GREMLIN Database
YTNL - Uncharacterized hydrolase YtnL
UniProt: O34980 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (360)
Sequences: 28895 (20672)
Seq/√Len: 1089.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_D156_R3.3731.00
215_E276_T3.1471.00
66_K70_K2.9381.00
215_E278_V2.8161.00
47_H64_F2.7591.00
221_A229_G2.7451.00
235_G311_L2.5351.00
213_K278_V2.5151.00
124_I385_T2.4791.00
340_K404_R2.4511.00
97_A154_K2.4491.00
217_E312_K2.4391.00
66_K78_P2.4251.00
336_D404_R2.4231.00
340_K400_E2.3971.00
299_F303_E2.3821.00
295_K299_F2.3731.00
216_I239_L2.3631.00
90_A154_K2.3551.00
217_E276_T2.3541.00
68_C71_E2.3321.00
215_E314_N2.3051.00
69_L87_A2.2201.00
143_L399_Y2.2131.00
213_K280_E2.2061.00
265_N278_V2.1681.00
236_A264_I2.1661.00
213_K316_K2.1491.00
236_A277_V2.1331.00
64_F68_C2.1091.00
296_Q300_A2.0951.00
97_A156_R2.0901.00
217_E314_N2.0311.00
88_D154_K2.0241.00
236_A279_I2.0191.00
99_A181_I1.9641.00
335_R339_H1.9431.00
143_L147_N1.9231.00
263_K280_E1.9121.00
38_E392_I1.8971.00
59_F63_A1.8821.00
341_A400_E1.8681.00
72_K142_F1.8521.00
237_S240_I1.8351.00
238_Q241_V1.8341.00
51_Y64_F1.8341.00
40_Q142_F1.8191.00
114_G121_H1.7881.00
170_T174_E1.7661.00
239_L302_T1.7471.00
67_K71_E1.7411.00
334_V401_S1.7261.00
63_A67_K1.6951.00
60_E63_A1.6891.00
74_I89_I1.6821.00
337_A404_R1.6501.00
232_P277_V1.6251.00
41_L395_S1.6181.00
303_E307_A1.6011.00
292_N296_Q1.5891.00
219_K230_F1.5861.00
297_R300_A1.5831.00
44_I68_C1.5731.00
220_G275_D1.5671.00
237_S241_V1.5591.00
64_F67_K1.5561.00
400_E403_K1.5511.00
43_G47_H1.5371.00
234_I244_Q1.5331.00
215_E316_K1.5311.00
68_C72_K1.5291.00
46_R50_Q1.5231.00
47_H60_E1.5181.00
230_F235_G1.5131.00
66_K85_V1.5131.00
142_F146_E1.5081.00
115_L118_A1.5071.00
332_G335_R1.5021.00
47_H50_Q1.5001.00
62_T104_I1.4981.00
59_F83_T1.4931.00
238_Q309_F1.4921.00
290_V293_Q1.4851.00
99_A158_L1.4851.00
39_K43_G1.4851.00
361_L366_G1.4801.00
65_I104_I1.4601.00
171_K174_E1.4581.00
339_H344_Q1.4561.00
333_L404_R1.4381.00
96_P182_D1.4341.00
99_A184_V1.4301.00
114_G118_A1.4261.00
293_Q297_R1.4251.00
171_K175_D1.4221.00
63_A78_P1.4211.00
250_N297_R1.4191.00
242_A301_V1.4141.00
242_A304_Q1.4091.00
67_K70_K1.4051.00
75_Q90_A1.4041.00
225_L228_N1.3961.00
210_D291_R1.3951.00
400_E404_R1.3931.00
70_K78_P1.3911.00
136_A394_A1.3911.00
47_H51_Y1.3821.00
41_L139_G1.3541.00
89_I145_K1.3521.00
212_F281_G1.3441.00
393_K396_Y1.3381.00
214_V279_I1.3331.00
338_A397_F1.3311.00
50_Q120_K1.3271.00
238_Q308_A1.3251.00
216_I236_A1.3251.00
68_C142_F1.3161.00
255_Q287_D1.3131.00
300_A304_Q1.2991.00
92_E152_K1.2861.00
123_G389_T1.2791.00
306_S313_A1.2751.00
76_I79_T1.2751.00
257_A294_V1.2691.00
341_A396_Y1.2681.00
42_I46_R1.2651.00
296_Q299_F1.2621.00
43_G46_R1.2591.00
266_G277_V1.2551.00
53_E61_T1.2401.00
230_F311_L1.2291.00
337_A400_E1.2231.00
70_K76_I1.2211.00
100_L402_A1.2211.00
302_T313_A1.2111.00
63_A66_K1.2101.00
335_R348_P1.1991.00
333_L337_A1.1971.00
145_K148_Q1.1951.00
392_I396_Y1.1911.00
295_K317_W1.1891.00
389_T393_K1.1881.00
44_I139_G1.1861.00
336_D340_K1.1841.00
216_I235_G1.1831.00
100_L137_L1.1791.00
46_R388_E1.1761.00
233_I264_I1.1641.00
132_F386_I1.1581.00
66_K76_I1.1561.00
49_H127_A1.1511.00
40_Q43_G1.1491.00
300_A303_E1.1461.00
77_R88_D1.1461.00
55_S165_A1.1451.00
332_G336_D1.1341.00
44_I64_F1.1341.00
246_I297_R1.1281.00
183_A405_L1.1111.00
48_L61_T1.1091.00
50_Q118_A1.0971.00
328_E332_G1.0941.00
212_F295_K1.0911.00
261_V281_G1.0881.00
242_A245_T1.0861.00
293_Q296_Q1.0841.00
65_I134_T1.0811.00
191_P379_W1.0801.00
38_E389_T1.0761.00
132_F189_N1.0711.00
336_D339_H1.0701.00
38_E42_I1.0651.00
102_A132_F1.0651.00
49_H130_H1.0621.00
41_L135_A1.0541.00
60_E64_F1.0541.00
139_G142_F1.0511.00
147_N399_Y1.0451.00
241_V245_T1.0441.00
96_P153_G1.0441.00
299_F315_V1.0411.00
95_G153_G1.0371.00
199_G202_T1.0371.00
89_I151_L1.0321.00
147_N403_K1.0321.00
51_Y60_E1.0301.00
97_A182_D1.0281.00
187_L398_L1.0271.00
84_G161_P1.0251.00
47_H68_C1.0241.00
240_I279_I1.0221.00
62_T85_V1.0221.00
112_K383_A1.0111.00
371_F374_D1.0091.00
295_K319_S1.0071.00
387_D390_A1.0061.00
141_A157_L1.0061.00
301_V304_Q1.0051.00
287_D290_V1.0051.00
46_R119_S1.0021.00
369_A373_T0.9991.00
337_A341_A0.9931.00
269_T272_V0.9861.00
75_Q88_D0.9861.00
234_I240_I0.9831.00
40_Q44_I0.9781.00
41_L391_I0.9731.00
238_Q245_T0.9681.00
93_S152_K0.9631.00
132_F391_I0.9621.00
396_Y400_E0.9591.00
124_I387_D0.9581.00
74_I87_A0.9551.00
236_A240_I0.9551.00
91_G154_K0.9541.00
297_R301_V0.9541.00
48_L64_F0.9531.00
243_L298_F0.9471.00
110_E122_K0.9451.00
240_I261_V0.9451.00
202_T206_M0.9441.00
399_Y403_K0.9391.00
140_A399_Y0.9311.00
395_S399_Y0.9311.00
179_D363_H0.9301.00
233_I266_G0.9211.00
104_I159_F0.9101.00
238_Q242_A0.9091.00
143_L396_Y0.9071.00
301_V305_I0.9021.00
264_I277_V0.8951.00
373_T386_I0.8921.00
183_A330_I0.8881.00
213_K318_H0.8861.00
170_T359_Y0.8831.00
98_I183_A0.8821.00
213_K270_W0.8771.00
337_A340_K0.8771.00
339_H343_L0.8741.00
334_V369_A0.8711.00
140_A398_L0.8701.00
331_T367_S0.8691.00
270_W280_E0.8681.00
304_Q307_A0.8661.00
69_L138_L0.8641.00
386_I391_I0.8631.00
62_T66_K0.8621.00
214_V302_T0.8621.00
185_I405_L0.8591.00
56_K162_A0.8581.00
217_E275_D0.8571.00
214_V239_L0.8551.00
72_K145_K0.8531.00
40_Q68_C0.8511.00
333_L336_D0.8491.00
74_I141_A0.8481.00
102_A134_T0.8481.00
233_I277_V0.8471.00
116_P119_S0.8451.00
265_N268_S0.8441.00
156_R181_I0.8431.00
76_I87_A0.8431.00
304_Q308_A0.8421.00
238_Q244_Q0.8401.00
333_L401_S0.8401.00
53_E133_H0.8381.00
329_A332_G0.8371.00
234_I237_S0.8351.00
202_T332_G0.8351.00
44_I142_F0.8321.00
89_I141_A0.8311.00
240_I264_I0.8311.00
378_D381_H0.8301.00
208_A285_T0.8291.00
242_A305_I0.8261.00
184_V364_I0.8261.00
47_H67_K0.8221.00
123_G387_D0.8211.00
61_T104_I0.8211.00
389_T392_I0.8211.00
137_L157_L0.8201.00
305_I308_A0.8201.00
142_F145_K0.8181.00
288_S292_N0.8171.00
216_I279_I0.8151.00
334_V367_S0.8101.00
327_D330_I0.8081.00
86_F156_R0.8071.00
261_V279_I0.8061.00
337_A401_S0.8021.00
331_T335_R0.8011.00
141_A145_K0.7981.00
119_S125_M0.7971.00
390_A393_K0.7971.00
391_I395_S0.7971.00
317_W320_G0.7961.00
104_I134_T0.7931.00
199_G203_G0.7921.00
186_G368_F0.7851.00
303_E306_S0.7841.00
251_V257_A0.7771.00
300_A307_A0.7771.00
248_S251_V0.7741.00
185_I401_S0.7741.00
234_I245_T0.7701.00
147_N150_S0.7691.00
153_G182_D0.7671.00
143_L395_S0.7631.00
241_V244_Q0.7591.00
292_N295_K0.7561.00
71_E142_F0.7501.00
114_G120_K0.7491.00
109_I117_Y0.7471.00
113_T118_A0.7461.00
285_T291_R0.7461.00
289_E293_Q0.7461.00
211_R282_T0.7451.00
210_D295_K0.7411.00
50_Q119_S0.7401.00
329_A333_L0.7381.00
56_K165_A0.7371.00
243_L259_L0.7341.00
68_C138_L0.7321.00
212_F298_F0.7311.00
208_A323_P0.7301.00
143_L146_E0.7191.00
62_T83_T0.7191.00
370_F373_T0.7181.00
106_A117_Y0.7151.00
100_L140_A0.7131.00
359_Y363_H0.7101.00
219_K381_H0.7101.00
74_I145_K0.7091.00
121_H124_I0.7071.00
62_T78_P0.7061.00
44_I135_A0.7041.00
377_H383_A0.7031.00
321_P324_L0.7021.00
136_A395_S0.7011.00
221_A273_I0.7011.00
72_K138_L0.6951.00
333_L405_L0.6951.00
45_R125_M0.6931.00
305_I309_F0.6931.00
283_V294_V0.6881.00
291_R295_K0.6881.00
144_L149_D0.6871.00
367_S370_F0.6861.00
206_M370_F0.6851.00
140_A395_S0.6851.00
106_A128_C0.6841.00
54_L108_P0.6811.00
338_A341_A0.6811.00
334_V397_F0.6801.00
89_I157_L0.6791.00
65_I159_F0.6781.00
292_N319_S0.6761.00
93_S154_K0.6761.00
95_G154_K0.6741.00
97_A153_G0.6731.00
44_I47_H0.6731.00
44_I48_L0.6701.00
98_I402_A0.6701.00
74_I157_L0.6661.00
136_A140_A0.6661.00
244_Q309_F0.6661.00
92_E150_S0.6651.00
48_L134_T0.6641.00
136_A398_L0.6571.00
359_Y362_E0.6571.00
196_G346_I0.6551.00
259_L283_V0.6551.00
231_D274_P0.6541.00
357_F366_G0.6531.00
306_S311_L0.6521.00
178_L364_I0.6501.00
388_E392_I0.6501.00
252_N255_Q0.6501.00
85_V159_F0.6481.00
156_R180_G0.6471.00
373_T390_A0.6471.00
235_G309_F0.6461.00
186_G357_F0.6451.00
100_L185_I0.6451.00
378_D383_A0.6441.00
139_G395_S0.6441.00
198_V202_T0.6421.00
230_F310_S0.6401.00
137_L187_L0.6391.00
239_L279_I0.6381.00
114_G119_S0.6381.00
42_I392_I0.6371.00
167_A171_K0.6361.00
69_L74_I0.6361.00
265_N280_E0.6351.00
185_I330_I0.6351.00
195_V390_A0.6341.00
135_A139_G0.6321.00
121_H126_H0.6321.00
65_I138_L0.6311.00
214_V315_V0.6311.00
238_Q305_I0.6301.00
327_D332_G0.6291.00
167_A321_P0.6291.00
73_G76_I0.6281.00
65_I85_V0.6281.00
40_Q139_G0.6261.00
42_I388_E0.6261.00
355_E368_F0.6251.00
184_V366_G0.6241.00
177_Q180_G0.6221.00
377_H381_H0.6201.00
198_V203_G0.6201.00
60_E67_K0.6191.00
134_T159_F0.6191.00
54_L57_E0.6181.00
76_I85_V0.6141.00
337_A397_F0.6141.00
46_R49_H0.6131.00
211_R270_W0.6131.00
227_H252_N0.6121.00
101_R158_L0.6111.00
184_V357_F0.6101.00
364_I367_S0.6101.00
263_K278_V0.6071.00
162_A165_A0.6071.00
288_S362_E0.6051.00
136_A187_L0.6051.00
396_Y399_Y0.6041.00
212_F315_V0.6021.00
44_I138_L0.6011.00
169_A173_I0.6011.00
330_I367_S0.6011.00
112_K115_L0.6001.00
239_L301_V0.5991.00
112_K382_P0.5981.00
397_F401_S0.5971.00
369_A397_F0.5961.00
101_R160_Q0.5961.00
70_K75_Q0.5951.00
265_N276_T0.5941.00
54_L124_I0.5941.00
115_L119_S0.5931.00
237_S244_Q0.5931.00
216_I232_P0.5911.00
45_R135_A0.5911.00
202_T328_E0.5901.00
139_G143_L0.5901.00
55_S166_G0.5901.00
296_Q303_E0.5881.00
232_P274_P0.5851.00
45_R388_E0.5851.00
184_V360_Y0.5841.00
223_A260_T0.5831.00
54_L117_Y0.5821.00
158_L172_V0.5791.00
370_F374_D0.5791.00
288_S322_P0.5781.00
164_E380_H0.5761.00
234_I241_V0.5761.00
174_E363_H0.5751.00
197_T346_I0.5741.00
223_A262_G0.5741.00
126_H385_T0.5731.00
378_D385_T0.5711.00
51_Y61_T0.5701.00
172_V176_G0.5691.00
52_P57_E0.5691.00
371_F394_A0.5671.00
285_T294_V0.5671.00
306_S312_K0.5671.00
91_G94_E0.5661.00
84_G172_V0.5661.00
234_I238_Q0.5621.00
77_R86_F0.5621.00
214_V313_A0.5581.00
216_I302_T0.5561.00
187_L394_A0.5551.00
281_G298_F0.5551.00
86_F158_L0.5541.00
125_M388_E0.5541.00
78_P81_L0.5531.00
127_A130_H0.5511.00
341_A397_F0.5501.00
392_I395_S0.5491.00
299_F317_W0.5491.00
214_V281_G0.5481.00
223_A282_T0.5471.00
252_N256_S0.5471.00
212_F317_W0.5451.00
176_G179_D0.5441.00
245_T248_S0.5431.00
158_L184_V0.5421.00
88_D97_A0.5401.00
72_K146_E0.5401.00
325_C328_E0.5401.00
197_T345_V0.5341.00
54_L109_I0.5341.00
138_L142_F0.5311.00
113_T116_P0.5291.00
90_A93_S0.5291.00
78_P83_T0.5281.00
243_L261_V0.5281.00
48_L135_A0.5271.00
173_I363_H0.5261.00
235_G305_I0.5261.00
216_I311_L0.5241.00
338_A345_V0.5241.00
283_V289_E0.5241.00
115_L385_T0.5241.00
190_K379_W0.5221.00
239_L305_I0.5211.00
55_S58_E0.5201.00
339_H345_V0.5191.00
92_E154_K0.5191.00
140_A144_L0.5191.00
97_A181_I0.5181.00
330_I333_L0.5181.00
368_F373_T0.5171.00
41_L45_R0.5161.00
95_G152_K0.5161.00
207_A258_I0.5131.00
224_A352_T0.5131.00
134_T137_L0.5121.00
98_I405_L0.5111.00
232_P273_I0.5101.00
260_T282_T0.5091.00
239_L243_L0.5081.00
196_G199_G0.5081.00
242_A308_A0.5081.00
235_G238_Q0.5081.00
289_E292_N0.5071.00
178_L181_I0.5061.00
187_L371_F0.5031.00
158_L360_Y0.5031.00
113_T117_Y0.5021.00
190_K370_F0.5001.00
371_F386_I0.5001.00
240_I281_G0.5001.00
266_G276_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ewtA 4 0.9183 100 0.299 Contact Map
1ysjA 2 0.8606 100 0.314 Contact Map
3io1A 4 0.8438 100 0.325 Contact Map
1xmbA 1 0.8678 100 0.33 Contact Map
3pfoA 2 0.9038 100 0.341 Contact Map
3rzaA 2 0.8486 100 0.362 Contact Map
1cg2A 4 0.8918 100 0.364 Contact Map
3gb0A 2 0.8486 100 0.372 Contact Map
3ramA 4 0.8798 100 0.38 Contact Map
3iszA 2 0.851 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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