GREMLIN Database
YTAP - Putative hydrolase YtaP
UniProt: O34973 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (240)
Sequences: 21406 (15281)
Seq/√Len: 986.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_W144_D3.8781.00
179_A188_C3.7001.00
164_G187_V3.5381.00
45_N147_S3.0681.00
41_L49_K3.0241.00
64_C106_G2.6821.00
43_D49_K2.6551.00
175_A188_C2.5871.00
151_Y155_R2.4861.00
105_Y296_Q2.3771.00
38_E56_K2.3411.00
103_L292_V2.3281.00
66_A158_V2.2241.00
159_Q162_R2.2061.00
242_V277_S2.1101.00
164_G295_L2.0681.00
190_D193_S2.0441.00
52_A108_L2.0331.00
42_L148_A2.0321.00
253_D275_V1.9961.00
256_E270_D1.9601.00
40_L52_A1.9021.00
66_A106_G1.8851.00
103_L296_Q1.8631.00
189_V291_A1.8611.00
271_C290_E1.8481.00
189_V295_L1.8031.00
99_E103_L1.7741.00
149_L185_I1.7671.00
57_P106_G1.7601.00
72_S169_S1.7511.00
56_K106_G1.7301.00
176_W190_D1.7221.00
249_A275_V1.7151.00
272_Y275_V1.7071.00
165_T178_T1.7031.00
168_M192_C1.6561.00
54_F108_L1.6541.00
54_F106_G1.6411.00
108_L148_A1.6181.00
57_P64_C1.6161.00
108_L152_M1.6031.00
66_A152_M1.6031.00
165_T175_A1.5841.00
271_C297_K1.5841.00
227_I230_L1.5841.00
60_T63_P1.5811.00
289_H293_R1.5721.00
42_L52_A1.5691.00
151_Y154_S1.5641.00
168_M191_L1.5451.00
162_R186_K1.5221.00
149_L163_I1.5091.00
242_V275_V1.4771.00
60_T64_C1.4571.00
70_Q145_S1.4441.00
240_V249_A1.4421.00
138_W141_M1.4371.00
106_G158_V1.4301.00
276_R290_E1.4231.00
243_H278_A1.4111.00
249_A253_D1.3961.00
242_V278_A1.3891.00
215_V218_L1.3721.00
145_S178_T1.3641.00
146_L181_L1.3621.00
217_S221_H1.3571.00
67_V105_Y1.3371.00
290_E293_R1.3331.00
150_D184_R1.3301.00
236_H259_L1.3191.00
110_I148_A1.3101.00
165_T188_C1.3031.00
146_L150_D1.2991.00
238_S256_E1.2941.00
146_L182_D1.2921.00
40_L151_Y1.2861.00
216_P219_A1.2751.00
143_Y181_L1.2741.00
216_P220_K1.2651.00
189_V237_L1.2631.00
212_Y216_P1.2571.00
45_N143_Y1.2531.00
187_V295_L1.2481.00
55_V109_A1.2461.00
240_V252_V1.2421.00
238_S255_I1.2401.00
253_D257_K1.2151.00
52_A148_A1.2141.00
39_T51_P1.2081.00
161_D186_K1.2001.00
238_S252_V1.1971.00
259_L268_A1.1911.00
68_L149_L1.1881.00
63_P159_Q1.1741.00
71_H112_H1.1711.00
66_A108_L1.1671.00
150_D154_S1.1651.00
136_V139_G1.1541.00
97_S101_T1.1481.00
38_E155_R1.1381.00
256_E272_Y1.1251.00
179_A234_R1.1151.00
70_Q110_I1.1131.00
150_D182_D1.1111.00
41_L51_P1.1041.00
66_A163_I1.0951.00
67_V100_L1.0821.00
65_P162_R1.0701.00
188_C236_H1.0631.00
274_V290_E1.0551.00
69_F166_I1.0471.00
36_I58_K1.0451.00
190_D238_S1.0451.00
67_V166_I1.0391.00
212_Y215_V1.0391.00
46_G113_W1.0381.00
69_F97_S1.0311.00
237_L274_V1.0251.00
44_L48_E1.0221.00
49_K119_R1.0161.00
147_S150_D1.0021.00
97_S109_A0.9981.00
98_D102_S0.9941.00
153_Q184_R0.9931.00
191_L239_L0.9881.00
142_I177_W0.9801.00
36_I56_K0.9801.00
256_E260_T0.9791.00
192_C283_E0.9751.00
242_V249_A0.9721.00
292_V296_Q0.9701.00
284_T288_R0.9671.00
139_G143_Y0.9641.00
217_S220_K0.9601.00
176_W255_I0.9571.00
218_L221_H0.9561.00
99_E292_V0.9561.00
213_Y217_S0.9441.00
257_K265_G0.9431.00
65_P159_Q0.9381.00
139_G181_L0.9271.00
68_L185_I0.9181.00
51_P111_D0.9151.00
276_R279_S0.9141.00
166_I189_V0.9131.00
213_Y216_P0.9131.00
187_V294_F0.9081.00
211_F214_Y0.9061.00
285_A288_R0.9051.00
253_D272_Y0.9021.00
176_W193_S0.9021.00
177_W181_L0.9011.00
254_K257_K0.9001.00
180_A231_I0.8991.00
106_G157_D0.8971.00
39_T53_Y0.8961.00
146_L185_I0.8961.00
37_V55_V0.8901.00
143_Y147_S0.8891.00
267_G270_D0.8841.00
188_C234_R0.8831.00
229_S258_E0.8821.00
153_Q158_V0.8761.00
271_C274_V0.8721.00
55_V101_T0.8721.00
223_S226_E0.8691.00
52_A110_I0.8621.00
172_G190_D0.8551.00
239_L274_V0.8551.00
195_V255_I0.8551.00
276_R286_V0.8531.00
187_V235_P0.8481.00
166_I191_L0.8461.00
153_Q160_P0.8461.00
146_L178_T0.8441.00
220_K226_E0.8441.00
67_V295_L0.8421.00
176_W236_H0.8421.00
68_L108_L0.8371.00
99_E102_S0.8371.00
186_K235_P0.8351.00
70_Q165_T0.8301.00
70_Q175_A0.8301.00
175_A190_D0.8271.00
73_H170_M0.8221.00
145_S174_M0.8191.00
286_V290_E0.8141.00
293_R297_K0.8081.00
260_T270_D0.8061.00
140_M143_Y0.8011.00
229_S266_Q0.7991.00
42_L110_I0.7971.00
258_E266_Q0.7941.00
150_D153_Q0.7911.00
153_Q156_S0.7891.00
172_G193_S0.7891.00
206_L209_H0.7871.00
237_L290_E0.7861.00
101_T107_V0.7841.00
165_T185_I0.7791.00
63_P157_D0.7781.00
159_Q186_K0.7771.00
61_E64_C0.7751.00
196_D223_S0.7731.00
71_H115_F0.7731.00
42_L147_S0.7721.00
44_L147_S0.7671.00
44_L50_A0.7671.00
268_A271_C0.7591.00
180_A255_I0.7571.00
225_S228_Q0.7531.00
200_L203_T0.7491.00
193_S247_T0.7481.00
240_V247_T0.7471.00
169_S281_H0.7391.00
48_E119_R0.7391.00
56_K157_D0.7321.00
196_D254_K0.7271.00
214_Y217_S0.7251.00
52_A151_Y0.7181.00
136_V140_M0.7181.00
199_V254_K0.7131.00
51_P118_R0.7121.00
164_G186_K0.7121.00
239_L276_R0.7111.00
111_D116_G0.7071.00
192_C241_G0.7061.00
141_M170_M0.7061.00
46_G143_Y0.7041.00
179_A236_H0.7011.00
213_Y219_A0.6981.00
94_P98_D0.6971.00
212_Y218_L0.6961.00
284_T287_I0.6951.00
238_S259_L0.6951.00
68_L148_A0.6951.00
231_I234_R0.6941.00
189_V239_L0.6941.00
293_R296_Q0.6911.00
199_V202_K0.6901.00
55_V97_S0.6891.00
250_E253_D0.6861.00
69_F109_A0.6851.00
212_Y219_A0.6811.00
215_V219_A0.6791.00
97_S107_V0.6771.00
100_L166_I0.6761.00
192_C240_V0.6751.00
67_V164_G0.6741.00
211_F215_V0.6701.00
213_Y218_L0.6641.00
181_L227_I0.6631.00
69_F107_V0.6611.00
240_V275_V0.6591.00
191_L291_A0.6551.00
40_L54_F0.6551.00
55_V107_V0.6541.00
73_H112_H0.6511.00
142_I146_L0.6501.00
175_A179_A0.6491.00
180_A227_I0.6471.00
153_Q163_I0.6441.00
244_D281_H0.6401.00
192_C282_F0.6371.00
39_T117_D0.6371.00
115_F118_R0.6361.00
54_F157_D0.6361.00
271_C275_V0.6351.00
176_W195_V0.6311.00
214_Y218_L0.6311.00
59_K64_C0.6291.00
56_K64_C0.6271.00
173_L177_W0.6251.00
70_Q112_H0.6251.00
254_K258_E0.6241.00
250_E254_K0.6211.00
101_T106_G0.6211.00
196_D199_V0.6151.00
228_Q266_Q0.6131.00
245_R280_G0.6121.00
231_I255_I0.6111.00
100_L105_Y0.6111.00
105_Y295_L0.6101.00
236_H268_A0.6091.00
31_E34_E0.6081.00
266_Q270_D0.6071.00
34_E58_K0.6021.00
112_H115_F0.6021.00
285_A289_H0.6021.00
113_W140_M0.6001.00
111_D118_R0.5981.00
112_H170_M0.5941.00
68_L145_S0.5921.00
56_K60_T0.5921.00
153_Q186_K0.5911.00
141_M174_M0.5901.00
169_S244_D0.5871.00
231_I259_L0.5861.00
139_G222_F0.5861.00
193_S240_V0.5851.00
228_Q259_L0.5821.00
105_Y164_G0.5821.00
228_Q255_I0.5811.00
228_Q258_E0.5781.00
205_N246_L0.5771.00
177_W227_I0.5771.00
75_G173_L0.5771.00
211_F219_A0.5751.00
194_Q197_H0.5741.00
258_E265_G0.5721.00
207_D210_G0.5721.00
40_L155_R0.5721.00
216_P221_H0.5721.00
199_V251_G0.5701.00
152_M155_R0.5691.00
158_V163_I0.5651.00
173_L194_Q0.5631.00
200_L204_Q0.5621.00
137_M197_H0.5561.00
65_P105_Y0.5561.00
249_A272_Y0.5551.00
206_L210_G0.5531.00
43_D46_G0.5511.00
252_V272_Y0.5511.00
146_L149_L0.5491.00
44_L113_W0.5471.00
259_L270_D0.5451.00
177_W180_A0.5431.00
100_L292_V0.5431.00
44_L143_Y0.5391.00
40_L108_L0.5361.00
50_A110_I0.5341.00
70_Q174_M0.5341.00
199_V203_T0.5341.00
228_Q231_I0.5331.00
192_C244_D0.5321.00
287_I291_A0.5311.00
170_M174_M0.5271.00
48_E113_W0.5271.00
194_Q247_T0.5251.00
44_L47_H0.5241.00
286_V289_H0.5221.00
183_D233_P0.5201.00
100_L107_V0.5191.00
236_H255_I0.5171.00
198_H202_K0.5171.00
142_I174_M0.5151.00
241_G281_H0.5141.00
50_A118_R0.5121.00
198_H220_K0.5091.00
196_D251_G0.5091.00
58_K102_S0.5071.00
211_F216_P0.5041.00
168_M282_F0.5031.00
240_V272_Y0.5021.00
51_P117_D0.5021.00
198_H216_P0.5011.00
184_R234_R0.5011.00
45_N48_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nuzA 2 0.9666 100 0.358 Contact Map
2z3zA 2 0.893 100 0.369 Contact Map
1xfdA 2 0.9197 100 0.37 Contact Map
4q1vA 2 0.9331 100 0.372 Contact Map
1vlqA 5 0.9231 100 0.376 Contact Map
4wjlA 2 0.9231 100 0.38 Contact Map
1l7aA 5 0.9231 100 0.382 Contact Map
4hxfB 4 0.9097 100 0.384 Contact Map
2ecfA 2 0.9164 100 0.384 Contact Map
3g8yA 2 0.9732 100 0.387 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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