GREMLIN Database
YFJR - Uncharacterized oxidoreductase YfjR
UniProt: O34969 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (275)
Sequences: 11491 (7540)
Seq/√Len: 454.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_K151_D3.6031.00
71_S103_K3.3051.00
140_A144_Q3.3031.00
27_T47_A2.9731.00
114_F142_A2.8391.00
2_K25_E2.7731.00
114_F145_A2.6891.00
17_R42_E2.6801.00
40_V46_A2.6701.00
48_D52_L2.3231.00
235_S275_D2.2891.00
37_E41_T2.2011.00
144_Q147_K2.1841.00
36_T46_A2.1541.00
108_H113_Q2.1461.00
89_I146_A2.0171.00
13_Q38_D1.9951.00
211_G216_Q1.9731.00
20_L44_A1.9671.00
140_A159_D1.9041.00
198_E201_Q1.8991.00
24_Y152_S1.8921.00
81_L108_H1.8891.00
114_F139_P1.8221.00
62_T90_H1.8171.00
4_A53_A1.8001.00
99_E250_R1.7771.00
247_A250_R1.7751.00
49_T52_L1.7701.00
18_N21_Q1.7661.00
85_A88_G1.7281.00
22_A152_S1.7271.00
32_T35_K1.7231.00
34_Q37_E1.7041.00
235_S269_I1.6771.00
2_K27_T1.6751.00
25_E45_Q1.6751.00
109_A139_P1.6751.00
105_A163_E1.6701.00
33_K37_E1.6531.00
106_A110_E1.6501.00
51_R55_K1.6391.00
192_M202_F1.6281.00
139_P142_A1.6201.00
134_I153_L1.6191.00
74_T90_H1.6091.00
63_M93_M1.5941.00
273_F276_L1.5771.00
107_A110_E1.5761.00
89_I142_A1.5631.00
116_L138_G1.5521.00
84_L88_G1.5511.00
134_I154_S1.5421.00
118_A134_I1.5241.00
143_K147_K1.5191.00
28_V44_A1.5181.00
103_K107_A1.4931.00
18_N130_A1.4891.00
105_A109_A1.4711.00
116_L146_A1.4611.00
61_I93_M1.4351.00
200_K204_E1.4241.00
143_K159_D1.4221.00
37_E40_V1.4191.00
66_D69_S1.4081.00
51_R83_G1.4021.00
124_P128_A1.3991.00
53_A57_A1.3941.00
220_T224_E1.3821.00
180_S184_A1.3731.00
27_T45_Q1.3711.00
160_V170_A1.3621.00
67_D100_F1.3571.00
125_D129_K1.3571.00
172_I243_L1.3521.00
262_K266_E1.3291.00
206_A210_F1.3281.00
27_T56_S1.3131.00
234_M268_G1.3121.00
101_S115_F1.3111.00
102_E163_E1.3071.00
89_I145_A1.3061.00
21_Q42_E1.3031.00
193_E199_Q1.3001.00
56_S85_A1.2941.00
58_D85_A1.2911.00
259_E263_S1.2911.00
235_S274_G1.2881.00
108_H115_F1.2491.00
260_L263_S1.2461.00
17_R128_A1.2461.00
79_G82_E1.2441.00
63_M120_V1.2421.00
131_A155_Q1.2361.00
207_S216_Q1.2341.00
91_I146_A1.2321.00
14_P128_A1.2271.00
116_L143_K1.2261.00
33_K48_D1.2201.00
68_D72_T1.2181.00
238_L269_I1.2161.00
21_Q128_A1.2021.00
59_I89_I1.1971.00
249_K259_E1.1931.00
4_A57_A1.1911.00
146_A150_L1.1861.00
190_L194_K1.1751.00
139_P162_E1.1721.00
16_A26_L1.1711.00
88_G113_Q1.1641.00
179_V241_T1.1611.00
71_S107_A1.1611.00
102_E169_A1.1611.00
248_A255_L1.1531.00
47_A53_A1.1521.00
5_V15_I1.1511.00
82_E111_K1.1441.00
246_A250_R1.1411.00
50_P83_G1.1381.00
84_L113_Q1.1361.00
81_L111_K1.1351.00
59_I149_L1.1341.00
93_M134_I1.1291.00
179_V237_G1.1221.00
39_L44_A1.1221.00
97_S100_F1.1191.00
5_V16_A1.1141.00
195_Y251_V1.1121.00
17_R21_Q1.1091.00
254_N259_E1.1081.00
5_V61_I1.0941.00
38_D41_T1.0941.00
64_L73_V1.0921.00
10_N124_P1.0691.00
245_L259_E1.0611.00
263_S266_E1.0611.00
102_E106_A1.0491.00
90_H108_H1.0451.00
71_S100_F1.0431.00
52_L55_K1.0411.00
107_A111_K1.0361.00
136_T143_K1.0341.00
67_D97_S1.0301.00
238_L266_E1.0301.00
162_E166_T1.0291.00
105_A139_P1.0261.00
93_M153_L1.0261.00
27_T57_A1.0251.00
30_N35_K1.0241.00
106_A109_A1.0221.00
242_N262_K1.0211.00
61_I149_L1.0191.00
84_L90_H1.0091.00
54_A83_G0.9891.00
159_D162_E0.9891.00
206_A209_L0.9881.00
246_A249_K0.9881.00
78_D107_A0.9871.00
38_D42_E0.9691.00
116_L136_T0.9601.00
173_S192_M0.9571.00
189_F203_L0.9531.00
8_L39_L0.9531.00
266_E270_E0.9511.00
234_M269_I0.9491.00
151_D157_I0.9421.00
177_L188_S0.9411.00
232_F236_L0.9391.00
207_S215_Y0.9391.00
127_A132_L0.9361.00
61_I91_I0.9361.00
70_V96_I0.9351.00
50_P54_A0.9331.00
27_T53_A0.9281.00
86_E112_G0.9271.00
201_Q204_E0.9211.00
121_L174_I0.9211.00
69_S72_T0.9161.00
31_R69_S0.9121.00
180_S257_L0.9111.00
173_S188_S0.9111.00
78_D82_E0.9101.00
74_T108_H0.9061.00
242_N246_A0.9051.00
121_L135_I0.9031.00
47_A52_L0.9021.00
20_L43_G0.9021.00
34_Q38_D0.8961.00
138_G143_K0.8911.00
135_I205_I0.8911.00
144_Q159_D0.8861.00
100_F103_K0.8851.00
51_R79_G0.8851.00
160_V166_T0.8831.00
18_N153_L0.8821.00
213_P217_N0.8781.00
13_Q17_R0.8781.00
89_I114_F0.8781.00
169_A195_Y0.8771.00
74_T80_L0.8751.00
5_V26_L0.8731.00
59_I145_A0.8711.00
33_K46_A0.8701.00
97_S246_A0.8671.00
71_S104_L0.8641.00
203_L219_G0.8631.00
194_K253_A0.8571.00
269_I274_G0.8551.00
50_P53_A0.8531.00
101_S168_N0.8521.00
35_K38_D0.8511.00
169_A247_A0.8501.00
91_I118_A0.8471.00
160_V205_I0.8461.00
238_L262_K0.8431.00
96_I100_F0.8401.00
15_I153_L0.8391.00
181_M212_S0.8341.00
19_V61_I0.8341.00
117_A164_S0.8311.00
8_L28_V0.8291.00
186_S281_L0.8281.00
203_L207_S0.8261.00
170_A197_L0.8251.00
268_G280_A0.8211.00
103_K106_A0.8201.00
242_N266_E0.8151.00
142_A145_A0.8121.00
200_K224_E0.8081.00
65_A69_S0.8031.00
183_E257_L0.8021.00
276_L280_A0.7981.00
192_M197_L0.7971.00
117_A167_A0.7961.00
62_T70_V0.7961.00
2_K58_D0.7951.00
46_A49_T0.7941.00
148_P151_D0.7841.00
114_F141_E0.7831.00
267_S270_E0.7811.00
257_L261_A0.7811.00
228_E276_L0.7811.00
6_I50_P0.7791.00
60_V80_L0.7681.00
28_V36_T0.7681.00
233_K236_L0.7681.00
99_E102_E0.7671.00
140_A162_E0.7661.00
13_Q42_E0.7641.00
181_M185_L0.7641.00
233_K275_D0.7541.00
185_L215_Y0.7511.00
176_F258_A0.7501.00
194_K251_V0.7501.00
263_S267_S0.7491.00
92_S115_F0.7481.00
142_A146_A0.7471.00
81_L113_Q0.7371.00
147_K157_I0.7351.00
247_A251_V0.7351.00
123_R126_A0.7351.00
15_I93_M0.7341.00
116_L142_A0.7331.00
15_I132_L0.7301.00
6_I29_Y0.7291.00
19_V26_L0.7281.00
95_T243_L0.7271.00
234_M280_A0.7261.00
177_L185_L0.7251.00
137_A167_A0.7231.00
64_L69_S0.7231.00
59_I91_I0.7211.00
20_L42_E0.7201.00
176_F244_A0.7161.00
24_Y149_L0.7131.00
31_R35_K0.7121.00
104_L115_F0.7111.00
3_I19_V0.7091.00
81_L107_A0.7081.00
5_V63_M0.7071.00
245_L262_K0.7061.00
207_S211_G0.7001.00
51_R54_A0.6981.00
3_I24_Y0.6971.00
158_F205_I0.6941.00
62_T74_T0.6911.00
15_I63_M0.6851.00
207_S210_F0.6831.00
219_G222_M0.6821.00
3_I149_L0.6761.00
141_E144_Q0.6751.00
200_K223_A0.6731.00
190_L193_E0.6711.00
20_L26_L0.6681.00
143_K157_I0.6671.00
118_A136_T0.6621.00
2_K56_S0.6611.00
36_T40_V0.6601.00
51_R78_D0.6591.00
100_F104_L0.6591.00
33_K36_T0.6591.00
249_K262_K0.6561.00
267_S271_K0.6541.00
60_V84_L0.6521.00
177_L184_A0.6501.00
70_V94_S0.6481.00
181_M214_V0.6461.00
170_A202_F0.6451.00
13_Q39_L0.6431.00
70_V100_F0.6400.99
64_L70_V0.6390.99
150_L157_I0.6390.99
172_I244_A0.6350.99
173_S191_M0.6350.99
80_L84_L0.6340.99
177_L181_M0.6310.99
182_L278_W0.6290.99
136_T150_L0.6280.99
197_L202_F0.6280.99
16_A28_V0.6280.99
219_G223_A0.6240.99
147_K159_D0.6230.99
137_A159_D0.6230.99
126_A131_A0.6220.99
150_L154_S0.6220.99
96_I168_N0.6150.99
156_Q204_E0.6130.99
242_N249_K0.6130.99
213_P216_Q0.6110.99
169_A197_L0.6110.99
191_M255_L0.6090.99
115_F163_E0.6080.99
73_V79_G0.6060.99
97_S243_L0.6050.99
57_A60_V0.6040.99
238_L242_N0.6040.99
268_G273_F0.6030.99
137_A164_S0.6030.99
96_I101_S0.6030.99
30_N33_K0.6020.99
11_M15_I0.6020.99
221_I226_K0.6010.99
118_A150_L0.6000.99
180_S261_A0.5990.99
203_L223_A0.5980.99
177_L206_A0.5980.99
68_D71_S0.5980.99
72_T78_D0.5970.99
46_A50_P0.5950.99
72_T79_G0.5930.99
53_A56_S0.5870.99
245_L249_K0.5860.99
86_E111_K0.5850.99
9_G65_A0.5830.99
14_P124_P0.5810.99
70_V92_S0.5810.99
208_A211_G0.5800.99
30_N69_S0.5780.99
52_L56_S0.5780.99
62_T92_S0.5760.99
164_S167_A0.5750.99
190_L253_A0.5730.99
55_K83_G0.5720.99
136_T157_I0.5710.99
85_A113_Q0.5710.99
60_V88_G0.5700.99
186_S222_M0.5650.99
17_R20_L0.5630.99
36_T39_L0.5620.99
140_A143_K0.5610.99
126_A129_K0.5600.99
91_I150_L0.5590.99
254_N270_E0.5570.99
70_V104_L0.5540.99
45_Q56_S0.5520.99
218_Y222_M0.5510.98
142_A163_E0.5510.98
47_A54_A0.5500.98
8_L16_A0.5490.98
149_L152_S0.5470.98
59_I146_A0.5470.98
99_E103_K0.5470.98
148_P152_S0.5460.98
98_V169_A0.5440.98
51_R82_E0.5430.98
17_R38_D0.5400.98
47_A51_R0.5370.98
254_N267_S0.5370.98
37_E46_A0.5360.98
61_I153_L0.5340.98
176_F191_M0.5330.98
74_T104_L0.5300.98
92_S101_S0.5270.98
178_L214_V0.5260.98
266_E269_I0.5260.98
226_K229_P0.5260.98
61_I150_L0.5250.98
257_L260_L0.5240.98
264_H267_S0.5190.98
263_S270_E0.5150.98
140_A147_K0.5130.98
189_F219_G0.5130.98
4_A27_T0.5120.98
199_Q223_A0.5100.98
58_D88_G0.5090.97
122_G132_L0.5090.97
166_T169_A0.5080.97
14_P130_A0.5080.97
18_N22_A0.5050.97
101_S163_E0.5030.97
84_L87_N0.5010.97
30_N36_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dojA 3 0.993 100 0.355 Contact Map
3pefA 5 0.993 100 0.356 Contact Map
3pduA 4 0.993 100 0.357 Contact Map
1vpdA 1 0.993 100 0.358 Contact Map
3ckyA 4 0.993 100 0.358 Contact Map
3obbA 4 0.9895 100 0.36 Contact Map
3zgyA 2 0.979 100 0.364 Contact Map
3g0oA 3 0.9825 100 0.367 Contact Map
2uyyA 3 0.993 100 0.369 Contact Map
1yb4A 4 0.9895 100 0.37 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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