ZNUA - BACSU - GREMLIN Contacts

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ZNUA - High-affinity zinc uptake system binding-protein ZnuA

UniProt:	O34966	Sequences: MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFYPMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPSAEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEVKNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYLAKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEIGAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	319 (288)
Sequences:	5829 (4656)
Seq/√Len:	274.3

ECOLI - ZNUA
BACSU - ZNUA MNTA
HALSA - Q9HHR6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_Q	190_Q	4.135	1.00
171_D	178_Y	3.970	1.00
57_K	174_N	3.866	1.00
54_V	58_G	3.854	1.00
57_K	177_Y	3.718	1.00
164_T	182_S	3.494	1.00
195_L	305_K	3.486	1.00
152_S	221_E	3.334	1.00
193_D	222_Y	3.195	1.00
161_K	186_I	3.173	1.00
175_K	179_E	2.930	1.00
171_D	174_N	2.637	1.00
157_Q	186_I	2.618	1.00
174_N	178_Y	2.615	1.00
50_T	90_V	2.590	1.00
168_V	179_E	2.579	1.00
164_T	168_V	2.501	1.00
52_Q	188_K	2.480	1.00
38_H	59_D	2.460	1.00
160_V	182_S	2.390	1.00
266_S	270_D	2.301	1.00
47_Y	62_L	2.143	1.00
49_F	156_A	2.102	1.00
174_N	177_Y	2.078	1.00
199_T	312_K	2.023	1.00
164_T	179_E	2.011	1.00
50_T	167_I	2.003	1.00
207_E	225_K	2.001	1.00
168_V	175_K	1.975	1.00
40_V	86_A	1.970	1.00
61_D	82_N	1.941	1.00
193_D	197_R	1.937	1.00
177_Y	181_N	1.927	1.00
270_D	274_S	1.927	1.00
50_T	163_I	1.926	1.00
182_S	186_I	1.898	1.00
140_E	143_H	1.830	1.00
47_Y	51_K	1.825	1.00
250_A	276_I	1.820	1.00
196_Y	308_L	1.820	1.00
36_K	59_D	1.768	1.00
248_T	252_E	1.762	1.00
298_L	302_D	1.720	1.00
249_Y	253_H	1.720	1.00
184_E	188_K	1.647	1.00
160_V	185_Y	1.639	1.00
154_V	221_E	1.633	1.00
195_L	309_D	1.622	1.00
120_G	162_N	1.609	1.00
90_V	117_A	1.600	1.00
166_Q	169_K	1.584	1.00
209_I	250_A	1.563	1.00
49_F	185_Y	1.562	1.00
176_E	180_K	1.560	1.00
299_G	302_D	1.546	1.00
188_K	301_I	1.542	1.00
244_A	248_T	1.512	1.00
88_L	166_Q	1.509	1.00
166_Q	170_Q	1.501	1.00
79_D	82_N	1.473	1.00
195_L	199_T	1.468	1.00
155_L	158_K	1.466	1.00
180_K	184_E	1.465	1.00
116_N	119_K	1.457	1.00
54_V	167_I	1.452	1.00
57_K	171_D	1.445	1.00
88_L	170_Q	1.435	1.00
121_I	124_M	1.433	1.00
309_D	313_D	1.419	1.00
38_H	87_D	1.404	1.00
207_E	253_H	1.403	1.00
199_T	309_D	1.403	1.00
38_H	61_D	1.400	1.00
154_V	193_D	1.395	1.00
179_E	183_K	1.393	1.00
53_I	182_S	1.389	1.00
117_A	159_E	1.380	1.00
48_E	52_Q	1.375	1.00
259_Y	314_S	1.341	1.00
158_K	162_N	1.331	1.00
183_K	187_A	1.328	1.00
194_K	198_T	1.317	1.00
196_Y	218_L	1.311	1.00
37_L	170_Q	1.310	1.00
39_V	167_I	1.307	1.00
188_K	305_K	1.305	1.00
190_Q	194_K	1.298	1.00
113_V	169_K	1.297	1.00
218_L	308_L	1.287	1.00
57_K	181_N	1.285	1.00
186_I	190_Q	1.272	1.00
149_V	159_E	1.269	1.00
161_K	164_T	1.267	1.00
52_Q	185_Y	1.265	1.00
183_K	186_I	1.257	1.00
41_T	47_Y	1.247	1.00
78_K	81_A	1.242	1.00
197_R	201_K	1.239	1.00
191_D	195_L	1.238	1.00
242_S	245_K	1.236	1.00
49_F	160_V	1.236	1.00
196_Y	304_M	1.220	1.00
91_Y	116_N	1.220	1.00
53_I	160_V	1.218	1.00
90_V	115_V	1.213	1.00
118_S	121_I	1.207	1.00
81_A	85_D	1.204	1.00
246_L	272_L	1.197	1.00
152_S	155_L	1.193	1.00
306_Q	310_A	1.190	1.00
219_A	224_L	1.188	1.00
187_A	191_D	1.177	1.00
124_M	220_K	1.175	1.00
165_A	168_V	1.168	1.00
73_W	79_D	1.158	1.00
39_V	58_G	1.155	1.00
91_Y	100_V	1.142	1.00
113_V	170_Q	1.139	1.00
305_K	309_D	1.136	1.00
162_N	166_Q	1.127	1.00
52_Q	301_I	1.121	1.00
75_P	99_W	1.119	1.00
250_A	278_A	1.117	1.00
247_K	275_E	1.112	1.00
176_E	179_E	1.112	1.00
187_A	190_Q	1.111	1.00
181_N	184_E	1.101	1.00
161_K	165_A	1.086	1.00
177_Y	180_K	1.076	1.00
238_P	268_V	1.071	1.00
71_H	148_H	1.061	1.00
247_K	272_L	1.057	1.00
46_M	117_A	1.052	1.00
205_K	256_K	1.050	1.00
291_K	295_D	1.043	1.00
55_K	177_Y	1.042	1.00
188_K	191_D	1.039	1.00
146_D	216_G	1.034	1.00
48_E	185_Y	1.031	1.00
180_K	183_K	1.026	1.00
17_L	20_A	1.017	1.00
53_I	178_Y	1.016	1.00
41_T	62_L	1.014	1.00
39_V	88_L	1.013	1.00
90_V	163_I	1.013	1.00
37_L	54_V	1.013	1.00
14_C	17_L	1.007	1.00
309_D	312_K	1.002	1.00
49_F	163_I	0.996	1.00
184_E	187_A	0.990	1.00
161_K	182_S	0.990	1.00
154_V	157_Q	0.988	1.00
257_V	281_E	0.987	1.00
158_K	161_K	0.978	1.00
206_K	223_G	0.977	1.00
227_V	249_Y	0.974	1.00
213_T	228_P	0.973	1.00
92_N	159_E	0.966	1.00
118_S	123_L	0.960	1.00
215_F	283_L	0.953	1.00
141_H	144_A	0.952	1.00
155_L	220_K	0.949	1.00
121_I	155_L	0.946	1.00
37_L	58_G	0.943	1.00
139_H	142_S	0.943	1.00
260_F	280_T	0.941	1.00
13_A	16_L	0.941	1.00
306_Q	309_D	0.940	1.00
157_Q	161_K	0.937	1.00
40_V	82_N	0.936	1.00
41_T	50_T	0.925	1.00
298_L	306_Q	0.925	1.00
115_V	166_Q	0.924	1.00
153_P	189_L	0.922	1.00
153_P	221_E	0.920	1.00
197_R	221_E	0.917	1.00
155_L	159_E	0.911	1.00
200_A	308_L	0.902	1.00
247_K	251_K	0.896	1.00
40_V	61_D	0.896	1.00
57_K	178_Y	0.895	1.00
40_V	63_L	0.893	1.00
273_A	280_T	0.893	1.00
193_D	221_E	0.891	1.00
258_I	273_A	0.887	1.00
54_V	60_V	0.873	1.00
156_A	304_M	0.873	1.00
207_E	227_V	0.868	1.00
164_T	186_I	0.867	1.00
14_C	18_V	0.865	1.00
185_Y	189_L	0.862	1.00
39_V	54_V	0.854	1.00
41_T	46_M	0.850	1.00
208_F	219_A	0.847	1.00
163_I	167_I	0.844	1.00
46_M	159_E	0.837	1.00
69_E	72_D	0.834	1.00
88_L	115_V	0.826	0.99
273_A	277_G	0.823	0.99
209_I	246_L	0.819	0.99
91_Y	114_F	0.816	0.99
208_F	226_Q	0.815	0.99
165_A	169_K	0.811	0.99
245_K	248_T	0.809	0.99
160_V	186_I	0.808	0.99
37_L	87_D	0.806	0.99
89_F	100_V	0.805	0.99
308_L	312_K	0.804	0.99
102_S	105_K	0.803	0.99
41_T	60_V	0.801	0.99
94_E	123_L	0.793	0.99
162_N	165_A	0.792	0.99
138_E	141_H	0.788	0.99
113_V	166_Q	0.788	0.99
90_V	166_Q	0.788	0.99
38_H	85_D	0.787	0.99
89_F	112_A	0.787	0.99
300_Y	304_M	0.783	0.99
208_F	224_L	0.771	0.99
210_T	215_F	0.769	0.99
190_Q	193_D	0.768	0.99
198_T	201_K	0.767	0.99
257_V	314_S	0.766	0.99
153_P	304_M	0.766	0.99
165_A	179_E	0.764	0.99
80_I	103_A	0.763	0.99
15_F	18_V	0.760	0.99
53_I	181_N	0.751	0.99
49_F	159_E	0.750	0.99
52_Q	181_N	0.744	0.99
203_A	206_K	0.744	0.99
48_E	51_K	0.743	0.99
89_F	104_E	0.741	0.99
195_L	312_K	0.739	0.99
195_L	308_L	0.736	0.99
179_E	182_S	0.736	0.99
161_K	183_K	0.727	0.99
121_I	126_G	0.722	0.99
225_K	253_H	0.717	0.99
245_K	249_Y	0.717	0.99
189_L	192_L	0.711	0.98
219_A	226_Q	0.709	0.98
248_T	251_K	0.708	0.98
208_F	311_L	0.707	0.98
241_A	244_A	0.705	0.98
304_M	308_L	0.704	0.98
117_A	162_N	0.704	0.98
281_E	310_A	0.700	0.98
154_V	197_R	0.698	0.98
195_L	198_T	0.696	0.98
267_K	270_D	0.695	0.98
239_S	242_S	0.694	0.98
191_D	194_K	0.694	0.98
21_C	24_S	0.694	0.98
168_V	182_S	0.692	0.98
39_V	50_T	0.691	0.98
50_T	54_V	0.689	0.98
200_A	224_L	0.688	0.98
149_V	155_L	0.688	0.98
40_V	83_I	0.687	0.98
69_E	234_P	0.685	0.98
39_V	60_V	0.685	0.98
46_M	92_N	0.679	0.98
104_E	114_F	0.677	0.98
63_L	83_I	0.674	0.98
87_D	170_Q	0.673	0.98
54_V	57_K	0.673	0.98
78_K	82_N	0.673	0.98
100_V	104_E	0.671	0.98
211_Q	260_F	0.671	0.98
302_D	305_K	0.668	0.98
52_Q	299_G	0.667	0.98
203_A	223_G	0.666	0.98
9_F	12_A	0.665	0.98
172_P	175_K	0.664	0.98
263_I	284_N	0.664	0.98
65_P	68_V	0.663	0.98
47_Y	60_V	0.662	0.98
156_A	159_E	0.660	0.98
12_A	15_F	0.660	0.98
168_V	178_Y	0.657	0.97
202_K	206_K	0.654	0.97
37_L	171_D	0.653	0.97
55_K	184_E	0.648	0.97
189_L	300_Y	0.648	0.97
53_I	164_T	0.646	0.97
160_V	164_T	0.645	0.97
210_T	213_T	0.642	0.97
58_G	167_I	0.642	0.97
259_Y	283_L	0.638	0.97
115_V	162_N	0.637	0.97
295_D	298_L	0.636	0.97
46_M	90_V	0.630	0.97
157_Q	164_T	0.630	0.97
188_K	299_G	0.629	0.97
94_E	118_S	0.627	0.97
231_G	234_P	0.626	0.97
263_I	288_G	0.626	0.97
269_A	273_A	0.626	0.97
196_Y	200_A	0.623	0.96
164_T	178_Y	0.622	0.96
83_I	103_A	0.622	0.96
275_E	278_A	0.618	0.96
279_K	313_D	0.618	0.96
42_T	97_E	0.617	0.96
153_P	193_D	0.616	0.96
37_L	167_I	0.612	0.96
197_R	223_G	0.609	0.96
260_F	269_A	0.609	0.96
148_H	212_H	0.608	0.96
53_I	168_V	0.608	0.96
121_I	158_K	0.607	0.96
209_I	255_V	0.604	0.96
260_F	264_A	0.602	0.96
94_E	147_P	0.601	0.96
280_T	283_L	0.601	0.96
212_H	261_E	0.600	0.96
156_A	300_Y	0.599	0.96
160_V	189_L	0.599	0.96
213_T	233_S	0.598	0.96
290_S	295_D	0.597	0.96
218_L	311_L	0.593	0.95
258_I	269_A	0.592	0.95
247_K	276_I	0.592	0.95
92_N	96_M	0.591	0.95
285_T	290_S	0.590	0.95
209_I	249_Y	0.590	0.95
98_T	101_P	0.588	0.95
194_K	197_R	0.584	0.95
70_P	263_I	0.581	0.95
271_T	274_S	0.578	0.95
42_T	91_Y	0.578	0.95
304_M	307_N	0.577	0.95
286_L	303_I	0.577	0.95
9_F	16_L	0.576	0.95
284_N	311_L	0.576	0.95
10_V	16_L	0.573	0.94
44_Y	48_E	0.572	0.94
271_T	275_E	0.572	0.94
287_E	290_S	0.571	0.94
51_K	60_V	0.571	0.94
301_I	305_K	0.571	0.94
9_F	13_A	0.570	0.94
92_N	149_V	0.569	0.94
153_P	301_I	0.567	0.94
272_L	276_I	0.567	0.94
192_L	301_I	0.566	0.94
211_Q	264_A	0.565	0.94
113_V	117_A	0.564	0.94
251_K	277_G	0.563	0.94
224_L	315_L	0.563	0.94
227_V	246_L	0.562	0.94
52_Q	160_V	0.559	0.94
202_K	205_K	0.559	0.94
77_P	240_A	0.555	0.93
199_T	203_A	0.555	0.93
216_G	220_K	0.555	0.93
127_S	141_H	0.554	0.93
83_I	107_M	0.552	0.93
99_W	103_A	0.551	0.93
157_Q	189_L	0.550	0.93
12_A	18_V	0.549	0.93
210_T	226_Q	0.547	0.93
250_A	258_I	0.547	0.93
17_L	21_C	0.546	0.93
20_A	23_N	0.545	0.93
43_F	96_M	0.544	0.93
285_T	289_L	0.543	0.93
18_V	21_C	0.543	0.93
101_P	105_K	0.543	0.93
39_V	90_V	0.542	0.93
125_E	145_M	0.541	0.93
263_I	286_L	0.540	0.92
76_T	79_D	0.540	0.92
43_F	69_E	0.540	0.92
310_A	313_D	0.540	0.92
262_E	284_N	0.539	0.92
64_I	70_P	0.539	0.92
284_N	303_I	0.538	0.92
24_S	32_S	0.537	0.92
45_P	48_E	0.537	0.92
210_T	219_A	0.537	0.92
118_S	149_V	0.537	0.92
12_A	16_L	0.536	0.92
19_A	22_G	0.536	0.92
261_E	264_A	0.535	0.92
284_N	287_E	0.535	0.92
159_E	163_I	0.534	0.92
172_P	178_Y	0.533	0.92
152_S	220_K	0.531	0.92
229_I	243_L	0.530	0.92
10_V	25_S	0.529	0.92
243_L	271_T	0.529	0.92
243_L	272_L	0.529	0.92
56_D	177_Y	0.528	0.92
146_D	212_H	0.527	0.92
226_Q	229_I	0.527	0.92
185_Y	301_I	0.527	0.92
108_G	112_A	0.526	0.92
15_F	19_A	0.526	0.92
260_F	282_V	0.525	0.91
199_T	308_L	0.525	0.91
71_H	212_H	0.523	0.91
45_P	286_L	0.523	0.91
55_K	60_V	0.521	0.91
151_L	304_M	0.518	0.91
214_A	261_E	0.518	0.91
120_G	124_M	0.517	0.91
191_D	305_K	0.517	0.91
109_Q	112_A	0.517	0.91
31_D	34_G	0.516	0.91
218_L	224_L	0.516	0.91
286_L	289_L	0.515	0.91
258_I	276_I	0.514	0.91
241_A	245_K	0.514	0.91
182_S	185_Y	0.513	0.90
153_P	222_Y	0.512	0.90
156_A	163_I	0.509	0.90
240_A	244_A	0.509	0.90
290_S	296_K	0.509	0.90
96_M	147_P	0.508	0.90
211_Q	261_E	0.508	0.90
115_V	163_I	0.507	0.90
146_D	219_A	0.507	0.90
200_A	203_A	0.507	0.90
75_P	103_A	0.507	0.90
192_L	305_K	0.506	0.90
231_G	242_S	0.505	0.90
48_E	299_G	0.504	0.90
44_Y	47_Y	0.503	0.90
192_L	304_M	0.502	0.90
21_C	25_S	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xrvA	1	0.815	100	0.113	Contact Map
2o1eA	1	0.8339	100	0.12	Contact Map
4utoA	1	0.8401	100	0.138	Contact Map
3cx3A	1	0.8307	100	0.151	Contact Map
2prsA	1	0.8245	100	0.167	Contact Map
4nnoA	1	0.8464	100	0.179	Contact Map
3ujpA	4	0.8433	100	0.18	Contact Map
1pq4A	1	0.815	100	0.18	Contact Map
1toaA	1	0.8464	100	0.189	Contact Map
4h0fA	1	0.8276	100	0.19	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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