.6130.98
35_N87_M0.6110.97
277_A286_P0.6080.97
217_G220_P0.6060.97
271_V276_Q0.6060.97
252_L255_I0.6050.97
81_I279_L0.6040.97
87_M313_Y0.6040.97
176_H180_V0.6040.97
254_V257_T0.6020.97
342_F345_P0.6020.97
152_T385_F0.6000.97
52_R61_A0.5990.97
296_S299_I0.5990.97
370_L373_I0.5990.97
299_I309_T0.5960.97
212_A215_I0.5950.97
83_I310_T0.5940.97
186_G189_V0.5930.97
79_Y287_R0.5930.97
132_I135_I0.5910.97
22_L332_V0.5910.97
321_A365_L0.5900.97
202_V210_A0.5900.97
136_P408_Y0.5900.97
275_T372_K0.5900.97
56_G60_T0.5890.97
231_S348_S0.5880.97
188_I191_V0.5870.97
270_L274_A0.5850.97
61_A306_G0.5850.97
94_A99_L0.5850.97
195_V378_F0.5840.97
204_I212_A0.5830.97
206_M211_V0.5800.97
68_A72_L0.5800.97
245_D248_S0.5790.96
184_I187_V0.5780.96
208_L215_I0.5780.96
182_L185_F0.5750.96
194_M201_G0.5740.96
269_T274_A0.5690.96
229_V238_Q0.5680.96
112_V258_F0.5680.96
106_Q242_H0.5680.96
97_V111_G0.5680.96
227_G231_S0.5670.96
408_Y412_M0.5670.96
276_Q321_A0.5650.96
118_I122_L0.5650.96
16_N19_I0.5620.96
228_S232_L0.5620.96
372_K375_W0.5600.96
94_A108_A0.5560.96
224_Q229_V0.5560.96
103_I106_Q0.5550.96
379_E383_P0.5550.96
52_R55_Q0.5550.96
163_T167_S0.5540.96
187_V360_I0.5530.95
88_G92_F0.5530.95
35_N38_T0.5530.95
218_L222_P0.5520.95
275_T279_L0.5520.95
265_D269_T0.5500.95
370_L384_A0.5490.95
66_S83_I0.5470.95
88_G93_F0.5450.95
73_M295_D0.5450.95
130_K289_G0.5440.95
386_L389_I0.5410.95
373_I381_A0.5410.95
274_A278_G0.5410.95
229_V237_G0.5400.95
231_S235_T0.5400.95
216_F221_V0.5400.95
86_G89_L0.5370.95
193_L197_R0.5370.95
63_A337_F0.5340.95
144_G275_T0.5330.94
200_A204_I0.5320.94
228_S231_S0.5310.94
145_A367_V0.5310.94
77_A294_A0.5310.94
273_V276_Q0.5300.94
361_I364_A0.5290.94
54_D57_A0.5290.94
85_P89_L0.5280.94
216_F222_P0.5280.94
380_V412_M0.5270.94
271_V286_P0.5260.94
141_L368_A0.5260.94
110_S241_I0.5260.94
201_G214_M0.5260.94
235_T239_A0.5250.94
103_I250_Q0.5250.94
78_R294_A0.5250.94
70_C333_T0.5240.94
251_M255_I0.5240.94
86_G315_E0.5240.94
153_F169_L0.5240.94
34_V37_I0.5240.94
92_F95_F0.5240.94
306_G404_G0.5230.94
228_S235_T0.5220.94
399_T403_I0.5220.94
370_L381_A0.5200.94
18_I336_L0.5190.94
38_T41_L0.5190.94
233_A237_G0.5180.94
273_V277_A0.5180.94
73_M310_T0.5180.94
298_S302_G0.5160.93
68_A302_G0.5150.93
210_A219_V0.5140.93
367_V388_M0.5130.93
280_M284_K0.5130.93
134_A417_K0.5130.93
115_S119_F0.5120.93
73_M77_A0.5100.93
81_I324_A0.5080.93
141_L145_A0.5070.93
229_V232_L0.5060.93
55_Q59_F0.5060.93
213_G219_V0.5060.93
94_A98_V0.5050.93
193_L198_V0.5040.93
224_Q230_P0.5040.93
81_I284_K0.5030.93
272_A277_A0.5010.92
262_G311_T0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8591 100 0.55 Contact Map
4huqS 1 0.3386 13.3 0.97 Contact Map
4us3A 1 0.8295 13.2 0.97 Contact Map
4z7fA 2 0.3409 5.9 0.974 Contact Map
2nr9A 2 0.4318 5.7 0.974 Contact Map
3o7qA 1 0.4227 5.3 0.975 Contact Map
4xp4A 1 0.8795 3.8 0.976 Contact Map
4b19A 1 0.0682 3.8 0.977 Contact Map
2khfA 1 0.0364 3.6 0.977 Contact Map
1btsA 1 0.0477 3.1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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