GREMLIN Database
YODQ - Uncharacterized metallohydrolase YodQ
UniProt: O34984 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 436 (361)
Sequences: 27228 (19109)
Seq/√Len: 1005.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_K163_L3.2171.00
213_T283_R3.0681.00
46_L50_R2.8851.00
213_T285_V2.7911.00
27_R44_V2.7861.00
219_A227_G2.7261.00
128_K399_Y2.6691.00
90_T161_D2.5731.00
97_S161_D2.4131.00
306_E310_K2.4051.00
211_R285_V2.3991.00
302_K306_E2.3821.00
215_K325_Q2.3751.00
214_V237_V2.3711.00
354_K418_D2.3281.00
350_S418_D2.3211.00
354_K414_L2.3011.00
48_K51_Q2.2801.00
215_K283_R2.2661.00
46_L58_V2.2511.00
150_A413_A2.2191.00
233_K322_H2.1781.00
52_F149_E2.1751.00
272_S285_V2.1731.00
234_S271_I2.1711.00
97_S163_L2.1561.00
215_K323_P2.1521.00
211_R287_E2.1461.00
303_L307_N2.1401.00
88_K161_D2.0991.00
234_S284_V2.0991.00
99_I187_A2.0331.00
270_T287_E2.0281.00
18_S406_I1.9961.00
234_S286_I1.9791.00
44_V48_K1.9711.00
31_E44_V1.9451.00
20_K149_E1.9391.00
213_T325_Q1.9311.00
49_L87_A1.9271.00
213_T327_E1.9251.00
39_F43_A1.8931.00
349_Q353_Q1.8891.00
236_H239_T1.8821.00
235_M238_I1.8801.00
150_A154_C1.8711.00
117_Y125_E1.8401.00
116_K397_N1.7841.00
211_R327_E1.7481.00
310_K314_Y1.7341.00
47_E51_Q1.7331.00
178_L182_M1.7321.00
355_M414_L1.7321.00
348_L415_F1.7171.00
43_A47_E1.7161.00
40_N43_A1.7151.00
48_K52_F1.6961.00
21_A409_A1.6681.00
237_V309_L1.6431.00
24_L48_K1.6421.00
118_E121_Q1.6411.00
304_E307_N1.6381.00
228_V233_K1.6231.00
149_E153_A1.6171.00
44_V47_E1.6051.00
299_E303_L1.6031.00
414_L417_M1.5981.00
353_Q359_E1.5941.00
26_K30_G1.5931.00
235_M239_T1.5831.00
230_A284_V1.5721.00
23_R27_R1.5631.00
54_M89_K1.5451.00
27_R30_G1.5441.00
217_L228_V1.5421.00
143_A408_S1.5351.00
42_Q104_I1.5301.00
27_R40_N1.5231.00
21_A146_F1.5181.00
273_G284_V1.5161.00
232_E242_Q1.4881.00
218_S282_D1.4861.00
297_K300_A1.4821.00
46_L85_I1.4761.00
346_S349_Q1.4751.00
39_F83_P1.4691.00
19_A23_R1.4601.00
47_E50_R1.4471.00
351_A418_D1.4471.00
55_D90_T1.4461.00
45_V104_I1.4401.00
48_K149_E1.4381.00
240_A311_D1.4371.00
99_I165_Q1.4321.00
93_G159_K1.4301.00
127_G403_E1.4201.00
414_L418_D1.4141.00
300_A304_E1.4071.00
96_R188_D1.4061.00
347_V418_D1.4011.00
27_R31_E1.3971.00
50_R56_I1.3841.00
99_I190_A1.3751.00
240_A308_W1.3591.00
214_V234_S1.3431.00
210_F288_G1.3391.00
179_S182_M1.3301.00
30_G124_E1.3171.00
262_I294_P1.3111.00
236_H315_H1.3041.00
303_L306_E1.3001.00
23_R26_K1.2791.00
407_E410_K1.2771.00
125_E128_K1.2721.00
139_G400_I1.2691.00
152_H155_D1.2691.00
33_S41_A1.2691.00
22_I26_K1.2681.00
264_V301_V1.2621.00
302_K328_W1.2611.00
102_G137_M1.2601.00
50_R58_V1.2591.00
179_S183_R1.2541.00
212_I286_I1.2411.00
211_R329_F1.2401.00
46_L56_I1.2351.00
124_E402_V1.2351.00
24_L146_F1.2351.00
307_N311_D1.2321.00
351_A414_L1.2201.00
57_D88_K1.2191.00
20_K23_R1.2141.00
43_A58_V1.2131.00
302_K330_G1.2081.00
406_I410_K1.2041.00
24_L44_V1.1991.00
97_S188_D1.1941.00
231_I273_G1.1931.00
352_Y411_I1.1891.00
403_E407_E1.1841.00
375_Y380_T1.1811.00
43_A46_L1.1751.00
214_V233_K1.1741.00
313_E324_V1.1731.00
92_A159_K1.1701.00
35_L172_C1.1671.00
89_K152_H1.1661.00
21_A142_T1.1601.00
154_C413_A1.1491.00
350_S354_K1.1491.00
355_M410_K1.1471.00
18_S22_I1.1431.00
208_M298_P1.1401.00
100_L144_L1.1401.00
346_S350_S1.1371.00
26_K122_A1.1351.00
139_G405_M1.1321.00
148_L164_F1.1271.00
300_A303_L1.1201.00
29_I131_G1.1181.00
307_N310_K1.1161.00
347_V351_A1.1121.00
231_I271_I1.1101.00
18_S403_E1.1051.00
115_W118_E1.1001.00
28_L41_A1.0971.00
200_L203_K1.0961.00
30_G121_Q1.0961.00
26_K402_V1.0931.00
100_L416_V1.0871.00
238_I286_I1.0751.00
117_Y123_V1.0701.00
29_I134_S1.0661.00
128_K401_E1.0661.00
27_R48_K1.0651.00
197_N393_A1.0641.00
31_E40_N1.0571.00
268_I288_G1.0511.00
401_E404_A1.0511.00
193_P412_I1.0481.00
294_P297_K1.0451.00
342_H346_S1.0441.00
26_K124_E1.0431.00
351_A355_M1.0401.00
240_A312_L1.0391.00
24_L149_E1.0341.00
54_M87_A1.0341.00
45_V141_N1.0271.00
139_G195_P1.0271.00
124_E127_G1.0251.00
42_Q85_I1.0231.00
228_V322_H1.0221.00
348_L383_I1.0171.00
306_E326_V1.0151.00
349_Q362_I1.0141.00
40_N44_V1.0121.00
244_L304_E1.0121.00
309_L324_V1.0021.00
20_K24_L0.9991.00
119_P122_A0.9961.00
144_L164_F0.9901.00
241_I305_L0.9881.00
32_K37_S0.9861.00
96_R160_G0.9861.00
350_S353_Q0.9851.00
178_L373_L0.9811.00
304_E308_W0.9781.00
117_Y121_Q0.9761.00
146_F149_E0.9761.00
154_C417_M0.9751.00
210_F302_K0.9751.00
308_W312_L0.9711.00
127_G401_E0.9681.00
239_T243_E0.9651.00
271_I284_V0.9641.00
240_A243_E0.9621.00
55_D88_K0.9591.00
413_A417_M0.9571.00
211_R277_P0.9501.00
110_G126_N0.9501.00
236_H240_A0.9441.00
276_W279_S0.9411.00
28_L44_V0.9411.00
353_Q358_T0.9391.00
102_G141_N0.9351.00
308_W311_D0.9331.00
147_A413_A0.9311.00
104_I166_S0.9281.00
410_K414_L0.9261.00
232_E238_I0.9221.00
238_I268_I0.9211.00
163_L187_A0.9211.00
277_P287_E0.9201.00
42_Q46_L0.9201.00
104_I141_N0.9161.00
36_G169_D0.9141.00
91_G161_D0.9121.00
84_N168_V0.9121.00
21_A405_M0.9111.00
49_L145_L0.9101.00
189_G419_W0.9071.00
20_K48_K0.9021.00
114_D117_Y0.9021.00
117_Y120_Y0.8971.00
351_A354_K0.8941.00
215_K282_D0.8911.00
147_A412_I0.8881.00
341_D344_L0.8871.00
347_V350_S0.8871.00
311_D315_H0.8861.00
189_G344_L0.8801.00
53_H56_I0.8791.00
203_K364_A0.8711.00
409_A413_A0.8701.00
310_K313_E0.8681.00
111_S114_D0.8661.00
117_Y122_A0.8651.00
52_F152_H0.8651.00
37_S40_N0.8651.00
212_I237_V0.8641.00
232_E235_M0.8631.00
114_D118_E0.8621.00
272_S275_A0.8621.00
236_H243_E0.8601.00
223_T226_E0.8601.00
154_C157_K0.8591.00
89_K148_L0.8521.00
212_I309_L0.8521.00
232_E243_E0.8511.00
150_A410_K0.8501.00
54_M152_H0.8491.00
238_I271_I0.8431.00
404_A407_E0.8431.00
236_H242_Q0.8411.00
56_I87_A0.8411.00
89_K158_L0.8411.00
299_E302_K0.8371.00
391_K397_N0.8351.00
33_S138_K0.8331.00
41_A104_I0.8281.00
311_D314_Y0.8271.00
86_V163_L0.8251.00
109_E120_Y0.8241.00
234_S238_I0.8221.00
307_N314_Y0.8211.00
48_K145_L0.8191.00
268_I286_I0.8191.00
54_M148_L0.8171.00
403_E406_I0.8141.00
343_P346_S0.8131.00
191_L415_F0.8121.00
27_R47_E0.8071.00
206_G292_I0.8041.00
150_A409_A0.7991.00
190_A380_T0.7971.00
343_P347_V0.7961.00
295_H376_H0.7941.00
400_I405_M0.7921.00
24_L142_T0.7911.00
209_W289_R0.7891.00
116_K125_E0.7831.00
25_L129_I0.7811.00
231_I284_V0.7801.00
292_I298_P0.7801.00
205_Q208_M0.7751.00
380_T386_G0.7731.00
137_M140_G0.7721.00
30_G122_A0.7691.00
163_L186_R0.7671.00
347_V415_F0.7671.00
345_I349_Q0.7651.00
405_M409_A0.7601.00
146_F409_A0.7601.00
52_F145_L0.7601.00
382_V385_F0.7601.00
190_A378_G0.7581.00
348_L411_I0.7531.00
148_L152_H0.7441.00
106_V120_Y0.7441.00
141_N166_S0.7431.00
296_E300_A0.7431.00
125_E130_Y0.7361.00
100_L147_A0.7361.00
382_V386_G0.7351.00
144_L193_P0.7331.00
266_V290_C0.7321.00
34_T108_P0.7311.00
42_Q83_P0.7311.00
147_A409_A0.7281.00
298_P334_L0.7271.00
230_A281_A0.7271.00
334_L376_H0.7271.00
122_A129_I0.7261.00
295_H299_E0.7241.00
373_L377_A0.7231.00
45_V166_S0.7221.00
36_G172_C0.7211.00
123_V126_N0.7201.00
24_L27_R0.7191.00
150_A153_A0.7161.00
143_A147_A0.7121.00
22_I124_E0.7111.00
298_P302_K0.7111.00
217_L395_Q0.7101.00
214_V286_I0.7091.00
177_T181_I0.7071.00
45_V145_L0.7031.00
208_M302_K0.7011.00
51_Q149_E0.7001.00
201_F205_Q0.6991.00
239_T242_Q0.6991.00
98_L189_G0.6991.00
143_A412_I0.6961.00
143_A409_A0.6951.00
351_A415_F0.6941.00
210_F305_L0.6931.00
378_G381_P0.6921.00
352_Y355_M0.6891.00
34_T37_S0.6881.00
200_L346_S0.6871.00
22_I402_V0.6871.00
290_C301_V0.6871.00
381_P386_G0.6861.00
93_G161_D0.6851.00
89_K164_F0.6851.00
329_F332_Q0.6831.00
24_L28_L0.6811.00
28_L141_N0.6801.00
299_E330_G0.6781.00
387_P400_I0.6771.00
241_I266_V0.6751.00
391_K395_Q0.6731.00
98_L416_V0.6731.00
312_L315_H0.6721.00
165_Q180_A0.6701.00
91_G94_G0.6691.00
94_G161_D0.6671.00
201_F204_Q0.6661.00
149_E152_H0.6641.00
356_K411_I0.6611.00
209_W277_P0.6611.00
24_L145_L0.6581.00
392_T395_Q0.6571.00
341_D346_S0.6561.00
345_I381_P0.6531.00
333_W336_N0.6531.00
20_K146_F0.6521.00
143_A193_P0.6491.00
219_A280_V0.6491.00
151_L156_V0.6481.00
292_I301_V0.6441.00
392_T399_Y0.6431.00
106_V132_R0.6391.00
272_S287_E0.6391.00
82_S179_S0.6371.00
97_S160_G0.6361.00
270_T285_V0.6341.00
347_V419_W0.6341.00
272_S283_R0.6341.00
204_Q369_T0.6331.00
45_V85_I0.6331.00
229_S281_A0.6311.00
26_K29_I0.6311.00
102_G144_L0.6271.00
26_K129_I0.6241.00
49_L54_M0.6231.00
50_R55_D0.6221.00
411_I415_F0.6211.00
214_V230_A0.6211.00
95_G161_D0.6211.00
371_G382_V0.6211.00
172_C175_A0.6191.00
130_Y399_Y0.6191.00
129_I402_V0.6191.00
22_I129_I0.6181.00
373_L376_H0.6181.00
92_A157_K0.6171.00
392_T397_N0.6161.00
190_A374_L0.6151.00
34_T120_Y0.6141.00
22_I406_I0.6141.00
192_I382_V0.6131.00
306_E328_W0.6121.00
115_W119_P0.6071.00
25_L402_V0.6061.00
228_V321_R0.6041.00
410_K413_A0.6031.00
25_L142_T0.6011.00
356_K407_E0.6001.00
121_Q132_R0.5991.00
35_L173_G0.5941.00
355_M358_T0.5931.00
191_L419_W0.5931.00
57_D184_G0.5931.00
236_H312_L0.5921.00
171_E394_H0.5911.00
201_F363_E0.5911.00
181_I377_A0.5911.00
54_M164_F0.5911.00
169_D172_C0.5911.00
109_E131_G0.5891.00
212_I326_V0.5881.00
28_L142_T0.5851.00
233_K312_L0.5831.00
240_A315_H0.5831.00
313_E322_H0.5831.00
214_V324_V0.5831.00
42_Q58_V0.5831.00
232_E239_T0.5821.00
90_T94_G0.5811.00
38_E169_D0.5801.00
40_N47_E0.5801.00
402_V406_I0.5801.00
237_V308_W0.5761.00
98_L419_W0.5751.00
378_G382_V0.5741.00
192_I371_G0.5731.00
101_N165_Q0.5721.00
232_E236_H0.5701.00
278_S291_G0.5681.00
118_E122_A0.5661.00
221_G269_G0.5651.00
31_E41_A0.5631.00
228_V323_P0.5611.00
97_S186_R0.5601.00
191_L344_L0.5591.00
221_G267_N0.5571.00
233_K236_H0.5541.00
385_F411_I0.5541.00
237_V286_I0.5531.00
245_E266_V0.5521.00
218_S396_A0.5521.00
91_G155_D0.5511.00
241_I268_I0.5501.00
34_T128_K0.5491.00
34_T109_E0.5491.00
237_V241_I0.5491.00
101_N167_V0.5491.00
95_G160_G0.5471.00
123_V130_Y0.5471.00
223_T365_S0.5471.00
385_F389_E0.5441.00
212_I288_G0.5431.00
303_L310_K0.5411.00
305_L326_V0.5401.00
177_T374_L0.5351.00
288_G305_L0.5341.00
309_L326_V0.5341.00
115_W120_Y0.5331.00
262_I297_K0.5311.00
271_I286_I0.5301.00
356_K360_P0.5291.00
349_Q359_E0.5291.00
204_Q208_M0.5291.00
374_L382_V0.5291.00
37_S128_K0.5281.00
313_E323_P0.5261.00
84_N180_A0.5251.00
81_E183_R0.5241.00
235_M242_Q0.5241.00
32_K118_E0.5241.00
165_Q190_A0.5231.00
230_A280_V0.5231.00
212_I305_L0.5221.00
206_G335_P0.5221.00
355_M411_I0.5221.00
196_T393_A0.5191.00
290_C296_E0.5181.00
202_I362_I0.5181.00
116_K119_P0.5171.00
182_M377_A0.5171.00
237_V312_L0.5161.00
221_G289_R0.5161.00
389_E404_A0.5151.00
38_E42_Q0.5151.00
342_H381_P0.5151.00
52_F153_A0.5151.00
28_L45_V0.5141.00
406_I409_A0.5111.00
21_A25_L0.5111.00
200_L349_Q0.5111.00
119_P123_V0.5111.00
165_Q374_L0.5091.00
204_Q384_V0.5091.00
86_V165_Q0.5091.00
351_A411_I0.5081.00
352_Y356_K0.5081.00
205_Q265_P0.5071.00
24_L52_F0.5071.00
96_R189_G0.5061.00
229_S247_V0.5061.00
393_A398_E0.5051.00
160_G188_D0.5041.00
57_D86_V0.5031.00
201_F208_M0.5031.00
274_G284_V0.5021.00
227_G280_V0.5021.00
103_H136_D0.5011.00
298_P332_Q0.5001.00
181_I373_L0.5001.00
104_I168_V0.5001.00
328_W332_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfoA 2 0.9702 100 0.243 Contact Map
3iszA 2 0.8257 100 0.318 Contact Map
4pqaA 2 0.8349 100 0.318 Contact Map
1cg2A 4 0.8601 100 0.326 Contact Map
3rzaA 2 0.8349 100 0.327 Contact Map
2pokA 2 0.9037 100 0.331 Contact Map
4mmoA 2 0.8624 100 0.332 Contact Map
2zogA 2 0.9266 100 0.332 Contact Map
4g1pA 2 0.9427 100 0.335 Contact Map
3dljA 2 0.922 100 0.335 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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