YOAP - BACSU - GREMLIN Contacts

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YOAP - Uncharacterized N-acetyltransferase YoaP

UniProt:	O34983	Sequences: MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGLVFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIADAKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAFKSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSPAIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	251 (245)
Sequences:	338 (239)
Seq/√Len:	15.2

BACSU - YOAP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
62_A	71_A	5.418	1.00
209_S	213_E	4.987	1.00
39_R	42_E	4.759	1.00
3_Y	91_H	3.951	1.00
11_I	37_K	3.919	1.00
64_E	211_K	3.587	0.99
8_K	41_D	3.318	0.99
47_Y	98_K	3.316	0.99
73_N	109_D	3.074	0.98
63_N	108_M	2.980	0.98
5_E	98_K	2.826	0.97
12_E	37_K	2.789	0.97
3_Y	47_Y	2.679	0.96
5_E	47_Y	2.548	0.95
126_K	130_E	2.416	0.93
172_K	229_D	2.348	0.92
99_C	181_Q	2.161	0.88
44_L	181_Q	2.058	0.85
100_I	149_L	2.051	0.85
109_D	152_N	1.996	0.83
150_T	157_S	1.961	0.82
23_K	28_A	1.952	0.82
101_A	105_A	1.942	0.81
100_I	134_F	1.941	0.81
23_K	55_V	1.941	0.81
76_Y	112_I	1.892	0.80
75_M	103_A	1.884	0.79
112_I	225_S	1.860	0.78
98_K	101_A	1.858	0.78
23_K	26_E	1.849	0.78
103_A	106_C	1.776	0.75
70_N	159_A	1.765	0.75
97_D	101_A	1.765	0.75
2_C	50_H	1.760	0.74
49_L	147_M	1.737	0.73
34_R	247_L	1.721	0.73
16_I	33_K	1.704	0.72
162_S	165_K	1.624	0.68
59_Y	102_D	1.576	0.66
126_K	145_Q	1.575	0.66
15_H	46_F	1.544	0.64
140_A	143_Y	1.534	0.64
36_L	39_R	1.529	0.63
80_L	131_H	1.523	0.63
38_A	209_S	1.462	0.60
38_A	141_A	1.449	0.59
54_K	83_S	1.428	0.58
109_D	156_D	1.412	0.57
123_L	181_Q	1.404	0.56
232_F	237_I	1.401	0.56
139_E	145_Q	1.400	0.56
69_I	207_Q	1.396	0.56
143_Y	236_E	1.379	0.55
93_K	132_M	1.369	0.55
100_I	104_K	1.366	0.54
6_I	40_M	1.360	0.54
180_A	207_Q	1.353	0.54
80_L	124_S	1.321	0.52
11_I	152_N	1.313	0.51
74_F	124_S	1.305	0.51
194_E	200_G	1.298	0.51
99_C	111_I	1.294	0.50
168_S	231_R	1.284	0.50
199_K	248_N	1.277	0.49
100_I	201_V	1.275	0.49
104_K	111_I	1.273	0.49
201_V	210_S	1.270	0.49
139_E	185_A	1.268	0.49
70_N	161_K	1.265	0.49
74_F	148_A	1.263	0.49
44_L	223_T	1.260	0.48
7_T	154_L	1.251	0.48
82_V	86_Y	1.247	0.48
6_I	228_F	1.241	0.47
204_Q	216_K	1.222	0.46
113_H	147_M	1.171	0.43
44_L	60_L	1.167	0.43
145_Q	238_M	1.165	0.43
48_R	51_E	1.160	0.43
143_Y	235_H	1.159	0.43
49_L	55_V	1.159	0.43
194_E	198_K	1.155	0.42
162_S	216_K	1.152	0.42
186_V	193_R	1.148	0.42
42_E	153_G	1.142	0.42
62_A	215_Q	1.140	0.42
78_N	222_T	1.138	0.42
96_L	128_F	1.136	0.41
23_K	103_A	1.135	0.41
38_A	135_T	1.134	0.41
28_A	55_V	1.131	0.41
60_L	223_T	1.129	0.41
3_Y	228_F	1.124	0.41
26_E	55_V	1.116	0.40
65_A	76_Y	1.115	0.40
196_T	218_P	1.115	0.40
83_S	122_Y	1.107	0.40
137_Q	148_A	1.090	0.39
69_I	136_L	1.080	0.38
104_K	197_E	1.079	0.38
32_K	35_W	1.078	0.38
76_Y	201_V	1.075	0.38
3_Y	225_S	1.070	0.38
80_L	128_F	1.066	0.38
135_T	141_A	1.059	0.37
136_L	210_S	1.058	0.37
20_L	209_S	1.056	0.37
181_Q	223_T	1.055	0.37
28_A	103_A	1.051	0.37
127_H	200_G	1.050	0.37
192_L	224_F	1.041	0.36
33_K	119_K	1.041	0.36
228_F	231_R	1.041	0.36
188_M	236_E	1.034	0.36
50_H	227_F	1.030	0.36
11_I	100_I	1.026	0.36
45_V	203_F	1.025	0.35
52_R	189_I	1.016	0.35
94_R	159_A	1.016	0.35
113_H	129_F	1.012	0.35
175_T	204_Q	1.012	0.35
94_R	210_S	1.011	0.35
67_V	76_Y	1.008	0.35
209_S	231_R	0.992	0.34
93_K	124_S	0.984	0.33
119_K	122_Y	0.980	0.33
3_Y	94_R	0.979	0.33
142_P	239_S	0.978	0.33
22_T	28_A	0.973	0.33
117_K	120_L	0.972	0.33
105_A	157_S	0.958	0.32
75_M	106_C	0.958	0.32
112_I	120_L	0.956	0.32
91_H	208_L	0.956	0.32
21_S	144_F	0.946	0.32
124_S	147_M	0.937	0.31
154_L	197_E	0.935	0.31
12_E	163_Q	0.923	0.30
53_A	86_Y	0.922	0.30
104_K	159_A	0.920	0.30
51_E	67_V	0.915	0.30
85_R	167_D	0.915	0.30
42_E	123_L	0.911	0.30
38_A	72_P	0.905	0.30
92_A	149_L	0.904	0.30
115_A	128_F	0.903	0.29
147_M	238_M	0.903	0.29
6_I	36_L	0.903	0.29
89_N	111_I	0.899	0.29
78_N	233_V	0.892	0.29
221_W	238_M	0.888	0.29
219_A	237_I	0.884	0.29
161_K	215_Q	0.883	0.29
206_I	227_F	0.880	0.28
122_Y	235_H	0.874	0.28
55_V	86_Y	0.871	0.28
57_I	77_I	0.868	0.28
89_N	179_T	0.859	0.27
20_L	179_T	0.858	0.27
113_H	181_Q	0.856	0.27
145_Q	166_S	0.856	0.27
92_A	240_I	0.855	0.27
126_K	129_F	0.851	0.27
38_A	164_V	0.845	0.27
136_L	139_E	0.843	0.27
74_F	230_G	0.840	0.27
85_R	112_I	0.839	0.27
81_W	84_G	0.837	0.26
153_G	172_K	0.834	0.26
235_H	242_K	0.828	0.26
96_L	132_M	0.824	0.26
3_Y	89_N	0.823	0.26
116_G	240_I	0.821	0.26
191_D	240_I	0.819	0.26
144_F	235_H	0.815	0.25
9_D	13_D	0.815	0.25
121_P	236_E	0.814	0.25
70_N	246_L	0.810	0.25
211_K	215_Q	0.806	0.25
112_I	143_Y	0.802	0.25
28_A	49_L	0.802	0.25
6_I	164_V	0.801	0.25
3_Y	112_I	0.798	0.25
3_Y	101_A	0.795	0.25
22_T	26_E	0.795	0.25
226_V	239_S	0.794	0.25
11_I	42_E	0.794	0.25
6_I	30_N	0.794	0.25
11_I	48_R	0.793	0.25
88_N	220_I	0.791	0.24
156_D	247_L	0.789	0.24
71_A	224_F	0.787	0.24
193_R	197_E	0.785	0.24
96_L	245_K	0.784	0.24
93_K	131_H	0.779	0.24
14_N	48_R	0.779	0.24
147_M	231_R	0.778	0.24
37_K	77_I	0.774	0.24
50_H	55_V	0.773	0.24
111_I	193_R	0.773	0.24
168_S	171_E	0.769	0.24
55_V	207_Q	0.766	0.23
184_F	226_V	0.765	0.23
22_T	55_V	0.759	0.23
56_F	81_W	0.757	0.23
194_E	197_E	0.757	0.23
229_D	246_L	0.749	0.23
135_T	150_T	0.747	0.23
53_A	115_A	0.746	0.23
18_C	81_W	0.742	0.22
121_P	235_H	0.739	0.22
9_D	105_A	0.739	0.22
72_P	135_T	0.738	0.22
145_Q	221_W	0.734	0.22
184_F	205_S	0.733	0.22
69_I	153_G	0.730	0.22
29_V	223_T	0.728	0.22
21_S	122_Y	0.723	0.22
40_M	154_L	0.721	0.22
192_L	225_S	0.719	0.22
89_N	152_N	0.717	0.22
106_C	231_R	0.713	0.21
97_D	151_W	0.712	0.21
15_H	33_K	0.711	0.21
26_E	103_A	0.709	0.21
37_K	194_E	0.705	0.21
3_Y	36_L	0.704	0.21
28_A	176_I	0.703	0.21
104_K	151_W	0.703	0.21
107_G	130_E	0.702	0.21
115_A	129_F	0.699	0.21
115_A	144_F	0.693	0.21
192_L	244_E	0.689	0.20
53_A	77_I	0.683	0.20
71_A	215_Q	0.683	0.20
17_C	68_P	0.681	0.20
111_I	196_T	0.678	0.20
93_K	114_I	0.673	0.20
7_T	152_N	0.672	0.20
176_I	226_V	0.669	0.20
2_C	37_K	0.665	0.20
23_K	73_N	0.665	0.20
107_G	152_N	0.664	0.20
33_K	46_F	0.663	0.20
15_H	178_Y	0.662	0.19
188_M	191_D	0.661	0.19
18_C	56_F	0.660	0.19
131_H	231_R	0.660	0.19
217_S	243_F	0.657	0.19
7_T	179_T	0.656	0.19
2_C	159_A	0.654	0.19
196_T	217_S	0.654	0.19
109_D	153_G	0.650	0.19
14_N	53_A	0.649	0.19
14_N	18_C	0.648	0.19
196_T	211_K	0.647	0.19
60_L	208_L	0.646	0.19
114_I	123_L	0.645	0.19
28_A	31_E	0.643	0.19
189_I	205_S	0.643	0.19
4_I	233_V	0.640	0.19
217_S	222_T	0.632	0.18
71_A	222_T	0.628	0.18
77_I	166_S	0.627	0.18
176_I	189_I	0.627	0.18
19_A	33_K	0.625	0.18
75_M	151_W	0.623	0.18
49_L	103_A	0.623	0.18
115_A	119_K	0.622	0.18
80_L	181_Q	0.622	0.18
117_K	145_Q	0.619	0.18
165_K	204_Q	0.618	0.18
152_N	197_E	0.614	0.18
104_K	200_G	0.613	0.18
80_L	247_L	0.612	0.18
69_I	89_N	0.610	0.18
100_I	111_I	0.609	0.18
136_L	147_M	0.605	0.18
2_C	172_K	0.605	0.18
232_F	235_H	0.605	0.18
82_V	146_L	0.604	0.18
128_F	184_F	0.603	0.17
147_M	221_W	0.601	0.17
44_L	239_S	0.596	0.17
7_T	246_L	0.594	0.17
29_V	76_Y	0.593	0.17
123_L	223_T	0.593	0.17
22_T	203_F	0.593	0.17
22_T	186_V	0.592	0.17
199_K	247_L	0.592	0.17
34_R	212_E	0.590	0.17
114_I	189_I	0.589	0.17
113_H	221_W	0.586	0.17
188_M	240_I	0.585	0.17
41_D	193_R	0.584	0.17
199_K	233_V	0.584	0.17
9_D	156_D	0.582	0.17
30_N	34_R	0.582	0.17
51_E	85_R	0.582	0.17
121_P	188_M	0.580	0.17
194_E	240_I	0.580	0.17
192_L	246_L	0.577	0.17
8_K	159_A	0.576	0.17
28_A	174_I	0.576	0.17
99_C	236_E	0.573	0.17
105_A	135_T	0.573	0.17
100_I	135_T	0.571	0.16
19_A	127_H	0.570	0.16
44_L	222_T	0.568	0.16
87_K	215_Q	0.567	0.16
198_K	223_T	0.567	0.16
14_N	17_C	0.567	0.16
60_L	98_K	0.566	0.16
36_L	56_F	0.566	0.16
226_V	233_V	0.566	0.16
44_L	78_N	0.566	0.16
21_S	119_K	0.563	0.16
6_I	137_Q	0.562	0.16
3_Y	98_K	0.562	0.16
75_M	108_M	0.561	0.16
16_I	52_R	0.558	0.16
114_I	150_T	0.557	0.16
28_A	185_A	0.556	0.16
31_E	185_A	0.554	0.16
66_W	125_D	0.554	0.16
98_K	137_Q	0.549	0.16
40_M	137_Q	0.549	0.16
3_Y	149_L	0.549	0.16
41_D	180_A	0.548	0.16
91_H	190_N	0.544	0.16
24_Q	86_Y	0.541	0.16
101_A	153_G	0.540	0.16
185_A	239_S	0.540	0.16
222_T	237_I	0.540	0.16
28_A	184_F	0.540	0.16
3_Y	139_E	0.540	0.16
72_P	97_D	0.540	0.16
11_I	34_R	0.536	0.15
116_G	121_P	0.535	0.15
199_K	212_E	0.534	0.15
165_K	227_F	0.534	0.15
8_K	40_M	0.534	0.15
93_K	197_E	0.533	0.15
176_I	181_Q	0.532	0.15
79_C	182_C	0.532	0.15
159_A	204_Q	0.526	0.15
47_Y	221_W	0.526	0.15
175_T	226_V	0.526	0.15
73_N	240_I	0.525	0.15
69_I	92_A	0.524	0.15
64_E	170_N	0.523	0.15
197_E	247_L	0.523	0.15
118_K	125_D	0.521	0.15
11_I	40_M	0.521	0.15
15_H	19_A	0.518	0.15
19_A	122_Y	0.518	0.15
141_A	166_S	0.517	0.15
100_I	175_T	0.516	0.15
144_F	179_T	0.512	0.15
60_L	181_Q	0.512	0.15
111_I	206_I	0.511	0.15
221_W	232_F	0.509	0.15
101_A	156_D	0.508	0.15
6_I	212_E	0.507	0.15
175_T	197_E	0.507	0.15
101_A	159_A	0.505	0.14
94_R	104_K	0.503	0.14
213_E	229_D	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2oh1A	1	0.5857	98.8	0.895	Contact Map
3dr6A	2	0.6056	98.8	0.895	Contact Map
2j8mA	2	0.5936	98.8	0.896	Contact Map
1n71A	4	0.5936	98.8	0.896	Contact Map
4jxqA	2	0.6494	98.8	0.897	Contact Map
2vezA	2	0.5418	98.7	0.9	Contact Map
1yr0A	2	0.5737	98.7	0.902	Contact Map
4u9vB	1	0.5777	98.7	0.902	Contact Map
1wwzA	2	0.5777	98.7	0.902	Contact Map
2jdcA	1	0.5498	98.6	0.902	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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