GREMLIN Database
DAPH - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase
UniProt: O34981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (185)
Sequences: 3749 (2476)
Seq/√Len: 182.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_N21_P3.6091.00
136_L140_A3.5731.00
127_G145_N3.1921.00
145_N171_D3.0551.00
11_S20_T2.9151.00
125_G144_K2.8651.00
105_E123_V2.6801.00
139_R156_G2.5841.00
107_G126_E2.4991.00
126_E144_K2.4531.00
108_D126_E2.3151.00
44_N66_S2.2771.00
170_D188_K2.2241.00
86_D89_N2.1651.00
84_M88_K2.1441.00
115_G133_N2.1361.00
171_D189_G2.1011.00
123_V141_T2.0721.00
86_D106_I2.0451.00
143_G170_D2.0321.00
167_V185_T2.0211.00
169_E185_T1.9501.00
146_C188_K1.9321.00
179_V194_A1.8951.00
171_D188_K1.8811.00
144_K170_D1.8171.00
169_E188_K1.7681.00
103_Q121_G1.7531.00
141_T167_V1.7031.00
132_M150_A1.6871.00
119_N138_G1.6611.00
178_A194_A1.6541.00
133_N151_G1.6381.00
110_A128_T1.6211.00
83_P93_R1.6211.00
118_I122_S1.6191.00
94_I111_V1.6151.00
107_G125_G1.6071.00
104_V118_I1.5901.00
40_K66_S1.5771.00
18_K21_P1.5521.00
140_A154_L1.5471.00
110_A144_K1.5391.00
146_C172_V1.5161.00
186_V190_A1.4941.00
142_V148_I1.4911.00
41_A62_E1.4801.00
136_L142_V1.4661.00
85_L89_N1.4471.00
80_S84_M1.4191.00
37_E68_I1.3911.00
129_M147_H1.3601.00
107_G144_K1.3461.00
184_V198_V1.3331.00
142_V146_C1.3291.00
101_R104_V1.3111.00
16_S50_V1.2791.00
157_V184_V1.2631.00
168_I172_V1.2611.00
37_E63_E1.2541.00
35_F39_A1.2511.00
142_V154_L1.2481.00
183_G200_N1.2421.00
113_M129_M1.2251.00
61_I65_Q1.2241.00
154_L157_V1.2201.00
106_I124_I1.2171.00
37_E40_K1.2151.00
29_E55_S1.2121.00
33_I59_T1.2041.00
149_G173_V1.1961.00
45_G57_I1.1911.00
72_V96_P1.1861.00
178_A192_V1.1831.00
47_T54_W1.1741.00
100_I104_V1.1521.00
106_I110_A1.1371.00
172_V187_G1.1181.00
121_G139_R1.1091.00
79_N83_P1.0921.00
101_R119_N1.0921.00
168_I180_V1.0841.00
76_D79_N1.0711.00
75_N79_N1.0671.00
113_M119_N1.0641.00
27_K31_E1.0531.00
151_G177_N1.0521.00
186_V198_V1.0501.00
128_T146_C1.0471.00
73_V76_D1.0271.00
19_S22_V1.0200.99
192_V198_V1.0190.99
138_G155_A1.0130.99
119_N135_V1.0120.99
147_H173_V0.9990.99
71_Y75_N0.9860.99
107_G128_T0.9850.99
40_K44_N0.9780.99
136_L148_I0.9740.99
34_N37_E0.9720.99
111_V129_M0.9680.99
193_A199_V0.9480.99
83_P87_L0.9480.99
91_K108_D0.9480.99
63_E68_I0.9450.99
172_V190_A0.9450.99
40_K43_I0.9390.99
82_I85_L0.9390.99
152_S157_V0.9330.99
75_N78_R0.9300.99
116_A132_M0.9270.99
125_G170_D0.9240.99
13_I20_T0.9230.99
71_Y74_E0.9110.99
74_E78_R0.9050.99
110_A125_G0.8990.99
77_R80_S0.8970.99
45_G48_G0.8890.99
154_L168_I0.8880.99
146_C170_D0.8850.99
139_R155_A0.8730.98
93_R98_A0.8600.98
151_G156_G0.8560.98
17_T51_F0.8550.98
105_E121_G0.8550.98
143_G167_V0.8540.98
146_C169_E0.8450.98
148_I152_S0.8450.98
152_S174_I0.8430.98
112_I116_A0.8410.98
124_I130_I0.8330.98
153_V177_N0.8210.98
100_I112_I0.8070.97
82_I86_D0.8060.97
131_D147_H0.8020.97
97_G117_S0.8000.97
180_V192_V0.7960.97
82_I100_I0.7900.97
128_T170_D0.7900.97
85_L88_K0.7880.97
94_I113_M0.7860.97
107_G110_A0.7860.97
173_V191_V0.7690.96
124_I128_T0.7600.96
78_R82_I0.7590.96
169_E187_G0.7570.96
128_T144_K0.7540.96
194_A199_V0.7510.96
168_I174_I0.7490.96
41_A59_T0.7420.96
64_N70_D0.7320.95
11_S61_I0.7300.95
133_N150_A0.7280.95
127_G144_K0.7270.95
151_G154_L0.7230.95
93_R100_I0.7210.95
73_V77_R0.7180.95
73_V84_M0.7130.95
135_V150_A0.7090.94
91_K106_I0.7050.94
185_T188_K0.7040.94
44_N48_G0.7040.94
8_E69_E0.6970.94
99_I115_G0.6940.94
37_E60_A0.6910.94
39_A43_I0.6910.94
128_T143_G0.6900.94
10_I64_N0.6890.94
117_S132_M0.6880.94
55_S58_Q0.6870.94
74_E83_P0.6870.94
60_A64_N0.6830.93
130_I134_V0.6800.93
121_G141_T0.6800.93
146_C168_I0.6780.93
79_N82_I0.6730.93
153_V156_G0.6720.93
143_G188_K0.6710.93
157_V183_G0.6690.93
110_A126_E0.6670.92
35_F38_S0.6650.92
72_V76_D0.6620.92
45_G62_E0.6600.92
180_V184_V0.6590.92
75_N83_P0.6580.92
176_A181_L0.6570.92
143_G146_C0.6510.92
67_K70_D0.6500.92
92_A109_N0.6480.91
20_T23_K0.6480.91
53_E57_I0.6460.91
17_T50_V0.6460.91
172_V188_K0.6440.91
78_R81_A0.6430.91
133_N153_V0.6430.91
26_V65_Q0.6410.91
97_G115_G0.6380.91
145_N170_D0.6360.91
169_E190_A0.6340.90
28_G31_E0.6320.90
125_G128_T0.6280.90
49_V55_S0.6270.90
36_G40_K0.6220.90
53_E58_Q0.6200.89
146_C174_I0.6100.89
180_V186_V0.6070.89
117_S135_V0.6060.88
177_N195_G0.6030.88
187_G190_A0.6020.88
151_G157_V0.5980.88
32_G38_S0.5980.88
6_A10_I0.5980.88
149_G153_V0.5970.88
123_V126_E0.5970.88
94_I114_M0.5940.87
104_V122_S0.5920.87
94_I98_A0.5910.87
78_R83_P0.5910.87
143_G169_E0.5900.87
93_R112_I0.5880.87
44_N62_E0.5860.87
135_V149_G0.5840.87
37_E41_A0.5830.86
86_D90_I0.5790.86
103_Q120_I0.5780.86
16_S51_F0.5780.86
176_A199_V0.5770.86
140_A157_V0.5770.86
194_A197_I0.5760.86
123_V144_K0.5760.86
181_L199_V0.5740.86
179_V183_G0.5710.85
29_E32_G0.5690.85
87_L90_I0.5690.85
11_S15_N0.5680.85
92_A111_V0.5600.84
89_N106_I0.5600.84
130_I148_I0.5570.84
12_F57_I0.5540.84
32_G128_T0.5540.84
142_V168_I0.5510.83
113_M116_A0.5510.83
8_E64_N0.5490.83
120_I139_R0.5480.83
77_R81_A0.5480.83
100_I106_I0.5470.83
74_E79_N0.5460.83
116_A133_N0.5460.83
33_I37_E0.5430.82
135_V153_V0.5430.82
105_E141_T0.5420.82
152_S156_G0.5350.81
61_I64_N0.5350.81
148_I174_I0.5340.81
183_G186_V0.5340.81
38_S42_F0.5280.81
112_I130_I0.5280.81
73_V78_R0.5260.80
43_I46_N0.5250.80
178_A181_L0.5230.80
44_N65_Q0.5220.80
101_R122_S0.5210.80
98_A118_I0.5210.80
14_Q17_T0.5180.79
134_V152_S0.5170.79
181_L197_I0.5170.79
86_D91_K0.5160.79
61_I68_I0.5160.79
17_T55_S0.5160.79
95_E99_I0.5100.78
17_T49_V0.5090.78
58_Q62_E0.5080.78
150_A153_V0.5080.78
38_S56_E0.5070.78
29_E58_Q0.5050.78
140_A153_V0.5030.77
28_G32_G0.5020.77
76_D83_P0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g3qA 3 0.9958 100 0.458 Contact Map
3r8yA 3 0.7881 100 0.467 Contact Map
1hm9A 3 0.9788 100 0.473 Contact Map
3tk8A 3 0.8051 100 0.475 Contact Map
2v0hA 3 0.9364 100 0.484 Contact Map
4fceA 3 0.9195 100 0.502 Contact Map
3gosA 3 0.9915 100 0.505 Contact Map
2iu8A 3 0.9831 100 0.512 Contact Map
3eg4A 3 0.9661 100 0.516 Contact Map
4hzdA 5 0.8771 100 0.522 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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