GREMLIN Database
YERB - Putative lipoprotein YerB
UniProt: O34968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (307)
Sequences: 807 (692)
Seq/√Len: 39.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_G287_T6.4791.00
122_H162_S4.9401.00
158_P161_N4.4291.00
299_V303_K3.5921.00
221_D228_T3.5081.00
55_V119_F3.4361.00
228_T244_P3.2571.00
104_A119_F2.8601.00
69_S241_T2.8501.00
221_D224_A2.8361.00
279_F284_V2.6531.00
226_F248_Q2.6191.00
53_A87_L2.5871.00
248_Q281_H2.5601.00
120_V150_F2.5551.00
230_S244_P2.5421.00
101_V164_T2.4911.00
261_D264_G2.4831.00
125_S128_A2.4621.00
252_I279_F2.3591.00
55_V108_F2.3541.00
219_N230_S2.3401.00
224_A228_T2.3151.00
66_S163_Y2.2711.00
251_F287_T2.1960.99
109_V132_L2.1640.99
74_V313_W2.1480.99
114_G291_Q2.0310.99
235_I244_P2.0300.99
95_P313_W2.0220.99
13_V16_L2.0070.99
275_K288_D1.9960.99
249_N312_T1.9750.99
269_D272_S1.9540.99
236_T245_V1.9470.99
275_K286_E1.9300.99
152_R161_N1.9140.98
218_Y315_N1.8540.98
89_I115_F1.8450.98
53_A89_I1.8330.98
200_S203_V1.8090.98
120_V169_I1.8030.98
114_G295_R1.7680.97
39_G189_F1.7310.97
114_G253_V1.7130.97
199_E202_N1.7090.97
287_T305_L1.6980.97
39_G309_P1.6960.97
288_D298_P1.6850.96
12_F15_F1.6760.96
17_L20_C1.6620.96
54_V101_V1.6600.96
228_T246_A1.6510.96
151_W165_S1.6460.96
253_V295_R1.6070.95
278_L287_T1.5990.95
226_F246_A1.5900.95
200_S227_Y1.5770.95
238_D241_T1.5660.95
202_N219_N1.5620.95
280_Q308_V1.5480.94
116_D179_K1.4870.93
124_W129_K1.4870.93
40_L309_P1.4860.93
199_E283_N1.4740.93
55_V87_L1.4240.91
121_H164_T1.4190.91
259_I266_R1.4190.91
142_G162_S1.4160.91
247_M311_K1.4030.91
229_R315_N1.4010.91
80_E160_H1.3990.91
19_S22_Q1.3950.90
121_H128_A1.3830.90
68_L100_P1.3670.90
82_Q266_R1.3560.89
278_L305_L1.3550.89
277_L286_E1.3480.89
218_Y247_M1.3450.89
251_F278_L1.3370.88
126_P265_R1.3360.88
299_V305_L1.3260.88
69_S245_V1.3200.88
63_R160_H1.3180.88
202_N207_Y1.3120.87
220_Y227_Y1.3030.87
68_L86_F1.2970.87
30_A33_L1.2940.87
254_E275_K1.2900.87
247_M315_N1.2830.86
256_S319_D1.2720.86
75_I114_G1.2720.86
90_F96_E1.2660.86
191_T309_P1.2650.85
251_F307_F1.2600.85
224_A246_A1.2490.85
129_K141_N1.2400.84
16_L19_S1.2340.84
14_F17_L1.2320.84
75_I253_V1.2210.83
29_T33_L1.2160.83
132_L139_Y1.2140.83
70_K93_Q1.2100.83
251_F314_I1.2070.83
203_V279_F1.2030.82
72_D92_S1.2000.82
70_K101_V1.1990.82
197_A200_S1.1970.82
78_L268_I1.1960.82
72_D77_A1.1810.81
274_G289_W1.1760.81
108_F119_F1.1740.81
75_I115_F1.1730.81
65_Q100_P1.1700.81
216_V229_R1.1700.81
72_D91_Q1.1630.80
277_L284_V1.1580.80
252_I317_V1.1430.79
230_S235_I1.1430.79
281_H308_V1.1390.79
63_R231_S1.1320.78
121_H124_W1.1310.78
251_F297_V1.1230.78
153_A156_S1.1160.77
296_I304_W1.1110.77
90_F166_Y1.1070.77
118_I173_A1.1040.77
152_R160_H1.1000.76
78_L318_P1.0910.76
189_F245_V1.0900.76
247_M313_W1.0890.76
120_V140_M1.0820.75
111_L316_I1.0780.75
95_P166_Y1.0770.75
56_V88_A1.0740.75
77_A316_I1.0680.74
35_A39_G1.0630.74
254_E277_L1.0580.73
151_W164_T1.0510.73
250_I279_F1.0360.72
218_Y229_R1.0350.72
197_A202_N1.0330.72
55_V77_A1.0250.71
203_V207_Y1.0250.71
51_P184_T1.0220.71
57_N232_D1.0050.70
66_S239_R0.9980.69
27_P30_A0.9980.69
82_Q257_H0.9930.69
139_Y178_Y0.9850.68
119_F260_I0.9830.68
17_L21_Q0.9800.68
151_W169_I0.9770.67
52_V120_V0.9730.67
142_G150_F0.9690.67
15_F18_V0.9630.66
146_D162_S0.9540.65
73_I115_F0.9500.65
13_V17_L0.9460.65
197_A207_Y0.9450.65
14_F34_K0.9400.64
254_E317_V0.9370.64
205_V305_L0.9360.64
124_W291_Q0.9340.64
187_L314_I0.9340.64
85_R102_R0.9300.63
227_Y238_D0.9290.63
85_R103_S0.9280.63
269_D273_G0.9120.62
164_T169_I0.9090.62
63_R86_F0.9030.61
261_D318_P0.9020.61
152_R158_P0.8970.61
31_K34_K0.8970.61
25_A29_T0.8940.60
62_A160_H0.8930.60
35_A189_F0.8860.60
225_E281_H0.8830.59
63_R68_L0.8790.59
290_K298_P0.8750.59
196_P199_E0.8750.59
273_G295_R0.8740.59
106_E260_I0.8740.59
237_T242_G0.8700.58
25_A30_A0.8690.58
27_P32_K0.8680.58
144_D199_E0.8630.58
156_S161_N0.8620.58
87_L104_A0.8530.57
68_L88_A0.8530.57
36_P39_G0.8530.57
57_N83_I0.8500.56
102_R105_R0.8460.56
50_R138_D0.8430.56
122_H143_L0.8410.56
253_V271_E0.8400.56
255_A316_I0.8370.55
17_L22_Q0.8370.55
124_W132_L0.8350.55
98_V148_S0.8300.55
57_N66_S0.8300.55
56_V98_V0.8300.55
78_L207_Y0.8250.54
25_A31_K0.8230.54
199_E235_I0.8220.54
51_P89_I0.8210.54
115_F314_I0.8180.54
204_R217_E0.8130.53
280_Q291_Q0.8120.53
272_S307_F0.8120.53
15_F30_A0.8080.53
65_Q86_F0.8070.53
28_D31_K0.8040.52
201_Y222_K0.8040.52
64_P156_S0.8020.52
37_L189_F0.8000.52
155_F159_P0.7990.52
54_V87_L0.7980.52
229_R247_M0.7970.52
122_H159_P0.7970.52
78_L266_R0.7970.52
295_R298_P0.7940.51
156_S159_P0.7870.51
32_K203_V0.7870.51
63_R242_G0.7870.51
55_V220_Y0.7850.51
253_V297_V0.7850.51
248_Q308_V0.7830.50
100_P232_D0.7810.50
264_G318_P0.7770.50
69_S243_K0.7760.50
121_H143_L0.7740.50
33_L41_K0.7710.49
74_V245_V0.7710.49
75_I87_L0.7680.49
190_Q193_D0.7660.49
76_E216_V0.7640.49
50_R118_I0.7630.49
81_G101_V0.7620.49
150_F162_S0.7580.48
53_A112_S0.7550.48
141_N145_F0.7550.48
197_A314_I0.7540.48
91_Q312_T0.7540.48
257_H268_I0.7530.48
205_V317_V0.7520.48
187_L297_V0.7520.48
276_G286_E0.7490.47
107_Y268_I0.7490.47
12_F16_L0.7480.47
291_Q294_G0.7450.47
104_A260_I0.7450.47
52_V169_I0.7440.47
227_Y282_G0.7440.47
152_R162_S0.7430.47
111_L128_A0.7390.46
191_T194_A0.7390.46
74_V290_K0.7390.46
55_V121_H0.7380.46
65_Q80_E0.7340.46
125_S265_R0.7280.45
107_Y265_R0.7250.45
55_V107_Y0.7230.45
57_N100_P0.7230.45
124_W172_A0.7230.45
169_I316_I0.7220.45
124_W141_N0.7200.45
109_V128_A0.7190.45
229_R313_W0.7180.45
149_L162_S0.7160.44
121_H139_Y0.7150.44
98_V166_Y0.7140.44
280_Q312_T0.7100.44
179_K183_E0.7080.44
78_L257_H0.7080.44
35_A38_T0.7040.43
233_G250_I0.7040.43
177_G241_T0.7030.43
222_K233_G0.7030.43
125_S164_T0.7020.43
12_F26_V0.7000.43
243_K303_K0.7000.43
79_A266_R0.7000.43
62_A152_R0.6990.43
217_E230_S0.6990.43
177_G201_Y0.6990.43
35_A92_S0.6950.42
57_N268_I0.6940.42
26_V154_D0.6940.42
276_G305_L0.6910.42
189_F307_F0.6880.42
114_G294_G0.6860.42
298_P304_W0.6860.42
100_P163_Y0.6850.42
237_T244_P0.6840.41
69_S238_D0.6800.41
29_T32_K0.6790.41
200_S207_Y0.6780.41
25_A28_D0.6720.40
10_L18_V0.6690.40
251_F300_K0.6670.40
299_V304_W0.6660.40
96_E192_S0.6660.40
62_A88_A0.6640.40
116_D209_T0.6630.40
58_N63_R0.6610.39
187_L312_T0.6580.39
75_I251_F0.6570.39
71_A88_A0.6570.39
14_F19_S0.6570.39
56_V68_L0.6550.39
126_P263_D0.6530.39
16_L20_C0.6530.39
168_Y171_K0.6520.39
198_N279_F0.6520.39
229_R257_H0.6490.38
10_L15_F0.6490.38
248_Q311_K0.6480.38
63_R152_R0.6460.38
288_D299_V0.6460.38
57_N86_F0.6460.38
27_P34_K0.6430.38
21_Q24_D0.6400.38
90_F246_A0.6380.37
10_L14_F0.6380.37
207_Y268_I0.6360.37
165_S242_G0.6360.37
171_K198_N0.6340.37
130_K134_S0.6330.37
72_D111_L0.6330.37
15_F20_C0.6330.37
63_R66_S0.6330.37
59_H160_H0.6320.37
77_A268_I0.6310.37
307_F312_T0.6310.37
63_R232_D0.6300.37
287_T290_K0.6300.37
139_Y169_I0.6290.37
155_F161_N0.6270.37
28_D32_K0.6260.36
255_A270_L0.6250.36
110_T131_Q0.6240.36
80_E159_P0.6240.36
152_R159_P0.6240.36
56_V233_G0.6220.36
80_E100_P0.6220.36
149_L164_T0.6200.36
156_S163_Y0.6180.36
126_P130_K0.6180.36
128_A160_H0.6170.36
197_A206_D0.6150.36
291_Q306_P0.6140.35
174_E243_K0.6140.35
72_D268_I0.6130.35
114_G251_F0.6130.35
107_Y160_H0.6100.35
76_E249_N0.6070.35
13_V40_L0.6060.35
164_T168_Y0.6060.35
255_A268_I0.6030.35
14_F89_I0.6010.34
14_F18_V0.5990.34
197_A203_V0.5980.34
258_H269_D0.5980.34
89_I97_T0.5980.34
288_D296_I0.5960.34
80_E161_N0.5960.34
36_P72_D0.5940.34
96_E234_V0.5930.34
69_S242_G0.5920.34
10_L13_V0.5920.34
22_Q222_K0.5910.34
26_V34_K0.5910.34
35_A91_Q0.5910.34
71_A90_F0.5910.34
121_H220_Y0.5900.33
73_I89_I0.5900.33
140_M176_K0.5880.33
77_A108_F0.5870.33
24_D28_D0.5840.33
81_G265_R0.5820.33
260_I265_R0.5820.33
52_V166_Y0.5820.33
108_F121_H0.5820.33
15_F32_K0.5810.33
56_V75_I0.5790.33
75_I314_I0.5790.33
261_D265_R0.5780.33
74_V86_F0.5760.32
278_L297_V0.5730.32
288_D301_D0.5710.32
36_P92_S0.5690.32
125_S143_L0.5680.32
98_V167_D0.5670.32
128_A143_L0.5650.31
82_Q121_H0.5650.31
112_S117_S0.5610.31
290_K316_I0.5610.31
157_K258_H0.5600.31
256_S269_D0.5600.31
156_S160_H0.5560.31
78_L265_R0.5560.31
107_Y119_F0.5540.31
92_S159_P0.5540.31
25_A33_L0.5510.30
285_I300_K0.5510.30
132_L172_A0.5510.30
78_L125_S0.5470.30
118_I138_D0.5470.30
47_T290_K0.5460.30
121_H214_N0.5440.30
280_Q305_L0.5430.30
174_E177_G0.5430.30
124_W143_L0.5380.29
115_F267_D0.5370.29
96_E256_S0.5360.29
113_N137_A0.5350.29
78_L218_Y0.5330.29
89_I117_S0.5330.29
114_G121_H0.5330.29
258_H293_N0.5330.29
256_S320_L0.5310.29
57_N62_A0.5300.29
66_S255_A0.5290.29
122_H161_N0.5280.29
38_T294_G0.5270.29
193_D225_E0.5260.29
114_G297_V0.5250.28
118_I140_M0.5240.28
149_L172_A0.5240.28
58_N80_E0.5210.28
245_V301_D0.5210.28
12_F22_Q0.5200.28
98_V168_Y0.5200.28
56_V130_K0.5200.28
38_T189_F0.5200.28
23_K32_K0.5190.28
10_L24_D0.5180.28
11_C29_T0.5180.28
207_Y233_G0.5170.28
11_C21_Q0.5160.28
48_E96_E0.5160.28
22_Q32_K0.5150.28
198_N202_N0.5140.28
116_D121_H0.5110.27
78_L208_G0.5110.27
121_H151_W0.5100.27
255_A266_R0.5100.27
30_A293_N0.5080.27
73_I232_D0.5080.27
28_D191_T0.5070.27
125_S165_S0.5060.27
100_P214_N0.5060.27
100_P124_W0.5060.27
124_W128_A0.5040.27
57_N172_A0.5030.27
125_S129_K0.5030.27
125_S268_I0.5030.27
82_Q128_A0.5000.27
108_F316_I0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2psbA 1 0.8731 100 0.145 Contact Map
3zbiC 1 0.0846 81.1 0.958 Contact Map
4yv7A 1 0.7674 72.5 0.961 Contact Map
4utoA 1 0.7221 72.2 0.961 Contact Map
1xt8A 1 0.6284 64 0.963 Contact Map
4wzzA 1 0.7704 58.4 0.965 Contact Map
4jg9A 2 0.3505 56.9 0.965 Contact Map
1yr2A 1 0.5952 56.5 0.965 Contact Map
2hyxA 2 0.852 51.5 0.966 Contact Map
2wtpA 2 0.2508 50.1 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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