GREMLIN Database
MOXC - Putative monooxygenase MoxC
UniProt: O34974 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (381)
Sequences: 4643 (2688)
Seq/√Len: 137.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
279_E369_R6.5631.00
224_R250_D4.0211.00
192_K197_Q3.8621.00
375_E379_N3.6311.00
399_F403_V3.6131.00
50_L416_D3.5011.00
368_E406_I3.4271.00
150_E194_K3.3791.00
406_I409_E3.2081.00
373_L376_T3.1161.00
144_E147_E3.0931.00
277_D402_K3.0621.00
49_G400_V2.9941.00
279_E366_T2.9231.00
153_Q229_K2.7951.00
147_E194_K2.7811.00
280_E284_K2.7701.00
250_D254_R2.7641.00
248_Y252_K2.7291.00
225_Q254_R2.6571.00
279_E283_E2.6541.00
45_T397_D2.5721.00
245_K249_A2.5331.00
50_L408_Q2.4641.00
255_A265_V2.4401.00
261_D264_S2.3811.00
160_R211_E2.3711.00
135_R199_E2.3261.00
408_Q415_Q2.2731.00
40_M44_Q2.2171.00
277_D281_E2.2171.00
147_E150_E2.1961.00
287_R291_E2.1911.00
125_L214_V2.1691.00
225_Q257_D2.1641.00
161_G189_L2.1621.00
253_S257_D2.0871.00
80_L92_L2.0741.00
375_E412_L2.0401.00
154_E193_G2.0311.00
48_K401_E2.0121.00
153_Q230_N1.9751.00
285_K398_A1.9611.00
276_A281_E1.9521.00
101_T109_Q1.9491.00
146_T222_T1.9431.00
45_T48_K1.9411.00
114_D209_Q1.8871.00
37_E118_G1.8601.00
225_Q258_E1.8551.00
376_T380_A1.8431.00
224_R254_R1.8331.00
147_E195_Y1.8311.00
372_S410_R1.8041.00
315_P318_E1.7721.00
93_V122_G1.7561.00
256_A262_P1.7531.00
158_V198_V1.7501.00
271_I374_I1.7441.00
150_E222_T1.7401.00
245_K380_A1.7021.00
131_E135_R1.6981.00
29_D32_A1.6901.00
10_G53_F1.6821.00
160_R230_N1.6791.00
40_M86_V1.6631.00
234_I251_V1.6561.00
228_A254_R1.6511.00
41_K397_D1.6481.00
229_K258_E1.6421.00
36_I82_A1.6351.00
161_G191_H1.6151.00
84_A117_S1.6041.00
190_N199_E1.5981.00
75_E78_T1.5791.00
150_E195_Y1.5711.00
379_N412_L1.5551.00
27_D394_G1.5311.00
345_R355_E1.5201.00
154_E194_K1.5161.00
50_L417_Y1.5051.00
32_A35_N1.4901.00
249_A253_S1.4871.00
241_L380_A1.4771.00
158_V191_H1.4561.00
97_S128_S1.4561.00
125_L156_L1.4471.00
366_T369_R1.4251.00
44_Q48_K1.4191.00
93_V215_F1.4151.00
41_K44_Q1.4131.00
37_E40_M1.4131.00
83_L92_L1.4021.00
7_I378_F1.3971.00
404_I408_Q1.3861.00
96_F106_I1.3801.00
190_N200_G1.3751.00
89_N420_G1.3691.00
50_L413_Y1.3661.00
164_N211_E1.3631.00
241_L376_T1.3511.00
275_V403_V1.3421.00
37_E88_K1.3361.00
228_A258_E1.3311.00
375_E410_R1.3291.00
286_Y290_A1.3281.00
50_L415_Q1.3191.00
221_E254_R1.3091.00
158_V196_F1.3061.00
397_D401_E1.2941.00
278_T281_E1.2921.00
41_K45_T1.2771.00
398_A402_K1.2761.00
284_K288_E1.2641.00
215_F233_A1.2631.00
402_K406_I1.2631.00
275_V367_P1.2551.00
45_T400_V1.2531.00
269_P383_A1.2521.00
36_I40_M1.2521.00
111_M202_L1.2511.00
241_L245_K1.2511.00
284_K287_R1.2461.00
192_K199_E1.2401.00
157_D230_N1.2401.00
271_I363_F1.2271.00
153_Q157_D1.2241.00
254_R258_E1.2151.00
282_A364_I1.2001.00
157_D229_K1.1981.00
273_P399_F1.1971.00
111_M207_S1.1881.00
111_M204_I1.1801.00
225_Q229_K1.1760.99
253_S262_P1.1710.99
251_V265_V1.1700.99
255_A258_E1.1690.99
191_H196_F1.1690.99
242_E245_K1.1640.99
128_S133_A1.1630.99
283_E369_R1.1580.99
275_V370_V1.1580.99
78_T112_S1.1560.99
43_A87_T1.1500.99
283_E287_R1.1440.99
285_K288_E1.1390.99
140_S197_Q1.1230.99
46_A396_L1.1210.99
317_D350_R1.1190.99
221_E250_D1.1070.99
54_I90_I1.1060.99
164_N206_R1.1010.99
250_D253_S1.0970.99
309_Y314_Y1.0950.99
316_L350_R1.0870.99
157_D161_G1.0770.99
8_Q268_F1.0690.99
118_G208_K1.0670.99
328_K335_T1.0650.99
240_S243_E1.0650.99
368_E372_S1.0620.99
350_R354_Q1.0620.99
236_T247_F1.0610.99
80_L94_G1.0600.99
43_A90_I1.0580.99
254_R257_D1.0550.99
367_P402_K1.0540.99
151_I196_F1.0530.99
157_D191_H1.0460.99
312_S315_P1.0420.99
275_V366_T1.0390.99
207_S211_E1.0340.99
280_E283_E1.0330.99
277_D401_E1.0320.99
161_G165_S1.0290.99
219_S238_S1.0290.99
110_L121_A1.0290.99
33_S205_G1.0250.99
56_I80_L1.0210.99
283_E286_Y1.0170.99
253_S256_A1.0170.99
371_A406_I1.0160.98
286_Y364_I1.0150.98
44_Q86_V1.0150.98
52_S414_R1.0070.98
371_A403_V1.0040.98
9_F413_Y1.0020.98
241_L382_A0.9960.98
278_T282_A0.9940.98
48_K400_V0.9920.98
395_T398_A0.9920.98
248_Y267_I0.9910.98
287_R290_A0.9890.98
277_D367_P0.9860.98
158_V161_G0.9860.98
8_Q266_R0.9850.98
414_R418_R0.9810.98
8_Q52_S0.9790.98
256_A261_D0.9780.98
53_F93_V0.9760.98
143_P151_I0.9720.98
363_F370_V0.9700.98
127_T152_A0.9690.98
84_A92_L0.9680.98
35_N118_G0.9650.98
46_A51_F0.9640.98
408_Q413_Y0.9640.98
347_L355_E0.9640.98
190_N201_P0.9600.98
78_T81_S0.9590.98
372_S375_E0.9580.98
270_G360_R0.9580.98
327_G332_Q0.9570.98
45_T49_G0.9560.98
131_E141_N0.9540.98
219_S247_F0.9530.98
275_V402_K0.9490.98
406_I410_R0.9400.98
273_P388_V0.9390.97
276_A285_K0.9360.97
43_A54_I0.9350.97
47_E89_N0.9320.97
226_F230_N0.9290.97
378_F412_L0.9290.97
277_D398_A0.9280.97
375_E409_E0.9240.97
288_E291_E0.9230.97
238_S244_T0.9190.97
198_V201_P0.9160.97
40_M85_S0.9140.97
233_A268_F0.9120.97
155_H159_V0.9060.97
369_R372_S0.9050.97
188_R199_E0.9030.97
404_I413_Y0.9030.97
48_K88_K0.9010.97
59_G63_S0.9000.97
106_I155_H0.8930.97
48_K397_D0.8850.96
136_N201_P0.8820.96
243_E246_A0.8820.96
51_F400_V0.8800.96
361_T373_L0.8730.96
50_L414_R0.8720.96
414_R420_G0.8690.96
24_R292_L0.8650.96
60_L133_A0.8610.96
222_T226_F0.8600.96
100_F142_L0.8570.96
191_H194_K0.8540.96
106_I110_L0.8480.95
102_E105_T0.8450.95
206_R210_G0.8400.95
7_I374_I0.8300.95
400_V404_I0.8260.95
246_A249_A0.8260.95
123_W159_V0.8240.95
367_P403_V0.8230.95
159_V163_W0.8220.95
215_F385_G0.8190.94
9_F404_I0.8190.94
125_L226_F0.8190.94
9_F51_F0.8160.94
339_K343_K0.8150.94
162_L189_L0.8090.94
363_F374_I0.8080.94
115_H208_K0.8040.94
37_E41_K0.8030.94
114_D211_E0.8000.94
104_F201_P0.7990.94
332_Q336_D0.7990.94
99_S143_P0.7980.94
224_R251_V0.7980.94
242_E376_T0.7960.94
44_Q88_K0.7950.94
249_A382_A0.7910.93
156_L230_N0.7890.93
11_A390_S0.7870.93
156_L226_F0.7860.93
49_G408_Q0.7860.93
16_V22_G0.7840.93
153_Q222_T0.7840.93
7_I413_Y0.7830.93
256_A264_S0.7820.93
47_E417_Y0.7810.93
158_V189_L0.7790.93
237_H360_R0.7720.93
165_S189_L0.7690.92
214_V231_A0.7670.92
158_V193_G0.7670.92
144_E329_N0.7630.92
213_V232_D0.7600.92
94_G121_A0.7580.92
227_A234_I0.7560.92
25_H288_E0.7540.92
251_V267_I0.7500.91
136_N200_G0.7470.91
276_A398_A0.7460.91
165_S187_H0.7450.91
77_I81_S0.7440.91
31_S35_N0.7440.91
414_R417_Y0.7420.91
8_Q414_R0.7410.91
266_R384_D0.7360.91
105_T137_H0.7340.91
263_S382_A0.7310.90
252_K263_S0.7280.90
403_V406_I0.7280.90
11_A46_A0.7260.90
329_N332_Q0.7250.90
236_T244_T0.7210.90
408_Q417_Y0.7200.90
91_G122_G0.7190.90
113_L121_A0.7190.90
18_G389_G0.7180.90
288_E292_L0.7180.90
328_K331_F0.7150.89
244_T377_W0.7140.89
46_A90_I0.7130.89
275_V406_I0.7130.89
9_F374_I0.7110.89
251_V255_A0.7100.89
25_H292_L0.7090.89
92_L117_S0.7080.89
11_A14_H0.7060.89
255_A261_D0.7060.89
328_K332_Q0.7040.89
14_H18_G0.7040.89
53_F387_I0.7040.89
152_A226_F0.7030.89
164_N210_G0.7000.88
334_T360_R0.6980.88
10_G387_I0.6980.88
146_T332_Q0.6940.88
49_G401_E0.6940.88
43_A83_L0.6940.88
252_K255_A0.6930.88
101_T133_A0.6930.88
219_S236_T0.6920.88
74_F204_I0.6870.87
245_K252_K0.6870.87
102_E138_S0.6870.87
12_M18_G0.6830.87
114_D119_G0.6820.87
211_E232_D0.6800.87
318_E321_P0.6790.87
374_I386_F0.6780.87
242_E380_A0.6770.87
77_I109_Q0.6750.87
13_I54_I0.6740.86
114_D207_S0.6730.86
342_A347_L0.6720.86
82_A85_S0.6710.86
105_T109_Q0.6670.86
53_F215_F0.6670.86
192_K195_Y0.6660.86
281_E284_K0.6640.86
77_I96_F0.6640.86
40_M83_L0.6640.86
7_I412_L0.6630.86
315_P350_R0.6610.85
371_A407_L0.6600.85
277_D284_K0.6570.85
136_N198_V0.6570.85
363_F403_V0.6540.85
148_R220_S0.6540.85
15_G73_R0.6510.85
75_E109_Q0.6460.84
141_N151_I0.6460.84
228_A250_D0.6460.84
110_L163_W0.6460.84
370_V403_V0.6450.84
363_F373_L0.6440.84
366_T402_K0.6430.84
245_K248_Y0.6430.84
275_V398_A0.6420.84
221_E224_R0.6420.84
255_A262_P0.6410.84
82_A116_I0.6400.84
80_L121_A0.6400.84
246_A250_D0.6390.83
221_E225_Q0.6380.83
51_F388_V0.6380.83
49_G404_I0.6370.83
322_D343_K0.6370.83
89_N417_Y0.6370.83
248_Y383_A0.6350.83
413_Y417_Y0.6330.83
127_T148_R0.6330.83
58_D76_P0.6300.83
78_T113_L0.6290.82
161_G187_H0.6290.82
86_V92_L0.6290.82
138_S197_Q0.6270.82
216_Q223_G0.6270.82
34_T205_G0.6260.82
32_A41_K0.6260.82
335_T338_I0.6260.82
46_A54_I0.6210.82
266_R385_G0.6200.82
315_P319_P0.6180.81
83_L86_V0.6140.81
284_K368_E0.6140.81
41_K393_P0.6130.81
318_E349_L0.6120.81
367_P398_A0.6120.81
376_T379_N0.6080.80
154_E158_V0.6080.80
96_F110_L0.6060.80
38_F42_K0.6050.80
336_D339_K0.6050.80
228_A251_V0.6050.80
156_L159_V0.6040.80
78_T116_I0.6030.80
124_N149_Y0.6030.80
101_T106_I0.6030.80
286_Y362_L0.6030.80
281_E285_K0.6030.80
110_L113_L0.6020.80
52_S91_G0.6010.80
156_L160_R0.6000.79
320_F352_V0.5990.79
270_G389_G0.5980.79
237_H337_R0.5980.79
301_Y306_F0.5980.79
345_R373_L0.5970.79
369_R373_L0.5970.79
258_E265_V0.5960.79
316_L319_P0.5950.79
407_L411_G0.5950.79
81_S85_S0.5950.79
188_R201_P0.5950.79
124_N148_R0.5940.79
41_K48_K0.5940.79
248_Y382_A0.5930.79
11_A396_L0.5930.79
11_A42_K0.5920.79
252_K384_D0.5920.79
166_W206_R0.5920.79
236_T269_P0.5920.79
273_P374_I0.5910.78
84_A113_L0.5910.78
367_P406_I0.5900.78
274_I289_F0.5890.78
162_L201_P0.5870.78
284_K409_E0.5860.78
414_R419_G0.5860.78
134_A141_N0.5860.78
36_I116_I0.5840.78
80_L83_L0.5840.78
239_N243_E0.5840.78
360_R390_S0.5810.77
162_L203_N0.5800.77
342_A345_R0.5800.77
148_R218_G0.5790.77
160_R232_D0.5790.77
248_Y380_A0.5790.77
224_R247_F0.5770.77
79_I116_I0.5750.77
351_E354_Q0.5740.76
55_F95_T0.5730.76
272_S391_D0.5730.76
63_S130_Q0.5720.76
238_S247_F0.5700.76
319_P351_E0.5700.76
217_A223_G0.5700.76
104_F162_L0.5680.76
50_L89_N0.5670.76
52_S399_F0.5660.75
318_E322_D0.5660.75
334_T337_R0.5660.75
14_H19_T0.5660.75
396_L400_V0.5650.75
237_H334_T0.5650.75
293_I353_A0.5640.75
274_I286_Y0.5620.75
146_T150_E0.5620.75
37_E85_S0.5610.75
329_N335_T0.5610.75
252_K267_I0.5600.75
215_F268_F0.5600.75
60_L136_N0.5600.75
131_E329_N0.5560.74
13_I39_Y0.5560.74
245_K382_A0.5540.74
113_L117_S0.5530.74
124_N217_A0.5510.73
273_P370_V0.5500.73
36_I83_L0.5500.73
375_E378_F0.5490.73
59_G129_P0.5490.73
397_D400_V0.5480.73
228_A255_A0.5480.73
189_L199_E0.5470.73
216_Q231_A0.5460.73
33_S74_F0.5440.73
284_K291_E0.5430.72
298_A353_A0.5430.72
216_Q234_I0.5420.72
330_A335_T0.5420.72
140_S192_K0.5420.72
101_T155_H0.5410.72
126_V149_Y0.5410.72
380_A383_A0.5410.72
153_Q225_Q0.5410.72
25_H392_I0.5370.72
373_L377_W0.5370.72
213_V233_A0.5360.71
270_G387_I0.5360.71
314_Y349_L0.5350.71
354_Q357_A0.5340.71
45_T401_E0.5330.71
52_S408_Q0.5320.71
100_F137_H0.5320.71
366_T374_I0.5310.71
151_I155_H0.5290.70
313_V318_E0.5280.70
108_R114_D0.5280.70
60_L137_H0.5270.70
59_G70_F0.5270.70
13_I38_F0.5270.70
339_K342_A0.5260.70
101_T105_T0.5260.70
96_F123_W0.5250.70
149_Y220_S0.5250.70
154_E191_H0.5240.70
156_L214_V0.5230.70
326_V332_Q0.5230.70
110_L123_W0.5230.70
372_S406_I0.5210.69
126_V148_R0.5210.69
126_V223_G0.5200.69
289_F392_I0.5190.69
388_V399_F0.5190.69
62_I128_S0.5180.69
393_P397_D0.5180.69
45_T393_P0.5170.69
290_A354_Q0.5160.69
95_T217_A0.5160.69
244_T383_A0.5160.69
55_F235_F0.5160.69
162_L198_V0.5150.68
15_G74_F0.5150.68
236_T267_I0.5150.68
295_I316_L0.5140.68
378_F383_A0.5140.68
105_T133_A0.5140.68
371_A412_L0.5130.68
316_L349_L0.5130.68
80_L113_L0.5120.68
59_G130_Q0.5110.68
56_I75_E0.5100.68
151_I195_Y0.5090.68
77_I94_G0.5080.67
370_V374_I0.5080.67
74_F205_G0.5080.67
368_E410_R0.5070.67
326_V335_T0.5070.67
149_Y223_G0.5070.67
311_L314_Y0.5060.67
84_A116_I0.5060.67
74_F112_S0.5060.67
11_A388_V0.5050.67
47_E88_K0.5050.67
244_T269_P0.5050.67
360_R389_G0.5040.67
114_D210_G0.5020.66
271_I388_V0.5020.66
335_T339_K0.5010.66
70_F73_R0.5010.66
283_E364_I0.5000.66
223_G226_F0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tvlA 2 0.8801 100 0.173 Contact Map
3sdoA 2 0.9796 100 0.209 Contact Map
3b9oA 2 0.9231 100 0.258 Contact Map
1nqkA 4 0.776 100 0.42 Contact Map
3raoA 2 0.7873 100 0.428 Contact Map
2wgkA 2 0.7715 100 0.438 Contact Map
1lucA 1 0.7149 100 0.446 Contact Map
2i7gA 2 0.7466 100 0.449 Contact Map
3c8nA 2 0.7353 100 0.457 Contact Map
1ezwA 3 0.7489 100 0.465 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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