GREMLIN Database
YOAP - Uncharacterized N-acetyltransferase YoaP
UniProt: O34983 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (245)
Sequences: 338 (239)
Seq/√Len: 15.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_A71_A5.4181.00
209_S213_E4.9871.00
39_R42_E4.7591.00
3_Y91_H3.9511.00
11_I37_K3.9191.00
64_E211_K3.5870.99
8_K41_D3.3180.99
47_Y98_K3.3160.99
73_N109_D3.0740.98
63_N108_M2.9800.98
5_E98_K2.8260.97
12_E37_K2.7890.97
3_Y47_Y2.6790.96
5_E47_Y2.5480.95
126_K130_E2.4160.93
172_K229_D2.3480.92
99_C181_Q2.1610.88
44_L181_Q2.0580.85
100_I149_L2.0510.85
109_D152_N1.9960.83
150_T157_S1.9610.82
23_K28_A1.9520.82
101_A105_A1.9420.81
100_I134_F1.9410.81
23_K55_V1.9410.81
76_Y112_I1.8920.80
75_M103_A1.8840.79
112_I225_S1.8600.78
98_K101_A1.8580.78
23_K26_E1.8490.78
103_A106_C1.7760.75
70_N159_A1.7650.75
97_D101_A1.7650.75
2_C50_H1.7600.74
49_L147_M1.7370.73
34_R247_L1.7210.73
16_I33_K1.7040.72
162_S165_K1.6240.68
59_Y102_D1.5760.66
126_K145_Q1.5750.66
15_H46_F1.5440.64
140_A143_Y1.5340.64
36_L39_R1.5290.63
80_L131_H1.5230.63
38_A209_S1.4620.60
38_A141_A1.4490.59
54_K83_S1.4280.58
109_D156_D1.4120.57
123_L181_Q1.4040.56
232_F237_I1.4010.56
139_E145_Q1.4000.56
69_I207_Q1.3960.56
143_Y236_E1.3790.55
93_K132_M1.3690.55
100_I104_K1.3660.54
6_I40_M1.3600.54
180_A207_Q1.3530.54
80_L124_S1.3210.52
11_I152_N1.3130.51
74_F124_S1.3050.51
194_E200_G1.2980.51
99_C111_I1.2940.50
168_S231_R1.2840.50
199_K248_N1.2770.49
100_I201_V1.2750.49
104_K111_I1.2730.49
201_V210_S1.2700.49
139_E185_A1.2680.49
70_N161_K1.2650.49
74_F148_A1.2630.49
44_L223_T1.2600.48
7_T154_L1.2510.48
82_V86_Y1.2470.48
6_I228_F1.2410.47
204_Q216_K1.2220.46
113_H147_M1.1710.43
44_L60_L1.1670.43
145_Q238_M1.1650.43
48_R51_E1.1600.43
143_Y235_H1.1590.43
49_L55_V1.1590.43
194_E198_K1.1550.42
162_S216_K1.1520.42
186_V193_R1.1480.42
42_E153_G1.1420.42
62_A215_Q1.1400.42
78_N222_T1.1380.42
96_L128_F1.1360.41
23_K103_A1.1350.41
38_A135_T1.1340.41
28_A55_V1.1310.41
60_L223_T1.1290.41
3_Y228_F1.1240.41
26_E55_V1.1160.40
65_A76_Y1.1150.40
196_T218_P1.1150.40
83_S122_Y1.1070.40
137_Q148_A1.0900.39
69_I136_L1.0800.38
104_K197_E1.0790.38
32_K35_W1.0780.38
76_Y201_V1.0750.38
3_Y225_S1.0700.38
80_L128_F1.0660.38
135_T141_A1.0590.37
136_L210_S1.0580.37
20_L209_S1.0560.37
181_Q223_T1.0550.37
28_A103_A1.0510.37
127_H200_G1.0500.37
192_L224_F1.0410.36
33_K119_K1.0410.36
228_F231_R1.0410.36
188_M236_E1.0340.36
50_H227_F1.0300.36
11_I100_I1.0260.36
45_V203_F1.0250.35
52_R189_I1.0160.35
94_R159_A1.0160.35
113_H129_F1.0120.35
175_T204_Q1.0120.35
94_R210_S1.0110.35
67_V76_Y1.0080.35
209_S231_R0.9920.34
93_K124_S0.9840.33
119_K122_Y0.9800.33
3_Y94_R0.9790.33
142_P239_S0.9780.33
22_T28_A0.9730.33
117_K120_L0.9720.33
105_A157_S0.9580.32
75_M106_C0.9580.32
112_I120_L0.9560.32
91_H208_L0.9560.32
21_S144_F0.9460.32
124_S147_M0.9370.31
154_L197_E0.9350.31
12_E163_Q0.9230.30
53_A86_Y0.9220.30
104_K159_A0.9200.30
51_E67_V0.9150.30
85_R167_D0.9150.30
42_E123_L0.9110.30
38_A72_P0.9050.30
92_A149_L0.9040.30
115_A128_F0.9030.29
147_M238_M0.9030.29
6_I36_L0.9030.29
89_N111_I0.8990.29
78_N233_V0.8920.29
221_W238_M0.8880.29
219_A237_I0.8840.29
161_K215_Q0.8830.29
206_I227_F0.8800.28
122_Y235_H0.8740.28
55_V86_Y0.8710.28
57_I77_I0.8680.28
89_N179_T0.8590.27
20_L179_T0.8580.27
113_H181_Q0.8560.27
145_Q166_S0.8560.27
92_A240_I0.8550.27
126_K129_F0.8510.27
38_A164_V0.8450.27
136_L139_E0.8430.27
74_F230_G0.8400.27
85_R112_I0.8390.27
81_W84_G0.8370.26
153_G172_K0.8340.26
235_H242_K0.8280.26
96_L132_M0.8240.26
3_Y89_N0.8230.26
116_G240_I0.8210.26
191_D240_I0.8190.26
144_F235_H0.8150.25
9_D13_D0.8150.25
121_P236_E0.8140.25
70_N246_L0.8100.25
211_K215_Q0.8060.25
112_I143_Y0.8020.25
28_A49_L0.8020.25
6_I164_V0.8010.25
3_Y112_I0.7980.25
3_Y101_A0.7950.25
22_T26_E0.7950.25
226_V239_S0.7940.25
11_I42_E0.7940.25
6_I30_N0.7940.25
11_I48_R0.7930.25
88_N220_I0.7910.24
156_D247_L0.7890.24
71_A224_F0.7870.24
193_R197_E0.7850.24
96_L245_K0.7840.24
93_K131_H0.7790.24
14_N48_R0.7790.24
147_M231_R0.7780.24
37_K77_I0.7740.24
50_H55_V0.7730.24
111_I193_R0.7730.24
168_S171_E0.7690.24
55_V207_Q0.7660.23
184_F226_V0.7650.23
22_T55_V0.7590.23
56_F81_W0.7570.23
194_E197_E0.7570.23
229_D246_L0.7490.23
135_T150_T0.7470.23
53_A115_A0.7460.23
18_C81_W0.7420.22
121_P235_H0.7390.22
9_D105_A0.7390.22
72_P135_T0.7380.22
145_Q221_W0.7340.22
184_F205_S0.7330.22
69_I153_G0.7300.22
29_V223_T0.7280.22
21_S122_Y0.7230.22
40_M154_L0.7210.22
192_L225_S0.7190.22
89_N152_N0.7170.22
106_C231_R0.7130.21
97_D151_W0.7120.21
15_H33_K0.7110.21
26_E103_A0.7090.21
37_K194_E0.7050.21
3_Y36_L0.7040.21
28_A176_I0.7030.21
104_K151_W0.7030.21
107_G130_E0.7020.21
115_A129_F0.6990.21
115_A144_F0.6930.21
192_L244_E0.6890.20
53_A77_I0.6830.20
71_A215_Q0.6830.20
17_C68_P0.6810.20
111_I196_T0.6780.20
93_K114_I0.6730.20
7_T152_N0.6720.20
176_I226_V0.6690.20
2_C37_K0.6650.20
23_K73_N0.6650.20
107_G152_N0.6640.20
33_K46_F0.6630.20
15_H178_Y0.6620.19
188_M191_D0.6610.19
18_C56_F0.6600.19
131_H231_R0.6600.19
217_S243_F0.6570.19
7_T179_T0.6560.19
2_C159_A0.6540.19
196_T217_S0.6540.19
109_D153_G0.6500.19
14_N53_A0.6490.19
14_N18_C0.6480.19
196_T211_K0.6470.19
60_L208_L0.6460.19
114_I123_L0.6450.19
28_A31_E0.6430.19
189_I205_S0.6430.19
4_I233_V0.6400.19
217_S222_T0.6320.18
71_A222_T0.6280.18
77_I166_S0.6270.18
176_I189_I0.6270.18
19_A33_K0.6250.18
75_M151_W0.6230.18
49_L103_A0.6230.18
115_A119_K0.6220.18
80_L181_Q0.6220.18
117_K145_Q0.6190.18
165_K204_Q0.6180.18
152_N197_E0.6140.18
104_K200_G0.6130.18
80_L247_L0.6120.18
69_I89_N0.6100.18
100_I111_I0.6090.18
136_L147_M0.6050.18
2_C172_K0.6050.18
232_F235_H0.6050.18
82_V146_L0.6040.18
128_F184_F0.6030.17
147_M221_W0.6010.17
44_L239_S0.5960.17
7_T246_L0.5940.17
29_V76_Y0.5930.17
123_L223_T0.5930.17
22_T203_F0.5930.17
22_T186_V0.5920.17
199_K247_L0.5920.17
34_R212_E0.5900.17
114_I189_I0.5890.17
113_H221_W0.5860.17
188_M240_I0.5850.17
41_D193_R0.5840.17
199_K233_V0.5840.17
9_D156_D0.5820.17
30_N34_R0.5820.17
51_E85_R0.5820.17
121_P188_M0.5800.17
194_E240_I0.5800.17
192_L246_L0.5770.17
8_K159_A0.5760.17
28_A174_I0.5760.17
99_C236_E0.5730.17
105_A135_T0.5730.17
100_I135_T0.5710.16
19_A127_H0.5700.16
44_L222_T0.5680.16
87_K215_Q0.5670.16
198_K223_T0.5670.16
14_N17_C0.5670.16
60_L98_K0.5660.16
36_L56_F0.5660.16
226_V233_V0.5660.16
44_L78_N0.5660.16
21_S119_K0.5630.16
6_I137_Q0.5620.16
3_Y98_K0.5620.16
75_M108_M0.5610.16
16_I52_R0.5580.16
114_I150_T0.5570.16
28_A185_A0.5560.16
31_E185_A0.5540.16
66_W125_D0.5540.16
98_K137_Q0.5490.16
40_M137_Q0.5490.16
3_Y149_L0.5490.16
41_D180_A0.5480.16
91_H190_N0.5440.16
24_Q86_Y0.5410.16
101_A153_G0.5400.16
185_A239_S0.5400.16
222_T237_I0.5400.16
28_A184_F0.5400.16
3_Y139_E0.5400.16
72_P97_D0.5400.16
11_I34_R0.5360.15
116_G121_P0.5350.15
199_K212_E0.5340.15
165_K227_F0.5340.15
8_K40_M0.5340.15
93_K197_E0.5330.15
176_I181_Q0.5320.15
79_C182_C0.5320.15
159_A204_Q0.5260.15
47_Y221_W0.5260.15
175_T226_V0.5260.15
73_N240_I0.5250.15
69_I92_A0.5240.15
64_E170_N0.5230.15
197_E247_L0.5230.15
118_K125_D0.5210.15
11_I40_M0.5210.15
15_H19_A0.5180.15
19_A122_Y0.5180.15
141_A166_S0.5170.15
100_I175_T0.5160.15
144_F179_T0.5120.15
60_L181_Q0.5120.15
111_I206_I0.5110.15
221_W232_F0.5090.15
101_A156_D0.5080.15
6_I212_E0.5070.15
175_T197_E0.5070.15
101_A159_A0.5050.14
94_R104_K0.5030.14
213_E229_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oh1A 1 0.5857 98.8 0.895 Contact Map
3dr6A 2 0.6056 98.8 0.895 Contact Map
2j8mA 2 0.5936 98.8 0.896 Contact Map
1n71A 4 0.5936 98.8 0.896 Contact Map
4jxqA 2 0.6494 98.8 0.897 Contact Map
2vezA 2 0.5418 98.7 0.9 Contact Map
1yr0A 2 0.5737 98.7 0.902 Contact Map
4u9vB 1 0.5777 98.7 0.902 Contact Map
1wwzA 2 0.5777 98.7 0.902 Contact Map
2jdcA 1 0.5498 98.6 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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