GREMLIN Database
MAO4 - Probable NAD-dependent malic enzyme 4
UniProt: O34962 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (376)
Sequences: 4268 (1949)
Seq/√Len: 100.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_N111_N4.2171.00
187_V208_V3.7611.00
339_E386_T3.6901.00
269_K273_Q3.4531.00
326_R330_D3.1891.00
337_N386_T3.1871.00
219_A251_V3.1761.00
381_K385_E3.0871.00
46_D49_E2.9901.00
247_S250_D2.9651.00
71_T111_N2.9291.00
181_S184_S2.8671.00
189_A200_I2.8501.00
115_K118_E2.8341.00
116_I120_V2.8141.00
119_T122_L2.7771.00
114_D146_R2.7551.00
302_S359_A2.7111.00
269_K295_D2.6571.00
269_K298_E2.6301.00
136_A139_N2.6101.00
50_D53_K2.6101.00
168_V206_Y2.6071.00
114_D117_V2.5981.00
199_I261_V2.5381.00
175_L185_I2.4761.00
252_I267_L2.4681.00
53_K56_D2.3511.00
216_S232_K2.3461.00
145_E149_K2.3011.00
69_D139_N2.2671.00
51_I82_E2.2531.00
294_E311_F2.2531.00
337_N388_V2.2401.00
201_K235_V2.1961.00
148_K335_H2.1591.00
171_L257_V2.1471.00
224_R232_K2.1341.00
42_E46_D2.0281.00
201_K234_E1.9851.00
54_V60_K1.9691.00
301_A304_V1.9661.00
12_K56_D1.9601.00
118_E122_L1.9081.00
113_V117_V1.8981.00
249_K271_M1.8961.00
205_H338_E1.8701.00
331_V380_A1.8541.00
110_T115_K1.8411.00
328_A336_I1.8211.00
253_V274_S1.8111.00
172_V346_E1.7891.00
73_V79_I1.7881.00
42_E45_K1.7611.00
200_I213_M1.7601.00
258_F267_L1.7581.00
174_A280_I1.7371.00
124_E152_N1.7261.00
190_N266_A1.6911.00
382_A385_E1.6901.00
382_A386_T1.6881.00
217_K232_K1.6841.00
92_A103_A1.6831.00
24_V35_A1.6321.00
146_R149_K1.6191.00
272_V281_I1.6091.00
278_D302_S1.6081.00
216_S263_V1.5911.00
168_V202_L1.5871.00
148_K338_E1.5651.00
71_T78_N1.5621.00
116_I143_I1.5611.00
346_E350_S1.5591.00
167_T284_M1.5491.00
222_E237_K1.5471.00
55_Y60_K1.5321.00
197_I235_V1.5191.00
176_K353_S1.4961.00
265_G295_D1.4841.00
165_I324_I1.4781.00
185_I257_V1.4751.00
108_L123_L1.4531.00
69_D136_A1.4461.00
249_K274_S1.4451.00
113_V142_I1.4441.00
267_L274_S1.4411.00
382_A388_V1.4411.00
288_N292_M1.4361.00
303_V362_V1.4321.00
271_M274_S1.4321.00
212_V219_A1.4311.00
118_E121_K1.4191.00
170_G282_F1.4171.00
292_M295_D1.4131.00
340_M383_A1.4061.00
54_V82_E1.4061.00
268_T271_M1.4011.00
332_R390_R1.4011.00
249_K270_E1.3871.00
230_D233_N1.3851.00
110_T122_L1.3840.99
106_I123_L1.3800.99
22_S26_V1.3700.99
192_A213_M1.3580.99
264_A288_N1.3530.99
44_C79_I1.3490.99
377_K381_K1.3400.99
139_N142_I1.3380.99
291_I296_A1.3340.99
185_I208_V1.3280.99
215_D232_K1.3240.99
221_Y228_M1.3140.99
293_P304_V1.3100.99
294_E298_E1.2990.99
320_A324_I1.2980.99
45_K48_H1.2890.99
215_D224_R1.2870.99
149_K335_H1.2850.99
114_D118_E1.2760.99
106_I127_F1.2760.99
196_G261_V1.2610.99
164_A202_L1.2600.99
338_E341_K1.2520.99
168_V345_V1.2510.99
67_V120_V1.2490.99
132_L155_V1.2480.99
320_A348_I1.2400.99
172_V206_Y1.2370.99
182_M208_V1.2350.99
142_I146_R1.2340.99
171_L203_L1.2300.99
200_I211_I1.2280.99
270_E273_Q1.2110.99
295_D298_E1.2100.99
108_L119_T1.2070.99
337_N382_A1.2030.99
190_N214_C1.1990.99
82_E109_N1.1990.99
117_V153_I1.1980.99
51_I122_L1.1950.99
276_A301_A1.1910.98
351_L370_R1.1810.98
84_A107_A1.1790.98
223_G233_N1.1560.98
330_D380_A1.1560.98
81_P84_A1.1520.98
216_S220_I1.1510.98
117_V146_R1.1500.98
222_E243_R1.1490.98
27_R31_D1.1420.98
268_T274_S1.1380.98
273_Q299_A1.1350.98
252_I274_S1.1300.98
113_V146_R1.1260.98
195_A261_V1.1210.98
121_K146_R1.1110.98
204_H211_I1.0960.97
114_D152_N1.0860.97
292_M311_F1.0820.97
104_F126_T1.0820.97
353_S356_E1.0800.97
220_I232_K1.0780.97
278_D359_A1.0780.97
206_Y342_I1.0770.97
190_N263_V1.0700.97
53_K57_Y1.0570.97
219_A244_K1.0570.97
272_V291_I1.0570.97
297_R360_D1.0550.97
109_N124_E1.0550.97
373_P377_K1.0540.97
85_L107_A1.0490.97
315_V363_I1.0420.96
331_V384_M1.0400.96
219_A247_S1.0330.96
178_S303_V1.0250.96
108_L125_P1.0180.96
221_Y224_R1.0120.96
50_D54_V1.0120.96
248_L267_L1.0100.96
171_L282_F1.0060.96
167_T203_L1.0050.96
113_V143_I1.0010.96
152_N334_T0.9970.95
276_A279_P0.9910.95
213_M220_I0.9900.95
210_D242_D0.9870.95
110_T119_T0.9840.95
206_Y346_E0.9810.95
358_S361_Y0.9750.95
333_A340_M0.9540.94
297_R359_A0.9530.94
180_K185_I0.9460.94
44_C73_V0.9450.94
130_V153_I0.9390.94
188_V251_V0.9390.94
351_L374_A0.9370.94
272_V295_D0.9360.94
68_T107_A0.9320.93
297_R304_V0.9290.93
55_Y332_R0.9260.93
351_L368_D0.9250.93
46_D53_K0.9230.93
221_Y226_N0.9220.93
334_T388_V0.9220.93
173_N349_A0.9190.93
52_N332_R0.9150.93
48_H84_A0.9150.93
176_K350_S0.9120.93
383_A388_V0.9100.93
180_K256_D0.9070.93
269_K272_V0.9070.93
354_E358_S0.9040.92
59_M63_M0.9030.92
243_R246_G0.8990.92
327_G379_V0.8990.92
296_A302_S0.8980.92
332_R391_I0.8960.92
249_K252_I0.8940.92
190_N248_L0.8930.92
109_N125_P0.8870.92
197_I213_M0.8870.92
190_N258_F0.8870.92
112_D115_K0.8860.92
228_M233_N0.8850.92
171_L280_I0.8840.92
323_G327_G0.8780.91
269_K299_A0.8760.91
297_R300_G0.8760.91
175_L182_M0.8760.91
110_T116_I0.8730.91
20_S104_F0.8720.91
296_A300_G0.8710.91
115_K119_T0.8700.91
267_L271_M0.8690.91
205_H342_I0.8650.91
175_L180_K0.8650.91
335_H388_V0.8640.91
263_V266_A0.8640.91
29_A365_A0.8580.90
219_A246_G0.8560.90
55_Y123_L0.8540.90
214_C248_L0.8510.90
45_K49_E0.8500.90
337_N340_M0.8490.90
275_M281_I0.8430.90
45_K288_N0.8410.89
188_V255_A0.8400.89
372_A376_A0.8380.89
296_A304_V0.8370.89
166_V320_A0.8340.89
178_S302_S0.8300.89
67_V108_L0.8300.89
12_K57_Y0.8260.89
187_V257_V0.8260.89
144_E161_H0.8230.88
27_R30_K0.8230.88
189_A259_I0.8180.88
213_M235_V0.8160.88
352_V361_Y0.8160.88
328_A340_M0.8130.88
186_K210_D0.8130.88
217_K226_N0.8080.87
40_V44_C0.8080.87
154_P328_A0.8070.87
333_A379_V0.8060.87
327_G331_V0.8040.87
216_S224_R0.8020.87
293_P297_R0.8010.87
224_R228_M0.7990.87
59_M104_F0.7970.87
350_S374_A0.7970.87
185_I256_D0.7950.87
342_I346_E0.7940.87
97_S100_G0.7940.87
85_L126_T0.7920.86
222_E242_D0.7920.86
327_G383_A0.7910.86
108_L116_I0.7900.86
282_F305_G0.7870.86
188_V214_C0.7860.86
327_G333_A0.7840.86
165_I341_K0.7820.86
145_E148_K0.7810.86
97_S369_K0.7750.85
344_A375_V0.7750.85
22_S93_V0.7740.85
22_S97_S0.7730.85
182_M185_I0.7730.85
247_S251_V0.7720.85
108_L113_V0.7720.85
265_G288_N0.7710.85
252_I271_M0.7700.85
197_I231_V0.7690.85
186_K244_K0.7650.84
372_A375_V0.7640.84
212_V237_K0.7640.84
212_V251_V0.7600.84
225_P228_M0.7570.84
350_S353_S0.7540.84
353_S357_L0.7530.83
43_P57_Y0.7530.83
221_Y245_D0.7500.83
28_N367_F0.7490.83
145_E231_V0.7490.83
10_L13_V0.7470.83
197_I232_K0.7460.83
282_F315_V0.7430.83
186_K253_V0.7430.83
175_L178_S0.7420.83
339_E382_A0.7420.83
350_S378_A0.7420.83
277_K301_A0.7410.83
116_I119_T0.7400.82
226_N233_N0.7400.82
284_M305_G0.7390.82
197_I229_N0.7370.82
117_V132_L0.7370.82
347_A350_S0.7360.82
229_N232_K0.7350.82
272_V296_A0.7340.82
331_V389_A0.7340.82
29_A367_F0.7320.82
219_A252_I0.7290.81
37_S308_R0.7270.81
195_A199_I0.7260.81
142_I145_E0.7250.81
145_E234_E0.7250.81
202_L345_V0.7190.81
214_C251_V0.7180.80
14_N19_E0.7140.80
384_M392_T0.7110.80
121_K153_I0.7100.80
26_V93_V0.7090.80
214_C219_A0.7070.79
354_E374_A0.7070.79
60_K126_T0.7050.79
194_A232_K0.7050.79
343_A382_A0.7040.79
265_G292_M0.7020.79
117_V130_V0.7000.79
40_V76_L0.6970.79
237_K251_V0.6970.79
178_S185_I0.6970.79
99_A372_A0.6950.78
67_V107_A0.6950.78
10_L34_L0.6940.78
55_Y61_G0.6920.78
305_G362_V0.6920.78
293_P306_T0.6910.78
113_V139_N0.6880.78
222_E233_N0.6870.78
189_A213_M0.6870.78
119_T123_L0.6850.77
347_A374_A0.6840.77
211_I360_D0.6830.77
186_K255_A0.6810.77
254_D276_A0.6810.77
380_A384_M0.6800.77
288_N295_D0.6800.77
324_I328_A0.6780.77
172_V182_M0.6780.77
213_M229_N0.6780.77
237_K243_R0.6780.77
60_K332_R0.6780.77
44_C76_L0.6760.76
176_K357_L0.6720.76
196_G284_M0.6710.76
81_P109_N0.6680.76
167_T199_I0.6680.76
96_K102_D0.6660.75
174_A177_L0.6650.75
324_I336_I0.6630.75
109_N112_D0.6630.75
152_N390_R0.6620.75
206_Y345_V0.6620.75
177_L359_A0.6560.74
63_M126_T0.6540.74
71_T139_N0.6520.74
182_M206_Y0.6510.74
82_E125_P0.6510.74
252_I255_A0.6480.73
201_K338_E0.6470.73
179_G183_S0.6460.73
106_I120_V0.6460.73
248_L258_F0.6440.73
220_I226_N0.6440.73
117_V143_I0.6430.73
188_V253_V0.6430.73
20_S63_M0.6430.73
108_L122_L0.6430.73
171_L187_V0.6390.72
177_L303_V0.6380.72
52_N390_R0.6380.72
221_Y246_G0.6360.72
101_V372_A0.6350.72
18_L59_M0.6350.72
114_D142_I0.6340.72
221_Y233_N0.6330.72
339_E385_E0.6310.71
20_S92_A0.6310.71
174_A282_F0.6310.71
378_A381_K0.6310.71
27_R97_S0.6300.71
106_I126_T0.6290.71
211_I235_V0.6280.71
371_V375_V0.6280.71
187_V207_G0.6280.71
223_G245_D0.6270.71
172_V175_L0.6270.71
370_R374_A0.6270.71
47_I83_A0.6260.71
228_M236_A0.6260.71
384_M389_A0.6250.71
203_L259_I0.6250.71
279_P302_S0.6240.70
106_I112_D0.6240.70
186_K212_V0.6210.70
21_K100_G0.6180.70
267_L281_I0.6180.70
65_A120_V0.6170.70
230_D234_E0.6150.69
115_K122_L0.6150.69
244_K251_V0.6140.69
381_K384_M0.6130.69
331_V383_A0.6120.69
37_S68_T0.6120.69
190_N267_L0.6120.69
244_K247_S0.6110.69
10_L14_N0.6110.69
70_G80_G0.6100.69
165_I320_A0.6070.68
220_I236_A0.6050.68
69_D81_P0.6050.68
129_G336_I0.6050.68
30_K34_L0.6050.68
210_D244_K0.6020.68
223_G228_M0.6020.68
94_L318_V0.6000.68
72_A137_A0.5990.67
76_L79_I0.5990.67
200_I235_V0.5980.67
201_K204_H0.5980.67
175_L280_I0.5970.67
62_N330_D0.5970.67
252_I258_F0.5970.67
366_P372_A0.5970.67
23_K59_M0.5960.67
205_H339_E0.5950.67
220_I224_R0.5950.67
64_V325_F0.5950.67
106_I116_I0.5940.67
48_H73_V0.5930.67
67_V116_I0.5930.67
228_M232_K0.5900.66
44_C84_A0.5870.66
72_A76_L0.5860.66
264_A268_T0.5850.66
106_I109_N0.5850.66
187_V203_L0.5850.66
130_V155_V0.5840.65
145_E230_D0.5830.65
300_G304_V0.5820.65
326_R373_P0.5820.65
95_F131_N0.5810.65
294_E297_R0.5810.65
45_K84_A0.5780.65
214_C252_I0.5750.64
192_A220_I0.5740.64
47_I89_E0.5740.64
113_V119_T0.5720.64
168_V182_M0.5720.64
273_Q279_P0.5690.63
19_E23_K0.5680.63
190_N213_M0.5670.63
12_K53_K0.5670.63
145_E201_K0.5640.63
78_N109_N0.5630.63
177_L358_S0.5630.63
192_A216_S0.5610.62
320_A375_V0.5600.62
123_L130_V0.5600.62
66_V103_A0.5600.62
219_A250_D0.5600.62
267_L272_V0.5590.62
136_A142_I0.5590.62
85_L105_P0.5580.62
343_A383_A0.5560.62
348_I371_V0.5560.62
204_H235_V0.5550.62
178_S280_I0.5520.61
292_M304_V0.5520.61
356_E361_Y0.5510.61
354_E357_L0.5500.61
18_L93_V0.5480.61
93_V97_S0.5480.61
343_A346_E0.5480.61
214_C271_M0.5460.60
98_F367_F0.5460.60
131_N156_F0.5450.60
218_G260_G0.5440.60
204_H237_K0.5440.60
233_N236_A0.5420.60
175_L181_S0.5420.60
168_V203_L0.5420.60
221_Y232_K0.5400.59
26_V35_A0.5390.59
120_V130_V0.5380.59
335_H339_E0.5380.59
132_L153_I0.5350.59
62_N326_R0.5350.59
340_M388_V0.5340.59
52_N334_T0.5330.58
208_V257_V0.5330.58
95_F129_G0.5330.58
318_V366_P0.5320.58
105_P323_G0.5310.58
316_N321_F0.5310.58
214_C285_A0.5300.58
273_Q298_E0.5300.58
167_T216_S0.5290.58
208_V211_I0.5280.58
370_R373_P0.5280.58
129_G154_P0.5280.58
347_A378_A0.5270.58
126_T332_R0.5230.57
274_S299_A0.5220.57
219_A243_R0.5220.57
293_P302_S0.5210.57
149_K152_N0.5200.57
37_S321_F0.5190.56
374_A377_K0.5180.56
72_A86_P0.5170.56
286_N317_N0.5170.56
59_M93_V0.5170.56
211_I251_V0.5160.56
219_A223_G0.5160.56
233_N237_K0.5150.56
11_H15_Q0.5140.56
190_N285_A0.5140.56
32_L318_V0.5120.55
175_L208_V0.5120.55
348_I375_V0.5100.55
170_G305_G0.5090.55
293_P296_A0.5090.55
23_K31_D0.5090.55
376_A380_A0.5080.55
228_M231_V0.5070.55
211_I237_K0.5070.55
170_G313_N0.5060.55
14_N23_K0.5060.55
12_K15_Q0.5060.55
66_V131_N0.5060.55
173_N362_V0.5050.54
101_V326_R0.5040.54
221_Y243_R0.5040.54
172_V349_A0.5040.54
77_G80_G0.5030.54
111_N116_I0.5030.54
251_V255_A0.5020.54
59_M92_A0.5010.54
383_A389_A0.5010.54
121_K130_V0.5000.54
343_A378_A0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o0sA 4 0.9829 100 0.126 Contact Map
1gq2A 6 0.9829 100 0.131 Contact Map
1pj3A 4 0.9902 100 0.135 Contact Map
3nv9A 2 0.9951 100 0.213 Contact Map
1vl6A 4 0.9098 100 0.29 Contact Map
2a9fA 2 0.9293 100 0.368 Contact Map
2dvmA 2 0.9878 100 0.391 Contact Map
1v8bA 4 0.8659 100 0.808 Contact Map
4ppmA 2 0.0415 99.9 0.85 Contact Map
4xijA 1 0.6146 99.6 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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