GREMLIN Database
YTTP - Probable HTH-type transcriptional regulator YttP
UniProt: O34970 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (178)
Sequences: 40378 (31956)
Seq/√Len: 2395.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R38_V3.9881.00
20_K29_E3.8841.00
15_M33_S3.4051.00
46_K50_G2.6871.00
17_F25_T2.3871.00
131_Q149_P2.2821.00
47_G50_G2.0901.00
12_S33_S2.0311.00
31_A41_I2.0221.00
16_L25_T2.0171.00
5_T8_K1.9991.00
82_Q136_E1.9731.00
16_L33_S1.9561.00
16_L29_E1.9381.00
131_Q135_E1.9261.00
16_L20_K1.9181.00
135_E148_L1.9071.00
7_D58_E1.8861.00
19_Q33_S1.8731.00
78_S81_E1.8341.00
8_K12_S1.7991.00
28_R32_K1.7971.00
6_K54_H1.7831.00
12_S15_M1.7681.00
14_V58_E1.7191.00
10_I54_H1.6601.00
37_N40_H1.6531.00
13_A17_F1.6041.00
7_D11_E1.5771.00
27_V42_S1.5691.00
29_E32_K1.5511.00
57_S118_I1.5131.00
27_V38_V1.4921.00
58_E62_G1.4911.00
14_V55_L1.4581.00
138_E145_T1.4551.00
54_H57_S1.4401.00
135_E139_K1.4371.00
135_E138_E1.4251.00
15_M19_Q1.4161.00
13_A51_L1.4101.00
45_F54_H1.4051.00
154_Q158_L1.4041.00
21_G25_T1.4031.00
68_E129_I1.3981.00
14_V59_F1.3931.00
137_G142_E1.3731.00
40_H43_Y1.3701.00
29_E33_S1.3631.00
27_V41_I1.3591.00
42_S47_G1.3511.00
21_G24_G1.3481.00
136_E140_Q1.3301.00
12_S16_L1.3191.00
25_T30_I1.3151.00
26_S29_E1.3071.00
53_E57_S1.3041.00
20_K24_G1.2801.00
84_L184_K1.2741.00
11_E58_E1.2711.00
138_E146_L1.2551.00
73_N76_T1.2461.00
127_K153_L1.2361.00
137_G143_Y1.2311.00
4_S8_K1.2291.00
36_V40_H1.2221.00
99_Q102_R1.2121.00
50_G54_H1.2101.00
84_L88_F1.1761.00
127_K131_Q1.1731.00
49_G53_E1.1601.00
22_F52_M1.1331.00
53_E118_I1.1301.00
80_Q84_L1.1241.00
10_I45_F1.1221.00
12_S34_A1.1191.00
39_A43_Y1.1161.00
138_E148_L1.1161.00
38_V42_S1.1141.00
88_F180_P1.1091.00
17_F22_F1.1091.00
82_Q133_I1.0991.00
66_T89_D1.0961.00
157_S161_M1.0811.00
13_A55_L1.0781.00
146_L151_F1.0711.00
6_K44_Y1.0651.00
37_N43_Y1.0621.00
81_E85_Q1.0461.00
78_S142_E1.0451.00
147_P150_H1.0371.00
133_I137_G1.0321.00
40_H44_Y1.0311.00
11_E15_M1.0271.00
10_I55_L1.0201.00
50_G53_E1.0171.00
180_P184_K1.0141.00
85_Q88_F1.0131.00
15_M99_Q1.0131.00
10_I58_E1.0001.00
14_V18_N0.9971.00
64_S125_K0.9961.00
70_A89_D0.9811.00
77_Q85_Q0.9781.00
81_E84_L0.9771.00
57_S61_E0.9721.00
129_I132_L0.9691.00
131_Q148_L0.9681.00
118_I121_T0.9651.00
20_K33_S0.9521.00
70_A85_Q0.9481.00
49_G114_L0.9461.00
124_M128_Y0.9431.00
4_S7_D0.9371.00
102_R106_R0.9351.00
30_I51_L0.9331.00
132_L136_E0.9331.00
68_E72_S0.9331.00
93_Y97_H0.9291.00
121_T125_K0.9231.00
54_H58_E0.9091.00
66_T69_T0.9061.00
101_T104_V0.9051.00
76_T82_Q0.8961.00
131_Q152_I0.8941.00
58_E61_E0.8821.00
31_A38_V0.8801.00
59_F62_G0.8761.00
38_V43_Y0.8761.00
79_T137_G0.8751.00
49_G112_S0.8701.00
149_P153_L0.8691.00
5_T44_Y0.8531.00
89_D92_S0.8531.00
73_N85_Q0.8511.00
85_Q89_D0.8501.00
132_L135_E0.8481.00
64_S68_E0.8431.00
127_K149_P0.8431.00
138_E141_R0.8411.00
117_E121_T0.8401.00
128_Y132_L0.8321.00
8_K11_E0.8301.00
166_P169_I0.8281.00
87_V155_L0.8231.00
136_E139_K0.8201.00
79_T140_Q0.8161.00
9_I41_I0.8151.00
8_K34_A0.8141.00
18_N99_Q0.8111.00
133_I136_E0.8091.00
88_F92_S0.8091.00
150_H181_Y0.8031.00
64_S129_I0.8011.00
41_I51_L0.7961.00
5_T36_V0.7911.00
61_E65_K0.7911.00
65_K69_T0.7861.00
128_Y131_Q0.7781.00
32_K38_V0.7781.00
116_R120_S0.7741.00
70_A73_N0.7731.00
125_K129_I0.7721.00
150_H154_Q0.7671.00
113_T117_E0.7661.00
57_S122_Y0.7631.00
111_D114_L0.7611.00
148_L152_I0.7591.00
20_K25_T0.7481.00
22_F48_K0.7341.00
76_T81_E0.7311.00
113_T116_R0.7291.00
84_L87_V0.7261.00
11_E14_V0.7241.00
99_Q103_F0.7231.00
28_R42_S0.7201.00
77_Q81_E0.7161.00
134_I155_L0.7151.00
125_K128_Y0.7131.00
9_I34_A0.7111.00
16_L19_Q0.7101.00
62_G65_K0.7021.00
107_E110_I0.6961.00
73_N77_Q0.6931.00
19_Q29_E0.6911.00
5_T37_N0.6821.00
71_A129_I0.6791.00
173_L177_P0.6761.00
27_V31_A0.6741.00
103_F106_R0.6701.00
87_V90_I0.6691.00
134_I148_L0.6651.00
57_S121_T0.6631.00
120_S124_M0.6621.00
69_T73_N0.6541.00
118_I122_Y0.6541.00
23_S107_E0.6481.00
17_F52_M0.6341.00
92_S96_N0.6341.00
104_V107_E0.6331.00
65_K68_E0.6331.00
9_I44_Y0.6321.00
154_Q157_S0.6271.00
23_S110_I0.6201.00
22_F49_G0.6121.00
102_R105_Y0.6091.00
10_I14_V0.6001.00
34_A37_N0.6001.00
106_R110_I0.5971.00
138_E143_Y0.5941.00
78_S82_Q0.5871.00
181_Y184_K0.5861.00
150_H153_L0.5861.00
76_T85_Q0.5841.00
134_I138_E0.5811.00
5_T40_H0.5801.00
31_A36_V0.5791.00
79_T142_E0.5791.00
100_L103_F0.5731.00
134_I151_F0.5721.00
158_L161_M0.5721.00
88_F183_Y0.5721.00
84_L180_P0.5711.00
93_Y96_N0.5691.00
147_P151_F0.5681.00
80_Q142_E0.5621.00
36_V44_Y0.5591.00
117_E120_S0.5581.00
97_H100_L0.5571.00
90_I94_Q0.5561.00
101_T105_Y0.5551.00
101_T106_R0.5551.00
174_Y177_P0.5541.00
157_S160_M0.5521.00
157_S165_Q0.5521.00
22_F25_T0.5511.00
135_E149_P0.5501.00
79_T143_Y0.5451.00
61_E122_Y0.5441.00
71_A132_L0.5421.00
107_E111_D0.5401.00
165_Q168_Y0.5361.00
60_Y125_K0.5331.00
88_F184_K0.5331.00
91_L95_H0.5331.00
151_F154_Q0.5321.00
100_L106_R0.5321.00
69_T89_D0.5291.00
66_T93_Y0.5271.00
173_L176_Q0.5241.00
62_G66_T0.5231.00
5_T43_Y0.5211.00
27_V48_K0.5201.00
79_T133_I0.5191.00
41_I46_K0.5171.00
31_A37_N0.5171.00
38_V41_I0.5151.00
122_Y126_E0.5151.00
99_Q105_Y0.5141.00
53_E117_E0.5121.00
34_A38_V0.5101.00
14_V62_G0.5091.00
92_S95_H0.5061.00
120_S123_L0.5041.00
178_H181_Y0.5031.00
145_T151_F0.5021.00
172_V176_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jykA 2 0.9372 100 0.253 Contact Map
3nrgA 2 0.9469 100 0.254 Contact Map
3npiA 2 0.9855 100 0.261 Contact Map
3f0cA 2 0.913 100 0.264 Contact Map
4kwaA 2 0.9227 100 0.266 Contact Map
2ibdA 2 0.9179 100 0.267 Contact Map
3dewA 2 0.9179 100 0.268 Contact Map
2qtqA 2 0.9372 100 0.268 Contact Map
3lsjA 2 0.9517 100 0.27 Contact Map
3himA 2 0.9227 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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